CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained.

abstract：:IFN-gamma plays a crucial role in the defense against infection with Candida albicans. Since IL-18 and IL-12 are strong stimuli of IFN-gamma production, we investigated whether endogenous IL-18 and IL-12 are involved in the host defense during disseminated candidiasis. IL-18 knockout (IL-18-/-) mice, but not IL-12-/- ...

journal_title：European journal of immunology

authors： Netea MG,Vonk AG,van den Hoven M,Verschueren I,Joosten LA,van Krieken JH,van den Berg WB,Van der Meer JW,Kullberg BJ

更新日期：2003-12-01 00:00:00

abstract：:Antibodies to framework determinants of the VH and V lambda fragments of MOPC 315 and antisera to the VH idiotype determinants of the A 5 A antibody were used to analyze the antigen receptors of mouse T (and B) cells. This was done by using the antibodies as inhibitors in (a) an assay in which the binding of radiolabe...

journal_title：European journal of immunology

authors： Eichmann K,Ben-Neriah Y,Hetzelberger D,Polke C,Givol D,Lonai P

更新日期：1980-02-01 00:00:00

abstract：:Chronic macrophage inflammation is a hallmark of type 2 diabetes (T2D) and linked to the development of secondary diabetic complications. T2D is characterized by excess concentrations of saturated fatty acids (SFA) that activate innate immune inflammatory responses, however, mechanism(s) by which SFAs control inflamma...

journal_title：European journal of immunology

authors： Davis FM,denDekker A,Joshi AD,Wolf SJ,Audu C,Melvin WJ,Mangum K,Riordan MO,Kunkel SL,Gallagher KA

更新日期：2020-12-01 00:00:00

abstract：:We generated cell hybrids between mouse T cell lymphoma EL4 cells and mouse fibroblast B82 cells (BELIII and BELIV) to examine the expression of T cell receptor (TcR)/CD3 genes and their lymphoid-specific transcription factor genes, which are normally detected in EL4 cells. In BELIII and BELIV, expression of the TcR a...

journal_title：European journal of immunology

authors： Yamada T,Hitomi Y,Satake M,Oikawa T

更新日期：1995-09-01 00:00:00

abstract：:CD4+ helper T lymphocytes and CD8+ killer T lymphocytes are both generated in the thymus from common precursor cells expressing CD4 and CD8. The development of immature CD4 CD8+ thymocytes into mature 'single-positive' T cells requires T cell antigen-receptor (TCR)-mediated positive selection signals. Although it is k...

journal_title：European journal of immunology

authors： Takahama Y,Tokoro Y,Sugawara T,Negishi I,Nakauchi H

更新日期：1997-12-01 00:00:00

abstract：:During the chronic phase of infection with the parasite Trypanosoma cruzi, mice develop inflammatory lesions in the heart and skeletal muscles, as well as in peripheral nerves and the liver. We demonstrated the presence, in the blood of chronically infected mice, of L3T4+ T cells able to transfer a specific T. cruzi d...

journal_title：European journal of immunology

authors： Hontebeyrie-Joskowicz M,Said G,Milon G,Marchal G,Eisen H

更新日期：1987-07-01 00:00:00

abstract：:The molecular mimicry represented by cross-recognition of determinants shared by unrelated antigens by antibodies or T cells is of broad immunological interest. In this study, we analyzed the cross-recognition by CD4+ T cells of a peptide epitope shared by two mycobacterial proteins of diverse sequence, represented by...

journal_title：European journal of immunology

authors： Harris DP,Vordermeier HM,Singh M,Moreno C,Jurcevic S,Ivanyi J

更新日期：1995-11-01 00:00:00

abstract：:Invariant NKT cells were stimulated with cholesteryl O-acyl α-glycosides in the context of CD1d. The activated NKT cells have potential to sustain the homeostasis in the body exposed to excess in either Th1- or Th2-immunity. ...

journal_title：European journal of immunology

authors： Shimamura M,Kamijo SI,Illarionov P

更新日期：2019-02-01 00:00:00

abstract：:Previously we implicated c-Jun N-terminal kinase (JNK) as an element that is involved in signal integration during co-stimulation of T lymphocytes. This pathway has now been traced to an upper level, comprising MAPKK SEK1/MKK4/JNKK1 which, similarly to JNK, must receive input both from the TCR and CD28. A large portio...

journal_title：European journal of immunology

authors： Avraham A,Jung S,Samuels Y,Seger R,Ben-Neriah Y

更新日期：1998-08-01 00:00:00

abstract：:We have studied the kinetics of the antigen induced response of naive and memory CD8 T cells expressing a transgenic T cell receptor (TCR) specific for the glycoprotein peptide amino acid 33-41 (GP33) of the lymphocytic choriomeningitis virus (LCMV). Memory T cells were generated in vivo by adoptive transfer of LCMV T...

journal_title：European journal of immunology

authors： Zimmermann C,Prévost-Blondel A,Blaser C,Pircher H

更新日期：1999-01-01 00:00:00

abstract：:In the present study, we sought evidence for a surface nucleosome receptor in the fibroblastic cell line CV-1, and questioned whether anti-double-stranded (ds) DNA and/or anti-histone autoantibodies could recognize and influence the fate of cell surface-bound nucleosomes. 125I-labeled mononucleosomes were shown to bin...

journal_title：European journal of immunology

authors： Koutouzov S,Cabrespines A,Amoura Z,Chabre H,Lotton C,Bach JF

更新日期：1996-02-01 00:00:00

abstract：:Immunity to tumor differentiation antigens, such as melanoma antigen recognized by T cells 1 (MART-1), has been comprehensively studied. Intriguingly, CD8(+) T cells specific for the MART-1(26(27)-35) epitope in the context of HLA-A0201 are about 100 times more abundant compared with T cells specific for other tumor-a...

journal_title：European journal of immunology

authors： Pinto S,Sommermeyer D,Michel C,Wilde S,Schendel D,Uckert W,Blankenstein T,Kyewski B

更新日期：2014-09-01 00:00:00

abstract：:A monoclonal antibody (12-15) reactive with the mouse CD2 was used to study the expression of the antigen in different lymphoid cell subsets. By two-color immunofluorescence using B or T cell-specific reagents and cell sorting in combination with biochemical analysis we provide evidence that the CD2 antigen is present...

journal_title：European journal of immunology

authors： Altevogt P,Michaelis M,Kyewski B

更新日期：1989-08-01 00:00:00

abstract：:Maintenance of peripheral tolerance and inactivation of autoreactive T cells is based on a delicate balance between pro-inflammatory and protective cytokines that is poorly understood. We have here addressed how the local expression of the inflammatory cytokine TNF-alpha can impair peripheral tolerance and lead to aut...

journal_title：European journal of immunology

authors： Skak K,Guerder S,Picarella DE,Brenden N,Flavell RA,Michelsen BK

更新日期：2003-05-01 00:00:00

abstract：:Accumulating evidence suggests that alloreactive memory T cells (Tm) may form a barrier to tolerance induction in large animals and humans due in part to a resistance to suppression by Treg. However, why Tm are resistant to regulation and how the Tm response to an allograft differs from that of naïve T cells, which ar...

journal_title：European journal of immunology

authors： Jones ND,Brook MO,Carvalho-Gaspar M,Luo S,Wood KJ

更新日期：2010-11-01 00:00:00

abstract：:The beta7 integrins alpha4beta7 and alphaEbeta7 play key roles in forming the gut-associated lymphoid tissue, and contribute to chronic inflammation. The alpha4beta7 integrin-mediated adhesion of activated lymphocytes is largely due to a transient increase in avidity from ligand-induced clustering of alpha4beta7 at th...

journal_title：European journal of immunology

authors： Krissansen GW,Singh J,Kanwar RK,Chan YC,Leung E,Lehnert KB,Kanwar JR,Yang Y

更新日期：2006-08-01 00:00:00

abstract：:The antigen receptor of the T lymphocytes is one of the most complex eukaryotic membrane structures studied to date. The T cell receptor (TcR) consists of two disulfide-linked glycoprotein chains (alpha/beta or gamma/delta) and is noncovalently associated with a group of small and invariable CD 3 proteins. Four CD 3 c...

journal_title：European journal of immunology

authors： Clevers H,Dunlap S,Terhorst C

更新日期：1988-05-01 00:00:00

abstract：:Global transcriptional technologies have revolutionised the study of lymphoid cell populations, but human γδ T lymphocytes specific for phosphoantigens remain far less deeply characterised by these methods despite the great therapeutic potential of these cells. Here we analyse the transcriptome of circulating TCRVγ(+)...

journal_title：European journal of immunology

authors： Pont F,Familiades J,Déjean S,Fruchon S,Cendron D,Poupot M,Poupot R,L'faqihi-Olive F,Prade N,Ycart B,Fournié JJ

更新日期：2012-01-01 00:00:00

abstract：:Plasmid cassette-transfer vectors pBHuC chi and pBHuC gamma l have been designed which enable the construction of recombinant baculoviruses directing the co-expression of complete immunoglobulin in insect cells. We describe the application of these vectors for the expression of a human/mouse chimeric monoclonal antibo...

journal_title：European journal of immunology

authors： Poul MA,Cerutti M,Chaabihi H,Ticchioni M,Deramoudt FX,Bernard A,Devauchelle G,Kaczorek M,Lefranc MP

更新日期：1995-07-01 00:00:00

abstract：:Leishmaniasis is currently classified as category 1 disease, i.e. emerging and uncontrolled. Since the importance of persistent infection for maintaining an effective long-lasting protective response is controversial, the present study asks whether immunisation with non-persistent parasites leads to protection against...

journal_title：European journal of immunology

authors： Kedzierski L,Curtis JM,Doherty PC,Handman E,Kedzierska K

更新日期：2008-11-01 00:00:00

abstract：:Rabbit kappa light (L) chain allotypes are controlled by the allelic genes b4, b5, b6, b9 and a recently described allele b4v. The product of the b4v gene differs from that of b4 by at least two amino acid substitutions in the constant region. A serologic distinction between the b4 and b4v allotyes has now been detect...

journal_title：European journal of immunology

authors： Smith LJ,Sogh JA,Kindt TJ,Mandy WJ

更新日期：1979-01-01 00:00:00

abstract：:Leukosialin (CD43) is a major glycoprotein of T lymphocytes which has an extracellular domain of 45 nm in length that is heavily O-glycosylated. Monoclonal antibodies (mAb) to the extracellular domain of human leukosialin induce aggregation of T lymphocytes, monocytes and some cell lines that express leukosialin. The ...

journal_title：European journal of immunology

authors： Cyster JG,Williams AF

更新日期：1992-10-01 00:00:00

abstract：:B cell development in organ cultures of fetal liver from mice at day 14 of gestation resembles in kinetics and cell numbers generated the one observed in vivo. This development in vitro can be blocked by an IL-7 receptor-specific monoclonal antibody. Monoclonal antibodies specific for the pre-B cell receptor, i. e. fo...

journal_title：European journal of immunology

authors： Ceredig R,Rolink AG,Melchers F,Andersson J

更新日期：2000-03-01 00:00:00

abstract：:CD27, which belongs to the tumor necrosis factor receptor family, is expressed on germinal center (GC) but not on naive B cells, suggesting an important function of this molecule in the regulation of the GC reaction. We described here the expression of CD70, which is the ligand for CD27. We observed that in most tonsi...

journal_title：European journal of immunology

authors： Lens SM,Keehnen RM,van Oers MH,van Lier RA,Pals ST,Koopman G

更新日期：1996-05-01 00:00:00

abstract：:Adaptive immune responses have long been considered the "territory" of antigenic proteins, whereas carbohydrates are characterized as T-cell-independent antigens that are not typically recognized by the complete adaptive machinery. The current modus operandi when searching for dominant epitopes is the use of synthetic...

journal_title：European journal of immunology

authors： Cobb BA,Kasper DL

更新日期：2005-02-01 00:00:00

abstract：:Mice of strain MRL/Mp-lpr/lpr develop resistance against tolerance induction with aggregate-freed rabbit gamma-globulin as early as 6 weeks of age and show very complete resistance when they are 10 weeks old; congenic mice MRL-Mp+/+ of 6 and 10 weeks can be rendered tolerant. By reconstitution experiments, it was show...

journal_title：European journal of immunology

authors： Amagai T,Cinader B

更新日期：1981-11-01 00:00:00

abstract：:This Viewpoint series provides authoritative and detailed outlines of exciting areas of DC research. Some of the subjects that frequently come up include development of DC; distribution of DC in lymphoid and non-lymphoid tissues such as skin, intestine and lung; different forms or subsets of DC; and the role of DC in ...

journal_title：European journal of immunology

authors： Steinman RM

更新日期：2010-08-01 00:00:00

abstract：:Interleukin-12 (IL-12) has been shown to be produced by monocytes by the ligation of CD40. In the present experiments, IL-12 is shown to be produced by murine spleen antigen-presenting cells (APC) by interaction with T helper 1 (Th1) clones through CD40-CD40 ligand (CD40L) interaction, but not with Th2 clones. The IL-...

journal_title：European journal of immunology

authors： Hino A,Nariuchi H

更新日期：1996-03-01 00:00:00

abstract：:The CD4 and CD8 coreceptor molecules on immature thymocytes participate in T cell repertoire selection. To examine more definitively the role of CD4 and CD8 in the negative and positive selection of immature thymocytes, we generated transgenic mice with elevated surface CD4 expression and mated them with mice expressi...

journal_title：European journal of immunology

authors： Van Oers NS,Garvin AM,Davis CB,Forbush KA,Carlow DA,Littman DR,Perlmutter RM,Teh HS

更新日期：1992-03-01 00:00:00

abstract：:LeIF, a gene homologue of the eukaryotic initiation factor 4A was first described as a leishmanial antigen that induced a Th1-type T cell response in peripheral blood mononuclear cells (PBMC) from leishmaniasis patients. Moreover, the interferon (IFN)-gamma production by PBMC was found to be interleukin (IL)-12 depend...

journal_title：European journal of immunology

authors： Probst P,Skeiky YA,Steeves M,Gervassi A,Grabstein KH,Reed SG

更新日期：1997-10-01 00:00:00