Somatic hypermutation and mismatch repair in non-B cells.

Abstract:

:Mismatch repair contributes to hypermutation in B lymphocytes, both by increasing the frequency of mutations and by changing the mutational patterns. In this paper, we investigated whether or not mismatch repair influences activation-induced cytidine deaminase (AID)-mediated hypermutation in a non-B lymphocyte line. We did so by regulating expression of MutL homologue MLH 1, which is essential in mismatch repair, in a kidney cell line that had been transduced by an AID-containing vector. Whether or not MLH1 was expressed, we found no difference in the mutation rates of an indicator gene. We conclude that in order to contribute to hypermutation, mismatch repair needs additional factors that are present in activated B lymphocytes, but absent in the cell line investigated.

journal_name

Eur J Immunol

authors

Klasen M,Spillmann FJ,Marra G,Cejka P,Wabl M

doi

10.1002/eji.200526221

keywords:

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

2222-9

issue

7

eissn

0014-2980

issn

1521-4141

journal_volume

35

pub_type

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