Fine specificity of the H-2 linked immune response gene for the gallinaceous lysozymes.

abstract：:The spleen is anatomically and functionally divided into two compartments: the red pulp, where particles are effectively removed from the blood, and the white pulp, where specific immune responses are generated. Here the isolation of white pulp from red pulp is described, allowing a detailed analysis of the cellular c...

journal_title：European journal of immunology

authors： Nolte MA,Hoen EN,van Stijn A,Kraal G,Mebius RE

更新日期：2000-02-01 00:00:00

abstract：:It has long been recognized that T cells in the cerebrospinal fluid (CSF) and other inflammatory compartments cannot be stimulated by mitogen and the reason for this has remained unknown. This question was investigated using mononuclear cells (MNC) isolated from the CSF of subjects with multiple sclerosis and other in...

journal_title：European journal of immunology

authors： Chofflon M,González V,Weiner HL,Hafler DA

更新日期：1989-10-01 00:00:00

abstract：:The variable region nucleotide sequences of seven (five IgM and two IgG) anti-histone monoclonal antibodies from a single MRL/Mp-lpr/lpr mouse have been determined. These antibodies are not clonally related and used diverse V, D and J genes. However, six of the seven antibodies have VH segments encoded by genes from t...

journal_title：European journal of immunology

authors： Monestier M

更新日期：1991-07-01 00:00:00

abstract：:Langerhans cells (LC) are the principal dendritic cell (DC) population in the epidermis of the skin. Owing to their prominent position at the environmental barrier, LC have long been considered to be prototypic sentinel DC. More recently, the precise role of LC in the initiation and control of cutaneous immune respons...

journal_title：European journal of immunology

authors： Kaplan DH,Kissenpfennig A,Clausen BE

更新日期：2008-09-01 00:00:00

abstract：:The lectin leucoagglutinin has been used to induce reactivity to interleukin 2 (IL2) in unseparated spleen cells and in highly purified Lyt-2+ lymph node T cells. Recombinant human IL2 and various other IL2-containing preparations, including concanavalin A-induced spleen cell supernatant, were compared for their capac...

journal_title：European journal of immunology

authors： Vohr HW,Hünig T

更新日期：1985-04-01 00:00:00

abstract：:B1 cells are a subset of B lymphocytes found in many species and are implicated in the development of autoimmunity. B1 cells have previously been shown to be suppressed by the T helper (Th)1 cytokine interferon (IFN)-gamma, and to be stimulated by the Th2 cytokines interleukin (IL)-2, IL-4, IL-5 and IL-10. To examine ...

journal_title：European journal of immunology

authors： Vogel LA,Lester TL,Van Cleave VH,Metzger DW

更新日期：1996-01-01 00:00:00

abstract：:The thymus is a primary lymphoid organ supporting the development of self-tolerant T cells. Key events in T-cell development in the thymus include lineage commitment, selection events, and thymic emigration. This review discusses the proposed role of sphingosine-1-phosphate and its receptors in the emigration of both ...

journal_title：European journal of immunology

authors： Drennan MB,Elewaut D,Hogquist KA

更新日期：2009-04-01 00:00:00

abstract：:Adult, male Lewis rats received a single injection of 5-bromo-2'-deoxyuridine (BrdUrd) i.v. to label proliferating cells in the S phase of the cell cycle. After 1 and 24 h the thymus, bone marrow, blood, spleen, peripheral, cervical and mesenteric lymph nodes as well as Peyer's patches were removed. In cell suspension...

journal_title：European journal of immunology

authors： Westermann J,Ronneberg S,Fritz FJ,Pabst R

更新日期：1989-06-01 00:00:00

abstract：:Mature T cells first appear in the thymus of the mouse a few days before birth, about 7-8 days after the thymus was colonized by stem cells. These mature cells are exported to the peripheral lymphoid organs beginning at about the time of birth, but because the number is very small at this stage, little is known about ...

journal_title：European journal of immunology

authors： Kelly KA,Scollay R

更新日期：1992-02-01 00:00:00

abstract：:Many pathogens are initially encountered in the gut, where the decision is made to mount an immune response or induce tolerance. The mesentric lymph node (mLN) has been shown to be involved in immune response and much more in oral tolerance induction. Furthermore, using an in vivo transplantation model, we showed rece...

journal_title：European journal of immunology

authors： Buettner M,Pabst R,Bode U

更新日期：2011-03-01 00:00:00

abstract：:Chronic skin inflammation resulting from a defective epidermal barrier is a hallmark of atopic dermatitis (AD). We previously demonstrated that mice lacking FGF receptors 1 and 2 in keratinocytes (K5-R1/R2 mice) develop an AD-like chronic dermatitis as a result of an impaired epidermal barrier. Here, we show that γδ T...

journal_title：European journal of immunology

authors： Sulcova J,Maddaluno L,Meyer M,Werner S

更新日期：2015-09-01 00:00:00

abstract：:The multimeric Fc gamma RIIIA (CD16) complex is expressed on the surface of natural killer (NK) cells and is composed of a 50-70-kDa transmembrane glycoprotein Fc gamma receptor (CD16), the T cell receptor (TCR)-zeta chain, and the Fc epsilon RI gamma chain. Cross-linking Fc gamma RIIIA initiates the rapid tyrosine ph...

journal_title：European journal of immunology

authors： Cone JC,Lu Y,Trevillyan JM,Bjorndahl JM,Phillips CA

更新日期：1993-10-01 00:00:00

abstract：:The T cell-dependent differentiation and function of B lymphocytes are tightly regulated by TNF ligands (L) and receptors interactions, such as CD40/CD40L, CD27/CD70 and CD134/CD314L. The LIGHT/HVEM system [homologous to lymphotoxin, inducible expression, competing for GpD of herpes virus, that binds to the herpes vir...

journal_title：European journal of immunology

authors： Duhen T,Pasero C,Mallet F,Barbarat B,Olive D,Costello RT

更新日期：2004-12-01 00:00:00

abstract：:There is a current need for safe, cheap, and effective vaccine adjuvants, to combine with sub-unit antigens to enhance their immunogenicity. In this study we have used probiotic Bacillus subtilis spores, known to be safe and fully tolerated by ingestion in man, and explored their ability to influence the magnitude and...

journal_title：European journal of immunology

authors： Barnes AG,Cerovic V,Hobson PS,Klavinskis LS

更新日期：2007-06-01 00:00:00

abstract：:The human T cell leukemia virus type-1 (HTLV-1) is the etiologic agent of adult T cell leukemia (ATL). Since the HTLV-I-encoded transactivator Tax has been shown to activate many cellular genes including cytokine genes interleukin (IL-)1alpha, 2, 5, 6, 8, 10 and 15, we ask whether Tax also affects IL-4 expression. In ...

journal_title：European journal of immunology

authors： Li-Weber M,Giaisi M,Chlichlia K,Khazaie K,Krammer PH

更新日期：2001-09-01 00:00:00

abstract：:Polymorphonuclear neutrophils (PMN) modulate the adaptive immune response through interactions with immature dendritic cells (iDC) while spontaneous apoptotic neutrophils PMNapo (PMNapo) may have an inhibitory effect on DC functions. We investigate the effect exerted by PMNapo in DC maturation and the role of Mycobact...

journal_title：European journal of immunology

authors： Alemán M,de la Barrera S,Schierloh P,Yokobori N,Baldini M,Musella R,Abbate E,Sasiain M

更新日期：2007-06-01 00:00:00

abstract：:Low zone tolerance (LZT) to contact allergens is induced by epicutaneous exposure to haptens in subsensitizing doses resulting in an inhibition of contact hypersensitivity (CHS), which, in contrast, occurs after sensitization with immunogenic doses of allergens. Performing the protocol of tolerance induction resulted ...

journal_title：European journal of immunology

authors： Seidel-Guyenot W,Alt R,Perschon S,Knop J,Steinbrink K

更新日期：2004-11-01 00:00:00

abstract：:Programmed cell death (PCD) is involved in the physiological regulation of lymphocyte turnover, as well in the antigen-driven selection of T and B cells. Here it is shown that the immunomodulator linomide (quinoline-3-carboxamide) inhibits the apoptotic decay of peripheral T lymphocytes in response to three different ...

journal_title：European journal of immunology

authors： Gonzalo JA,González-García A,Kalland T,Hedlung G,Martínez C,Kroemer G

更新日期：1994-01-01 00:00:00

abstract：:The immunologic mechanisms that protect the fetus from rejection were the subject of numerous investigations. Reports showing the uterus as a favorable site of implantation focused our attention to the decidua which is the maternal tissue intimately attached to fetal structures. Explants of human decidua were cultured...

journal_title：European journal of immunology

authors： Golander A,Zakuth V,Shechter Y,Spirer Z

更新日期：1981-10-01 00:00:00

abstract：:Pairs of monoclonal antibodies (mAb) defining epitopes T 11.1 and T 11.2 on the CD 2 molecule are mitogenic for purified human T cells in the presence of a submitogenic dose of 12-O-tetradecanoylphorbol 13-acetate (TPA). Anti-CD 28 mAb can substitute for the action of TPA in the anti-CD 2-induced proliferative respons...

journal_title：European journal of immunology

authors： Pierrès A,Lopez M,Cerdan C,Nunes J,Olive D,Mawas C

更新日期：1988-05-01 00:00:00

abstract：:The presence of dominant epitopes suppresses generation of CTL activity toward other non-dominant epitopes found on the same antigen-presenting cell (APC). This phenomenon, termed immunodomination, drastically restricts the diversity of the repertoire of CTL responses. Under various experimental conditions we assessed...

journal_title：European journal of immunology

authors： Roy-Proulx G,Meunier MC,Lanteigne AM,Brochu S,Perreault C

更新日期：2001-08-01 00:00:00

abstract：:The biological behavior of immune cells is determined by their intrinsic properties and interactions with other cell populations within their microenvironment. Several studies have confirmed the existence of tight spatial interactions between mast cells (MCs) and Tregs in different settings. For instance, we have rece...

journal_title：European journal of immunology

authors： Frossi B,D'Incà F,Crivellato E,Sibilano R,Gri G,Mongillo M,Danelli L,Maggi L,Pucillo CE

更新日期：2011-07-01 00:00:00

abstract：:Despite accounting for only a minor fraction of all cells in Hodgkin's lymphoma tissue, the Hodgkin and Reed-Sternberg (HRS) cells represent the malignant tumor cell clone in Hodgkin's disease (HD). By far the most abundant cell type in the tumor tissue are CD4+ T cells. Some of them intimately associate with HRS cell...

journal_title：European journal of immunology

authors： Roers A,Montesinos-Rongen M,Hansmann ML,Rajewsky K,Küppers R

更新日期：1998-08-01 00:00:00

abstract：:We have previously shown, through transfection experiments, that the murine B7 (mB7) molecule, a ligand for the CD28 and CTLA-4 receptors, is a sufficient costimulatory signal for the antigen-specific and major histocompatibility complex (MHC)-restricted activation of murine CD4+ T lymphocytes. In addition to mB7, ano...

journal_title：European journal of immunology

authors： Razi-Wolf Z,Falo LD Jr,Reiser H

更新日期：1994-04-01 00:00:00

abstract：:Th cells can adopt a number of different phenotypes. We performed microarray-assisted mRNA profiling on antigen-stimulated, TCR transgenic murine splenocytes that were cultured in the presence of cytokines. Transcriptome snapshots of Th cells differentiating into Th1 and Th2 phenotypes were obtained at various time po...

journal_title：European journal of immunology

authors： van den Ham HJ,de Waal L,Zaaraoui-Boutahar F,Bijl M,van Ijcken WF,Osterhaus AD,de Boer RJ,Andeweg AC

更新日期：2013-04-01 00:00:00

abstract：:Sand fly saliva contains maxadilan, a peptide that causes vasodilation and modifies the secretion of pro-inflammatory cytokines by macrophages. We show that 1 to 10 microg maxadilan protected BALB/c mice against a lethal dose of LPS. Maxadilan reduced serum levels of TNF-alpha by approximately tenfold, while it caused...

journal_title：European journal of immunology

authors： Bozza M,Soares MB,Bozza PT,Satoskar AR,Diacovo TG,Brombacher F,Titus RG,Shoemaker CB,David JR

更新日期：1998-10-01 00:00:00

abstract：:Hypoxia and glucose deprivation are often observed in the microenvironment surrounding solid tumors in vivo. However, how they interfere with MHC class I antigen processing and CD8(+) T-cell responses remains unclear. In this study, we analyzed the production of antigenic peptides presented by classical MHC class I in...

journal_title：European journal of immunology

authors： Sasaki T,Kanaseki T,Shionoya Y,Tokita S,Miyamoto S,Saka E,Kochin V,Takasawa A,Hirohashi Y,Tamura Y,Miyazaki A,Torigoe T,Hiratsuka H,Sato N

更新日期：2016-04-01 00:00:00

abstract：:The development of preventive or therapeutic recombinant vaccines and the generation of serodiagnostic assays for infectious diseases depend essentially on the availability of molecularly defined antigens. A major bottleneck for the identification of suitable target antigens for many pathogens is the isolation of suff...

journal_title：European journal of immunology

authors： Sahin U,Türeci O,Graf C,Meyer RG,Lennerz V,Britten CM,Dumrese C,Scandella E,Wölfel T,Ludewig B

更新日期：2006-04-01 00:00:00

abstract：:FoxP3(+) Treg cells and anergic T cells are the two regulatory phenotypes of T-cell responses associated with helminth infection. Here, we examine the T-cell responses in mice during Fasciola hepatica infection, and to its tegumental coat antigens (FhTeg) that are shed from the fluke every 2-3 h. FhTeg comprises a ric...

journal_title：European journal of immunology

authors： Aldridge A,O'Neill SM

更新日期：2016-05-01 00:00:00

abstract：:The pathways leading to activation of mucosal lamina propria (LP) T cells differ from those of peripheral T cells. LP T cells exhibit enhanced IFN-gamma secretion when activated through the CD2 pathway. This study demonstrates CD2 signaling is followed by activation of STAT proteins in both peripheral blood mononuclea...

journal_title：European journal of immunology

authors： Gonsky R,Deem RL,Young HA,Targan SR

更新日期：2003-05-01 00:00:00