Role of Ia. W39 in the interaction of antigen-presenting cells with T and B lymphocytes.

abstract：:During mammalian pregnancy, one or more semiallogeneic fetuses gestate in direct contact with the maternal circulation and uterine tissue. However, a damaging maternal immune response is not normally provoked. We studied two possible mechanisms for this maternal-fetal tolerance, alone and in combination. First, we dir...

journal_title：European journal of immunology

authors： Rogers AM,Boime I,Connolly J,Cook JR,Russell JH

更新日期：1998-11-01 00:00:00

abstract：:Impaired control of chronic pathogen replication may be associated to alterations of NK-cell function. Whether mechanisms underlying this dysfunction involve perturbations of differentiating NK cells is still unknown. We studied an "in vitro" model of differentiation from CD34(+)Lin(-) precursors growing only myelomon...

journal_title：European journal of immunology

authors： Costa P,Sivori S,Bozzano F,Martini I,Moretta A,Moretta L,De Maria A

更新日期：2009-01-01 00:00:00

abstract：:In humans and in BALB/c mice, immune responses to the hormone insulin use evolutionarily related VHV (human) and VHIX (murine) gene families. To determine if these structural relationships include regulatory elements, BALB/c mice were pretreated with autologous immunoglobulin G (IgG) monoclonal antibodies (mAb) that r...

journal_title：European journal of immunology

authors： Thomas JW

更新日期：1992-09-01 00:00:00

abstract：:Human T cell clones expressing the T cell receptor (TcR) gamma/delta were isolated from peripheral blood lymphocytes of two unrelated donors. The TcR gamma/delta+ clones derived from one of these donors were all of the Ti gamma A+, delta-TCS1-, BB3+ phenotype indicating the exclusive use of the V gamma 9 and V delta 3...

journal_title：European journal of immunology

authors： Koning F,Knot M,Wassenaar F,Van den Elsen P

更新日期：1989-11-01 00:00:00

abstract：:The approximately 20-kDa heat-labile toxin produced by enterotoxigenic Bacteroides fragilis is known to be associated with the development of enteritis. However, the molecular mechanism involved is not yet fully understood. In this study, we assessed whether B. fragilis enterotoxin (BFT)-induced enteritis is related t...

journal_title：European journal of immunology

authors： Kim JM,Jung HY,Lee JY,Youn J,Lee CH,Kim KH

更新日期：2005-09-01 00:00:00

abstract：:We have previously reported the development of a two-step culture system in which soluble anti-mu monoclonal antibodies prime small resting murine B cells to secrete immunoglobulin (Ig) in response to restimulation with a mixture of interleukin-4 (IL-4) and IL-5. Here we have extended these studies to investigate the ...

journal_title：European journal of immunology

authors： Phillips C,Klaus GG

更新日期：1993-02-01 00:00:00

abstract：:DNA vaccines induce CTL attack on target tumor epitopes, but tumor elimination in vivo also requires sufficient effector CTL to enter the site, guided by inflammatory chemokines. Many herpesviruses contain genes for chemokine and chemokine receptor-like proteins to protect infected cells from immune attack. To assess ...

journal_title：European journal of immunology

authors： Rice J,de Lima B,Stevenson FK,Stevenson PG

更新日期：2002-12-01 00:00:00

abstract：:Plaque-forming cell (PFC) assays were used to investigate in vitro the immunoregulatory mechanism operating in the self-limiting anti-glomerular basement membrane (GBM) autoantibody response of Brown Norway (BN) rats given HgCl2. The peak splenic PFC response occurred at day 9; thereafter the response fell sharply and...

journal_title：European journal of immunology

authors： Chalopin JM,Lockwood CM

更新日期：1984-05-01 00:00:00

abstract：:Stilbene disulfonates are known to competitively inhibit Cl-/HCO3- flux through Band 3-related anion exchange (AE) proteins. To study the role of AE in lymphocyte activation, stilbene disulfonates were added to cultures of rat splenocytes (SPL). Four different stilbene derivatives were tested and each directly stimula...

journal_title：European journal of immunology

authors： Deane KH,Mannie MD

更新日期：1992-05-01 00:00:00

abstract：:Stem cell antigen-1 (Sca1, Ly-6A/E) is a well-established marker of murine hematopoietic stem cells, and also is expressed on memory T cells. It has been suggested that the functional maintenance of T-cell memory requires the expression of Sca1 on a specialized population of memory T cells termed "memory stem cells". ...

journal_title：European journal of immunology

authors： Whitmire JK,Eam B,Whitton JL

更新日期：2009-06-01 00:00:00

abstract：:Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1) is a critical component of the NF-kappaB signaling cascade mediated by TCR engagement. In addition to activation of naïve T cells, TCR signaling is important for the development of agonist-selected T-cell subsets such as Treg...

journal_title：European journal of immunology

authors： Medoff BD,Sandall BP,Landry A,Nagahama K,Mizoguchi A,Luster AD,Xavier RJ

更新日期：2009-01-01 00:00:00

abstract：:As shown recently, CD3+/TcR+ functional T lymphocytes can be derived in culture from embryonic liver cell precursors at a gestational age (6-8 weeks) preceding the colonization of the epithelial thymus. In this report, we analyzed the V beta repertoire of T lymphocytes derived from embryonic liver by applying a quanti...

journal_title：European journal of immunology

authors： Poggi A,Demarest JF,Costa P,Biassoni R,Pella N,Pantaleo G,Mingari MC,Moretta L

更新日期：1994-09-01 00:00:00

abstract：:Prior to acquiring a memory phenotype, antigen-activated CD8(+) T cells need to expand and then undergo a contraction phase. Utilizing two different antigenic stimuli, we provide evidence that the tumor necrosis factor receptors OX40 and CD30 integrate synergistic signals during the expansion phase to help maintain CD...

journal_title：European journal of immunology

authors： Bekiaris V,Gaspal F,Kim MY,Withers DR,Sweet C,Anderson G,Lane PJ

更新日期：2009-08-01 00:00:00

abstract：:The expression of human leukocyte function-associated antigens (HLFA, equivalents of murine LFA-1) was studied on early lympho-hemopoietic cells in infant thymus and normal bone marrow by double immunofluorescence methods, cell sorting and colony-forming assays. Monoclonal antibodies MHM-24 recognizing the alpha chain...

journal_title：European journal of immunology

authors： Campana D,Sheridan B,Tidman N,Hoffbrand AV,Janossy G

更新日期：1986-05-01 00:00:00

abstract：:Glycosylphosphatidylinositol-anchored (GPI)-Db molecules are defective in mediating cytotoxic T lymphocytes (CTL) lysis of transfected lymphoma cells, compared to their transmembrane (TM) counterpart. This defect is manifest when antigenic peptide must be processed and presented through the endogenous pathway. These s...

journal_title：European journal of immunology

authors： Cariappa A,Flyer DC,Rollins CT,Roopenian DC,Flavell RA,Brown D,Waneck GL

更新日期：1996-09-01 00:00:00

abstract：:In mice infected with the non-lethal malaria parasite Plasmodium chabaudi chabaudi AS, a prominent switch from a Th1 to a Th2 type of response occurs in CD4+ T cells at the time of peak parasitemia or shortly thereafter (9-15 days after infection). This is accompanied by a major increase in IL-4, and a similar decreas...

journal_title：European journal of immunology

authors： Poorafshar M,Helmby H,Troye-Blomberg M,Hellman L

更新日期：2000-09-01 00:00:00

abstract：:The regulation of neutrophil half-life by members of the coagulation cascade is critical for the resolution of the inflammatory response. We have demonstrated that soluble fibrinogen (sFbg) delays human neutrophil (PMN) apoptosis through a mechanism that involves CD11b interactions, and phosphorylation of focal adhesi...

journal_title：European journal of immunology

authors： Rubel C,Gómez S,Fernández GC,Isturiz MA,Caamaño J,Palermo MS

更新日期：2003-05-01 00:00:00

abstract：:CD25+ FOXP3+CD4+ T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high-level expression of FOXP3 (FOXP3high) is sufficient to confer suppressive activity to normal non-Treg. Here, we showed for the first time that vascular...

journal_title：European journal of immunology

authors： Suzuki H,Onishi H,Wada J,Yamasaki A,Tanaka H,Nakano K,Morisaki T,Katano M

更新日期：2010-01-01 00:00:00

abstract：:CD4+CD25(hi)CD127(lo/-) regulatory T cells (Treg) have been implicated in the resolution of asthma-associated inflammation while the opposite role of CD4+ invariant NKT (iNKT) cells has been the subject of recent investigations. Studies here focused on mechanisms of interaction between CD4+ iNKT cells and Treg to furt...

journal_title：European journal of immunology

authors： Nguyen KD,Vanichsarn C,Nadeau KC

更新日期：2008-07-01 00:00:00

abstract：:The beta7 integrins alpha4beta7 and alphaEbeta7 play key roles in forming the gut-associated lymphoid tissue, and contribute to chronic inflammation. The alpha4beta7 integrin-mediated adhesion of activated lymphocytes is largely due to a transient increase in avidity from ligand-induced clustering of alpha4beta7 at th...

journal_title：European journal of immunology

authors： Krissansen GW,Singh J,Kanwar RK,Chan YC,Leung E,Lehnert KB,Kanwar JR,Yang Y

更新日期：2006-08-01 00:00:00

abstract：:Immunizations via the i.n. and intravaginal (ivag) routes effectively generate strong genital tract antibody-mediated immunity. To what extent the same is true for T-cell responses is incompletely known. Therefore, we set out to investigate optimal conditions for stimulation of genital tract CD4(+) T-cell responses, ...

journal_title：European journal of immunology

authors： Marks E,Helgeby A,Andersson JO,Schön K,Lycke NY

更新日期：2011-09-01 00:00:00

abstract：:The host protective immune response to blood stage malaria infection was studied using Plasmodium chabaudi chabaudi (P.chabaudi) in NIH mice. It has been shown previously that CD4+ cells are critically required for protection against erythrocytic infection. Mice lacking a functional CD4+ cell compartment suffer unremi...

journal_title：European journal of immunology

authors： Taylor-Robinson AW,Phillips RS

更新日期：1994-01-01 00:00:00

abstract：:The IgG2a(b) heavy chain allopeptide determinant gamma2a(b) 436-451 (Kabat numbering) presented by the major histocompatibility complex (MHC) class II molecule I-Ad is recognized by T cells which cross-react with a corneal self antigen and with the UL6 protein of the herpes simplex virus which induce autoimmune kerati...

journal_title：European journal of immunology

authors： Bartnes K,Leon F,Briand JP,Travers PJ,Hannestad K

更新日期：1999-01-01 00:00:00

abstract：:Listeria monocytogenes induces the formation of inflammasomes and subsequent caspase-1 activation, and the adaptor apoptosis-associated speck-like protein containing a CARD (ASC) is crucial for this response. However, the role of ASC in L. monocytogenes infection in vivo is unclear. In this study, we demonstrate that ...

journal_title：European journal of immunology

authors： Tsuchiya K,Hara H,Fang R,Hernandez-Cuellar E,Sakai S,Daim S,Chen X,Dewamitta SR,Qu H,Mitsuyama M,Kawamura I

更新日期：2014-12-01 00:00:00

abstract：:A major contributing factor to the final magnitude and breadth of CD8(+) T-cell responses to complex antigens is immunodomination, where CD8(+) T cells recognizing their cognate ligand inhibit the proliferation of other CD8(+) T cells engaged with the same APC. In this study, we examined how the half-life of cell s...

journal_title：European journal of immunology

authors： Galea I,Stasakova J,Dunscombe MS,Ottensmeier CH,Elliott T,Thirdborough SM

更新日期：2012-01-01 00:00:00

abstract：:Adoptive lymphocyte transfers between Iga, Igb and Igd allotype-congenic mouse strains revealed host barriers against the production of certain donor allotypes. First, as recipients of Igb cells, Iga and Igd mice permitted the production of donor Ig-4b but not that of Ig-1 b. The apparent mediators of this Ig-1 b barr...

journal_title：European journal of immunology

authors： Bosma MJ,Bosma GC,Owen JL

更新日期：1978-08-01 00:00:00

abstract：:Recent studies have shown that in humans the germinal center reactions produce three types of V(D)J mutated B cells in similar proportions, i.e. Ig-switched, IgD-IgM+ (IgM-only) and IgD+IgM+ cells, and that together they form the CD27+ compartment of recirculating B cells. We investigated the Ig isotype switch capacit...

journal_title：European journal of immunology

authors： Werner-Favre C,Bovia F,Schneider P,Holler N,Barnet M,Kindler V,Tschopp J,Zubler RH

更新日期：2001-01-01 00:00:00

abstract：:Heterologous adenovirus-based vectors hold promise as preventative HIV vaccines but their capacity to induce effective T-cell immunity in established infection has not been explored. We vaccinated rhesus macaques chronically infected with SIVmac251 and undergoing antiretroviral therapy (ART) with human adenovirus sero...

journal_title：European journal of immunology

authors： Soloff AC,Liu X,Gao W,Day RD,Gambotto A,Barratt-Boyes SM

更新日期：2009-09-01 00:00:00

abstract：:cDNA of the T cell receptor beta (TCRB) have been isolated from the anuran amphibian Xenopus and they show strong structural homology to TCRB sequences of other vertebrates. Ten BV families, two D segments, ten J segments, and a single C region have been defined so far. Each V family consists of one to two members per...

journal_title：European journal of immunology

authors： Chretien I,Marcuz A,Fellah J,Charlemagne J,Du Pasquier L

更新日期：1997-03-01 00:00:00

abstract：:Considering the role of interleukin-8 (IL-8) in a large number of acute and chronic inflammatory diseases, the regulation of IL-8-mediated biological responses is important. Alpha-melanocyte-stimulating hormone (alpha-MSH), a tridecapeptide, inhibits most forms of inflammation by an unknown mechanism. In the present s...

journal_title：European journal of immunology

authors： Manna SK,Sarkar A,Sreenivasan Y

更新日期：2006-03-01 00:00:00