The tyrosine kinase Abl is a component of macrophage podosomes and is required for podosome formation and function.

abstract：:Current concepts of activation of the alternative pathway of complement (APC) focus on the central role of an amplification mechanism triggered by C3b which is covalently bound to the surfact of activating substances. Using sulfated polyanions as model substances, an efficient fluid-phase activation of complement is d...

journal_title：European journal of immunology

authors： Bitter-Suermann D,Burger R,Hadding U

更新日期：1981-04-01 00:00:00

abstract：:In the lung, dendritic cells (DC) are key antigen-presenting cells capable of triggering specific cellular responses to inhaled pathogens, and thus, they may be important in the initiation of an early response to mycobacterial infections. The ability of DC to enhance antigen presentation to naive T cells within the lu...

journal_title：European journal of immunology

authors： Demangel C,Bean AG,Martin E,Feng CG,Kamath AT,Britton WJ

更新日期：1999-06-01 00:00:00

abstract：:Anchor residues in peptides determine the specificity of binding to major histocompatibility complex class I molecules through interactions of their side chains with pockets in the peptide-binding groove. We have compared the kinetics of association of a Sendai virus nucleoprotein-derived peptide (FAPGNYPAL, termed SV...

journal_title：European journal of immunology

authors： Neefjes JJ,Dierx J,Ploegh HL

更新日期：1993-04-01 00:00:00

abstract：:By stimulating peripheral blood mononuclear cells of four healthy donors with a mixture of overlapping peptides representing the core domain of p53, we established two CD4+ alphabeta T cell clones and four lines that recognized wild-type and mutant p53 proteins as well as p53 self peptides in an HLA class II-restricte...

journal_title：European journal of immunology

authors： Fujita H,Senju S,Yokomizo H,Saya H,Ogawa M,Matsushita S,Nishimura Y

更新日期：1998-01-01 00:00:00

abstract：:This study was performed to investigate whether gamma delta T cells could also be divided into subsets, identified by a cytokine profile, as described for alpha beta T helper (Th) cell subsets. Cytokine production was studied in 22 gamma delta T cell clones obtained from the synovial fluid and peripheral blood of one ...

journal_title：European journal of immunology

authors： Chomarat P,Kjeldsen-Kragh J,Quayle AJ,Natvig JB,Miossec P

更新日期：1994-09-01 00:00:00

abstract：:Interleukin-18 (IL-18) is not only a co-stimulus for the induction of interferon-gamma but also has direct proinflammatory effects by inducing tumor necrosis factor-alpha (TNF-alpha), IL-1, IL-8 and IL-6. However, the cascade of events leading to induction of cytokines by IL-18 is unclear. The aim of the present study...

journal_title：European journal of immunology

authors： Netea MG,Kullberg BJ,Verschueren I,Van Der Meer JW

更新日期：2000-10-01 00:00:00

abstract：:HLA class II association with insulin-dependent diabetes mellitus (IDDM) is well established but is still difficult to map to a particular locus. Polymorphism of the genes coding for transporter associated with antigen processing (TAP1 and TAP2), and located in the HLA class II region, was studied in 167 IDDM patients...

journal_title：European journal of immunology

authors： Caillat-Zucman S,Bertin E,Timsit J,Boitard C,Assan R,Bach JF

更新日期：1993-08-01 00:00:00

abstract：:HLA class II molecules are involved in the OKT3-induced T cell activation, since monoclonal antibodies (mAb) to monomorphic determinants of class II antigens are able to inhibit T cell proliferation. This effect involves several of the events leading to T cell activation and proliferation, i.e. interleukin (IL) 1, IL ...

journal_title：European journal of immunology

authors： Ruggiero G,Racioppi L,Manzo C,Pirozzi G,D'Oro U,Ferrone S,Zappacosta S,Fontana S

更新日期：1991-01-01 00:00:00

abstract：:The IFN stimulated gene 15 (ISG15) encodes a 15-kDa ubiquitin-like protein, that is induced by type I IFNs and is conjugated to the bulk of newly synthesized polypeptides at the ribosome. ISG15 functions as an antiviral molecule possibly by being covalently conjugated to viral proteins and disturbing virus particle as...

journal_title：European journal of immunology

authors： Held T,Basler M,Knobeloch KP,Groettrup M

更新日期：2020-07-20 00:00:00

abstract：:Prostein is a prostate tissue-specific protein that is uniquely and abundantly expressed in normal and cancerous prostate tissues. Due to this expression profile, we examined the immunogenicity of prostein as a potential vaccine candidate for prostate cancer. To determine the presence of CD8 T cells specific for natur...

journal_title：European journal of immunology

authors： Friedman RS,Spies AG,Kalos M

更新日期：2004-04-01 00:00:00

abstract：:Activation of the alternative complement pathway by human B cell lymphoma lines is correlated with the presence of Epstein Barr virus (EBV) in the cell genome. EBV-negative B cell lymphoma lines produce little activation of the alternative pathway as measured either by C3 deposition on the cell surface or C3 conversio...

journal_title：European journal of immunology

authors： McConnell I,Klein G,Lint TF,Lachmann PJ

更新日期：1978-07-01 00:00:00

abstract：:In the thymus, in order to become MHC-restricted self-tolerant T cells, developing thymocytes need to interact with cortical and medullary thymic epithelial cells (TECs). Although the presence of a common bipotent progenitor for these functionally and structurally distinct epithelial subsets has been clearly establish...

journal_title：European journal of immunology

authors： Peterson P,Laan M

更新日期：2013-03-01 00:00:00

abstract：:The relative complement-mediated lytic capability of the IgG subclass isotypes was studied using a matched set of mouse-human chimeric anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies. The subclass pattern was shown to be highly dependent on variations in antigen concentration and to lesser extent on variation in ...

journal_title：European journal of immunology

authors： Michaelsen TE,Garred P,Aase A

更新日期：1991-01-01 00:00:00

abstract：:T cell-depleted B cells from a patient with LFA-1 deficiency were tested in costimulation assays for responsiveness to recombinant human IL4 (BSF-1) and purified low molecular weight B cell growth factor (BCGFlow). In both cases the response of LFA-1-deficient B cells was comparable with normal controls. Monoclonal an...

journal_title：European journal of immunology

authors： Shields JG,Smith SH,Strobel S,Levinsky RJ,Defrance T,De Vries J,Banchereau J,Callard RE

更新日期：1988-02-01 00:00:00

abstract：:T-cell activation and the subsequent transformation of activated T cells into T-cell blasts require profound changes in cell volume. However, the impact of cell volume regulation for T-cell immunology has not been characterized. Here we studied the role of the cell-volume regulating osmolyte transporter Taut for T-cel...

journal_title：European journal of immunology

authors： Kaesler S,Sobiesiak M,Kneilling M,Volz T,Kempf WE,Lang PA,Lang KS,Wieder T,Heller-Stilb B,Warskulat U,Häussinger D,Lang F,Biedermann T

更新日期：2012-04-01 00:00:00

abstract：:The properties of human lymphocyte fractions isolated either by sheep red cell(E) rosetting or by fluorescence-activated cell sorting after staining with UCHT1 monoclonal anti-T cell antibody have been compared. Two populations of E+ cells with very different phenotype and function have been identified. E+/UCHT1+ cell...

journal_title：European journal of immunology

authors： Beverley PC,Callard RE

更新日期：1981-04-01 00:00:00

abstract：:The interaction of CD40 ligand (CD40L) on activated T cells with CD40 on B cells, monocytes and dendritic cells is essential for humoral immunity and for up-regulation of antigen-presenting cell (APC) functions, as a result of signaling through CD40. There are also some indications that after interaction with CD40, CD...

journal_title：European journal of immunology

authors： Peng X,Kasran A,Warmerdam PA,de Boer M,Ceuppens JL

更新日期：1996-07-01 00:00:00

abstract：:Anti-idiotypes produced against monoclonal anti-H-2 antibodies have been used to examine idiotope sharing among a panel of anti-major histocompatibility complex (MHC) antibodies detecting the same and different specificities. Both xenogeneic anti-100-30 and anti-3-83, which did not react with predominant idiotypes in ...

journal_title：European journal of immunology

authors： Bluestone JA,Auchincloss H Jr,Sachs DH,Fibi M,Hämmerling GJ

更新日期：1983-06-01 00:00:00

abstract：:The simultaneous detection of Ig and theta on the surface of mouse lymphocytes permits the detection of four cell types (Ig-theta-, Ig-theta+, Ig+theta-, and Ig+theta+) which also have distinct electrophoretic profiles. All types are present in variable proportions in all lymphoid organs studied. Results obtained in c...

journal_title：European journal of immunology

authors： Roelants GE,Loor F,von Boehmer H,Sprent J,Hägg LB,Mayor KS,Rydén A

更新日期：1975-02-01 00:00:00

abstract：:One of the clear paradoxes in tumor immunology is the fact that cross-presentation of cell-associated tumor antigens to CD8(+) T cells is efficient, yet CTL generation is weak, and tumors continue to grow. We examined, for the first time whether this may be due to alterations in the phenotype or function of cross-pres...

journal_title：European journal of immunology

authors： McDonnell AM,Prosser AC,van Bruggen I,Robinson BW,Currie AJ

更新日期：2010-06-01 00:00:00

abstract：:A panel of HLA-DRB1*0401-restricted CD4+ mouse T cell hybridomas specific for bovine type II collagen were generated from transgenic mice expressing the human HLA-DRA1*0101/-DRB1*0401 and CD4 molecules. The vast majority recognized a single peptide determinant corresponding to residues 261-273 (CII 261-273). This dete...

journal_title：European journal of immunology

authors： Fugger L,Rothbard JB,Sonderstrup-McDevitt G

更新日期：1996-04-01 00:00:00

abstract：:Peptides presented by MHC class I molecules are mostly derived from proteins synthesized by the antigen-presenting cell itself, while peptides presented by MHC class II molecules are predominantly from materials acquired by endocytosis. External antigens can also be presented by MHC class I molecules in a process refe...

journal_title：European journal of immunology

authors： Hari A,Ganguly A,Mu L,Davis SP,Stenner MD,Lam R,Munro F,Namet I,Alghamdi E,Fürstenhaupt T,Dong W,Detampel P,Shen LJ,Amrein MW,Yates RM,Shi Y

更新日期：2015-02-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) causes severe bronchiolitis in infants worldwide. The immunological factors responsible for RSV susceptibility in infants are poorly understood. Here, we used the BALB/c mouse model of neonatal RSV infection to study the mechanisms leading to severe disease upon reexposure to the viru...

journal_title：European journal of immunology

authors： Remot A,Descamps D,Jouneau L,Laubreton D,Dubuquoy C,Bouet S,Lecardonnel J,Rebours E,Petit-Camurdan A,Riffault S

更新日期：2016-04-01 00:00:00

abstract：:Reactive nitrogen intermediates (RNI), like nitric oxide (NO) and peroxynitrite, have antiviral effects against certain viruses. Hantaviruses, like other members of the Bunyaviridae family, have previously not been shown to be sensitive to RNI. In this study, we compared the effects of NO and peroxynitrite on hantavir...

journal_title：European journal of immunology

authors： Klingström J,Akerström S,Hardestam J,Stoltz M,Simon M,Falk KI,Mirazimi A,Rottenberg M,Lundkvist A

更新日期：2006-10-01 00:00:00

abstract：:A mouse T cell hybrid specific for pigeon cytochrome c in the context of I-Ek responds by secreting interleukin 2 when co-cultured with the native antigen and the B cell lymphoma, LK-35.2, or naive splenic B cells as antigen-presenting cells (APC). Cytochromes c and their corresponding C-terminal fragments which are n...

journal_title：European journal of immunology

authors： Lakey EK,Margoliash E,Flouret G,Pierce SK

更新日期：1986-07-01 00:00:00

abstract：:Although the role of interleukin 2 (IL 2) in mature T lymphocyte function is well documented, its effect on hematopoietic progenitor cells is less well characterized. Here we have used recombinant retroviruses to transduce and express a cDNA clone encoding the p55 component of the human IL 2 receptor (h-p55), in a mur...

journal_title：European journal of immunology

authors： Collins MK,Malde P,Miyajima A,Arai K,Smith KA,Mulligan RC

更新日期：1990-03-01 00:00:00

abstract：:We previously demonstrated that cholera toxin (CT) is highly efficient as a combined carrier and adjuvant for dendritic cell (DC) vaccination, inducing strong Th1-dominated B cell and CD4(+) T cell responses. In this study we show that vaccination with DC pre-pulsed ex vivo with CT-conjugated OVA (OVA-CT) gives rise t...

journal_title：European journal of immunology

authors： Eriksson K,Sun JB,Nordström I,Fredriksson M,Lindblad M,Li BL,Holmgren J

更新日期：2004-05-01 00:00:00

abstract：:NKp44 (NCR2) is a distinct member of natural cytotoxicity receptors (NCRs) family that can induce cytokine production and cytolytic activity in human NK cells. Heparan sulfate proteoglycans (HSPGs) are differentially expressed in various normal and cancerous tissues. HSPGs were reported to serve as ligands/co-ligands ...

journal_title：European journal of immunology

authors： Brusilovsky M,Radinsky O,Cohen L,Yossef R,Shemesh A,Braiman A,Mandelboim O,Campbell KS,Porgador A

更新日期：2015-04-01 00:00:00

abstract：:Th cells can adopt a number of different phenotypes. We performed microarray-assisted mRNA profiling on antigen-stimulated, TCR transgenic murine splenocytes that were cultured in the presence of cytokines. Transcriptome snapshots of Th cells differentiating into Th1 and Th2 phenotypes were obtained at various time po...

journal_title：European journal of immunology

authors： van den Ham HJ,de Waal L,Zaaraoui-Boutahar F,Bijl M,van Ijcken WF,Osterhaus AD,de Boer RJ,Andeweg AC

更新日期：2013-04-01 00:00:00

abstract：:A panel of closely and distantly related lysozymes and lysozyme-peptide fragments were utilized in assessing the specificity repertoire of murine anti-hen egg white lysozyme hybridomas. The 44 monoclonal antibodies could be divided into a minimum of 18 fine specificity groups in tests using the lysozyme panel. Two hyb...

journal_title：European journal of immunology

authors： Metzger DW,Ch'ng LK,Miller A,Sercarz EE

更新日期：1984-01-01 00:00:00