Leptin: nourishment for the immune system.

abstract：:The pathogenesis of immune-mediated drug-induced liver injury (DILI) following halogenated anesthetics, carbamazepine or alcohol has not been fully elucidated. Detecting cytochrome P450 2E1 (CYP2E1) IgG4 auto-antibodies in anesthetic DILI patients suggests a role for IL-4 in this hapten-mediated process. We investigat...

journal_title：European journal of immunology

authors： Njoku DB,Li Z,Washington ND,Mellerson JL,Talor MV,Sharma R,Rose NR

更新日期：2009-06-01 00:00:00

abstract：:Endoglin is an homodimeric membrane antigen with capacity to bind transforming growth factor-beta (TGF-beta) and whose expression is up-regulated on myeloid cells upon differentiation to macrophages. We have isolated full-length cDNA clones from a lambda gt 10 library, prepared from phorbol 12-myristate 13-acetate-dif...

journal_title：European journal of immunology

authors： Bellón T,Corbí A,Lastres P,Calés C,Cebrián M,Vera S,Cheifetz S,Massague J,Letarte M,Bernabéu C

更新日期：1993-09-01 00:00:00

abstract：:Lymphocyte proliferation in response to monocytes pulsed with an antigenic extract of Candida albicans was measured in vitro and the effects of modifying major histocompatibility complex (MHC) class II antigen expression at the surface of the antigen-presenting cells was investigated. The study shows that no simple co...

journal_title：European journal of immunology

authors： Rhodes J,Ivanyi J,Cozens P

更新日期：1986-04-01 00:00:00

abstract：:The MHC class Ib molecule H2-M3 presents N-formylated peptides from the N terminus of proteins encoded by the mitochondrial genome to CTL. A panel of CTL specific for a peptide derived from a mitochondrial protein, either COI or ND1, was used to determine the optimal peptide length for sensitizing antigen-deficient ta...

journal_title：European journal of immunology

authors： Dabhi VM,Lindahl KF

更新日期：1998-11-01 00:00:00

abstract：:To understand further the roles that negative regulatory signals may play in B cell immune responses, we compared three inhibitors of B cell proliferation: cross-linking CD19 with monoclonal antibody (mAb), signaling through Fc receptors by intact anti-mu mAb, and transforming growth factor-beta (TGF-beta). Each agent...

journal_title：European journal of immunology

authors： Barrett TB,Shu GL,Draves KE,Pezzutto A,Clark EA

更新日期：1990-05-01 00:00:00

abstract：:Neurotropic coronavirus infection of mice results in acute encephalomyelitis followed by viral persistence. Whereas cellular immunity controls acute infection, humoral immunity regulates central nervous system (CNS) persistence. Maintenance of serum Ab was correlated with tissue distribution of virus-specific Ab-secre...

journal_title：European journal of immunology

authors： Tschen SI,Stohlman SA,Ramakrishna C,Hinton DR,Atkinson RD,Bergmann CC

更新日期：2006-03-01 00:00:00

abstract：:Lipids are key regulators of immune responses. In this study we investigated the direct impact of oxidized phospholipids (ox-PL) on T cell activation and function. We could demonstrate that ox-PL strongly inhibit proliferation of purified human T cells induced with anti-CD3/CD28 or anti-CD3/CD63 mAb, whereas prolifera...

journal_title：European journal of immunology

authors： Seyerl M,Blüml S,Kirchberger S,Bochkov VN,Oskolkova O,Majdic O,Stöckl J

更新日期：2008-03-01 00:00:00

abstract：:In the past 15 years, it became clear that the symbiotic microbiota has an important impact on the development and regulation of the immune system. Consequently, it is incorrect to interpret a phenotype solely as a direct result of the genotype, without considering the impact of the microbiota. In fact, ignorance of t...

journal_title：European journal of immunology

authors： Eberl G,Vieira P

更新日期：2020-06-01 00:00:00

abstract：:Interferon (IFN) was detected upon co-culture of cloned Sendai virus (SV)-specific T lymphocyte with SV-presenting syngeneic stimulator cells. The antiviral activity was defined as IFN-alpha, beta. The T cell clones, upon contact with antigen-presenting stimulator cells, stimulated adherent cells present in the stimul...

journal_title：European journal of immunology

authors： Ertl HC,Brown EG,Finberg RW

更新日期：1982-12-01 00:00:00

abstract：:Developing T cells undergo distinct selection processes that determine the T cell receptor (TcR) repertoire. One of these processes is positive selection. Positive selection involves the differentiation to mature T cells of thymocytes bearing TcR capable of recognizing antigens in the context of self-major histocompat...

journal_title：European journal of immunology

authors： Carrera AC,Baker C,Roberts TM,Pardoll DM

更新日期：1992-09-01 00:00:00

abstract：:Blockade of the immune response, caused by a high dose of Salmonella typhi Vi antigen (200 microgram i.v.) and cyclophosphamide (CY)-induced tolerance to Vi antigen, were analyzed. The results of the study show that blockade of the immune response cannot be attributed to masking of the response resulting from neutrali...

journal_title：European journal of immunology

authors： Prigozhina TB,Fontalin LN

更新日期：1980-08-01 00:00:00

abstract：:Langerhans cells (LC) are the principal dendritic cell (DC) population in the epidermis of the skin. Owing to their prominent position at the environmental barrier, LC have long been considered to be prototypic sentinel DC. More recently, the precise role of LC in the initiation and control of cutaneous immune respons...

journal_title：European journal of immunology

authors： Kaplan DH,Kissenpfennig A,Clausen BE

更新日期：2008-09-01 00:00:00

abstract：:Anti-peroxidase antibody (Ab)-secreting hybrids have been produced by fusion of peroxidase (PO)-immunized mouse lymph node cells and immunoglobulin (Ig)-secreting P3-X63-Ag8 (X63) myeloma cells. Identification of Ab-secreting hybrids can be performed as early as day 5 after cell fusion by the hemolytic plaque assay. I...

journal_title：European journal of immunology

authors： Zagury D,Phalente L,Bernard J,Hollande E,Buttin G

更新日期：1979-01-01 00:00:00

abstract：:Cells in homeostasis metabolize glucose mainly through the tricarboxylic acid cycle and oxidative phosphorylation, while activated cells switch their basal metabolism to aerobic glycolysis. In this study, we examined whether metabolic reprogramming toward aerobic glycolysis is important for the host response to Mycoba...

journal_title：European journal of immunology

authors： Lachmandas E,Beigier-Bompadre M,Cheng SC,Kumar V,van Laarhoven A,Wang X,Ammerdorffer A,Boutens L,de Jong D,Kanneganti TD,Gresnigt MS,Ottenhoff TH,Joosten LA,Stienstra R,Wijmenga C,Kaufmann SH,van Crevel R,Netea MG

更新日期：2016-11-01 00:00:00

abstract：:Genetic and environmental factors both influence autoimmune disease occurrence, but the identity and mechanism of action of environmental factors are poorly understood. Here we show that pinworm-infected neonatal but not adult mice, injected with an ovarian self peptide of the zona pellucida protein 3 (pZP3) in water ...

journal_title：European journal of immunology

authors： Agersborg SS,Garza KM,Tung KS

更新日期：2001-03-01 00:00:00

abstract：:Cervical thymus mimics the thoracic thymus in supporting T-cell development and exists in a subset of mice and humans. Importantly, it remains unknown whether the cervical thymus can generate T cells that are self-tolerant in the complete absence of signals from the thoracic thymus. Using a fetal liver reconstitution ...

journal_title：European journal of immunology

authors： Smolarchuk C,Zhu LF,Chan WF,Anderson CC

更新日期：2014-08-01 00:00:00

abstract：:T cell receptor (TCR) genes are initially activated in hematopoietic stem cells that have been committed to the T cell lineage during ontogeny. We have established cell lines derived from hematopoietic organs which express truncated TCR delta mRNA (1.3 kbp). In this study, cDNA clones of this mRNA were analyzed to cha...

journal_title：European journal of immunology

authors： Shimamura M,Ohta S

更新日期：1995-06-01 00:00:00

abstract：:Listeria monocytogenes induces the formation of inflammasomes and subsequent caspase-1 activation, and the adaptor apoptosis-associated speck-like protein containing a CARD (ASC) is crucial for this response. However, the role of ASC in L. monocytogenes infection in vivo is unclear. In this study, we demonstrate that ...

journal_title：European journal of immunology

authors： Tsuchiya K,Hara H,Fang R,Hernandez-Cuellar E,Sakai S,Daim S,Chen X,Dewamitta SR,Qu H,Mitsuyama M,Kawamura I

更新日期：2014-12-01 00:00:00

abstract：:The autoimmune regulator (AIRE) promotes "promiscuous" expression of tissue-restricted antigens (TRA) in thymic medullary epithelial cells to facilitate thymic deletion of autoreactive T-cells. Here, we show that AIRE-deficient mice showed an earlier development of myelin oligonucleotide glycoprotein (MOG)-induced exp...

journal_title：European journal of immunology

authors： Ko HJ,Kinkel SA,Hubert FX,Nasa Z,Chan J,Siatskas C,Hirubalan P,Toh BH,Scott HS,Alderuccio F

更新日期：2010-12-01 00:00:00

abstract：:In the fetus the peripheral T cell pool expands as the fetus grows, but the mechanisms that regulate T cell homeostasis during fetal life are unknown. Here, we show that the peripheral T cell pool in the sheep fetus is established by the export from the fetal thymus of twice as many CD8+ as CD4+ thymic emigrants every...

journal_title：European journal of immunology

authors： Holder JE,Washington EA,Cunningham CP,Cahill RN,Kimpton WG

更新日期：2006-10-01 00:00:00

abstract：:Transcriptional up-regulation of the VCAM-1 gene, induced by proinflammatory cytokines such as IL-1beta and TNF-alpha, requires activation of not only NF-kappaB, but also involves interferon regulatory factor (IRF)-1. During a study of gene induction by mechanical stimuli in cultured human endothelial cells, we noted ...

journal_title：European journal of immunology

authors： Ochi H,Masuda J,Gimbrone MA

更新日期：2002-07-01 00:00:00

abstract：:IL-10, produced by a wide variety of cells, is a highly pleiotropic cytokine that plays a critical role in the control of immune responses. However, its regulatory activity in tumor immunity remains poorly understood. In this study, we report that IL-10 deficiency robustly suppressed the formation of malignant pleural...

journal_title：European journal of immunology

authors： Zhai K,Shi XY,Yi FS,Huang ZY,Wu XZ,Dong SF,Wang W,Wu MT,Shi HZ

更新日期：2020-11-01 00:00:00

abstract：:The forkhead-family transcription factor FoxP3 is important for the development and function of CD4+CD25+ regulatory T cells. While the overall phenotypic effects of FoxP3 expression are evident, the mechanism by which FoxP3 regulates T cell activation is not well understood. CD4+ T cells from mice that express a FoxP...

journal_title：European journal of immunology

authors： Kasprowicz DJ,Droin N,Soper DM,Ramsdell F,Green DR,Ziegler SF

更新日期：2005-12-01 00:00:00

abstract：:The outcomes of many diseases differ between women and men, with women experiencing a higher incidence and more severe pathogenesis of autoimmune and some infectious diseases. It has been suggested that this is partially due to activation of plasmacytoid dendritic cells (pDCs), the main producers of interferon (IFN)-α...

journal_title：European journal of immunology

authors： Ziegler SM,Beisel C,Sutter K,Griesbeck M,Hildebrandt H,Hagen SH,Dittmer U,Altfeld M

更新日期：2017-02-01 00:00:00

abstract：:It has been reported that, following the initial expression of the T cell receptor (TcR) alpha/beta, newly generated thymocytes pass through a developmental window characterized by ineffective coupling between the alpha/beta and CD3 components resulting in resistance to deletion (negative selection). However, we now p...

journal_title：European journal of immunology

authors： Jenkinson EJ,Kingston R,Owen JJ

更新日期：1990-11-01 00:00:00

abstract：:Germinal centers support the differentiation of memory B cells and long-lived antibody-secreting cells during infection or upon vaccination. Here, we constructed mice with T cells that selectively lack the chemokine receptor CXCR5 to determine if expression of this receptor by T cells is mandatory for germinal center ...

journal_title：European journal of immunology

authors： Arnold CN,Campbell DJ,Lipp M,Butcher EC

更新日期：2007-01-01 00:00:00

abstract：:Two different subpopulations of anti-acetylcholine receptor antibodies were studied during the evolution of experimental autoimmune myasthenia in one rabbit immunized with Torpedo acetylcholine receptor. The results show that the subpopulation of antibodies directed against the toxin-binding site of the receptor might...

journal_title：European journal of immunology

authors： Zurn AD,Fulpius BW

更新日期：1977-08-01 00:00:00

abstract：:Interactions between CD8+ T cells and endothelial cells are important in both protective and pathologic immune responses. Endothelial cells regulate the recruitment of CD8+ T cells into tissues, and the activation of CD8+ T cells by antigen presentation and costimulatory signals. PD-L1 and PD-L2 are recently described...

journal_title：European journal of immunology

authors： Rodig N,Ryan T,Allen JA,Pang H,Grabie N,Chernova T,Greenfield EA,Liang SC,Sharpe AH,Lichtman AH,Freeman GJ

更新日期：2003-11-01 00:00:00

abstract：:A novel surface molecule, Tp90, is described which appears to be involved in an antigen-independent pathway of human T lymphocyte activation. The Tp90 molecule was identified by a monoclonal antibody (mAb), MX20, obtained from a fusion using spleen cells of a mouse immunized with cells from two T cell leukemia lines, ...

journal_title：European journal of immunology

authors： Carrel S,Salvi S,Giuffrè L,Isler P,Cerottini JC

更新日期：1987-06-01 00:00:00

abstract：:Dendritic cells (DC) were cultured from mouse bone marrow (BM) progenitors in low concentrations of granulocyte-macrophage colony-stimulating factor (GM-CSF) (GM(lo) DC) by two different protocols. The phenotype and functional properties of these GM(lo) DC were compared to those of standard BM-DC cultures generated in...

journal_title：European journal of immunology

authors： Lutz MB,Suri RM,Niimi M,Ogilvie AL,Kukutsch NA,Rössner S,Schuler G,Austyn JM

更新日期：2000-07-01 00:00:00