Spontaneous or Mycobacterium tuberculosis-induced apoptotic neutrophils exert opposite effects on the dendritic cell-mediated immune response.

abstract：:Chemokines are chemotactic cytokines with a key role in the control of cell trafficking and positioning under homeostatic and inflammatory conditions. D6 is a promiscuous 7-transmembrane-domain receptor expressed on lymphatic vessels which recognizes most inflammatory, but not homeostatic, CC chemokines. In vitro expe...

journal_title：European journal of immunology

authors： Martinez de la Torre Y,Locati M,Buracchi C,Dupor J,Cook DN,Bonecchi R,Nebuloni M,Rukavina D,Vago L,Vecchi A,Lira SA,Mantovani A

更新日期：2005-05-01 00:00:00

abstract：:In the lung, dendritic cells (DC) are key antigen-presenting cells capable of triggering specific cellular responses to inhaled pathogens, and thus, they may be important in the initiation of an early response to mycobacterial infections. The ability of DC to enhance antigen presentation to naive T cells within the lu...

journal_title：European journal of immunology

authors： Demangel C,Bean AG,Martin E,Feng CG,Kamath AT,Britton WJ

更新日期：1999-06-01 00:00:00

abstract：:Mycoplasma arthritidis produces in culture a polyclonal mitogen which is active for murine and human T lymphocytes in the presence of accessory cells (AC). We studied the requirements for processing and presentation by AC of Mycoplasma arthritidis supernatant (MAS) mitogen to human T cells. As inhibitors of AC process...

journal_title：European journal of immunology

authors： Bauer A,Rutenfranz I,Kirchner H

更新日期：1988-12-01 00:00:00

abstract：:F liver protein occurs in serum at low concentration, and therefore induces tolerance of self only in T cells. T cells which mature in cultured thymus lobes in the absence of this protein become reactive towards it but can be prevented from doing so by exposure to the protein while in culture. The threshold of toleran...

journal_title：European journal of immunology

authors： Robertson K,Simon K,Schneider S,Timms E,Mitchison A

更新日期：1992-01-01 00:00:00

abstract：:The present study tests whether the specific inhibition of helper T (Th) cell (and T hybridomas) by suppressor T (Ts) cells is a phenotypic trait of Th cells correlating with their acquired specificity for antigen/major histocompatibility complex or a genotypic trait not related to selection of the T cell repertoire f...

journal_title：European journal of immunology

authors： Araneo BA,Dowell T,Bertelsen K

更新日期：1988-04-01 00:00:00

abstract：:It is widely believed that IL-4 exerts its influence by profiling the immune response during priming and expansion of immune cells, and thereby modulates the outcome of chronic inflammation. In the present investigation, collagen antibody-induced arthritis (CAIA) was used to delineate the role of IL-4 in a T cell-inde...

journal_title：European journal of immunology

authors： Nandakumar KS,Holmdahl R

更新日期：2006-06-01 00:00:00

abstract：:Analysis of mice transgenic for immunoglobulin genes should allow definition of the cis-acting DNA sequences required to target somatic mutation to antibody V genes. We have looked for mutations in a chimeric kappa transgene encoding a V region specific for the hapten 2-phenyloxazolone (phOx) linked to a rat C kappa g...

journal_title：European journal of immunology

authors： Sharpe MJ,Neuberger M,Pannell R,Surani MA,Milstein C

更新日期：1990-06-01 00:00:00

abstract：:Leishmaniasis is currently classified as category 1 disease, i.e. emerging and uncontrolled. Since the importance of persistent infection for maintaining an effective long-lasting protective response is controversial, the present study asks whether immunisation with non-persistent parasites leads to protection against...

journal_title：European journal of immunology

authors： Kedzierski L,Curtis JM,Doherty PC,Handman E,Kedzierska K

更新日期：2008-11-01 00:00:00

abstract：:We have followed the fate of mature CD8+ T cells with a male-specific transgenic T cell receptor after antigenic stimulation with hemopoietic cells in the absence or presence of help. Our data show that mature CD8+ T cells can be deleted after a 3-week period of transient activation and that help, e.g. in the form of ...

journal_title：European journal of immunology

authors： Kirberg J,Bruno L,von Boehmer H

更新日期：1993-08-01 00:00:00

abstract：:Leukocyte adhesion deficiency (LAD) is a recessive autosomal disease characterized by life-threatening recurrent bacterial infections, by defective functions of leukocytes and by deficient membrane expression of leukocyte adhesion glycoproteins. These proteins, LFA-1, Mac-1 and p150,95, are alpha 1/beta 1 heterodimers...

journal_title：European journal of immunology

authors： Dimanche-Boitrel MT,Guyot A,De Saint-Basile G,Fischer A,Griscelli C,Lisowska-Grospierre B

更新日期：1988-10-01 00:00:00

abstract：:Macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19 are members of the CC chemokine subfamily which exert their effects through specific receptors, CCR6 and CCR7, respectively. Previously, we have reported that human neutrophils have the capacity to produce a number of chemokines, including I...

journal_title：European journal of immunology

authors： Scapini P,Laudanna C,Pinardi C,Allavena P,Mantovani A,Sozzani S,Cassatella MA

更新日期：2001-07-01 00:00:00

abstract：:A survey of KIR2DL4 polymorphism revealed seven common sequences in the Australian population. The seven sequences encode three different amino acid sequences of the immunoglobulin domains. Two of the sequences encoding different amino acid sequences in the immunoglobulin domains also occur on some chromosomes with a ...

journal_title：European journal of immunology

authors： Witt CS,Whiteway JM,Warren HS,Barden A,Rogers M,Martin A,Beilin L,Christiansen FT

更新日期：2002-01-01 00:00:00

abstract：:The effect of anti-Ia antibody on the development of murine neonatal self-Ia-reactive T lymphocytes in the thymus was studied. A C57BL/6 (B6) mouse pregnant with (B6 X C3H/He)F1 (B6C3F1) embryos was injected with monoclonal anti-I-Ek (m alpha I-Ek) antibody every other day starting from the 12th day of gestation. The ...

journal_title：European journal of immunology

authors： Kimoto M,Kishimoto S

更新日期：1986-07-01 00:00:00

abstract：:Patients undergoing allogeneic bone marrow transplantation offer a unique system to analyze NK cell development in vivo. We analyzed NK cells from 23 such patients to assess the acquisition of activating receptors. Four patients displayed an immature NK cell surface phenotype at engraftment, as their cells were CD16(-...

journal_title：European journal of immunology

authors： Vitale C,Chiossone L,Morreale G,Lanino E,Cottalasso F,Moretti S,Dini G,Moretta L,Mingari MC

更新日期：2004-02-01 00:00:00

abstract：:Following antigen encounter and subsequent resolution of the immune response, a single naïve T cell is able to generate multiple subsets of memory T cells with different phenotypic and functional properties and gene expression profiles. Single-cell technologies, first and foremost flow cytometry, have revealed the com...

journal_title：European journal of immunology

authors： Mahnke YD,Brodie TM,Sallusto F,Roederer M,Lugli E

更新日期：2013-11-01 00:00:00

abstract：:All leukocytes express the cell surface glycoprotein CD45, which has intrinsic intracellular protein tyrosine phosphatase activity. CD45 is known to play a regulatory role in activation-induced signaling in lymphocytes; however, little is known of its role in non-lymphoid leukocytes. Therefore, we examined the potenti...

journal_title：European journal of immunology

authors： Mitchell GB,Khandaker MH,Rahimpour R,Xu L,Lazarovits AI,Pickering JG,Suria H,Madrenas J,Pomerantz DK,Feldman RD,Kelvin DJ

更新日期：1999-05-01 00:00:00

abstract：:Myeloid leukocytes form actin-based plasma membrane protrusions, called podosomes, that are implicated in myeloid cell recruitment into tissues and cell migration within the interstitium. In this study, we show that tyrosine kinases of the Abl family are present in podosomes formed by murine and human macrophages. Sil...

journal_title：European journal of immunology

authors： Baruzzi A,Berton G

更新日期：2012-10-01 00:00:00

abstract：:A novel surface molecule, Tp90, is described which appears to be involved in an antigen-independent pathway of human T lymphocyte activation. The Tp90 molecule was identified by a monoclonal antibody (mAb), MX20, obtained from a fusion using spleen cells of a mouse immunized with cells from two T cell leukemia lines, ...

journal_title：European journal of immunology

authors： Carrel S,Salvi S,Giuffrè L,Isler P,Cerottini JC

更新日期：1987-06-01 00:00:00

abstract：:Class I molecules, encoded by diverse alleles at several loci of the major histocompatibility complex (MHC) are assembled in the endoplasmic reticulum (ER) from heavy chain, beta2 microglobulin and peptide in association with accessory proteins of the peptide loading complex. We show here, that mutations in the alpha2...

journal_title：European journal of immunology

authors： Beissbarth T,Sun J,Kavathas PB,Ortmann B

更新日期：2000-04-01 00:00:00

abstract：:Leukosialin (CD43) is a major glycoprotein of T lymphocytes which has an extracellular domain of 45 nm in length that is heavily O-glycosylated. Monoclonal antibodies (mAb) to the extracellular domain of human leukosialin induce aggregation of T lymphocytes, monocytes and some cell lines that express leukosialin. The ...

journal_title：European journal of immunology

authors： Cyster JG,Williams AF

更新日期：1992-10-01 00:00:00

abstract：:The purpose of this work was to study the interrelationship of proliferation and secretion of plasminogen activator (PA) and interferon (IFN) by murine macrophages. For induction of macrophage proliferation and secretion of PA, concanavalin A (Con A) was used. Secretion of IFN was induced by polyinosinic polycytidylic...

journal_title：European journal of immunology

authors： Neumann C,Sorg C

更新日期：1983-02-01 00:00:00

abstract：:Accumulating evidence suggest that infection with Chlamydia pneumoniae is associated with atherosclerosis, but the mechanisms involved remain unclear. Inflammation is important in the initial phase of atherogenesis, and cytokines are important in the initiation and progression of inflammation. The aim of this study wa...

journal_title：European journal of immunology

authors： Netea MG,Selzman CH,Kullberg BJ,Galama JM,Weinberg A,Stalenhoef AF,Van der Meer JW,Dinarello CA

更新日期：2000-02-01 00:00:00

abstract：:The approximately 20-kDa heat-labile toxin produced by enterotoxigenic Bacteroides fragilis is known to be associated with the development of enteritis. However, the molecular mechanism involved is not yet fully understood. In this study, we assessed whether B. fragilis enterotoxin (BFT)-induced enteritis is related t...

journal_title：European journal of immunology

authors： Kim JM,Jung HY,Lee JY,Youn J,Lee CH,Kim KH

更新日期：2005-09-01 00:00:00

abstract：:In humans and in BALB/c mice, immune responses to the hormone insulin use evolutionarily related VHV (human) and VHIX (murine) gene families. To determine if these structural relationships include regulatory elements, BALB/c mice were pretreated with autologous immunoglobulin G (IgG) monoclonal antibodies (mAb) that r...

journal_title：European journal of immunology

authors： Thomas JW

更新日期：1992-09-01 00:00:00

abstract：:Hypoxia and glucose deprivation are often observed in the microenvironment surrounding solid tumors in vivo. However, how they interfere with MHC class I antigen processing and CD8(+) T-cell responses remains unclear. In this study, we analyzed the production of antigenic peptides presented by classical MHC class I in...

journal_title：European journal of immunology

authors： Sasaki T,Kanaseki T,Shionoya Y,Tokita S,Miyamoto S,Saka E,Kochin V,Takasawa A,Hirohashi Y,Tamura Y,Miyazaki A,Torigoe T,Hiratsuka H,Sato N

更新日期：2016-04-01 00:00:00

abstract：:Activation of mature CD8+ T cells requires recognition, via the T cell receptor (TCR), of peptide + MHC (pMHC) complexes with an avidity that exceeds a designated threshold. Multiple indicators of T cell avidity have been described that provide unique information on the characteristics of T cell interactions. However,...

journal_title：European journal of immunology

authors： La Gruta NL,Doherty PC,Turner SJ

更新日期：2006-11-01 00:00:00

abstract：:The present experiments address functional antibody diversity and clonal distribution in murine available repertoires. IgM-containing supernatants were prepared by unbiased, polyclonal stimulation of resting splenic B cells from C57BL/6 mice, to ensure similar numbers of responding clones/culture and equivalent growth...

journal_title：European journal of immunology

authors： Nobrega A,Grandien A,Haury M,Hecker L,Malanchère E,Coutinho A

更新日期：1998-04-01 00:00:00

abstract：:To investigate the role of interferon-gamma (IFN-gamma) in experimental autoimmune thyroidits (EAT), H-2k mice with a disrupted IFN-gamma receptor (IFN-gamma R) gene were immunized with porcine thyroglobulin (pTg). We observed that EAT occurred on day 19 and remitted on day 35 in IFN-gamma R-deficient (IFN-gamma R(0/0...

journal_title：European journal of immunology

authors： Alimi E,Huang S,Brazillet MP,Charreire J

更新日期：1998-01-01 00:00:00

abstract：:Effects of carrageenan (CAR) treatment on the response of interferon (IFN) production in vivo and in vitro after stimulation with an IFN-gamma inducer, staphylococcal enterotoxin A (SEA), was investigated. The IFN-gamma production in mice stimulated with SEA was impaired after i.v. administration of a 20 mg/kg dose of...

journal_title：European journal of immunology

authors： Suzuki F,Maeda H,Pollard RB

更新日期：1986-04-01 00:00:00

abstract：:Brain invasion by Borrelia burgdorferi, the agent of Lyme disease, results in an inflammatory and neurodegenerative disorder called neuroborreliosis. In humans, neuroborreliosis has been correlated with enhanced concentration of glial fibrillary acidic protein in the cerebrospinal fluid, a sign of astrogliosis. Rhesus...

journal_title：European journal of immunology

authors： Ramesh G,Alvarez AL,Roberts ED,Dennis VA,Lasater BL,Alvarez X,Philipp MT

更新日期：2003-09-01 00:00:00