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Induction of optimal anti-viral neutralizing B cell responses by dendritic cells requires transport and release of virus particles in secondary lymphoid organs.

Abstract：

:Dendritic cells (DC) are sentinels of the immune system, transporting antigens from the periphery to secondary lymphoid organs. This study investigates the interactions of DC with B cells for the induction of anti-viral neutralizing antibody responses. Using the vesicular stomatitis virus glycoprotein (VSV-G) as a model antigen, we show that DC contain infection with cytopathic VSV in the presence of a functional IFN system, facilitating transport and release of low levels of live virus in secondary lymphoid organs. DC exposed to live virus induced efficient neutralizing anti-viral B cell responses. In contrast, DC transporting UV-inactivated viral antigens were poor activators of anti-viral B cells, although they were capable of very efficiently inducing virus-specific Th cells. Transgenic DC expressing a membrane-bound form of VSV-G induced neutralizing B cell responses; however, this DC-induced, Th-dependent B cell response was significantly slower than the anti-viral B cell response induced by DC infected with live VSV, and was strongly dependent on concomitant priming of T help. These results suggest that DC may play a double role during infection with cytopathic virus: they transport and release live virus in secondary lymphoid tissues for optimal direct B cell induction and offer MHC class II-associated determinants for induction of T help.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Ludewig B,Maloy KJ,López-Macías C,Odermatt B,Hengartner H,Zinkernagel RM

doi

10.1002/1521-4141(200001)30:1<185::AID-IMMU185>3.0

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

185-96

issue

1

eissn

0014-2980

issn

1521-4141

pii

10.1002/(SICI)1521-4141(200001)30:01<185::AID-IMMU

journal_volume

30

pub_type

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