Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells.

abstract：:IFN-gamma plays a crucial role in the defense against infection with Candida albicans. Since IL-18 and IL-12 are strong stimuli of IFN-gamma production, we investigated whether endogenous IL-18 and IL-12 are involved in the host defense during disseminated candidiasis. IL-18 knockout (IL-18-/-) mice, but not IL-12-/- ...

journal_title：European journal of immunology

authors： Netea MG,Vonk AG,van den Hoven M,Verschueren I,Joosten LA,van Krieken JH,van den Berg WB,Van der Meer JW,Kullberg BJ

更新日期：2003-12-01 00:00:00

abstract：:Antigen-free (AGF) and germ-free (GF) mice, although essentially free of serum IgG, maintain normal levels of circulating IgM. Using a quantitative immunoblot assay, we have now analyzed the repertoire of serum IgM from AGF, GF, and specific pathogen-free (SPF) BALB/c mice, on large panels of natural antigens from hom...

journal_title：European journal of immunology

authors： Haury M,Sundblad A,Grandien A,Barreau C,Coutinho A,Nobrega A

更新日期：1997-06-01 00:00:00

abstract：:Durch Pflanzenkrankheiten entstehen weltweit hohe Ernteverluste. Eine der häufigsten Infektionen in der Familie der Kreuzb&luml;tengewächse wird durch den Pilz Plasmodiophora brassicae verursacht. Die Krankheit äußert sich in Form von Wurzeltumoren, den "Kohlherniegallen". Da es auf verseuchten Böden zu hohen Ernteaus...

journal_title：European journal of immunology

authors： Ludwig-Müller J

更新日期：2000-01-01 00:00:00

abstract：:Dendritic cells (DC) are extremely proficient inducers of naïve CD4+ T cell activation due to their high expression level of peptide-MHC and an array of accessory molecules involved in cell migration, adhesion and co-signaling, including PD-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). Whether PD-L1 and PD-L2 have a s...

journal_title：European journal of immunology

authors： Kuipers H,Muskens F,Willart M,Hijdra D,van Assema FB,Coyle AJ,Hoogsteden HC,Lambrecht BN

更新日期：2006-09-01 00:00:00

abstract：:Bispecific antibodies binding to the TCR/CD3 complex and to a tumor-associated surface molecule can be used to target cytotoxic T lymphocytes against tumor cells. We reasoned that high-affinity binding to CD3 may reduce the efficiency of T cell stimulation and target the bispecific reagent to T cells rather than to tu...

journal_title：European journal of immunology

authors： Bortoletto N,Scotet E,Myamoto Y,D'Oro U,Lanzavecchia A

更新日期：2002-11-01 00:00:00

abstract：:NK cells are the main cells of the innate immune system that produce IFN-γ, and they express this cytokine at early stages of maturation in response to cytokine stimulation. Conversely, acquisition of IFN-γ-competence in CD4(+) T helper cells requires a differentiation process from naïve toward type 1 (Th1) cells, whi...

journal_title：European journal of immunology

authors： Luetke-Eversloh M,Cicek BB,Siracusa F,Thom JT,Hamann A,Frischbutter S,Baumgrass R,Chang HD,Thiel A,Dong J,Romagnani C

更新日期：2014-07-01 00:00:00

abstract：:Developing T cells undergo distinct selection processes that determine the T cell receptor (TcR) repertoire. One of these processes is positive selection. Positive selection involves the differentiation to mature T cells of thymocytes bearing TcR capable of recognizing antigens in the context of self-major histocompat...

journal_title：European journal of immunology

authors： Carrera AC,Baker C,Roberts TM,Pardoll DM

更新日期：1992-09-01 00:00:00

abstract：:In intestine, neutrophils are recruited in response to bacterial infiltration and their anti-cellular activities contribute to inflammatory bowel diseases. In contrast, little is known regarding the recruitment of MPhi to the intestinal epithelium. Extracellular adenosine and uridine 5'-triphosphate (ATP and UTP) can ...

journal_title：European journal of immunology

authors： Langlois C,Gendron FP

更新日期：2009-10-01 00:00:00

abstract：:The regulation of neutrophil half-life by members of the coagulation cascade is critical for the resolution of the inflammatory response. We have demonstrated that soluble fibrinogen (sFbg) delays human neutrophil (PMN) apoptosis through a mechanism that involves CD11b interactions, and phosphorylation of focal adhesi...

journal_title：European journal of immunology

authors： Rubel C,Gómez S,Fernández GC,Isturiz MA,Caamaño J,Palermo MS

更新日期：2003-05-01 00:00:00

abstract：:As we approach the centenary of Elie Metchnikoff's Nobel Prize (1908), it is opportune to reflect upon the history of macrophage immunobiology, take stock of current knowledge and anticipate questions for the future. Starting from his appreciation of phagocytosis as an important determinant of host defence against inf...

journal_title：European journal of immunology

authors： Gordon S

更新日期：2007-11-01 00:00:00

abstract：:During their development, B and T lymphocytes are thought to undergo several cycles of chromatin remodeling at their antigen receptor loci that serve to regulate access of a common V(D)J recombinase to particular gene segments. We used germ-line transcription and susceptibility to DNasel as markers to examine tissue a...

journal_title：European journal of immunology

authors： Haines BB,Brodeur PH

更新日期：1998-12-01 00:00:00

abstract：:The turnover of mature and immature B cells defined by a range of cell surface markers was investigated by feeding normal or bcl-2-transgenic (bcl-2-Tg) mice 5'-bromo-2-deoxyuridine (BrdUrd) for up to 6 weeks. In peripheral lymphoid tissue, B cells accumulated BrdUrd with a 50% labeling time of 4.3 weeks and a pattern...

journal_title：European journal of immunology

authors： Fulcher DA,Basten A

更新日期：1997-05-01 00:00:00

abstract：:MPhi and DC are key elements in the control of tissue homeostasis and response to insult. In this work, we demonstrate that MPhi and DC are the major producers of the phenylalanine catabolizing enzyme IL-4-induced gene 1 (IL4I1) under inflammatory conditions. IL4I1 was first described in B cells, which indeed can prod...

journal_title：European journal of immunology

authors： Marquet J,Lasoudris F,Cousin C,Puiffe ML,Martin-Garcia N,Baud V,Chereau F,Farcet JP,Molinier-Frenkel V,Castellano F

更新日期：2010-09-01 00:00:00

abstract：:Dendritic cells (DC) are the main orchestrators of specific immune responses. Depending on microbial information they encounter in peripheral tissues, they promote the development of Th1, Th2 or unpolarized Th cell responses. In this study we have investigated the immunomodulatory effect of non-pathogenic intestinal G...

journal_title：European journal of immunology

authors： Smits HH,van Beelen AJ,Hessle C,Westland R,de Jong E,Soeteman E,Wold A,Wierenga EA,Kapsenberg ML

更新日期：2004-05-01 00:00:00

abstract：:In human T lymphocytes a functional complex is formed between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56lck and a phosphoprotein, pp32, a possible common substrate. Here we demonstrate that the previously described pp32 protein is composed of two distinct molecules (pp29 and pp32) in both r...

journal_title：European journal of immunology

authors： Schraven B,Schirren A,Kirchgessner H,Siebert B,Meuer SC

更新日期：1992-07-01 00:00:00

abstract：:The present experiments address functional antibody diversity and clonal distribution in murine available repertoires. IgM-containing supernatants were prepared by unbiased, polyclonal stimulation of resting splenic B cells from C57BL/6 mice, to ensure similar numbers of responding clones/culture and equivalent growth...

journal_title：European journal of immunology

authors： Nobrega A,Grandien A,Haury M,Hecker L,Malanchère E,Coutinho A

更新日期：1998-04-01 00:00:00

abstract：:Role of CD45 in B cell antigen receptor (BcR)-mediated signaling events in mature B cells was examined using BAL-17 and its CD45-negative clones. In the CD45-negative clones, BcR stimulation induced tyrosine phosphorylation almost identical to the parental cells, with a few exceptions of reduced phosphorylation, espec...

journal_title：European journal of immunology

authors： Ogimoto M,Katagiri T,Mashima K,Hasegawa K,Mizuno K,Yakura H

更新日期：1995-08-01 00:00:00

abstract：:The migration of monocytes to sites of inflammation is largely determined by their response to chemokines. Although the chemokine specificities and expression patterns of chemokine receptors are well defined, it is still a matter of debate how cells integrate the messages provided by different chemokines that are conc...

journal_title：European journal of immunology

authors： Kuscher K,Danelon G,Paoletti S,Stefano L,Schiraldi M,Petkovic V,Locati M,Gerber BO,Uguccioni M

更新日期：2009-04-01 00:00:00

abstract：:Bacterial antigens recognized by CD8(+) T cells in the context of MHC class I are thought to play a crucial role in protection against pathogenic intracellular bacteria. Here, we demonstrate the induction of HLA-A*0201-restricted CD8(+) T cell responses against six new high-affinity HLA-A*0201-binding CTL epitopes, en...

journal_title：European journal of immunology

authors： Charo J,Geluk A,Sundbäck M,Mirzai B,Diehl AD,Malmberg KJ,Achour A,Huriguchi S,van Meijgaarden KE,Drijfhout JW,Beekman N,van Veelen P,Ossendorp F,Ottenhoff TH,Kiessling R

更新日期：2001-12-01 00:00:00

abstract：:Tissue factor (TF) is a transmembrane glycoprotein that plays an essential role in hemostasis by activating coagulation. TF is also expressed by monocytes/macrophages as part of the innate immune response to infections. In the current study, we determined the role of TF expressed by myeloid cells during Mycobacterium ...

journal_title：European journal of immunology

authors： Venkatasubramanian S,Tripathi D,Tucker T,Paidipally P,Cheekatla S,Welch E,Raghunath A,Jeffers A,Tvinnereim AR,Schechter ME,Andrade BB,Mackman N,Idell S,Vankayalapati R

更新日期：2016-02-01 00:00:00

abstract：:To investigate the effect of HIV-specific CD8(+) T cells on viral plasma load and disease progression, we enumerated HLA-A2-, B8- and B57-restricted CD8(+) T cells directed against several HIV epitopes in a total of 54 patients by the use of tetrameric HLA-peptide complexes. In patients with high CD4(+) T cell numbers...

journal_title：European journal of immunology

authors： Kostense S,Ogg GS,Manting EH,Gillespie G,Joling J,Vandenberghe K,Veenhof EZ,van Baarle D,Jurriaans S,Klein MR,Miedema F

更新日期：2001-03-01 00:00:00

abstract：:NKp46 is a novel triggering receptor expressed by all human NK cells that is involved in natural cytotoxicity. In this study we show that the surface density of NKp46 may vary in different NK cells and that a precise correlation exists between the NKp46 phenotype of NK clones and their natural cytotoxicity against HLA...

journal_title：European journal of immunology

authors： Sivori S,Pende D,Bottino C,Marcenaro E,Pessino A,Biassoni R,Moretta L,Moretta A

更新日期：1999-05-01 00:00:00

abstract：:Interleukin-HP1 (HP1) is a murine T cell-derived lymphokine, originally described as a growth factor for B cell hybridomas and plasmacytomas, that was recently shown to stimulate growth and differentiation of normal B and T lymphocytes. Here, we describe a cDNA for HP1 that was isolated from a library prepared using m...

journal_title：European journal of immunology

authors： Van Snick J,Cayphas S,Szikora JP,Renauld JC,Van Roost E,Boon T,Simpson RJ

更新日期：1988-02-01 00:00:00

abstract：:Antigenic peptides have been found associated with heat shock proteins (HSP) including cytoplasmic HSP70 and heat shock cognate protein 70 as well as the endoplasmic reticulum-resident glucose-regulated protein 94. Recently, HSP70 transfection has been reported to increase MHC class I cell surface expression and antig...

journal_title：European journal of immunology

authors： Dressel R,Lübbers M,Walter L,Herr W,Günther E

更新日期：1999-12-01 00:00:00

abstract：:The transcriptional repressor Gfi1 is a nuclear zinc-finger protein that is expressed in T cell precursors in the thymus, but is down-regulated in mature, resting T cells. Gfi1 expression rises transiently to levels seen in thymocytes upon antigenic activation. We show here that lack of Gfi1 causes delayed cell cycle ...

journal_title：European journal of immunology

authors： Pargmann D,Yücel R,Kosan C,Saba I,Klein-Hitpass L,Schimmer S,Heyd F,Dittmer U,Möröy T

更新日期：2007-12-01 00:00:00

abstract：:Transcription factors (TFs) regulate cell-type-specific gene expression programs by combinatorial binding to cis-genomic elements, particularly enhancers, subsequently leading to the recruitment of cofactors, and the general transcriptional machinery to target genes. Using data integration of genome-wide TF binding pr...

journal_title：European journal of immunology

authors： Fang Z,Hecklau K,Gross F,Bachmann I,Venzke M,Karl M,Schuchhardt J,Radbruch A,Herzel H,Baumgrass R

更新日期：2015-11-01 00:00:00

abstract：:To study allelic exclusion of TcR genes we analyzed two types (I and II) of TcR beta transgenic mice. T cells derived from both types of mice contained similar amounts of transgenic RNA transcripts; however, surface expression of the transgenic beta chain was drastically reduced in type II compared to type I. In type ...

journal_title：European journal of immunology

authors： Pircher H,Ohashi P,Miescher G,Lang R,Zikopoulos A,Bürki K,Mak TW,MacDonald HR,Hengartner H

更新日期：1990-02-01 00:00:00

abstract：:In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been analyzed. Class II molecules are not expressed in plasma cells because of an active suppression resulting in the abrogation of class II gene transcription. We s...

journal_title：European journal of immunology

authors： Sartoris S,Tosi G,De Lerma Barbaro A,Cestari T,Accolla RS

更新日期：1996-10-01 00:00:00

abstract：:Gradual depletion of CD4+ T cells is a typical characteristic of pathogenic SIV infection. Intriguingly, we find a spontaneous CD4+ T-cell homeostasis in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection. ...

journal_title：European journal of immunology

authors： Zhang MX,Zheng HY,Jiang J,Song JH,Chen M,Xiao Y,Lian XD,Song TZ,Tian RR,Pang W,Zheng YT

更新日期：2018-02-01 00:00:00

abstract：:Antigen-specific human T lymphocytes were selected by adsorption of peripheral blood mononuclear cells on monolayers of antigen-treated autologous monocytes. The enriched cell populations were propagated in interleukin 2-containing medium for 60-80 days. Their activity was tested by a proliferative response against th...

journal_title：European journal of immunology

authors： Barak V,Fuks Z,Galilli N,Treves AJ

更新日期：1983-11-01 00:00:00