Abstract:
:Haemophilus influenzae type b capsular polysaccharide (PRP) conjugate vaccines, which are thought to induce T cell-dependent antibody production, induce protective responses after a single dose in individuals under 15 months of age. However, multiple doses of these vaccines are required to induce protective antibody responses in infants, with the exception of PRP conjugated to meningococcal outer membrane proteins (OMPC), which does so after a single dose. The basis for this difference is not fully understood, although others have proposed that OMPC and porins, the major protein component of OMPC, act as adjuvants or mitogens. In this report OMPC is shown to enhance CD40 ligand-mediated, T cell-dependent antibody production in mice. This paralleled the induction by OMPC of CD86, CD80 and CD40 costimulatory molecules on human neonatal and murine B cells and of Th1 cytokines. Neither porins nor lipopolysaccharide fully reproduced the effects of OMPC. These studies indicate that OMPC acts both as carrier and adjuvant, and thereby enhances T cell-dependent antibody responses in human infants.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Pérez-Melgosa M,Ochs HD,Linsley PS,Laman JD,van Meurs M,Flavell RA,Ernst RK,Miller SI,Wilson CBdoi
10.1002/1521-4141(200108)31:8<2373::aid-immu2373>3keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
2373-81issue
8eissn
0014-2980issn
1521-4141pii
10.1002/1521-4141(200108)31:8<2373::AID-IMMU2373>3journal_volume
31pub_type
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