Induction of the Igkappa 3' enhancer by distinct pathways can be inhibited by cross-linking of the CD40 receptor.

abstract：:A human lymphoid cell ine (S95) with surface-located IgG is described. The line was derived from a patient with Hodgkin's disease and is aneuploid. Its characteristics are suggestive of a malignant B lymphocyte derivation, but no ultimate proof of malignancy can be forwarded. The line produces immunoglobulin (IgG) whi...

journal_title：European journal of immunology

authors： Nilsson K,Ghetie V,Sjöquist J

更新日期：1975-08-01 00:00:00

abstract：:We have established IgG rheumatoid factor (RF)-secreting hybridoma cell lines from the synovial tissues of three patients from whom we have previously characterized several IgM RF. The IgG RF bind human and rabbit IgG and form intracellular complement-fixing complexes indicative of a self association process in vivo. ...

journal_title：European journal of immunology

authors： Randen I,Pascual V,Victor K,Thompson KM,Førre O,Capra JD,Natvig JB

更新日期：1993-06-01 00:00:00

abstract：:Elucidating the signaling events that promote T-cell tolerance versus activation provides important insights for manipulating immunity in vivo. Previous studies have suggested that the absence of PKCtheta results in the induction of anergy and that the balance between the induction of the transcription factors NFAT, A...

journal_title：European journal of immunology

authors： Deenick EK,Po L,Chapatte L,Murakami K,Lu YC,Elford AR,Saibil SD,Ruland J,Gerondakis S,Mak TW,Ohashi PS

更新日期：2010-03-01 00:00:00

abstract：:A fusion between the mouse AKR thymoma BW5147 and a culture of homogeneously OX8+ (CD8) rat T lymphoblasts yield interleukin (IL) 2-dependent T cell hybridomas when selected in HAT medium supplemented with IL 2-containing supernatants of concanvalin A-activated cells and dexamethasone. IL 2-independent variants can be...

journal_title：European journal of immunology

authors： Somoza C,Fernández-Ruiz E,Jotterand-Bellomo M,Sanz E,Nabholz M,Silva A

更新日期：1989-07-01 00:00:00

abstract：:Hematopoietic development is a delicate balance of cell fate decisions in multipotent cells between self-renewal and differentiation. In multiple developmental systems, the Notch receptors are important factors regulating these processes. Hematopoietic progenitor cells have been shown to express Notch1, and studies wi...

journal_title：European journal of immunology

authors： Jönsson JI,Xiang Z,Pettersson M,Lardelli M,Nilsson G

更新日期：2001-11-01 00:00:00

abstract：:Terminal differentiation of B cells into antibody-secreting cells is the foundation of humoral immune response. B-1 cells, which are different from B-2 cells, preferentially differentiate into plasma cells. CMTM7 is a MARVEL-domain-containing membrane protein predominantly expressed in B cells that plays an important ...

journal_title：European journal of immunology

authors： Liu Z,Liu Y,Li T,Wang P,Mo X,Lv P,Ma D,Han W

更新日期：2020-06-01 00:00:00

abstract：:We investigated whether percutaneous sensitization with different allergens through barrier-disrupted skin regulates the balance of Th1/Th2 cytokine expression. When mice were sensitized with the typical hapten picryl chloride (PiCl) by a single topical application to intact skin, there was an up-regulation in the lym...

journal_title：European journal of immunology

authors： Kondo H,Ichikawa Y,Imokawa G

更新日期：1998-03-01 00:00:00

abstract：:By stimulating peripheral blood mononuclear cells of four healthy donors with a mixture of overlapping peptides representing the core domain of p53, we established two CD4+ alphabeta T cell clones and four lines that recognized wild-type and mutant p53 proteins as well as p53 self peptides in an HLA class II-restricte...

journal_title：European journal of immunology

authors： Fujita H,Senju S,Yokomizo H,Saya H,Ogawa M,Matsushita S,Nishimura Y

更新日期：1998-01-01 00:00:00

abstract：:B cells from bursa of Fabricius of newly hatched chickens are able to reconstitute the B cell compartment of chemically bursectomized chickens. The resulting B cell chimerism can be detected with monoclonal antibodies against donor B cell alloantigen. Chimeric chickens accept donor-type skin grafts and are unresponsiv...

journal_title：European journal of immunology

authors： Lehtonen L,Vainio O,Veromaa T,Toivanen P

更新日期：1989-03-01 00:00:00

abstract：:Target cells expressing influenza virus hemagglutinin (HA) could be recognized by cytotoxic T lymphocytes (CTL) in conjunction with the murine major histocompatibility complex class I antigen, H-2Kd, when both antigens were encoded by recombinant vaccinia virus. This recognition occurred if HA and H-2Kd were encoded b...

journal_title：European journal of immunology

authors： Andrew ME,Coupar BE,Boyle DB,Blanden RV

更新日期：1987-10-01 00:00:00

abstract：:Physical exercise, mental stress, or infusion of beta-adrenergic agonists result in an increase in the number of natural killer (NK) cells in the peripheral circulation. In view of the specific migration pattern of NK cells in vivo, it has been suggested that these cells may be released from the marginating pool in bl...

journal_title：European journal of immunology

authors： Benschop RJ,Oostveen FG,Heijnen CJ,Ballieux RE

更新日期：1993-12-01 00:00:00

abstract：:A multiparametric analysis of the resident immune populations in the parotid, submandibular and sublingual salivary glands was done in single-cell suspensions. The incidence of T and B cells and of macrophages was assessed using phenotypic markers in immunofluorescent staining and a functional assay was used to enumer...

journal_title：European journal of immunology

authors： Oudghiri M,Seguin J,Deslauriers N

更新日期：1986-03-01 00:00:00

abstract：:T90/44 is a cell surface antigen which is present on human T cells of the helper and cytotoxic subsets and which binds the 9.3 monoclonal antibody (9.3 mAb). It is expressed in the form of 90-kDa disulfide-bonded dimers of a 44-kDa polypeptide and of free 44-kDa subunits. The function of T90/44 was investigated in a s...

journal_title：European journal of immunology

authors： Lesslauer W,Koning F,Ottenhoff T,Giphart M,Goulmy E,van Rood JJ

更新日期：1986-10-01 00:00:00

abstract：:Toll-like receptors (TLRs) are playing important roles in stimulating the innate immune response and intensifying adaptive immune response against invading pathogens. Appropriate regulation of TLR activation is important to maintain a balance between preventing tumor activation and inhibiting autoimmunity. Toll-like r...

journal_title：European journal of immunology

authors： Kim TW,Hong S,Talukder AH,Pascual V,Liu YJ

更新日期：2016-03-01 00:00:00

abstract：:Interleukin-HP1 (HP1) is a murine T cell-derived lymphokine, originally described as a growth factor for B cell hybridomas and plasmacytomas, that was recently shown to stimulate growth and differentiation of normal B and T lymphocytes. Here, we describe a cDNA for HP1 that was isolated from a library prepared using m...

journal_title：European journal of immunology

authors： Van Snick J,Cayphas S,Szikora JP,Renauld JC,Van Roost E,Boon T,Simpson RJ

更新日期：1988-02-01 00:00:00

abstract：:Adenosine monophosphate-activated protein kinase (AMPK) is a serine/threonine kinase and is crucial for cellular energy homeostasis. The exact role of AMPK during memory CD8(+) T-cell differentiation, a process that changes from the metabolically active state of effector T cells to one of quiescence in memory cells is...

journal_title：European journal of immunology

authors： Araki K,Ahmed R

更新日期：2013-04-01 00:00:00

abstract：:The essential role of the transcription factor Foxp3 in the development and function of Treg has been well documented. The role of Foxp3 in non-Treg, however, is not fully understood. Emerging evidence indicates that Foxp3 expression is not confined to CD4+CD25+ Treg. The present study shows that in Foxp3 transgenic (...

journal_title：European journal of immunology

authors： Guo L,Tian J,Marinova E,Zheng B,Han S

更新日期：2010-01-01 00:00:00

abstract：:An approach to the preparation of antigen-specific human monoclonal antibodies focuses on mice transgenic for human immunoglobulin gene miniloci; the V gene segments in these miniloci undergo productive rearrangement to yield mouse B cells expressing human immunoglobulin (Ig) chains. The general usefulness of this str...

journal_title：European journal of immunology

authors： Wagner SD,Popov AV,Davies SL,Xian J,Neuberger MS,Brüggemann M

更新日期：1994-11-01 00:00:00

abstract：:Cells from the monoclonal B cell lymphoma I.29 expressing surface IgM (mu +) are capable of differentiating in vitro to IgM secretion and of switching to IgA or IgE production in response to lipopolysaccharide (LPS) stimulation. To determine whether a single mu + B cell is capable of undertaking both differentiative p...

journal_title：European journal of immunology

authors： Alberini C,Biassoni R,DeAmbrosis S,Vismara D,Sitia R

更新日期：1987-04-01 00:00:00

abstract：:Studies of chronic viral infections have highlighted the phenotypic and functional heterogeneity of antigen-specific T cells and suggested that polyfunctional T cells that secrete multiple cytokines and are able to proliferate on encounter with antigen are more likely than single cytokine secretors to represent correl...

journal_title：European journal of immunology

authors： Wilkinson KA,Wilkinson RJ

更新日期：2010-08-01 00:00:00

abstract：:A considerable fraction of T cells express two distinct T cell receptors (TCR), mainly due to expression of two TCR alpha chains. It has been suggested that such dual-TCR cells could have a role in autoimmunity. However, as such cells express less of each TCR, they could be less sensitive to their physiological ligand...

journal_title：European journal of immunology

authors： Blichfeldt E,Munthe LA,Røtnes JS,Bogen B

更新日期：1996-12-01 00:00:00

abstract：:Injection into mice of a free reactive form of the hapten (4-hydroxy-3,5-dinitrophenyl)acetyl (NNP), induces a state of specific unresponsiveness to the hapten, upon its challenge with thymus-cependent and independent carriers. This unresponsiveness is maintained in vitro. Both induction and expression of the unrespon...

journal_title：European journal of immunology

authors： Gronowicz E,Coutinho A

更新日期：1976-06-01 00:00:00

abstract：:In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been analyzed. Class II molecules are not expressed in plasma cells because of an active suppression resulting in the abrogation of class II gene transcription. We s...

journal_title：European journal of immunology

authors： Sartoris S,Tosi G,De Lerma Barbaro A,Cestari T,Accolla RS

更新日期：1996-10-01 00:00:00

abstract：:The F1 progeny of autoimmune NZB and normal SWR mice uniformly develop severe and accelerated lupus nephritis. The (SWR x NZB)F1 mice produce an oligoclonally expanded population of nephritogenic anti-DNA autoantibodies that share a recurrent cross-reactive idiotype (Id564), use highly homologous VH genes and surprisi...

journal_title：European journal of immunology

authors： O'Keefe TL,Datta SK,Imanishi-Kari T

更新日期：1992-03-01 00:00:00

abstract：:The encephalitogenic peptide pMOG 35-55 from the myelin oligodendrocyte glycoprotein was used to induce experimental autoimmune encephalomyelitis (EAE) in H-2b mice with the interleukin-6 (IL-6) gene intact or disrupted. The IL-6+/+ mice developed a chronic form of EAE ascending paralysis, whereas the IL-6-/- mice wer...

journal_title：European journal of immunology

authors： Mendel I,Katz A,Kozak N,Ben-Nun A,Revel M

更新日期：1998-05-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) induces a strong cytotoxic T lymphocyte (CTL) response in humans following infection. HIV-specific CTL can be detected directly in the blood and lungs of infected patients, and can be expanded in vitro by stimulation with autologous HIV-infected lymphoblasts. Furthermore...

journal_title：European journal of immunology

authors： Chenciner N,Michel F,Dadaglio G,Langlade-Demoyen P,Hoffenbach A,Leroux A,Garcia-Pons F,Rautmann G,Guy B,Guillon JM

更新日期：1989-09-01 00:00:00

abstract：:CD4+ alpha beta T cell populations that develop in mice deficient in MHC class II (through 'knockout' of either the Aalpha, or the Abeta chain of the I-A(b) molecule) comprise a major 'single-positive' (SP) CD4+ CD8- subset (60-90%) and a minor 'double-positive' (DP) CD4+ CD8alpha beta+ subset (10-40%). Many DP T cell...

journal_title：European journal of immunology

authors： Krajina T,Leithäuser F,Reimann J

更新日期：2004-03-01 00:00:00

abstract：:CD16 is an IgG Fc receptor that is predominantly expressed on human natural killer (NK) cells and granulocytes. The CD16 antigen expressed on neutrophils is a 50 to 70-kDa glycoprotein attached to the plasma membrane by a phosphatidylinositol-glycan linkage that is susceptible to cleavage by phosphatidylinositol-speci...

journal_title：European journal of immunology

authors： Lanier LL,Phillips JH,Testi R

更新日期：1989-04-01 00:00:00

abstract：:There is an antigen presenting cell (APC) in the lymphoid organs capable of presenting exogenous antigen (Ag) with major histocompatibility complex (MHC) class I molecules. This study was initiated to isolate clones of these APC to definitively establish their phenotype and to further study their properties. Murine bo...

journal_title：European journal of immunology

authors： Kovacsovics-Bankowski M,Rock KL

更新日期：1994-10-01 00:00:00

abstract：:HLA class II association with insulin-dependent diabetes mellitus (IDDM) is well established but is still difficult to map to a particular locus. Polymorphism of the genes coding for transporter associated with antigen processing (TAP1 and TAP2), and located in the HLA class II region, was studied in 167 IDDM patients...

journal_title：European journal of immunology

authors： Caillat-Zucman S,Bertin E,Timsit J,Boitard C,Assan R,Bach JF

更新日期：1993-08-01 00:00:00