Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centers.

abstract：:The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3+ T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline-injected MRL lpr/lpr controls, UDA-treated animals did n...

journal_title：European journal of immunology

authors： Musette P,Galelli A,Chabre H,Callard P,Peumans W,Truffa-Bachi P,Kourilsky P,Gachelin G

更新日期：1996-08-01 00:00:00

abstract：:The effect of fractionated total lymphoid irradiation (TLI) on the maturation of B cells was examined in mice. At various times after irradiation of the mice, their spleen cells were tested for the mitogenic responses to dextran sulfate and lipopolysaccharide. In parallel the cells were stained with fluorescent anti-T...

journal_title：European journal of immunology

authors： Zan-Bar I

更新日期：1983-01-01 00:00:00

abstract：:The human promyelocytic U937 cells express detectable levels of MHC class II (MHC-II) molecules. Treatment with 12-o--tetradecanoyl phorbol 13-acetate (TPA), inducing macrophage-like differentiation, produces a dramatic decrease of MHC-II expression as result of down-modulation of the activation of immune response gen...

journal_title：European journal of immunology

authors： De Lerma Barbaro A,Procopio FA,Mortara L,Tosi G,Accolla RS

更新日期：2005-02-01 00:00:00

abstract：:During their development, B and T lymphocytes are thought to undergo several cycles of chromatin remodeling at their antigen receptor loci that serve to regulate access of a common V(D)J recombinase to particular gene segments. We used germ-line transcription and susceptibility to DNasel as markers to examine tissue a...

journal_title：European journal of immunology

authors： Haines BB,Brodeur PH

更新日期：1998-12-01 00:00:00

abstract：:We recently reported that parenteral injection of malaria palmitoyl-tailed peptides without adjuvant efficiently induces B, Th and CTL responses. We now show that intranasal (IN) or sub-lingual (SL) delivery of such lipopeptides induces strong systemic immune responses, as demonstrated by specific Th cell responses fr...

journal_title：European journal of immunology

authors： BenMohamed L,Belkaid Y,Loing E,Brahimi K,Gras-Masse H,Druilhe P

更新日期：2002-08-01 00:00:00

abstract：:The cell surface expression and biosynthesis of Langerhans cells (LC)-derived major histocompatibility complex (MHC) class II molecules from epidermal cells (EC) prepared freshly and cultured for up to 3 days was investigated. Based on the constitutive expression of MHC class II determinants by LC, a panning and magne...

journal_title：European journal of immunology

authors： Becker D,Reske-Kunz AB,Knop J,Reske K

更新日期：1991-05-01 00:00:00

abstract：:The recently discovered B6.C-H-2bm12 (bm12) histocompatibility mutant bears a mutation of the I-A subregion of the H-2b haplotype. We have studied cytotoxic T lymphocytes (CTL) generated in secondary mixed lymphocyte culture (MLC) between the bm12 mutant and the strain of origin C57BL/6 (B6). In both directions, stron...

journal_title：European journal of immunology

authors： de Waal LP,Melief CJ,Melvold RW

更新日期：1981-03-01 00:00:00

abstract：:In the murine system, we tested in vivo the immunogenicity of different preparations of the yeast-derived surface antigen (S-antigen or S-protein) of hepatitis B virus (HBV). Native S-protein molecules self-assemble into stable 22-nm particles. BALB/c mice immunized with low doses of native S-particles without adjuvan...

journal_title：European journal of immunology

authors： Schirmbeck R,Melber K,Mertens T,Reimann J

更新日期：1994-05-01 00:00:00

abstract：:H-2 gene-dependent nonresponsiveness and responsiveness to H-2-matched male cells can be observed in cytotoxic assays in several mouse strains. H-2 genes of several low responder strains can complement each other in cis or trans position to produce high responders. One of the H-2 gene products functions at the level o...

journal_title：European journal of immunology

authors： von Boehmer H,Fathman CG,Haas W

更新日期：1977-07-01 00:00:00

abstract：:The glycolipid alpha-galactosylceramide (alpha-GalCer) is a potent activator of invariant natural killer T (iNKT) cells and has been shown to be an effective agent against cancer, infections and autoimmune diseases. The effectiveness of alpha-GalCer and its alkyl chain analogues depends on efficient loading and presen...

journal_title：European journal of immunology

authors： Denkberg G,Stronge VS,Zahavi E,Pittoni P,Oren R,Shepherd D,Salio M,McCarthy C,Illarionov PA,van der Merwe A,Besra GS,Dellabona P,Casorati G,Cerundolo V,Reiter Y

更新日期：2008-03-01 00:00:00

abstract：:Expression of the high-affinity receptor for IgE (FcεRI) provides mast cells with the ability to react in a proinflammatory manner to antigens (Ags). In particular, the immediate secretion of preformed mediators from secretory lysosomes (degranulation) is typical for FcεRI-mediated mast cell activation. In addition to...

journal_title：European journal of immunology

authors： Huber M

更新日期：2013-07-01 00:00:00

abstract：:It is widely believed that IL-4 exerts its influence by profiling the immune response during priming and expansion of immune cells, and thereby modulates the outcome of chronic inflammation. In the present investigation, collagen antibody-induced arthritis (CAIA) was used to delineate the role of IL-4 in a T cell-inde...

journal_title：European journal of immunology

authors： Nandakumar KS,Holmdahl R

更新日期：2006-06-01 00:00:00

abstract：:Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception ...

journal_title：European journal of immunology

authors： Wellington D,Yin Z,Abdel-Haq A,Zhang L,Forbester J,Kite K,Rajapaksa U,Laurenson-Schafer H,Makvandi-Nejad S,Jin B,Bowes E,Manoharan K,Maldonado-Perez D,Verrill C,Humphreys IR,Dong T

更新日期：2020-10-30 00:00:00

abstract：:The regulation of neutrophil half-life by members of the coagulation cascade is critical for the resolution of the inflammatory response. We have demonstrated that soluble fibrinogen (sFbg) delays human neutrophil (PMN) apoptosis through a mechanism that involves CD11b interactions, and phosphorylation of focal adhesi...

journal_title：European journal of immunology

authors： Rubel C,Gómez S,Fernández GC,Isturiz MA,Caamaño J,Palermo MS

更新日期：2003-05-01 00:00:00

abstract：:Naïve phenotype (NP) T cells spontaneously initiate homeostatic proliferation (HP) as T-cell output is reduced because of physiologic thymic involution with age. However, the effects of sustained HP on overall immune function are poorly understood. We demonstrated that the NP CD8+ T cell population in adult thymectomi...

journal_title：European journal of immunology

authors： Kato A,Takaori-Kondo A,Minato N,Hamazaki Y

更新日期：2018-10-01 00:00:00

abstract：:Cure of leishmaniasis requires a type 1 immune response characterized by IFN-gamma production. Leishmania major infection leads to a type 2 response suppressing cure of susceptible BALB/c mice, and L. major causes an exacerbated type 2 response in mouse strains with a gene knockout (KO) such that they lack IL-12p40 (I...

journal_title：European journal of immunology

authors： Wilson ME,Recker TJ,Rodriguez NE,Young BM,Burnell KK,Streit JA,Kline JN

更新日期：2002-12-01 00:00:00

abstract：:Stem cell factor (SCF) is encoded at the Sl locus of the mouse and is the ligand for the c-kit receptor. Recombinant rat SCF164 (rrSCF164) induces proliferation and promotes maturation of mouse mast cells in vitro and in vivo and can also induce c-kit receptor-dependent mouse mast cell degranulation. We now report tha...

journal_title：European journal of immunology

authors： Tsai M,Tam SY,Galli SJ

更新日期：1993-04-01 00:00:00

abstract：:Antigen-induced stimulation of T cells is mediated via the CD3 antigen receptor (Ti) complex and monoclonal antibodies (mAb) reacting with CD3 and Ti result in rapid intracellular Ca2+ mobilization, followed by monocyte-dependent proliferation. Combinations of mAb to CD2, the sheep red blood cell receptor, also mobili...

journal_title：European journal of immunology

authors： O'Flynn K,Knott LJ,Russul-Saib M,Abdul-Gaffar R,Morgan G,Beverley PC,Linch DC

更新日期：1986-05-01 00:00:00

abstract：:Retinoic acid (RA), which is the biologically active form of vitamin A, acts through the nuclear hormone receptor RAR (RA receptor) to induce either gene activation or repression. RA production and its effects have been linked to macrophages, dendritic cells, T and B cells, and iNKT cells in the immune system and play...

journal_title：European journal of immunology

authors： Nagy L

更新日期：2012-07-01 00:00:00

abstract：:The NKG2D receptor is expressed by human NK, gammadelta T and alpha/beta T lymphocytes and its engagement results in the stimulation of effector cells. We evaluated the role of NKG2D receptor in anti-colorectal cancer (CRC) immune response. The cell surface expression of stress-inducible NKG2D ligands MICA/B (MHC clas...

journal_title：European journal of immunology

authors： Maccalli C,Pende D,Castelli C,Mingari MC,Robbins PF,Parmiani G

更新日期：2003-07-01 00:00:00

abstract：:The interaction of KB-V1, a multidrug resistant (MDR) variant of the KB-3-1 human oral carcinoma, with human complement was investigated. KB-V1 cells were found to be more sensitive than KB-3-1 cells to complement-mediated lysis. Detailed analysis of the capacity of KB cells to activate human complement demonstrated t...

journal_title：European journal of immunology

authors： Bomstein Y,Fishelson Z

更新日期：1997-09-01 00:00:00

abstract：:Resistance and susceptibility to the intestinal nematode Trichuris muris has been shown to be dependent upon the induction of T helper type 2 (Th2) or Th1 cells, respectively. This study demonstrates that in a normally resistant strain of mouse, i.e. BALB/K which mounts a dominant Th2 response, sub-threshold levels of...

journal_title：European journal of immunology

authors： Bancroft AJ,Else KJ,Grencis RK

更新日期：1994-12-01 00:00:00

abstract：:We have explored how IL-15 influences Th1 or Th2 type immune response in vivo. Intraperitoneal application of an IL-15-IgG2b fusion protein (FP) to mice did neither significantly affect the footpad swelling nor the production of hemagglutinizing antibodies in a delayed type hypersensitivity reaction to sheep red blood...

journal_title：European journal of immunology

authors： Rückert R,Herz U,Paus R,Ungureanu D,Pohl T,Renz H,Bulfone-Paus S

更新日期：1998-10-01 00:00:00

abstract：:Regulatory T cells (Treg) are vital in maintaining the homeostasis of immune reactions. In chronic infections, such as schistosomiasis, it remains unclear whether engagement of the TLR family is required to induce Treg activity. Thus, we performed in vivo studies using TLR2-/- mice infected with Schistosoma mansoni an...

journal_title：European journal of immunology

authors： Layland LE,Rad R,Wagner H,da Costa CU

更新日期：2007-08-01 00:00:00

abstract：:The deposition of immune complexes, followed by activation of complement and/or Fc receptors and generation of chemoattractants, is the most common feature of human glomerulonephritis. Recently we have shown that primary cultured human glomerular mesangial cells (HMC), which are normally negative for IgG Fc receptors,...

journal_title：European journal of immunology

authors： Uciechowski P,Schwarz M,Gessner JE,Schmidt RE,Resch K,Radeke HH

更新日期：1998-09-01 00:00:00

abstract：:Peptide ligands presented by MHC class I molecules are generated in a cascade of proteolytic events starting with the proteasome in the cytosol and frequently terminating with trimming aminopeptidases in the endoplasmic reticulum. Several cytosolic proteases can carry out intermediate proteolytic steps between these s...

journal_title：European journal of immunology

authors： Endert Pv

更新日期：2008-03-01 00:00:00

abstract：:We have established IgG rheumatoid factor (RF)-secreting hybridoma cell lines from the synovial tissues of three patients from whom we have previously characterized several IgM RF. The IgG RF bind human and rabbit IgG and form intracellular complement-fixing complexes indicative of a self association process in vivo. ...

journal_title：European journal of immunology

authors： Randen I,Pascual V,Victor K,Thompson KM,Førre O,Capra JD,Natvig JB

更新日期：1993-06-01 00:00:00

abstract：:The active role of chemokines in the central nervous system (CNS) during the pathogenesis of experimental autoimmune encephalomyelitis (EAE) has been clearly established. In this study the expression pattern of several chemokines and cytokines was elucidated using reverse transcription-PCR and immunohistochemistry in ...

journal_title：European journal of immunology

authors： Nygårdas PT,Määttä JA,Hinkkanen AE

更新日期：2000-07-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells elaborate a cytolytic protein named perforin or cytolysin. It was widely held that, in vivo, high quantities of perforin are not present in resting lymphocytes and are usually produced only by activated lymphocytes found under pathological conditions. Until n...

journal_title：European journal of immunology

authors： Zheng LM,Ojcius DM,Young JD

更新日期：1993-09-01 00:00:00

abstract：:Studies of experimental autoimmune encephalomyelitis (EAE) in rodents have revealed that encephalitogenic T cell lines reactive with myelin basic protein (BP) are frequently dominated by clones expressing a restricted T cell receptor repertoire. Using the rat EAE model, we have begun to examine the basis for clonal do...

journal_title：European journal of immunology

authors： Sun D,Hu XZ,Coleclough C

更新日期：1995-01-01 00:00:00