Increased efficiency of folding and peptide loading of mutant MHC class I molecules.

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells elaborate a cytolytic protein named perforin or cytolysin. It was widely held that, in vivo, high quantities of perforin are not present in resting lymphocytes and are usually produced only by activated lymphocytes found under pathological conditions. Until n...

journal_title：European journal of immunology

authors： Zheng LM,Ojcius DM,Young JD

更新日期：1993-09-01 00:00:00

abstract：:Interleukin (IL)-7 and IL-2 are important lymphoproliferative cytokines which both use the gamma c chain as part of their respective receptors. To learn more of their signaling mechanisms a comparison was made of the patterns of intracellular tyrosine phosphorylated proteins induced by these cytokines in the murine T ...

journal_title：European journal of immunology

authors： Crawley JB,Willcocks J,Foxwell BM

更新日期：1996-11-01 00:00:00

abstract：:The role of monocytes, B cells, and adherent and nonadherent T cells in the response of purified protein derivative of tuberculin (PPD) as measured by [3H]thymidine uptake in vitro has been explored. The response to PPD was found to be highly dependent on monocytes, to approximately the same extent as previously found...

journal_title：European journal of immunology

authors： Arala-Chaves MP,Porto MT,Hope L,Fudenberg HH

更新日期：1979-04-01 00:00:00

abstract：:The interaction between TCR and peptide-MHC is well described in terms of the recognition of the peptide, but the recognition of the MHC is less well understood. At issue is whether particular V gene products may have higher affinity for some MHC over others and to what extent the bound peptide influences V gene selec...

journal_title：European journal of immunology

authors： Battaglia M,Gorski J

更新日期：2002-08-01 00:00:00

abstract：:Pairs of monoclonal antibodies (mAb) defining epitopes T 11.1 and T 11.2 on the CD 2 molecule are mitogenic for purified human T cells in the presence of a submitogenic dose of 12-O-tetradecanoylphorbol 13-acetate (TPA). Anti-CD 28 mAb can substitute for the action of TPA in the anti-CD 2-induced proliferative respons...

journal_title：European journal of immunology

authors： Pierrès A,Lopez M,Cerdan C,Nunes J,Olive D,Mawas C

更新日期：1988-05-01 00:00:00

abstract：:The NLRP3 inflammasome is a molecular complex that translates signals from pathogens and tissue damage into inflammatory responses, and plays crucial roles in numerous neurological diseases. Activation of the NLRP3 inflammasome leads to caspase-1 dependent cleavage of pro-IL-1β to form mature IL-1β. By acting on the P...

journal_title：European journal of immunology

authors： Suzuki T,Kohyama K,Moriyama K,Ozaki M,Hasegawa S,Ueno T,Saitoe M,Morio T,Hayashi M,Sakuma H

更新日期：2020-02-01 00:00:00

abstract：:The exact identification of B cell subsets is instrumental to understand their dynamics under physiological and pathological conditions. Human memory B cells are currently identified according to the expression of CD27, which is absent on naive B cells. We report here that the ATP-binding cassette (ABC)B1 transporter ...

journal_title：European journal of immunology

authors： Wirths S,Lanzavecchia A

更新日期：2005-12-01 00:00:00

abstract：:Checkpoint blockade of CTLA-4 results in long-lasting survival benefits in metastatic cancer patients. However, patients treated with CTLA-4 blockade have suffered from immune-related adverse events, most likely due to the breadth of the induced T-cell activation. Here, we investigated the efficacy of a local low-dose...

journal_title：European journal of immunology

authors： van Hooren L,Sandin LC,Moskalev I,Ellmark P,Dimberg A,Black P,Tötterman TH,Mangsbo SM

更新日期：2017-02-01 00:00:00

abstract：:Human plasmacytoid dendritic cells (PDC) are believed to link innate and adaptive immunity by producing type I interferon (IFN-I) and triggering adaptive T cell-mediated immunity. However, it remains elusive to which degree both PDC functions are linked. Here we show that CMV antigen targeted to PDC using a CD303 (blo...

journal_title：European journal of immunology

authors： Jaehn PS,Zaenker KS,Schmitz J,Dzionek A

更新日期：2008-07-01 00:00:00

abstract：:Two out of 25 monoclonal anti-DNA autoantibodies that were produced by human-human hybridoma were found to have lymphocytotoxic activity. The antibodies reacted with normal B and T lymphocytes at cold (4 degrees C) as well as at warm (37 degrees C) temperatures. The lymphocytotoxic activity of the monoclonal anti-DNA ...

journal_title：European journal of immunology

authors： Shoenfeld Y,Zamir R,Joshua H,Lavie G,Pinkhas J

更新日期：1985-10-01 00:00:00

abstract：:The MOPC460 idiotype is expressed in mice with the IghCa allotypic haplotype after anti-2,4-dinitrophenyl (DNP) immunization. We have previously shown that two monoclonal syngeneic anti-idiotypic antibodies (IDM 92-13 and IDM 41-27) define two distinct idiotopes (the 460.92 and the 460.41) on the M460 idiotype. The cu...

journal_title：European journal of immunology

authors： Sanchez P,Juy D,Cazenave PA

更新日期：1983-12-01 00:00:00

abstract：:Recent studies have shown that in humans the germinal center reactions produce three types of V(D)J mutated B cells in similar proportions, i.e. Ig-switched, IgD-IgM+ (IgM-only) and IgD+IgM+ cells, and that together they form the CD27+ compartment of recirculating B cells. We investigated the Ig isotype switch capacit...

journal_title：European journal of immunology

authors： Werner-Favre C,Bovia F,Schneider P,Holler N,Barnet M,Kindler V,Tschopp J,Zubler RH

更新日期：2001-01-01 00:00:00

abstract：:We have investigated the effects of intravenous immunoglobulin (IVIg), a therapeutic preparation of normal human polyspecific IgG, on the synthesis and release of cytokines by peripheral blood monocytes. IVIg was found to selectively induce gene transcription and secretion of interleukin-1 receptor antagonist (IL-1ra)...

journal_title：European journal of immunology

authors： Ruiz de Souza V,Carreno MP,Kaveri SV,Ledur A,Sadeghi H,Cavaillon JM,Kazatchkine MD,Haeffner-Cavaillon N

更新日期：1995-05-01 00:00:00

abstract：:Regulatory T (T(reg)) cells play a key role in the maintenance of the immune system homeostasis. T(reg) cells can be generated in the periphery under control of TGF-beta, a cytokine involved in the negative control of the immune system. However, TGF-beta cooperates with IL-6 in the generation of Th17 cells, a novel cl...

journal_title：European journal of immunology

authors： Fantini MC,Rizzo A,Fina D,Caruso R,Becker C,Neurath MF,Macdonald TT,Pallone F,Monteleone G

更新日期：2007-11-01 00:00:00

abstract：:In the lymphoid tissues, adaptive immune responses are initiated by the interaction of interdigitating dendritic cells (IDC) with naive T cells. To understand this interplay better, we used mature Langerhans cells (mLC), migrating from human epidermis, as the correlate of IDC ex vivo to evaluate the different effects ...

journal_title：European journal of immunology

authors： Ludewig B,Graf D,Gelderblom HR,Becker Y,Kroczek RA,Pauli G

更新日期：1995-07-01 00:00:00

abstract：:In order to analyze the effect of a high local concentration of macrophage colony-stimulating factor (M-CSF; CSF-1) on tumor growth, the plasmacytoma cell line J558L was transfected with the human M-CSF gene and injected into syngeneic BALB/c mice. In contrast to the parental tumors, M-CSF transfectants were heavily i...

journal_title：European journal of immunology

authors： Dorsch M,Hock H,Kunzendorf U,Diamantstein T,Blankenstein T

更新日期：1993-01-01 00:00:00

abstract：:The essential role of the transcription factor Foxp3 in the development and function of Treg has been well documented. The role of Foxp3 in non-Treg, however, is not fully understood. Emerging evidence indicates that Foxp3 expression is not confined to CD4+CD25+ Treg. The present study shows that in Foxp3 transgenic (...

journal_title：European journal of immunology

authors： Guo L,Tian J,Marinova E,Zheng B,Han S

更新日期：2010-01-01 00:00:00

abstract：:Macrophage scavenger receptors are trimeric integral membrane glycoproteins which have been implicated in various macrophage functions including uptake of oxidized lipoprotein and the serum-dependent, divalent cation-independent adhesion of macrophages to tissue culture-treated plastic. In this study we have used a re...

journal_title：European journal of immunology

authors： Hughes DA,Fraser IP,Gordon S

更新日期：1995-02-01 00:00:00

abstract：:CD82, a member of tetraspan family (tetraspanin), is a multifunctional molecule that is involved in cell activation, costimulation, and cell spreading of T cells. Here we show that immobilized anti-CD82 monoclonal antibody (mAb) as well as anti-alpha4beta1 integrin mAb induced tyrosine phosphorylation of pp105/Crk-ass...

journal_title：European journal of immunology

authors： Iwata S,Kobayashi H,Miyake-Nishijima R,Sasaki T,Souta-Kuribara A,Nori M,Hosono O,Kawasaki H,Tanaka H,Morimoto C

更新日期：2002-05-01 00:00:00

abstract：:CD30 is a costimulatory molecule of the TNF receptor superfamily, expressed on activated T and B cells. Previously, we have shown in a murine asthma model the crucial role of CD30 signaling for the development of this Th2-cell-mediated disease. In the present study, we investigated the role of CD30 in the maintenance ...

journal_title：European journal of immunology

authors： Polte T,Fuchs L,Behrendt AK,Hansen G

更新日期：2009-07-01 00:00:00

abstract：:The purpose of this work was to study the interrelationship of proliferation and secretion of plasminogen activator (PA) and interferon (IFN) by murine macrophages. For induction of macrophage proliferation and secretion of PA, concanavalin A (Con A) was used. Secretion of IFN was induced by polyinosinic polycytidylic...

journal_title：European journal of immunology

authors： Neumann C,Sorg C

更新日期：1983-02-01 00:00:00

abstract：:In this report, we provide new evidence of a crosstalk between T cell activation and adhesion processes through a functional cytokeleton. We show that CD82 signaling induces long-lasting adhesion, spreading and development of membrane extensions, involving actin polymerization. Addition of various co-stimuli (phorbol ...

journal_title：European journal of immunology

authors： Lagaudrière-Gesbert C,Lebel-Binay S,Hubeau C,Fradelizi D,Conjeaud H

更新日期：1998-12-01 00:00:00

abstract：:T lymphocyte subsets expressing either T cell receptor alpha/beta or gamma/delta were selected from human peripheral blood T cells and proliferative responses to molecular mass-fractionated mycobacterial lysates were determined. alpha/beta T cells primarily responded to fractions greater than 30 kDa whereas gamma/delt...

journal_title：European journal of immunology

authors： Pfeffer K,Schoel B,Gulle H,Kaufmann SH,Wagner H

更新日期：1990-05-01 00:00:00

abstract：:The outcomes of many diseases differ between women and men, with women experiencing a higher incidence and more severe pathogenesis of autoimmune and some infectious diseases. It has been suggested that this is partially due to activation of plasmacytoid dendritic cells (pDCs), the main producers of interferon (IFN)-α...

journal_title：European journal of immunology

authors： Ziegler SM,Beisel C,Sutter K,Griesbeck M,Hildebrandt H,Hagen SH,Dittmer U,Altfeld M

更新日期：2017-02-01 00:00:00

abstract：:The distribution of the murine receptor for interleukin (IL) 6 was examined on a variety of cells. Binding sites for IL 6 were found on many cell lines including fibroblasts and bone marrow-derived macrophages. The highest density of binding sites was found on B cell hybridomas and plasmacytomas, irrespective of their...

journal_title：European journal of immunology

authors： Coulie PG,Stevens M,Van Snick J

更新日期：1989-11-01 00:00:00

abstract：:Mice carrying the nude mutation (nu/nu) lack a functioning thymus and do not contain detectable levels of immunocompetent T cells. We now report that nu/nu mice to have lymphocytes which can be activated in vivo by heterologous erythrocytes and a Lyt-1 T cell-derived factor (interleukin 2) to generate T helper cells. ...

journal_title：European journal of immunology

authors： Stötter H,Rüde E,Wagner H

更新日期：1980-09-01 00:00:00

abstract：:We have proposed earlier that the poor capacity of the lipocalin allergen Bos d 2 to stimulate highly allergic subjects' peripheral blood mononuclear cells could be ascribed to endogenous lipocalins and could be related to the allergenic potential of the molecule. Here, we have characterized the proliferative and cyto...

journal_title：European journal of immunology

authors： Kinnunen T,Buhot C,Närvänen A,Rytkönen-Nissinen M,Saarelainen S,Pouvelle-Moratille S,Rautiainen J,Taivainen A,Maillère B,Mäntyjärvi R,Virtanen T

更新日期：2003-06-01 00:00:00

abstract：:Priming mice with a chicken gamma globulin (CGG) carrier protein significantly accelerated the onset of somatic mutation in the V chi Ox1 gene when the mice were subsequently immunized with 2-phenyl-5-oxazolone (phOx) coupled to CGG. The first mutations were already detected 7 days after immunization, while in the tru...

journal_title：European journal of immunology

authors： Källberg E,Gray D,Leanderson T

更新日期：1995-08-01 00:00:00

abstract：:Differential screening of a subtracted cDNA library led to the detection of two distinct but homologous mouse cDNA, called CTLA-2 alpha and CTLA-2 beta. The corresponding transcripts have a tissue distribution restricted to T lymphocytes, where they are inducible upon activation, and to mast cells. The open-frame regi...

journal_title：European journal of immunology

authors： Denizot F,Brunet JF,Roustan P,Harper K,Suzan M,Luciani MF,Mattei MG,Golstein P

更新日期：1989-04-01 00:00:00

abstract：:Multiple myeloma is a fatal B cell malignancy characterized by the accumulation of plasma cells within the bone marrow. IL-6 is a major survival factor for myeloma cells. Bcl-2 protein family regulates pathways to apoptosis that are activated upon growth factor deprivation. Pro-apoptotic proteins that have only a sing...

journal_title：European journal of immunology

authors： Gomez-Bougie P,Bataille R,Amiot M

更新日期：2004-11-01 00:00:00