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Recombinant CD40 ligand stimulation of murine B cell growth and differentiation: cooperative effects of cytokines.

Abstract：

:The ligand for the B cell surface antigen CD40 was recently cloned from a murine thymoma cDNA library and shown to be expressed on activated T cells. In this study, we investigate the biological effects of murine recombinant CD40 ligand. The recombinant CD40 ligand expressed on the CV-1/EBNA monkey fibroblast cell line directly activated resting B cell to express elevated levels of cell surface class II major histocompatibility complex and CD23 molecules. CD40 ligand also stimulated B cell proliferation, reaching maximal levels on day 2 of culture and declining thereafter. This effect was positively regulated by other cytokines, most notably interleukin (IL)-4 and IL-5. By itself, CD40 ligand had no effect upon immunoglobulin secretion by B cells. However, when B cells were treated with CD40 ligand plus cytokines, immunoglobulin secretion was stimulated in a cytokine-dependent and isotype-specific manner. IL-4 was a potent co-stimulator of IgE and IgG1 in the presence of CD40 ligand, and IL-5 acted synergistically with IL-4 in these responses as well as in IgM and IgG3 production. Taken together, the results indicate that CD40 ligand is a potent regulatory molecule for B cell growth and differentiation, and its activities are potentiated in a cytokine-specific manner.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Maliszewski CR,Grabstein K,Fanslow WC,Armitage R,Spriggs MK,Sato TA

doi

10.1002/eji.1830230510

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

1044-9

issue

5

eissn

0014-2980

issn

1521-4141

journal_volume

23

pub_type

杂志文章

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