Abstract:
:By means of a novel technique for identification and isolation of MHC class II-restricted antigen-specific T cells, we describe here in non-transgenic BALB / c mice physiological positive selection of an oligoclonal population of T cells which recognizes both a self MHC-derived peptide (Ialpha52) and a bacterial homologoue (Hi15). The results support a model for self peptide-mediated generation of T cells which have specificity for microbial antigens through molecular mimicry. This mechanism may be a model for the ontogeny of a physiological T cell response to infectious agents. Loss of control of these circuits may be part of the inciting factors of autoimmunity.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Bonnin D,Prakken B,Samodal R,La Cava A,Carson DA,Albani Sdoi
10.1002/(SICI)1521-4141(199912)29:12<3826::AID-IMMkeywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
3826-36issue
12eissn
0014-2980issn
1521-4141journal_volume
29pub_type
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