The RNA-binding protein HuR/ELAVL1 regulates IFN-β mRNA abundance and the type I IFN response.

abstract：:We have previously identified a molecule on the T cell surface, which, in addition to CD2 is involved in the rosette phenomenon. This is a 32-kDa single polypeptide chain which we have termed E2. The studies reported here show striking patterns on the glycosylation status of E2. It is a heavily sialylated and glycosyl...

journal_title：European journal of immunology

authors： Aubrit F,Gelin C,Pham D,Raynal B,Bernard A

更新日期：1989-08-01 00:00:00

abstract：:Age-associated thymic involution results in a diminished capacity to regenerate T cell populations, although the magnitude of this effect is unknown. In this report, thymic function was studied in aged vs. young adult mice after lethal irradiation and administration of T cell-depleted bone marrow (BM) from young mice....

journal_title：European journal of immunology

authors： Mackall CL,Punt JA,Morgan P,Farr AG,Gress RE

更新日期：1998-06-01 00:00:00

abstract：:Specific members of the Rho family of GTPases exert unique influences on thymocyte proliferation, differentiation and deletion. Dbs is a guanine nucleotide exchange factor which is expressed throughout thymocyte development and is able to activate the Rho family GTPases CDC42, RhoA and RhoG. Transgenic mice expressing...

journal_title：European journal of immunology

authors： Klinger MB,Guilbault B,Kay RJ

更新日期：2004-03-01 00:00:00

abstract：:DC-based vaccination against Leishmania major induces a parasite-specific Th1 response and long-lasting protective immunity in susceptible mice. Since distinct DC subsets have been proposed to direct the predominant development of either Th1 or Th2 cells, we analyzed the capability of plasmacytoid DC (pDC) to induce p...

journal_title：European journal of immunology

authors： Remer KA,Apetrei C,Schwarz T,Linden C,Moll H

更新日期：2007-09-01 00:00:00

abstract：:Mast cells are important cellular constituents of epithelial-mesenchymal interactions, densely located at sites of microbial entry into the host where they are continuously exposed to products from commensals. In order to avoid excessive activation and the associated pathology, mast cell responses to TLR agonists must...

journal_title：European journal of immunology

authors： Sandig H,Jobbings CE,Roldan NG,Whittingham-Dowd JK,Orinska Z,Takeuchi O,Akira S,Bulfone-Paus S

更新日期：2013-04-01 00:00:00

abstract：:The invariant chain (Ii) binds to newly synthesized major histocompatibility complex (MHC) class II molecules and is targeted to an acidic compartment where it is degraded. To evaluate its role on the conformation and the subcellular distribution of murine MHC class II molecules we have established stable L cell trans...

journal_title：European journal of immunology

authors： Humbert M,Raposo G,Cosson P,Reggio H,Davoust J,Salamero J

更新日期：1993-12-01 00:00:00

abstract：:Continuous antigen stimulation of CD4(+)CD25(-) T cells leads to generation of adaptive CD4(+)CD25(+)FOXP3(+) regulatory T (T(R)) cells. Here, we show that highly suppressive adaptive CD8(+)CD25(+)FOXP3(+) T cells can be generated in the same manner by continuous antigen stimulation in the presence of CD14(+) monocyte...

journal_title：European journal of immunology

authors： Mahic M,Henjum K,Yaqub S,Bjørnbeth BA,Torgersen KM,Taskén K,Aandahl EM

更新日期：2008-03-01 00:00:00

abstract：:Interferon regulatory factor-1 (IRF-1) is a transcription factor regulating the expression of several cytokines. Using IRF-1 knockout (KO) mice, the role of IRF-1 in the production and activity of IL-18 was evaluated. Administration of IL-12 or concanavalin A significantly increased levels of circulating IL-18 in wild...

journal_title：European journal of immunology

authors： Fantuzzi G,Reed D,Qi M,Scully S,Dinarello CA,Senaldi G

更新日期：2001-02-01 00:00:00

abstract：:To elucidate the rapid destruction of allogeneic bone marrow (BM) grafts in nonsensitized rats we have assessed: (a) the 21-h tissue localization of 51Cr-labeled allogeneic vs. syngeneic BM cells, (b) the ability of allogeneic BM cells to proliferate in the BM or irradiated recipients, (c) the survival of allogeneic v...

journal_title：European journal of immunology

authors： Rolstad B,Benestad HB

更新日期：1984-09-01 00:00:00

abstract：:A major contributing factor to the final magnitude and breadth of CD8(+) T-cell responses to complex antigens is immunodomination, where CD8(+) T cells recognizing their cognate ligand inhibit the proliferation of other CD8(+) T cells engaged with the same APC. In this study, we examined how the half-life of cell s...

journal_title：European journal of immunology

authors： Galea I,Stasakova J,Dunscombe MS,Ottensmeier CH,Elliott T,Thirdborough SM

更新日期：2012-01-01 00:00:00

abstract：:The activation requirements for antigen-dependent proliferation of CD4+ T cells are well documented, while the events leading to the inactivation phase are poorly understood. Here, we tested the hypothesis that the lymphocyte-activation gene 3 (LAG-3), a second major histocompatibility complex (MHC) class II ligand, p...

journal_title：European journal of immunology

authors： Huard B,Tournier M,Hercend T,Triebel F,Faure F

更新日期：1994-12-01 00:00:00

abstract：:X-linked agammaglobulinemia (XLA) is a primary immunodeficiency of the B-cell compartment caused by a defective gene encoding for the tyrosine kinase (btk) essential for B cell differentiation. Affected males undergo recurrent pyogenic infections and deficient immunoglobulin production. Peripheral blood T cells from 6...

journal_title：European journal of immunology

authors： Amedei A,Romagnani C,Benagiano M,Azzurri A,Fomia F,Torrente F,Plebani A,D'Elios MM,Del Prete G

更新日期：2001-06-01 00:00:00

abstract：:CSF1R (colony stimulating factor 1 receptor) is the main receptor for CSF1 and has crucial roles in regulating myelopoeisis. CSF1R can be proteolytically released from the cell surface by ADAM17 (A disintegrin and metalloprotease 17). Here, we identified CSF1R as a major substrate of ADAM17 in an unbiased degradomics ...

journal_title：European journal of immunology

authors： Qing X,Rogers L,Mortha A,Lavin Y,Redecha P,Issuree PD,Maretzky T,Merad M,McIlwain D,Mak TW,Overall CM,Blobel CP,Salmon JE

更新日期：2016-12-01 00:00:00

abstract：:Intravenous immunoglobulin G (IVIg) therapy is widely used to treat autoimmune and inflammatory diseases. Recent evidence suggests that in mice, splenic resident cells might be important for the anti-inflammatory activity of IVIg in a model of serum transfer arthritis. Splenectomized human immunothrombocytopenia (ITP)...

journal_title：European journal of immunology

authors： Schwab I,Biburger M,Krönke G,Schett G,Nimmerjahn F

更新日期：2012-04-01 00:00:00

abstract：:Antigen-induced stimulation of T cells is mediated via the CD3 antigen receptor (Ti) complex and monoclonal antibodies (mAb) reacting with CD3 and Ti result in rapid intracellular Ca2+ mobilization, followed by monocyte-dependent proliferation. Combinations of mAb to CD2, the sheep red blood cell receptor, also mobili...

journal_title：European journal of immunology

authors： O'Flynn K,Knott LJ,Russul-Saib M,Abdul-Gaffar R,Morgan G,Beverley PC,Linch DC

更新日期：1986-05-01 00:00:00

abstract：:IL-33 is a novel multi-functional IL-1 family member that, in contrast to other family members, is associated with Th2 responses. IL-33 signals via a heterodimer composed of its receptor, IL-1 receptor-like-1 (IL-1RL1), more commonly known as ST2L, and the IL-1R accessory protein. ST2L is expressed by endothelial cell...

journal_title：European journal of immunology

authors： Turnquist HR,Thomson AW

更新日期：2009-12-01 00:00:00

abstract：:The activating NK cell receptor NKG2D binds to numerous stress-induced cell surface glycoproteins with MHC class I-related ectodomains. In humans, NKG2D ligands (NKG2DL) are members of the MHC-encoded MIC and non-MHC-encoded ULBP families of proteins. The redundancy of NKG2DL raises questions about unique features ass...

journal_title：European journal of immunology

authors： Wittenbrink M,Spreu J,Steinle A

更新日期：2009-06-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are chronic conditions that result from uncontrolled intestinal inflammation. Pathogenic Th17 cells, characterized by production of IL-17A in the absence of IL-10, are thought to contribute to this inflammation, but in humans, antibody-mediated blockade of IL-17A is an ineffective IBD...

journal_title：European journal of immunology

authors： Boardman DA,Garcia RV,Ivison SM,Bressler B,Dhar TM,Zhao Q,Levings MK

更新日期：2020-09-01 00:00:00

abstract：:Beside diabetes, non-obese diabetic (NOD) mice develop sporadic lymphoid infiltration of the thyroid gland, mimicking Hashimoto's thyroiditis. We have examined the prevalence of those manifestations in NOD mice, the influence of the major histocompatibility complex (MHC) and the association with autoantibodies. The in...

journal_title：European journal of immunology

authors： Damotte D,Colomb E,Cailleau C,Brousse N,Charreire J,Carnaud C

更新日期：1997-11-01 00:00:00

abstract：:Th cells can adopt a number of different phenotypes. We performed microarray-assisted mRNA profiling on antigen-stimulated, TCR transgenic murine splenocytes that were cultured in the presence of cytokines. Transcriptome snapshots of Th cells differentiating into Th1 and Th2 phenotypes were obtained at various time po...

journal_title：European journal of immunology

authors： van den Ham HJ,de Waal L,Zaaraoui-Boutahar F,Bijl M,van Ijcken WF,Osterhaus AD,de Boer RJ,Andeweg AC

更新日期：2013-04-01 00:00:00

abstract：:Vitamin A deficiency is known to be accompanied with immune deficiency and susceptibility to a wide range of infectious diseases. Experimental evidence suggests that the active metabolites of vitamin A that mediate its effects on the immune system are the retinoic acids (RA), which are ligands for the nuclear RA recep...

journal_title：European journal of immunology

authors： Kiss I,Rühl R,Szegezdi E,Fritzsche B,Tóth B,Pongrácz J,Perlmann T,Fésüs L,Szondy Z

更新日期：2008-01-01 00:00:00

abstract：:Site-directed mutagenesis of a recombinant Fc hinge fragment has recently been used to localize the site of the mouse IgG1 (mIgG1) molecule that is involved in the intestinal transfer of recombinant Fc hinge fragments in neonatal mice. This site encompasses Ile-253, His-310, Gln-311, His-433 and Asn-434, localized at ...

journal_title：European journal of immunology

authors： Medesan C,Radu C,Kim JK,Ghetie V,Ward ES

更新日期：1996-10-01 00:00:00

abstract：:For long-term attack on tumor cells in patients with prostate cancer, induction of cytolytic T cells is desirable. Several lineage-specific target proteins are known and algorithms have identified candidate MHC class I-binding peptides, particularly for HLA-A*0201. We have designed tolerance-breaking DNA fusion vaccin...

journal_title：European journal of immunology

authors： Vittes GE,Harden EL,Ottensmeier CH,Rice J,Stevenson FK

更新日期：2011-08-01 00:00:00

abstract：:Reciprocal induction of the Th1 and Th17 immune responses is essential for optimal protection against Mycobacterium tuberculosis (Mtb); however, only a few Mtb antigens are known to fulfill this task. A functional role for resuscitation-promoting factor (Rpf) E, a latency-associated member of the Rpf family, in promot...

journal_title：European journal of immunology

authors： Choi HG,Kim WS,Back YW,Kim H,Kwon KW,Kim JS,Shin SJ,Kim HJ

更新日期：2015-07-01 00:00:00

abstract：:The role of TGF-beta1 in the regulation of T cell responses has been perplexing, possibly because it is dependent on the type of T cell being regulated and its cytokine microenvironment. In the present study, we demonstrate that TGF-beta1 has a profound inhibitory effect on naive CD4+ T cell undergoing differentiation...

journal_title：European journal of immunology

authors： Lúdvíksson BR,Seegers D,Resnick AS,Strober W

更新日期：2000-07-01 00:00:00

abstract：:A specialized subpopulation of T lymphocytes is reactive to the MHC class I-like molecule CD1d. It is not clear which cells are the major antigen-presenting cells in vivo in the activation of CD1-restricted immune responses. We have characterized a subset of B lymphocytes expressing six- to eightfold higher levels of ...

journal_title：European journal of immunology

authors： Makowska A,Faizunnessa NN,Anderson P,Midtvedt T,Cardell S

更新日期：1999-10-01 00:00:00

abstract：:Majority of HIV-2-infected individuals meet the criteria of long-term non-progressors. This has been linked to superior qualitative HIV-2-specific cellular immune responses that correlate with viral control. However, it is unknown whether this is due to frequent targeting of immunodominant Gag epitopes in HIV-2 than H...

journal_title：European journal of immunology

authors： Ondondo BO,Rowland-Jones SL,Dorrell L,Peterson K,Cotten M,Whittle H,Jaye A

更新日期：2008-12-01 00:00:00

abstract：:Plasticity and heterogeneity are hallmarks of myelomonocytic differentiation and polarized activation. Evidence published in this issue of the European Journal of Immunology, together with other recent data, add new elements and perspectives to the current understanding of mononuclear phagocyte differentiation and act...

journal_title：European journal of immunology

authors： Mantovani A,Sica A,Locati M

更新日期：2007-01-01 00:00:00

abstract：:Interleukin (IL)-4-transgenic mice were used as a model system to study the consequences of low levels of IL-4 expression for the expression of other cytokines examined by quantitative polymerase chain reaction (PCR). For this purpose, a plasmid was constructed which contains, in tandem array, 5' and 3' primer sequenc...

journal_title：European journal of immunology

authors： Platzer C,Richter G,Uberla K,Müller W,Blöcker H,Diamantstein T,Blankenstein T

更新日期：1992-05-01 00:00:00

abstract：:The role of mineralocorticoid receptors (MRs) in human T-cell migration is not yet understood. We have recently shown that the MR antagonist spironolactone selectively increases the numbers of circulating naïve and central memory T cells during early sleep, which is the time period in the 24 h cycle hallmarked by pred...

journal_title：European journal of immunology

authors： Besedovsky L,Linz B,Born J,Lange T

更新日期：2014-06-01 00:00:00