Neonatal bacillus Calmette-Guérin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes.

abstract：:Follicular helper T (Tfh) cells provide crucial help to germinal center B (GCB) cells for proper antibody production, and a specialized subset of regulatory T cells, follicular regulatory T (Tfr) cells, modulate this process. However, Tfr-cell function in the GC is not well understood. Here, we define Tfr cells as a C...

journal_title：European journal of immunology

authors： Wu H,Chen Y,Liu H,Xu LL,Teuscher P,Wang S,Lu S,Dent AL

更新日期：2016-05-01 00:00:00

abstract：:The contribution of Gal alpha 1,3Gal (alpha-Gal) to cell-mediated organ xenograft rejection is controversial. We have used recombinant lentiviruses encoding a porcine alpha 1,3 galactosyltransferase (alpha 1,3GalT) to obtain alpha-Gal-expressing primary human aortic endothelial cells (HAEC) at a frequency of 70-90%. T...

journal_title：European journal of immunology

authors： He Z,Ehrnfelt C,Kumagai-Braesch M,Islam KB,Holgersson J

更新日期：2004-04-01 00:00:00

abstract：:Two cloned murine helper T lymphocyte (HTL) lines were used to investigate the immunoregulatory properties of highly purified interleukin 2 (IL2). The clone, designated J6.19, secretes lymphokines, including IL2, and proliferates when stimulated with ovalbumin in the presence of I-Ak-bearing spleen cells, while the al...

journal_title：European journal of immunology

authors： Otten G,Wilde DB,Prystowsky MB,Olshan JS,Rabin H,Henderson LE,Fitch FW

更新日期：1986-03-01 00:00:00

abstract：:The analysis of an Ia specificity was performed in several H-2 haplotypes by evaluating the affinity of the binding to mouse spleen cells of a monoclonal anti-Ia alloantibody. We used the monoclonal antibody 10-2.16 (Oi et al., Curr. Top. Microbiol. Immunol. 1978. 81: 115.) which recognizes on I-A gene products a publ...

journal_title：European journal of immunology

authors： Birnbaum D,Kourilsky FM

更新日期：1981-09-01 00:00:00

abstract：:In order to characterize the murine anti-human xenogeneic mixed lymphocyte reactions (MLR), we studied T cell proliferative responses against various human lymphoid cells by immunization of mice either with cellular or purified HLA-DR antigens. Data presented here indicated that small amounts of soluble HLA-DR antigen...

journal_title：European journal of immunology

authors： Viguier M,Lotteau V,Charron D,Debré P

更新日期：1987-11-01 00:00:00

abstract：:The poxvirus A39R protein is a member of the semaphorin family that binds to Plexin C1, a molecule expressed on neutrophils and dendritic cells (DC). We previously showed that binding of A39R to Plexin C1 induces local rearrangement of the actin cytoskeleton and inhibits integrin-mediated adhesion, leading to cell ret...

journal_title：European journal of immunology

authors： Walzer T,Galibert L,De Smedt T

更新日期：2005-02-01 00:00:00

abstract：:In hematopoietic stem cell transplantation (HSCT), when no HLA full-matched donor is available, alternative donors could include one HLA-mismatched donor. Recently, the low expressed HLA-C alleles have been identified as permissive mismatches for the best donor choice. Concerning HLA-A, the degree of variability of ex...

journal_title：European journal of immunology

authors： René C,Lozano C,Villalba M,Eliaou JF

更新日期：2015-12-01 00:00:00

abstract：:In this report we investigated the production and role of interleukin (IL)2 and IL4 in the generation of antigen-specific cytotoxic T cells (CTL). We used as our model the ultraviolet-light-induced epithelial tumor 1591, a highly immunogenic regressor tumor which evokes a strong cell-mediated immune response leading t...

journal_title：European journal of immunology

authors： Horvat B,Loukides JA,Anandan L,Brewer E,Flood PM

更新日期：1991-08-01 00:00:00

abstract：:Two different subpopulations of anti-acetylcholine receptor antibodies were studied during the evolution of experimental autoimmune myasthenia in one rabbit immunized with Torpedo acetylcholine receptor. The results show that the subpopulation of antibodies directed against the toxin-binding site of the receptor might...

journal_title：European journal of immunology

authors： Zurn AD,Fulpius BW

更新日期：1977-08-01 00:00:00

abstract：:Interleukin-12 (IL-12) and Flt3 ligand (FL) regulate hematopoiesis by stimulating proliferation, differentiation and migration of progenitor and/or stem cells. In this study, we evaluated the in vivo effect of IL-12 alone or in combination with FL on dendritic cell (DC) generation and accumulation in murine spleen, ly...

journal_title：European journal of immunology

authors： Esche C,Cai Q,Peron JM,Hunter O,Subbotin VM,Lotze MT,Shurin MR

更新日期：2000-09-01 00:00:00

abstract：:We have established idiotope (Id)-specific T cell lines and clones derived from at least 4 different BALB/c mice immunized with the light chain (lambda 2(315] of the BALB/c myeloma protein M315 (alpha, lambda 2). Independently derived clones were indistinguishable in that they reacted to V lambda 2(315), one or more o...

journal_title：European journal of immunology

authors： Bogen B,Malissen B,Haas W

更新日期：1986-11-01 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE) is an animal model for the human disease, multiple sclerosis. The LEW rat strain is very susceptible to induction of EAE, whereas the closely related, major histocompatibility complex (MHC)-identical, inbred strain LER is resistant. In this report, the two rat strains have...

journal_title：European journal of immunology

authors： Blankenhorn EP,Stranford SA,Smith PD,Hickey WF

更新日期：1991-09-01 00:00:00

abstract：:Human herpesvirus 6B (HHV-6B) is a ubiquitous pathogen with frequent reactivation observed in immunocompromised patients such as BM transplant (BMT) recipients. Adoptive immunotherapy is a promising therapeutic avenue for the treatment of opportunistic infections, including herpesviruses. While T-cell immunotherapy ca...

journal_title：European journal of immunology

authors： Iampietro M,Morissette G,Gravel A,Dubuc I,Rousseau M,Hasan A,O'Reilly RJ,Flamand L

更新日期：2014-12-01 00:00:00

abstract：:Leptin, a protein produced by adipocytes, exerts several functions, including modulation of the immune response. A report in this issue of the European Journal of Immunology describes for the first time the effect of either leptin receptor deficiency or blockade on murine dendritic cell (DC) maturation, survival and f...

journal_title：European journal of immunology

authors： Fantuzzi G

更新日期：2006-12-01 00:00:00

abstract：:Mouse peritoneal macrophages activated with interferon-gamma (IFN-gamma) and lipopolysaccharide produce substantial amounts of nitric oxide (NO), which correlates with the elimination of the intracellular protozoan parasite Leishmania major. Both the production of NO and the leishmanicidal function of the activated ma...

journal_title：European journal of immunology

authors： Li Y,Severn A,Rogers MV,Palmer RM,Moncada S,Liew FY

更新日期：1992-02-01 00:00:00

abstract：:Cellular metabolism is dynamically regulated in NK cells and strongly influences their responses. Metabolic dysfunction is linked to defective NK cell responses in diseases such as obesity and cancer. The transcription factors, sterol regulatory element binding protein (SREBP) and cMyc, are crucial for controlling NK ...

journal_title：European journal of immunology

authors： O'Brien KL,Assmann N,O'Connor E,Keane C,Walls J,Choi C,Oefner PJ,Gardiner CM,Dettmer K,Finlay DK

更新日期：2020-09-18 00:00:00

abstract：:The contribution of direct and indirect alloresponses by CD4(+) Th1 and Th2 cells in acute and chronic rejection of allogeneic transplants remains unclear. In the present study, we addressed this question using a transplant model in a single MHC class I-disparate donor-recipient mouse combination. BALB/c-dm2 (dm2) mut...

journal_title：European journal of immunology

authors： Illigens BM,Yamada A,Anosova N,Dong VM,Sayegh MH,Benichou G

更新日期：2009-11-01 00:00:00

abstract：:A serological cross-reactivity between env gp120 glycoprotein of the human immunodeficiency virus (HIV) and a human cellular surface protein has been defined by a monoclonal antibody (M38) raised against HIV. The cellular antigen is a protein of ca. 80 kDa expressed on a small fraction of mononuclear cells in peripher...

journal_title：European journal of immunology

authors： Beretta A,Grassi F,Pelagi M,Clivio A,Parravicini C,Giovinazzo G,Andronico F,Lopalco L,Verani P,Buttò S

更新日期：1987-12-01 00:00:00

abstract：:We show that, in vitro, the response of thymocytes to certain stimuli, and their survival largely depend on the nature of the culture environment, i.e. whether thymocytes are stimulated within intact thymus lobes or in cell suspension. Exposure of isolated thymocytes to 12-O-tetra-decanoylphorbol 13-acetate (TPA)+iono...

journal_title：European journal of immunology

authors： Moore NC,Jenkinson EJ,Owen JJ

更新日期：1992-10-01 00:00:00

abstract：:Changes in endothelial permeability are crucial in the pathogenesis of many diseases. Adenosine is one of the endogenous mediators controlling endothelial permeability under normal conditions, and an endothelial cell surface enzyme CD73 is a key regulator of adenosine production. Here we report that IFN-beta is a nove...

journal_title：European journal of immunology

authors： Kiss J,Yegutkin GG,Koskinen K,Savunen T,Jalkanen S,Salmi M

更新日期：2007-12-01 00:00:00

abstract：:In the present study, interleukin 1 (IL 1)-containing media from different sources, namely a murine macrophage cell line (P388D1), rabbit peritoneal macrophages, and human peripheral blood mononuclear cells, were compared for their effect on thymocyte proliferation and on collagenase and PGE2 secretion by chondrocytes...

journal_title：European journal of immunology

authors： Evêquoz V,Bettens F,Kristensen F,Trechsel U,Stadler BM,Dayer JM,De Weck AL,Fleisch H

更新日期：1984-06-01 00:00:00

abstract：:Radiolabeled protein A from Staphylococcus aureus (SpA) injected i.v. into mice and rabbits forms a soluble [(IgG)2-(SpA)1]2 complex (Mr = 684 000) which is identical in composition to that formed by SpA in vitro with an equivalent amount or an excess of IgG. A soluble rabbit IgG-SpA complex injected into a mice or ra...

journal_title：European journal of immunology

authors： Dima S,Medeşan C,Moţa G,Moraru I,Sjöquist J,Gheţie V

更新日期：1983-08-01 00:00:00

abstract：:The deposition of immune complexes, followed by activation of complement and/or Fc receptors and generation of chemoattractants, is the most common feature of human glomerulonephritis. Recently we have shown that primary cultured human glomerular mesangial cells (HMC), which are normally negative for IgG Fc receptors,...

journal_title：European journal of immunology

authors： Uciechowski P,Schwarz M,Gessner JE,Schmidt RE,Resch K,Radeke HH

更新日期：1998-09-01 00:00:00

abstract：:The aim of this study was to investigate malignant lymphomas of donor origin induced in F1 mice undergoing a chronic graft-versus-host reaction (GVHR) after injection of parental strain spleen cells. A total of 3 X 10(8) or 4 X 10(8) C57BL/10 spleen cells were administered to 7-8-week-old H-2 incompatible (C57BL/10 X ...

journal_title：European journal of immunology

authors： Gleichmann E,Peters K,Lattmann E,Gleichmann H

更新日期：1976-06-01 00:00:00

abstract：:Both interleukin-7 (IL-7) and IL-7 receptor (R) gene knockout (IL-7-/- and IL-7R-/-) mice were employed in order to directly investigate the importance of the IL-7 and IL-7R signaling pathway for the development of intestinal intraepithelial lymphocytes (IEL). Loss of the IL-7R-specific gene resulted in complete defic...

journal_title：European journal of immunology

authors： Fujihashi K,McGhee JR,Yamamoto M,Peschon JJ,Kiyono H

更新日期：1997-09-01 00:00:00

abstract：:Invariant NKT cells were stimulated with cholesteryl O-acyl α-glycosides in the context of CD1d. The activated NKT cells have potential to sustain the homeostasis in the body exposed to excess in either Th1- or Th2-immunity. ...

journal_title：European journal of immunology

authors： Shimamura M,Kamijo SI,Illarionov P

更新日期：2019-02-01 00:00:00

abstract：:Four cell lines derived from spontaneous BALB/c lymphoma tumors were analyzed with regard to the type of their membrane immunoglobulins (Ig). Using lactoperoxidase iodination of membrane proteins combined with immunoprecipitation and electrophoresis on polyacrylamide gel, three of these cell lines (X16c, L10A and K46)...

journal_title：European journal of immunology

authors： Laskov R,Kim JK,Woods VL,McKeever PE,Asofsky R

更新日期：1981-06-01 00:00:00

abstract：:There is a current need for safe, cheap, and effective vaccine adjuvants, to combine with sub-unit antigens to enhance their immunogenicity. In this study we have used probiotic Bacillus subtilis spores, known to be safe and fully tolerated by ingestion in man, and explored their ability to influence the magnitude and...

journal_title：European journal of immunology

authors： Barnes AG,Cerovic V,Hobson PS,Klavinskis LS

更新日期：2007-06-01 00:00:00

abstract：:Myeloid dendritic cells (DC) and macrophages evolve from a common precursor. However, factors controlling monocyte differentiation toward DC or macrophages are poorly defined. We report that the surface density of the GM-CSF receptor (GM-CSFR) alpha subunit in human peripheral blood monocytes varies among donors. Alth...

journal_title：European journal of immunology

authors： Conti L,Cardone M,Varano B,Puddu P,Belardelli F,Gessani S

更新日期：2008-03-01 00:00:00

abstract：:We have demonstrated that analogues of alpha-mannosyl ceramide (alpha-ManCer) consisting of a series of immunosuppressive 2-aminoalcohol derivatives in place of sphingosine promote a greater immune response from mouse invariant Valpha19-Jalpha26 (AV19-AJ33) TCR-bearing NKT (Valpha19 NKT) cells than alpha-ManCer itself...

journal_title：European journal of immunology

authors： Shimamura M,Huang YY,Okamoto N,Suzuki N,Yasuoka J,Morita K,Nishiyama A,Amano Y,Mishina T

更新日期：2007-07-01 00:00:00