"In vivo" activated splenic T cells are refractory to interleukin 2 growth "in vitro".

abstract：:The distribution of the murine receptor for interleukin (IL) 6 was examined on a variety of cells. Binding sites for IL 6 were found on many cell lines including fibroblasts and bone marrow-derived macrophages. The highest density of binding sites was found on B cell hybridomas and plasmacytomas, irrespective of their...

journal_title：European journal of immunology

authors： Coulie PG,Stevens M,Van Snick J

更新日期：1989-11-01 00:00:00

abstract：:Even if omalizumab is broadly used in the treatment of severe, allergic asthma, the immunological effects in long-term treated patients have not been fully elucidated. To this aim, a cohort of 15 allergic asthmatic patients treated with omalizumab for at least three years was compared with 12 allergic asthma patients ...

journal_title：European journal of immunology

authors： Maggi L,Rossettini B,Montaini G,Matucci A,Vultaggio A,Mazzoni A,Palterer B,Parronchi P,Maggi E,Liotta F,Annunziato F,Cosmi L

更新日期：2018-12-01 00:00:00

abstract：:Human plasmacytoid dendritic cells (PDC) are believed to link innate and adaptive immunity by producing type I interferon (IFN-I) and triggering adaptive T cell-mediated immunity. However, it remains elusive to which degree both PDC functions are linked. Here we show that CMV antigen targeted to PDC using a CD303 (blo...

journal_title：European journal of immunology

authors： Jaehn PS,Zaenker KS,Schmitz J,Dzionek A

更新日期：2008-07-01 00:00:00

abstract：:The diversity of the human immune repertoire and how it relates to a functional immune response has not yet been studied in detail in humanized NOD.SCID.gammac(-/-) immunodeficient mice. Here, we used a multiplex PCR on genomic DNA to quantify the combinatorial diversity of all possible V-J rearrangements at the TCR-b...

journal_title：European journal of immunology

authors： Marodon G,Desjardins D,Mercey L,Baillou C,Parent P,Manuel M,Caux C,Bellier B,Pasqual N,Klatzmann D

更新日期：2009-08-01 00:00:00

abstract：:Plasmid cassette-transfer vectors pBHuC chi and pBHuC gamma l have been designed which enable the construction of recombinant baculoviruses directing the co-expression of complete immunoglobulin in insect cells. We describe the application of these vectors for the expression of a human/mouse chimeric monoclonal antibo...

journal_title：European journal of immunology

authors： Poul MA,Cerutti M,Chaabihi H,Ticchioni M,Deramoudt FX,Bernard A,Devauchelle G,Kaczorek M,Lefranc MP

更新日期：1995-07-01 00:00:00

abstract：:Ig class switch recombination (CSR) is dependent upon the expression of activation-induced deaminase and targeted to specific isotypes by germ-line transcript expression and isotype-specific factors. NF-kappaB plays critical roles in multiple aspects of B cell biology and has been implicated in the mechanism of CSR by...

journal_title：European journal of immunology

authors： Wang L,Wuerffel R,Kenter AL

更新日期：2006-12-01 00:00:00

abstract：:Orally administrated iron is suspected to increase susceptibility to enteric infections among children in infection endemic regions. Here we investigated the effect of dietary iron on the pathology and local immune responses in intestinal infection models. Mice were held on iron-deficient, normal iron, or high iron di...

journal_title：European journal of immunology

authors： Kortman GA,Mulder ML,Richters TJ,Shanmugam NK,Trebicka E,Boekhorst J,Timmerman HM,Roelofs R,Wiegerinck ET,Laarakkers CM,Swinkels DW,Bolhuis A,Cherayil BJ,Tjalsma H

更新日期：2015-09-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) employs multiple mechanisms to evade the immune system and succeeds to persist lifelong in the host. Human dendritic cells (DC) are the main antigen-presenting cells and play the key role in inducing and maintaining immune responses. Here, we studied the interaction of HCMV with DC. We fou...

journal_title：European journal of immunology

authors： Beck K,Meyer-König U,Weidmann M,Nern C,Hufert FT

更新日期：2003-06-01 00:00:00

abstract：:Cells of the innate immune system build immunological memory via epigenetic reprogramming after stimulations with microbial ligands. This functional readjustment allows for enhanced nonspecific inflammatory responses upon secondary challenges, a process termed "trained immunity." The epigenomic blueprint of trained mo...

journal_title：European journal of immunology

authors： Crișan TO,Netea MG,Joosten LA

更新日期：2016-04-01 00:00:00

abstract：:MS is a multifactorial disease in which a series of genetic and non-genetic, environmental factors plays a role in its etiology. In particular, HLA class II alleles, mainly HLADRB1*15:01 (HLA-DR15), increase the risk for this disease. Out of several environmental factors, and with regard to infections, EBV remains to ...

journal_title：European journal of immunology

authors： Olsson T

更新日期：2020-12-22 00:00:00

abstract：:Plasmodium falciparum stimulates peripheral blood gamma delta + T cells from unexposed donors. The responding cells bear V gamma 9+ chains of the T cell receptor, the majority of which, but not all, are associated with V delta 2 chains. We have analyzed whether the precursor frequency of these V gamma 9+ cells approac...

journal_title：European journal of immunology

authors： Goodier M,Krause-Jauer M,Langhorne J

更新日期：1992-10-01 00:00:00

abstract：:Cytokines are the main agents known to regulate Th1 / Th2 commitment, where they may operate through paracrine activity within clusters of T cells gathered around dendritic cells (DC). An in vitro system is used here to test this possibility, using clusters around DC composed of naive TCR-transgenic ovalbumin peptide ...

journal_title：European journal of immunology

authors： Schuhbauer DM,Mitchison NA,Mueller B

更新日期：2000-05-01 00:00:00

abstract：:Colony-stimulating factors are required for survival proliferation, differentiation and functional activation of granulocytes, macrophages and their precursor cells. In the present report, however, we demonstrate antiproliferative activity of recombinant human (rh) granulocyte-macrophage colony-stimulating factor (GM-...

journal_title：European journal of immunology

authors： Lindemann A,Riedel D,Oster W,Mertelsmann R,Herrmann F

更新日期：1988-03-01 00:00:00

abstract：:Hybrid virus-like particles (VLP) were prepared by self-assembly of the modified porcine parvovirus (PPV) VP2 capsid protein carrying a CD8+ or CD4+ T cell epitope. Immunization of mice with a single dose of these hybrid pseudo-particles, without adjuvant, induced strong cytotoxic T lymphocyte and T helper (Th) respon...

journal_title：European journal of immunology

authors： Lo-Man R,Rueda P,Sedlik C,Deriaud E,Casal I,Leclerc C

更新日期：1998-04-01 00:00:00

abstract：:CD5 is expressed on T cells and a subset of B cells (B1a). It can attenuate TCR signalling and impair CTL activation and is a therapeutic targetable tumour antigen expressed on leukemic T and B cells. However, the potential therapeutic effect of functionally blocking CD5 to increase T cell anti-tumour activity against...

journal_title：European journal of immunology

authors： Alotaibi F,Rytelewski M,Figueredo R,Zareardalan R,Zhang M,Ferguson PJ,Maleki Vareki S,Najajreh Y,El-Hajjar M,Zheng X,Min WP,Koropatnick J

更新日期：2020-05-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) induces a strong cytotoxic T lymphocyte (CTL) response in humans following infection. HIV-specific CTL can be detected directly in the blood and lungs of infected patients, and can be expanded in vitro by stimulation with autologous HIV-infected lymphoblasts. Furthermore...

journal_title：European journal of immunology

authors： Chenciner N,Michel F,Dadaglio G,Langlade-Demoyen P,Hoffenbach A,Leroux A,Garcia-Pons F,Rautmann G,Guy B,Guillon JM

更新日期：1989-09-01 00:00:00

abstract：:The MOPC460 idiotype is expressed in mice with the IghCa allotypic haplotype after anti-2,4-dinitrophenyl (DNP) immunization. We have previously shown that two monoclonal syngeneic anti-idiotypic antibodies (IDM 92-13 and IDM 41-27) define two distinct idiotopes (the 460.92 and the 460.41) on the M460 idiotype. The cu...

journal_title：European journal of immunology

authors： Sanchez P,Juy D,Cazenave PA

更新日期：1983-12-01 00:00:00

abstract：:Previous studies demonstrated that mannan is a potent inhibitor of splenic entry of lymphocytes and mediates its inhibitory effect at an unidentified site in the spleen rather than acting directly on lymphocytes. This report describes the in vivo site of action of mannan. In vivo localization studies with fluoresceina...

journal_title：European journal of immunology

authors： Weston SA,Parish CR

更新日期：1992-08-01 00:00:00

abstract：:The role of B cells and antibody in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) remains controversial. We previously demonstrated that B cells are required for EAE to be induced by the 120-amino acid extracellular domain of myelin oligodendrocyte glycoprotein (MOG). In the present study, the ro...

journal_title：European journal of immunology

authors： Lyons JA,Ramsbottom MJ,Cross AH

更新日期：2002-07-01 00:00:00

abstract：:In the fetus the peripheral T cell pool expands as the fetus grows, but the mechanisms that regulate T cell homeostasis during fetal life are unknown. Here, we show that the peripheral T cell pool in the sheep fetus is established by the export from the fetal thymus of twice as many CD8+ as CD4+ thymic emigrants every...

journal_title：European journal of immunology

authors： Holder JE,Washington EA,Cunningham CP,Cahill RN,Kimpton WG

更新日期：2006-10-01 00:00:00

abstract：:Mitogens such as pokeweed mitogen, Staphylococcus aureus Cowan I, concanavalin A and phytohemagglutinin and monoclonal anti-CD antibodies were examined for their capacity to induce IgE synthesis by peripheral blood leukocytes obtained from both atopic and nonatopic individuals. While lectins failed to induce IgE synth...

journal_title：European journal of immunology

authors： Yang XD,De Weck AL,Stadler BM

更新日期：1988-03-01 00:00:00

abstract：:Elucidating the signaling events that promote T-cell tolerance versus activation provides important insights for manipulating immunity in vivo. Previous studies have suggested that the absence of PKCtheta results in the induction of anergy and that the balance between the induction of the transcription factors NFAT, A...

journal_title：European journal of immunology

authors： Deenick EK,Po L,Chapatte L,Murakami K,Lu YC,Elford AR,Saibil SD,Ruland J,Gerondakis S,Mak TW,Ohashi PS

更新日期：2010-03-01 00:00:00

abstract：:The role of complement receptors on the localization of T and B cells in the spleen of mice was studied using short-term homing experiments in cobra venom factor (CoF)-treated animals. The localization ratio of B and T cells in the spleen of CoF-treated mice decreased significantly compared to control recipients. No c...

journal_title：European journal of immunology

authors： Kraal G,Van Hoogstraten I,Klerx JP,Van Dijk H

更新日期：1985-07-01 00:00:00

abstract：:In the present study, interleukin 1 (IL 1)-containing media from different sources, namely a murine macrophage cell line (P388D1), rabbit peritoneal macrophages, and human peripheral blood mononuclear cells, were compared for their effect on thymocyte proliferation and on collagenase and PGE2 secretion by chondrocytes...

journal_title：European journal of immunology

authors： Evêquoz V,Bettens F,Kristensen F,Trechsel U,Stadler BM,Dayer JM,De Weck AL,Fleisch H

更新日期：1984-06-01 00:00:00

abstract：:The viral CC chemokine macrophage inhibitory protein-II (vMIP-II) encoded by human herpes virus 8 (HHV-8) binds to multiple chemokine receptors, however, its ability to control the initial recruitment of specific leukocyte subtypes from the peripheral circulation has not been fully clarified. Here we show that vMIP-II...

journal_title：European journal of immunology

authors： Weber KS,Gröne HJ,Röcken M,Klier C,Gu S,Wank R,Proudfoot AE,Nelson PJ,Weber C

更新日期：2001-08-01 00:00:00

abstract：:The DC-derived chemokine CCL17, a ligand of CCR4, has been shown to promote various inflammatory diseases such as atopic dermatitis, atherosclerosis, and inflammatory bowel disease. Under steady-state conditions, and even after systemic stimulation with LPS, CCL17 is not expressed in resident splenic DCs as opposed to...

journal_title：European journal of immunology

authors： Globisch T,Steiner N,Fülle L,Lukacs-Kornek V,Degrandi D,Dresing P,Alferink J,Lang R,Pfeffer K,Beyer M,Weighardt H,Kurts C,Ulas T,Schultze JL,Förster I

更新日期：2014-02-01 00:00:00

abstract：:Dendritic cells (DCs) are essential in dictating the nature and effectiveness of immune responses. In the intestine DCs can be separated into discrete subsets, defined by expression of CD11b and CD103, each with different developmental requirements and distinct functional potential. Recent evidence has shown that diff...

journal_title：European journal of immunology

authors： Redpath SA,Heieis GA,Reynolds LA,Fonseca NM,Kim SS,Perona-Wright G

更新日期：2018-01-01 00:00:00

abstract：:In the past 15 years, it became clear that the symbiotic microbiota has an important impact on the development and regulation of the immune system. Consequently, it is incorrect to interpret a phenotype solely as a direct result of the genotype, without considering the impact of the microbiota. In fact, ignorance of t...

journal_title：European journal of immunology

authors： Eberl G,Vieira P

更新日期：2020-06-01 00:00:00

abstract：:This study was performed to investigate whether gamma delta T cells could also be divided into subsets, identified by a cytokine profile, as described for alpha beta T helper (Th) cell subsets. Cytokine production was studied in 22 gamma delta T cell clones obtained from the synovial fluid and peripheral blood of one ...

journal_title：European journal of immunology

authors： Chomarat P,Kjeldsen-Kragh J,Quayle AJ,Natvig JB,Miossec P

更新日期：1994-09-01 00:00:00

abstract：:Human peripheral blood T lymphocytes are stimulated to grow and divide by lectins such as concanavalin A (Con A) and Phaseolus vulgaris phytohemagglutinin (PHA), as well as a few anti-T cell monoclonal antibodies. The latter antibodies recognize the T3 antigen. It has been suggested previously that PHA and Con A media...

journal_title：European journal of immunology

authors： Kanellopoulos JM,De Petris S,Leca G,Crumpton MJ

更新日期：1985-05-01 00:00:00