Abstract:
:The mer receptor tyrosine kinase mediates phagocytosis of apoptotic cells and modulates cytokine production; it is also required for prevention of systemic autoimmune disease. Using a mer-specific antibody, we have confirmed the presence of mer on macrophages and now report its expression on NK cells, NKT cells, and dendritic cells (DC). We found that DC do not require mer for ingestion of apoptotic cells, as DC from mer-deficient mice phagocytose apoptotic cells normally. Mer was observed in splenic sections on cells outside follicular areas, probably representing DC and macrophages. Mer apparently participates in NKT-cell antigen-induced signaling, as NKT cells from mer-deficient mice evinced much lower cytokine production after in vivo alpha-galactosylceramide stimulation; this defect was intrinsic to the mer-deficient NKT cells. Taken together, these studies show mer expression on cells of the innate immune system. Mer, through its binding of lipid antigens, may not only mediate ingestion of apoptotic cells, but also signal events in NK cells, NKT cells, and DC.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Behrens EM,Gadue P,Gong SY,Garrett S,Stein PL,Cohen PLdoi
10.1002/eji.200324076keywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
2160-7issue
8eissn
0014-2980issn
1521-4141journal_volume
33pub_type
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journal_title:European journal of immunology
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