Abstract:
:Antibodies to framework determinants of the VH and V lambda fragments of MOPC 315 and antisera to the VH idiotype determinants of the A 5 A antibody were used to analyze the antigen receptors of mouse T (and B) cells. This was done by using the antibodies as inhibitors in (a) an assay in which the binding of radiolabeled streptococcal carbohydrate (A-CHO) antigen by primed and unprimed T and B cells is determined and (b) an assay in which the helper activity of group A streptococcal vaccine-primed T cells is determined. The results suggest that the major proportion of primed and unprimed T cells binding A-CHO (70-90%) exhibit VH framework and VH idiotypic determinants. This population appears to include the helper T cells. A minor proportion of T cells (10-30%) express V lambda-related framework determinants and lack VH framework and VH idiotypic determinants. This population does not include T helper cells. Taken together, the data suggest that a subpopulation of T cells, including the helper cells, uses entire Ig VH regions as part of their antigen receptor system.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Eichmann K,Ben-Neriah Y,Hetzelberger D,Polke C,Givol D,Lonai Pdoi
10.1002/eji.1830100207subject
Has Abstractpub_date
1980-02-01 00:00:00pages
105-12issue
2eissn
0014-2980issn
1521-4141journal_volume
10pub_type
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