Abstract:
:HLA class II association with insulin-dependent diabetes mellitus (IDDM) is well established but is still difficult to map to a particular locus. Polymorphism of the genes coding for transporter associated with antigen processing (TAP1 and TAP2), and located in the HLA class II region, was studied in 167 IDDM patients (116 adult-onset and 51 childhood-onset patients) and 98 normal controls using oligotyping after genomic amplification. A dominant protective effect was observed for the TAP2*0201 allele [relative risk (RR) = 0.3, corrected probability (pc) < 0.001]. Conversely, susceptibility to IDDM was associated with apparent homozygosity for the TAP2*0101 allele (RR = 3.4, pc < 0.001). Protection was independent from but additive to the protection conferred by the DRB1*02 DQB1*0602 haplotype (RR = 0.06, pc < 0.05), and antagonistic to the DRB1*03 DQB1*0201 and DRB1*04 DQB1*0302 haplotypes predisposing effect (RR = 1.1, not significant), arguing in favor of an absence of linkage disequilibrium between TAP2 and HLA class II genes. This was assessed by chi 2 analysis. TAP1 allelic distribution was not different among diabetics and controls. A significant association was observed between the presence of TAP2*0101 and that of islet cell antibodies (p < 0.05). These data suggest that the TAP2 gene, which encodes protein required for delivery of antigen peptides to class I molecules in the endoplasmic reticulum, could modulate the autoimmune response leading to beta cell destruction. From a practical point of view, they make the combined screening of HLA class II and TAP2 loci a highly valuable tool in IDDM prediction.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Caillat-Zucman S,Bertin E,Timsit J,Boitard C,Assan R,Bach JFdoi
10.1002/eji.1830230808subject
Has Abstractpub_date
1993-08-01 00:00:00pages
1784-8issue
8eissn
0014-2980issn
1521-4141journal_volume
23pub_type
杂志文章abstract::TCR- but not CD2-triggered IL-2 production is p56(lck) dependent. To test the hypothesis that p59(fyn), a second src-family protein tyrosine kinase (PTK) expressed in T lymphocytes, might be an essential upstream component of the CD2 signaling pathway, we generated human (h) CD2 transgenic (tg) fyn(+/+) and fyn(-/-) m...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(2000012)30:12<3507::AID-IMMU3507
更新日期:2000-12-01 00:00:00
abstract::Bispecific antibodies binding to the TCR/CD3 complex and to a tumor-associated surface molecule can be used to target cytotoxic T lymphocytes against tumor cells. We reasoned that high-affinity binding to CD3 may reduce the efficiency of T cell stimulation and target the bispecific reagent to T cells rather than to tu...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200211)32:11<3102::AID-IMMU3102>
更新日期:2002-11-01 00:00:00
abstract::The problem of the structural relationship between suppressive IgG-binding factor and low-affinity receptors for the Fc portion of IgG (Fc gamma RII) has not yet been solved. In the present work we have isolated a recombinant soluble Fc gamma RII containing only the two external domains of Fc gamma RII, and analyzed i...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830191213
更新日期:1989-12-01 00:00:00
abstract::Induction of the glucocorticoid-induced leucine zipper (GILZ) by glucocorticoids plays a role in their antiinflammatory action, whereas GILZ expression is reduced under inflammatory conditions. The mechanisms regulating GILZ expression during inflammation, however, have not yet been characterized. Here, we investigate...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142081
更新日期:2012-05-01 00:00:00
abstract::Mast cells are widely distributed in tissues, particularly near surfaces exposed to the environment. Mast cells can be activated to secrete diverse mediators and cytokines by IgE and specific Ag and many other stimuli, including products derived from either pathogens or the host during innate immune responses. Althoug...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.201040559
更新日期:2010-07-01 00:00:00
abstract::T-cell activation and the subsequent transformation of activated T cells into T-cell blasts require profound changes in cell volume. However, the impact of cell volume regulation for T-cell immunology has not been characterized. Here we studied the role of the cell-volume regulating osmolyte transporter Taut for T-cel...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201141690
更新日期:2012-04-01 00:00:00
abstract::Prior to acquiring a memory phenotype, antigen-activated CD8(+) T cells need to expand and then undergo a contraction phase. Utilizing two different antigenic stimuli, we provide evidence that the tumor necrosis factor receptors OX40 and CD30 integrate synergistic signals during the expansion phase to help maintain CD...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200939424
更新日期:2009-08-01 00:00:00
abstract::Anchor residues in peptides determine the specificity of binding to major histocompatibility complex class I molecules through interactions of their side chains with pockets in the peptide-binding groove. We have compared the kinetics of association of a Sendai virus nucleoprotein-derived peptide (FAPGNYPAL, termed SV...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230411
更新日期:1993-04-01 00:00:00
abstract::The antigen receptor of the T lymphocytes is one of the most complex eukaryotic membrane structures studied to date. The T cell receptor (TcR) consists of two disulfide-linked glycoprotein chains (alpha/beta or gamma/delta) and is noncovalently associated with a group of small and invariable CD 3 proteins. Four CD 3 c...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830180508
更新日期:1988-05-01 00:00:00
abstract::Although potentially autoreactive T cells are present even in healthy subjects, most individuals do not develop autoimmune disease. It has been well demonstrated that CD4+ CD25+ regulatory T cells play a significant role in controlling the expansion of autoreactive T cells in the periphery. However, some healthy indiv...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636383
更新日期:2007-01-01 00:00:00
abstract::Although alterations in CD3-associated signal-transducing molecules in tumor-infiltrating T cells of patients with advanced cancer have been previously described, the mechanism behind these changes is not known. We demonstrate that macrophages isolated from metastatic lymph nodes of patients with malignant melanoma do...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830260620
更新日期:1996-06-01 00:00:00
abstract::The glycoprotein CD8 is believed to play an important role in the maturation and function of MHC class I-restricted T lymphocytes. CD8 has been proposed to function as a co-receptor of the TcR to participate in signal transduction, possibly through its cytoplasmic domain that binds to protein tyrosine kinase p56lck. A...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830231117
更新日期:1993-11-01 00:00:00
abstract::NK cells are innate lymphocytes crucial for surveillance against pathogens and tumors. Although the basic mechanisms through which NK cells operate have been established, many questions are still unresolved. Are all NK cells equal or can we identify subsets with distinct developmental origin and function? How do NK ce...
journal_title:European journal of immunology
pub_type:
doi:10.1002/eji.200838883
更新日期:2008-11-01 00:00:00
abstract::Antibodies against bacterial capsular polysaccharides play a critical protective role. Responses to these antigens can occur without the help or control of T cells and are associated with marginal zone (MZ) B cells. Capsular antigens are diverse and some cross-react with self-carbohydrate epitopes. This diversity may ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/immu.200310003
更新日期:2003-02-01 00:00:00
abstract::Granzyme A (TSP-1) is a serine esterase expressed in cytotoxic T and natural killer (NK) cell lines. Its presence in in vivo primed T cells is disputed at present. Here we show that normal rat NK cells contain granzyme A in vivo and that its expression is augmented by their short-term in vitro treatment with IL 2. Gra...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190328
更新日期:1989-03-01 00:00:00
abstract::The migration of monocytes to sites of inflammation is largely determined by their response to chemokines. Although the chemokine specificities and expression patterns of chemokine receptors are well defined, it is still a matter of debate how cells integrate the messages provided by different chemokines that are conc...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200838906
更新日期:2009-04-01 00:00:00
abstract::Interactions between CD8+ T cells and endothelial cells are important in both protective and pathologic immune responses. Endothelial cells regulate the recruitment of CD8+ T cells into tissues, and the activation of CD8+ T cells by antigen presentation and costimulatory signals. PD-L1 and PD-L2 are recently described...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200324270
更新日期:2003-11-01 00:00:00
abstract::Stimulation of human peripheral blood lymphocytes via T cell receptor/CD3 complex resulted in a bimodal activation of protein kinase(s) C (PKC). Within 10 min of stimulation PKC-alpha was translocated to, and thus activated in, the plasma membranes of human lymphocytes, followed by a fast dissociation of this isotype ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830231205
更新日期:1993-12-01 00:00:00
abstract::Polyclonal differentiation of unprimed B cells into IgM-producing cells induced by lipopolysaccharide (LPS) or T cell-derived lymphokine B151-TRF2 has been shown to contain a process of I-A-restricted B-B cell interaction, so that the B cell responses are inhibited by monoclonal antibodies (mAb) specific for I-A molec...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830191208
更新日期:1989-12-01 00:00:00
abstract::We have previously reported that a subset of T cells in T cell receptor (TCR)-transgenic mice may express two different alpha chains on their surface. The expression of two functional alpha chains has also been demonstrated for human peripheral blood T cells. In this report, we show that a proportion of normal murine ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250622
更新日期:1995-06-01 00:00:00
abstract::Mature T cells first appear in the thymus of the mouse a few days before birth, about 7-8 days after the thymus was colonized by stem cells. These mature cells are exported to the peripheral lymphoid organs beginning at about the time of birth, but because the number is very small at this stage, little is known about ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220207
更新日期:1992-02-01 00:00:00
abstract::Chemokine receptor CXCR6 mediates the chemotaxis and adhesion of leukocytes to soluble and membrane-anchored forms of CXCL16, and is an HIV-1 co-receptor. Here, we describe the effects of mutation of acidic extracellular CXCR6 residues on receptor function. Although most CXCR6 mutants examined were expressed at levels...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200838269
更新日期:2008-08-01 00:00:00
abstract::On the premise that an individual with an intact immune system has the capability to develop both cellular and antibody immune responses supported by the balance between the lymphokines secreted by T helper (Th) cells, we studied the interaction between different types of Th cell clones in vivo and the parameters that...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250312
更新日期:1995-03-01 00:00:00
abstract::A mouse lymphocyte surface molecule which is selectively expressed by mucosal T cells and detected with the monoclonal antibody (mAb) M290 has provisionally been identified as a beta 7 integrin. Identification was based on close homology of its beta subunit at the N terminus with the recently reported, highly distinct...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830211041
更新日期:1991-10-01 00:00:00
abstract::Anti-HLA alloantisera inhibit mixed lymphocyte responses in which normal lymphocytes are used as stimulator cells. These same antisera are unable to inhibit lymphocyte proliferative responses stimulated by lymphoblastoid cells from cultured lymphoid cell lines. They also fail to inhibit either the generation of cytoto...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830060402
更新日期:1976-04-01 00:00:00
abstract::Mouse peritoneal macrophages activated with interferon-gamma (IFN-gamma) and lipopolysaccharide produce substantial amounts of nitric oxide (NO), which correlates with the elimination of the intracellular protozoan parasite Leishmania major. Both the production of NO and the leishmanicidal function of the activated ma...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220223
更新日期:1992-02-01 00:00:00
abstract::Macrophage-chemotactic factor (MChF)-producing T cell hybridomas were established. These hybridomas produced MChF upon the specific antigenic stimulation with phosphorylcholine (PC)-conjugated protein in the presence of I-Ed-positive antigen-presenting cells. The hybridomas also secreted MChF after co-culture with con...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830140804
更新日期:1984-08-01 00:00:00
abstract::The CD4+ T cell response is of critical importance in determining the fate of many viral infections. Clearance of HCV has a strong association with the MHC class II antigen HLA-DR11 suggesting a key role for CD4+ T cells. We used an epitope-prediction program to identify multiple novel HLA-DR11-restricted epitopes der...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200105)31:5<1438::AID-IMMU1438>3
更新日期:2001-05-01 00:00:00
abstract::It has been reported that Thy-1+CD3+CD4-CD8- cells as well as Langerhans cells migrate from organ-cultured murine skin into culture medium. We examined whether these Thy-1+ populations of migrating cells were derived from Thy-1+ dendritic epidermal T cells (Thy-1+ DEC) and found that they were Thy-1+CD3+CD4-CD8-gamma/...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230746
更新日期:1993-07-01 00:00:00
abstract::This study was performed as a means to examine the effects of environment and stem cell origin on the molding of T cell receptor gene rearrangements during T cell development. Lethally irradiated adult mice were first reconstituted with (C57BL/6 x DBA/2)F1 stem cells, which derived either from a fetal liver or adult b...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830211208
更新日期:1991-12-01 00:00:00