Cytokine-dependent regulation of dendritic cell differentiation in the splenic microenvironment.

abstract：:Traumatic brain injury (TBI) elicits innate inflammatory responses that can lead to secondary brain injury. To better understand the mechanisms involved in TBI-induced inflammation, we examined the nature of macrophages responding to TBI in mice. In this model, brain macrophages were increased >20-fold the day after i...

journal_title：European journal of immunology

authors： Hsieh CL,Kim CC,Ryba BE,Niemi EC,Bando JK,Locksley RM,Liu J,Nakamura MC,Seaman WE

更新日期：2013-08-01 00:00:00

abstract：:Transporter associated with antigen processing (TAP)-competent and TAP-deficient cell lines were transfected with expression plasmids encoding either the wild-type (wt) large tumor antigen (T-Ag) of SV40, or a truncated cytoplasmic variant (cT-Ag) of this viral protein. Stable expression of comparable levels of both f...

journal_title：European journal of immunology

authors： Schirmbeck R,Böhm W,Reimann J

更新日期：1997-08-01 00:00:00

abstract：:Cyclosporin A (CsA), an immunosuppressive drug which completely suppresses the humoral response to thymus-dependent antigens, does not affect the generation of T helper (Th) cells during an in vitro stimulation of murine spleen cells with sheep red blood cells. The appearance of Th cells depends on time and their deve...

journal_title：European journal of immunology

authors： Motta I,Colle JH,Shidani B,Truffa-Bachi P

更新日期：1991-03-01 00:00:00

abstract：:The present study tests whether the specific inhibition of helper T (Th) cell (and T hybridomas) by suppressor T (Ts) cells is a phenotypic trait of Th cells correlating with their acquired specificity for antigen/major histocompatibility complex or a genotypic trait not related to selection of the T cell repertoire f...

journal_title：European journal of immunology

authors： Araneo BA,Dowell T,Bertelsen K

更新日期：1988-04-01 00:00:00

abstract：:In previous publications it was shown by avidity measurements, cross-reactivity patterns and genetic analyses, that the tetrapeptide T-T-G-G is the immuno-dominant epitope of the synthetic polypeptide (T, G)-A--L. In the present study this close immunological relationship between the random multichain copolymer (T, G)...

journal_title：European journal of immunology

authors： Cramer M,Schwartz M,Mozes E,Sela M

更新日期：1976-09-01 00:00:00

abstract：:Monoclonal antibodies (mAb) derived from BALB/c mice immunized with human anti-HLA-A2 cloned cytotoxic T lymphocytes (CTL) were screened for their ability to block, in the absence of complement, the cytolytic activity of the immunizing CTL clone. Eight cytolysis-inhibiting mAb have been derived. One of these was direc...

journal_title：European journal of immunology

authors： Malissen B,Rebai N,Liabeuf A,Mawas C

更新日期：1982-09-01 00:00:00

abstract：:Human peripheral blood natural killer (NK) cells (CD56+, CD16+, CD3 epsilon- lymphocytes) express CD69 after their stimulation by interleukin-2 (IL-2) or interferon-alpha (IFN-alpha). This activation antigen represents a triggering surface molecule in NK cell clones as its stimulation triggers the cytolytic machinery ...

journal_title：European journal of immunology

authors： Borrego F,Peña J,Solana R

更新日期：1993-05-01 00:00:00

abstract：:Lymphocyte function-associated-antigen-1 (LFA-1) is able to bind selectively to its ligands intercellular adhesion molecules 1 and 3 (ICAM-1 and ICAM-3), suggesting that LFA-1 can exist in distinct ligand-specific binding states. In the case of ICAM-1, apart from ligand itself and the recently cloned molecule cytohesi...

journal_title：European journal of immunology

authors： Buckley CD,Ferguson ED,Littler AJ,Bossy D,Simmons DL

更新日期：1997-04-01 00:00:00

abstract：:The monoclonal antibody OKT3 can induce T suppressor cells of the in vitro antibody response when used at concentrations as low as 10 ng/ml and in cultures containing as few as 4% OKT3-pretreated T cells. These suppressor cells are radioresistant, cyclosporin sensitive and belong to the T4 as well as the T8 subpopulat...

journal_title：European journal of immunology

authors： Delfraissy JF,Wallon C,Boué F,Vazquez A,Galanaud P

更新日期：1985-05-01 00:00:00

abstract：:A monoclonal antibody (mAb) directed to a human leukocyte 55-kDa cell surface molecule with identical cellular distribution and biochemical properties to the CD4 was able to inhibit T cell proliferation induced either in a mixed lymphocyte culture or by activation with mAb anti-CD3, anti-CD2 or phytohemagglutinin. The...

journal_title：European journal of immunology

authors： Carrera AC,Sanchez-Madrid F,Lopez-Botet M,Bernabeu C,De Landazuri MO

更新日期：1987-02-01 00:00:00

abstract：:The surface expression of given HLA class I alleles protects target cells from lysis mediated by natural killer (NK) clones specific for these (or related) alleles. We could define two groups of NK clones specifically recognizing either Cw4 and related C alleles ("group 1") or Cw3 and related C alleles ("group 2"), re...

journal_title：European journal of immunology

authors： Ciccone E,Pende D,Vitale M,Nanni L,Di Donato C,Bottino C,Morelli L,Viale O,Amoroso A,Moretta A

更新日期：1994-04-01 00:00:00

abstract：:Tissue macrophages and their precursors-the blood monocytes-respond rapidly to a bacterial infection with the release of inflammatory mediators. These mediators are involved in the recruitment of phagocytic cells, principally neutrophils, from the blood to the site of infection. To initiate this process macrophages an...

journal_title：European journal of immunology

authors： Jack RS,Grunwald U,Stelter F,Workalemahu G,Schütt C

更新日期：1995-05-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune disease inducible in rodents by immunization of brain-specific antigens such as myelin basic protein (MBP). It is also well known that various strains of rats differ in their susceptibility to EAE upon active immunization. To elucidate the...

journal_title：European journal of immunology

authors： Matsumoto Y,Kawai K,Fujiwara M

更新日期：1990-09-01 00:00:00

abstract：:Recently activated peripheral T cells treated with IL-2 for 4 days expressed Fas ligand (FasL)-mediated cytotoxicity. These IL-2-treated T cells had high nuclear expression of SP1 and NFAT, but lacked the Egr-2 and Egr-3 that could be induced by anti-CD3 stimulation and had been implicated in FasL gene activation. A m...

journal_title：European journal of immunology

authors： Xiao S,Matsui K,Fine A,Zhu B,Marshak-Rothstein A,Widom RL,Ju ST

更新日期：1999-11-01 00:00:00

abstract：:Mice carrying the lpr gene, SCG and MRL-lpr/lpr mice, were used to characterize the phenotype and lpr gene of abnormally proliferating T cells in these mice. A major population which expanded in these mice were T cells expressing intermediate (int) levels of T cell receptor (TCR) (and CD3) and the phenotype of interle...

journal_title：European journal of immunology

authors： Yamagiwa S,Kuwano Y,Hasegawa K,Sato K,Ohtsuka K,Iiai T,Tomiyama K,Watanabe H,Sugahara S,Seki S,Asakura H,Abo T

更新日期：1996-07-01 00:00:00

abstract：:The mechanisms underlying the relatively slow progression of human immunodeficiency virus type 2 (HIV-2) compared with HIV-1 infection are undefined and could be a result of more effective immune responses. We used HIV-2 and HIV-1 IFN-gamma enzyme-linked immunospot assays to evaluate CD8(+) T cell responses in antiret...

journal_title：European journal of immunology

authors： Gillespie GM,Pinheiro S,Sayeid-Al-Jamee M,Alabi A,Kaye S,Sabally S,Sarge-Njie R,Njai H,Joof K,Jaye A,Whittle H,Rowland-Jones S,Dorrell L

更新日期：2005-05-01 00:00:00

abstract：:Clonal deletion, anergy and suppression have all been considered mechanisms of immunological tolerance. Although adoptive transfer of immunosuppression has been shown to occur in the periphery, particularly for transplantation tolerance, it has proven difficult to characterize this phenomenon further, due to the lack ...

journal_title：European journal of immunology

authors： Teng YT,Gorczynski RM,Iwasaki S,Williams DB,Hozumi N

更新日期：1995-09-01 00:00:00

abstract：:Mature T cells may be produced in the thymus, or by expansion in the periphery. While thymus output of virgin cells ensures repertoire diversity, peripheral expansion increases the size of rare clones, and thus the efficiency of immune responses. We studied the role of both phenomena in the generation of the CD8+ T ce...

journal_title：European journal of immunology

authors： Tanchot C,Rocha B

更新日期：1995-08-01 00:00:00

abstract：:CD5 is expressed on T cells and a subset of B cells (B1a). It can attenuate TCR signalling and impair CTL activation and is a therapeutic targetable tumour antigen expressed on leukemic T and B cells. However, the potential therapeutic effect of functionally blocking CD5 to increase T cell anti-tumour activity against...

journal_title：European journal of immunology

authors： Alotaibi F,Rytelewski M,Figueredo R,Zareardalan R,Zhang M,Ferguson PJ,Maleki Vareki S,Najajreh Y,El-Hajjar M,Zheng X,Min WP,Koropatnick J

更新日期：2020-05-01 00:00:00

abstract：:Bone marrow mesenchymal progenitor cells (BMSC) are used for regenerating tissues of mesodermal origin, as well as tissues of different embryological derivation. Experimental evidence shows that BMSC are able to suppress the activation of the immune response by mechanisms that are still not completely understood. Thus...

journal_title：European journal of immunology

authors： Augello A,Tasso R,Negrini SM,Amateis A,Indiveri F,Cancedda R,Pennesi G

更新日期：2005-05-01 00:00:00

abstract：:Tyrosine kinase 2 (Tyk2) contributes to the signals triggered by IL-12 for IFN-gamma production by NK cells and T cells. We found in this study that Tyk2-deficient (-/-) mice showed increased susceptibility at the early stage after an i.p. infection with Listeria monocytogenes, accompanied by impaired IFN-gamma produc...

journal_title：European journal of immunology

authors： Aizu K,Li W,Yajima T,Arai T,Shimoda K,Nimura Y,Yoshikai Y

更新日期：2006-11-01 00:00:00

abstract：:Toll-like receptors (TLRs) are playing important roles in stimulating the innate immune response and intensifying adaptive immune response against invading pathogens. Appropriate regulation of TLR activation is important to maintain a balance between preventing tumor activation and inhibiting autoimmunity. Toll-like r...

journal_title：European journal of immunology

authors： Kim TW,Hong S,Talukder AH,Pascual V,Liu YJ

更新日期：2016-03-01 00:00:00

abstract：:The CD4 and CD8 coreceptor molecules on immature thymocytes participate in T cell repertoire selection. To examine more definitively the role of CD4 and CD8 in the negative and positive selection of immature thymocytes, we generated transgenic mice with elevated surface CD4 expression and mated them with mice expressi...

journal_title：European journal of immunology

authors： Van Oers NS,Garvin AM,Davis CB,Forbush KA,Carlow DA,Littman DR,Perlmutter RM,Teh HS

更新日期：1992-03-01 00:00:00

abstract：:The in vitro immune response of murine spleen cells to the T cell-independent antigen, 2,4-dinitrophenyl-beta-alanyl-glycyl-glycyl-N(2-aminoethyl)carbamyl-methylated Ficoll (DAGG-Ficoll), requires the presence of macrophages, or 24-hr culture supernates from peritoneal cells. Complete reconstitution of the response by...

journal_title：European journal of immunology

authors： Nordin AA

更新日期：1978-11-01 00:00:00

abstract：:Patients undergoing allogeneic bone marrow transplantation offer a unique system to analyze NK cell development in vivo. We analyzed NK cells from 23 such patients to assess the acquisition of activating receptors. Four patients displayed an immature NK cell surface phenotype at engraftment, as their cells were CD16(-...

journal_title：European journal of immunology

authors： Vitale C,Chiossone L,Morreale G,Lanino E,Cottalasso F,Moretti S,Dini G,Moretta L,Mingari MC

更新日期：2004-02-01 00:00:00

abstract：:The role of redox regulation in immune-mediated arthritis has been previously described. However, the relationship between innate immune cells, including innate lymphoid cells (ILCs) and phagocyte-derived ROS, in this process remains unclear. Here, we characterize ILCs and measure the IL-1 family cytokines along with ...

journal_title：European journal of immunology

authors： Chan TY,Yen CL,Huang YF,Lo PC,Nigrovic PA,Cheng CY,Wang WZ,Wu SY,Shieh CC

更新日期：2019-11-01 00:00:00

abstract：:We investigated the efficacy of a combination of anti-CD80 and CD86 (CD80 + 86) monoclonal antibodies (mAb), anti-interleukin (IL)-12 mAb, or both, for prophylaxis in a mouse acute graft-versus-host-disease (GVHD) model. The treatment with a combination of anti-CD80 + 86 mAb efficiently reduced the lethality of GVHD, ...

journal_title：European journal of immunology

authors： Saito K,Yagita H,Hashimoto H,Okumura K,Azuma M

更新日期：1996-12-01 00:00:00

abstract：:The transfer of maternal antibodies to the offspring and their inhibitory effects on active infant immunization is an important factor hampering the use of certain vaccines, such as measles or respiratory syncytial virus vaccine, in early infancy. The resulting delay in protection by conventional or novel vaccines may...

journal_title：European journal of immunology

authors： Siegrist CA,Barrios C,Martinez X,Brandt C,Berney M,Córdova M,Kovarik J,Lambert PH

更新日期：1998-12-01 00:00:00

abstract：:Epidermal keratinocytes differentiate and form a multilayered epidermis, which is the primary barrier between the body and the outer environment. As the epidermis is constantly exposed to a variety of microbial pathogens, its function of resisting microbial pathogens is vital. This characteristic feature is formed dur...

journal_title：European journal of immunology

authors： Sayama K,Komatsuzawa H,Yamasaki K,Shirakata Y,Hanakawa Y,Ouhara K,Tokumaru S,Dai X,Tohyama M,Ten Dijke P,Sugai M,Ichijo H,Hashimoto K

更新日期：2005-06-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a major part in providing innate immunity against pathogenic microorganisms. Recent studies show that these receptors are also expressed on T cells, which are the sentinels of adaptive immunity. Here, we have investigated the regulatory role of the T-cell receptor in the functioning of ...

journal_title：European journal of immunology

authors： Akhade AS,Qadri A

更新日期：2015-09-01 00:00:00