Abstract:
:Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals against the causative agent of smallpox (variola virus), but it also uses a number of strategies meant to evade or blunt the host's antiviral immune response. Natural killer T (NKT) cells are a subset of immunoregulatory CD1d-restricted T lymphocytes believed to bridge the innate and adaptive immune responses. It is shown here that the VV-encoded molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d-mediated antigen presentation to NKT cells. These are the first poxvirus-encoded molecules identified that can play such a role in the evasion of an important component of the innate immune response.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Webb TJ,Litavecz RA,Khan MA,Du W,Gervay-Hague J,Renukaradhya GJ,Brutkiewicz RRdoi
10.1002/eji.200636024subject
Has Abstractpub_date
2006-10-01 00:00:00pages
2595-600issue
10eissn
0014-2980issn
1521-4141journal_volume
36pub_type
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