Five types of lymphocytes (Ig-theta-, Ig-theta+weak, Ig-theta+strong, Ig+theta- and Ig+theta+) characterized by double immunofluorescence and electrophoretic mobility. Organ distribution in normal and nude mice.

abstract：:Although many B lymphocytes contain two completely rearranged immunoglobulin (Ig) heavy (H) chain genes, only one of the alleles specifies a protein product. This phenomenon is termed allelic exclusion and is controlled in part by the membrane portion of Ig H chains. We have identified a mature B cell line derived fro...

journal_title：European journal of immunology

authors： Picarella D,Serunian LA,Rosenberg N

更新日期：1991-01-01 00:00:00

abstract：:High frequencies of CD5+TcR alpha/beta- T cells were induced in the peritoneal cavity of rats immunized with syngeneic W439 lymphoma cells. These TcR alpha/beta- cells expressed TcR delta mRNA as analyzed by the polymerase chain reaction technique. The delta + (TcR gamma/delta +) T cells were of the CD2+, CD3+, CD4-, ...

journal_title：European journal of immunology

authors： Ericsson PO,Hansson J,Widegren B,Dohlsten M,Sjögren HO,Hedlund G

更新日期：1991-11-01 00:00:00

abstract：:Analysis of proliferation and cytokine production at the single-cell level indicated that proliferation of pre-existing type 2 cytokine(+) human peripheral naive T cells (CD4(+) and CD8(+)) accounts for the accumulation of type 2 T cells in lymphocytes cultured with IL-2, with or without IL-4, and independently from T...

journal_title：European journal of immunology

authors： Loza MJ,Perussia B

更新日期：2003-04-01 00:00:00

abstract：:Cellular immune responses are likely to play a key role in determining the clinical outcome in acute infection with hepatitis C virus (HCV), but the dynamics of such responses and their relationship to viral clearance are poorly understood. In a previous study we have shown highly activated, multispecific cytotoxic T ...

journal_title：European journal of immunology

authors： Lechner F,Gruener NH,Urbani S,Uggeri J,Santantonio T,Kammer AR,Cerny A,Phillips R,Ferrari C,Pape GR,Klenerman P

更新日期：2000-09-01 00:00:00

abstract：:An association between T-cell lymphopenia and autoimmunity has long been proposed, but it remains to be elucidated whether T-cell lymphopenia affects B-cell responses to autoantigens. Human neonatal thymectomy (Tx) results in a decrease in T-cell numbers and we used this model to study the development of autoreactivit...

journal_title：European journal of immunology

authors： van den Broek T,Madi A,Delemarre EM,Schadenberg AWL,Tesselaar K,Borghans JAM,Nierkens S,Redegeld FA,Otten HG,Rossetti M,Albani S,Sorek R,Cohen IR,Jansen NJG,van Wijk F

更新日期：2017-11-01 00:00:00

abstract：:We have studied the effect of T cell receptor (TcR) cross-linking and TcR-CD4 cross-linking on the induction of interleukin (IL) 2 and IL 2 receptor mRNA expression in peripheral T cells. We confirm our previous results using bioassays, suggesting that CD4 is involved in T cell activation by up-regulating the expressi...

journal_title：European journal of immunology

authors： Jönsson JI,Eichmann K

更新日期：1990-07-01 00:00:00

abstract：:The regulation of neutrophil half-life by members of the coagulation cascade is critical for the resolution of the inflammatory response. We have demonstrated that soluble fibrinogen (sFbg) delays human neutrophil (PMN) apoptosis through a mechanism that involves CD11b interactions, and phosphorylation of focal adhesi...

journal_title：European journal of immunology

authors： Rubel C,Gómez S,Fernández GC,Isturiz MA,Caamaño J,Palermo MS

更新日期：2003-05-01 00:00:00

abstract：:The F1 progeny of autoimmune NZB and normal SWR mice uniformly develop severe and accelerated lupus nephritis. The (SWR x NZB)F1 mice produce an oligoclonally expanded population of nephritogenic anti-DNA autoantibodies that share a recurrent cross-reactive idiotype (Id564), use highly homologous VH genes and surprisi...

journal_title：European journal of immunology

authors： O'Keefe TL,Datta SK,Imanishi-Kari T

更新日期：1992-03-01 00:00:00

abstract：:Anti-CD3 mAb can modulate graft rejection and attenuate autoimmune diseases but their mechanism(s) of action remain unclear. CD8(+) T cells with regulatory function are induced in vitro by Teplizumab, a humanized anti-CD3 antibody and inhibit responses of autologous and allogeneic T cells. They inhibit CD4(+) T-cell p...

journal_title：European journal of immunology

authors： Ablamunits V,Bisikirska B,Herold KC

更新日期：2010-10-01 00:00:00

abstract：:Tapasin is a 48-kDa endoplasmic reticulum (ER)-resident glycoprotein that binds to the transporter associated with antigen processing (TAP) and mediates an interaction between TAP and newly synthesized MHC class I molecules. It is also essential for the proper antigen presenting function of HLA-A*0101 (HLA-A1), HLA-A*...

journal_title：European journal of immunology

authors： Lewis JW,Sewell A,Price D,Elliott T

更新日期：1998-10-01 00:00:00

abstract：:Using sheep erythrocytes (SRBC) as the antigen, two subpopulations of spleen antigen-binding lymphocytes could be distinguished by a marked difference in the susceptibility of their receptors to trypsin. In unimmunized animals, 30% of the antigen-binding cells were trypsin-resistant, whereas at 5 days after immunizati...

journal_title：European journal of immunology

authors： Ashman RF

更新日期：1976-06-01 00:00:00

abstract：:To evaluate a long peptide-based allergy vaccine in a murine model, CBA/J mice were sensitized with low dose alum-adsorbed phospholipase A2 (PLA2), a major bee venom allergen. Presensitized mice were treated by daily i.p. injections of a mixture of three long overlapping peptides (44- to 60-mer) spanning the entire PL...

journal_title：European journal of immunology

authors： von Garnier C,Astori M,Kettner A,Dufour N,Heusser C,Corradin G,Spertini F

更新日期：2000-06-01 00:00:00

abstract：:Mouse peritoneal macrophages activated with interferon-gamma (IFN-gamma) and lipopolysaccharide produce substantial amounts of nitric oxide (NO), which correlates with the elimination of the intracellular protozoan parasite Leishmania major. Both the production of NO and the leishmanicidal function of the activated ma...

journal_title：European journal of immunology

authors： Li Y,Severn A,Rogers MV,Palmer RM,Moncada S,Liew FY

更新日期：1992-02-01 00:00:00

abstract：:Constitutive expression of CD25, the IL-2 receptor alpha-chain, defines a distinct population of CD4+ T cells (Treg) with suppressive activity in vitro and in vivo. IL-2 has been implicated in the generation and maintenance of Treg, however, a functional contribution of the IL-2 receptor during suppression is thus far...

journal_title：European journal of immunology

authors： de la Rosa M,Rutz S,Dorninger H,Scheffold A

更新日期：2004-09-01 00:00:00

abstract：:The MHC-related 1 (MR1) protein is a monomorphic, evolutionarily conserved MHC class I-like molecule, which is necessary for the development and functions of mucosal-associated invariant T (MAIT) cells, a new subset of innate-like lymphocytes. Multiple isoforms of the MR1 gene are naturally transcribed, but only the f...

journal_title：European journal of immunology

authors： Lion J,Debuysscher V,Wlodarczyk A,Hodroge A,Serriari NE,Choteau L,Ouled-haddou H,Plistat M,Lassoued K,Lantz O,Treiner E

更新日期：2013-05-01 00:00:00

abstract：:Staphylococcus aureus is the main pathogen associated with septic arthritis. Upon infection, neutrophils are quickly recruited to the joint by different chemoattractants, especially CXCR1/2 binding chemokines. Although their excessive accumulation is associated with intense pain and permanent articular damage, neutrop...

journal_title：European journal of immunology

authors： Boff D,Oliveira VLS,Queiroz Junior CM,Silva TA,Allegretti M,Verri WA Jr,Proost P,Teixeira MM,Amaral FA

更新日期：2018-03-01 00:00:00

abstract：:Persistent polyclonal B cell lymphocytosis (PPBL) is a hematological disorder diagnosed predominantly in women, characterized by a polyclonal increase in the number of peripheral blood B lymphocytes. Abnormality of the B cell population was evidenced by the finding of multiple bcl-2/Ig gene rearrangements and an addit...

journal_title：European journal of immunology

authors： Loembé MM,Néron S,Delage R,Darveau A

更新日期：2002-12-01 00:00:00

abstract：:The contribution of T cell responses to immunity against respiratory syncytial virus (RSV) is not fully defined, but this is an important issue for vaccine design. Recent studies demonstrating RSV-induced pulmonary T cell suppression suggest that RSV may have evolved strategies to escape T cell immunity. Here we evalu...

journal_title：European journal of immunology

authors： Ostler T,Ehl S

更新日期：2002-09-01 00:00:00

abstract：:The transcription factor Hhex (hematopoietically expressed homeobox gene) is critical for development of multiple lymphoid lineages beyond the common lymphoid progenitor. In addition, Hhex regulates hematopoietic stem cell (HSC) self-renewal, emergency hematopoiesis, and acute myeloid leukemia initiation and maintenan...

journal_title：European journal of immunology

authors： Jackson JT,O'Donnell K,Light A,Goh W,Huntington ND,Tarlinton DM,McCormack MP

更新日期：2020-07-01 00:00:00

abstract：:Gene targeting in hybridoma cells provides a tool for generating chimeric antibodies with great ease and at high yield. We present an evaluation of integration vectors for the chimerization of the immunoglobulin heavy chain locus which are universally applicable to hybridomas of different isotypes and mouse strains. T...

journal_title：European journal of immunology

authors： Kardinal C,Hooijberg E,Lang P,Zeidler R,Mocikat R

更新日期：1995-03-01 00:00:00

abstract：:Low concentrations of type-I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID-19). However, following the type-I interferon response (IR) in early stage disease is a major challenge. We evaluated detection of a molecular interferon signature on a FilmArray® syst...

journal_title：European journal of immunology

authors： Mommert M,Perret M,Hockin M,Viel S,Belot A,Richard JC,Mezidi M,Fassier JB,Javouhey E,ANTOINE Study Group.,COVID-SER Study Group.,COVID-HCL Study Group.,Hemmert A,Mallet F,Trouillet-Assant S,Brengel-Pesce K

更新日期：2020-12-12 00:00:00

abstract：:We recently constructed IL-15 transgenic (Tg) mice using cDNA encoding a secretable isoform of the IL-15 precursor protein under the control of an MHC class I promoter. The IL-15 Tg mice exhibited resistance against a primary infection with Listeria monocytogenes. The numbers of memory CD8(+) T cells were markedly inc...

journal_title：European journal of immunology

authors： Yajima T,Nishimura H,Ishimitsu R,Yamamura K,Watase T,Busch DH,Pamer EG,Kuwano H,Yoshikai Y

更新日期：2001-03-01 00:00:00

abstract：:The thymus provides the microenvironment in which thymocytes develop into mature T cells, and interactions with thymic stromal cells are thought to provide the necessary signals for thymocyte maturation. Recognition of self-MHC by T cells is a basic requirement for mature T-cell functions, and those thymocytes that do...

journal_title：European journal of immunology

authors： Szondy Z,Garabuczi É,Tóth K,Kiss B,Köröskényi K

更新日期：2012-07-01 00:00:00

abstract：:Interleukin-12 (IL-12) and Flt3 ligand (FL) regulate hematopoiesis by stimulating proliferation, differentiation and migration of progenitor and/or stem cells. In this study, we evaluated the in vivo effect of IL-12 alone or in combination with FL on dendritic cell (DC) generation and accumulation in murine spleen, ly...

journal_title：European journal of immunology

authors： Esche C,Cai Q,Peron JM,Hunter O,Subbotin VM,Lotze MT,Shurin MR

更新日期：2000-09-01 00:00:00

abstract：:Biochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II-restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive. Here we show that endogenous presentation of an epitope derived from t...

journal_title：European journal of immunology

authors： Nimmerjahn F,Milosevic S,Behrends U,Jaffee EM,Pardoll DM,Bornkamm GW,Mautner J

更新日期：2003-05-01 00:00:00

abstract：:Despite all the structural and functional data that have been accumulated regarding major histocompatibility complex (MHC) class II molecules during recent years, the relative contribution of putative T cell receptor (TcR)-contacting residues and peptide-binding MHC polymorphisms to MHC-restricted and allospecific T c...

journal_title：European journal of immunology

authors： Coppin HL,Carmichael P,Lombardi G,L'Faqihi FE,Salter R,Parham P,Lechler RI,de Preval C

更新日期：1993-02-01 00:00:00

abstract：:Unexpected fetal loss is one of the common complications of pregnancy; however, the pathogenesis of many miscarriages, particularly those not associated with infections, is unknown. We previously found that activated DEC-205+ dendritic cells (DCs) and NK1.1+ invariant natural killer T (iNKT) cells are recruited into t...

journal_title：European journal of immunology

authors： Negishi Y,Ichikawa T,Takeshita T,Takahashi H

更新日期：2018-06-01 00:00:00

abstract：:CD16-positive (CD14(++) CD16(+) and CD14(+) CD16(++) ) monocytes have unique features with respect to phenotype and function. We have used transcriptional profiling for comparison of CD16-positive monocytes and classical monocytes. We show herein that 187 genes are greater than fivefold differentially expressed, incl...

journal_title：European journal of immunology

authors： Frankenberger M,Hofer TP,Marei A,Dayyani F,Schewe S,Strasser C,Aldraihim A,Stanzel F,Lang R,Hoffmann R,Prazeres da Costa O,Buch T,Ziegler-Heitbrock L

更新日期：2012-04-01 00:00:00

abstract：:An anti-T cell receptor (TcR) monoclonal antibody (mAb), LC4, directed against a human leukemic T cell line, SUP-T13, caused DNA fragmentation ("apoptosis") and cell death upon binding to this cell line. Cross-linking of receptor molecules was necessary for this effect since F(ab')2, but not Fab', fragments of LC4 cou...

journal_title：European journal of immunology

authors： Takahashi S,Maecker HT,Levy R

更新日期：1989-10-01 00:00:00

abstract：:The biological behavior of immune cells is determined by their intrinsic properties and interactions with other cell populations within their microenvironment. Several studies have confirmed the existence of tight spatial interactions between mast cells (MCs) and Tregs in different settings. For instance, we have rece...

journal_title：European journal of immunology

authors： Frossi B,D'Incà F,Crivellato E,Sibilano R,Gri G,Mongillo M,Danelli L,Maggi L,Pucillo CE

更新日期：2011-07-01 00:00:00