SWAP-70-deficient mast cells are impaired in development and IgE-mediated degranulation.

abstract：:Murine cytolytic T cell lines have been analyzed for the expression of two surface glycoproteins called T145 and T130. T145, known to be expressed by activated cytolytic T cells, is also expressed by such lines, but T130, which has been described by a universal T cell marker, is not. Our results suggest a structural r...

journal_title：European journal of immunology

authors： Conzelmann A,Pink R,Acuto O,Mach JP,Dolivo S,Nabholz M

更新日期：1980-11-01 00:00:00

abstract：:Expression of activation markers and proliferative status were measured in peripheral CD4+ and CD8+ T cells of various T cell receptor (TCR)-transgenic mice either before or after intentional antigenic stimulation. In the absence of intentional immunization, CD4+ T cells persisted as resting or partially activated and...

journal_title：European journal of immunology

authors： Bruno L,von Boehmer H,Kirberg J

更新日期：1996-12-01 00:00:00

abstract：:Cytomegaloviruses (CMVs) are highly prevalent, persistent human pathogens that not only evade but also shape our immune responses. Natural killer (NK) cells play an important role in the control of CMV and CMVs have in turn developed a plethora of immunoevasion mechanisms targeting NK cells. This complex interplay can...

journal_title：European journal of immunology

authors： Goodier MR,Jonjić S,Riley EM,Juranić Lisnić V

更新日期：2018-01-01 00:00:00

abstract：:This Viewpoint series provides authoritative and detailed outlines of exciting areas of DC research. Some of the subjects that frequently come up include development of DC; distribution of DC in lymphoid and non-lymphoid tissues such as skin, intestine and lung; different forms or subsets of DC; and the role of DC in ...

journal_title：European journal of immunology

authors： Steinman RM

更新日期：2010-08-01 00:00:00

abstract：:Cross-linking of surface immunoglobulin (sIg) by antibodies against IgM, IgG and IgD activates B cells and in some circumstances can induce cell proliferation. We studied the potential link between anti-Ig-induced changes in the cytosolic free Ca2+ concentration ([Ca2+]i), inositol phosphate production and the ability...

journal_title：European journal of immunology

authors： Roifman CM,Mills GB,Stewart D,Cheung RK,Grinstein S,Gelfand EW

更新日期：1987-12-01 00:00:00

abstract：:Postganglionic sympathetic neurons innervate secondary lymphoid organs and secrete norepinephrine (NE) as the primary neurotransmitter. NE binds and signals through five distinct members of the adrenergic receptor family. In this study, we show elevated expression of the β2-adrenergic receptor (ADRB2) on primary human...

journal_title：European journal of immunology

authors： Estrada LD,Ağaç D,Farrar JD

更新日期：2016-08-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a major part in providing innate immunity against pathogenic microorganisms. Recent studies show that these receptors are also expressed on T cells, which are the sentinels of adaptive immunity. Here, we have investigated the regulatory role of the T-cell receptor in the functioning of ...

journal_title：European journal of immunology

authors： Akhade AS,Qadri A

更新日期：2015-09-01 00:00:00

abstract：:Glycosylphosphatidylinositol-anchored (GPI)-Db molecules are defective in mediating cytotoxic T lymphocytes (CTL) lysis of transfected lymphoma cells, compared to their transmembrane (TM) counterpart. This defect is manifest when antigenic peptide must be processed and presented through the endogenous pathway. These s...

journal_title：European journal of immunology

authors： Cariappa A,Flyer DC,Rollins CT,Roopenian DC,Flavell RA,Brown D,Waneck GL

更新日期：1996-09-01 00:00:00

abstract：:Treatment of systemic lupus erythematosus patients with epratuzumab (Emab), a humanized monoclonal antibody targeting CD22, leads to moderately reduced B-cell numbers but does not completely deplete B cells. Emab appears to induce immunomodulation of B cells, but the exact mode of action has not been defined. In the p...

journal_title：European journal of immunology

authors： Özgör L,Brandl C,Shock A,Nitschke L

更新日期：2016-09-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I and II products are specialized to present antigens via different intracellular processing routes. Peptides originating from proteins in the cytoplasm can gain access to class I peptide-binding grooves, most likely in the rough endoplasmic reticulum. Peptides from protein...

journal_title：European journal of immunology

authors： Zaghouani H,Kuzu Y,Kuzu H,Brumeanu TD,Swiggard WJ,Steinman RM,Bona CA

更新日期：1993-11-01 00:00:00

abstract：:We show that, in vitro, the response of thymocytes to certain stimuli, and their survival largely depend on the nature of the culture environment, i.e. whether thymocytes are stimulated within intact thymus lobes or in cell suspension. Exposure of isolated thymocytes to 12-O-tetra-decanoylphorbol 13-acetate (TPA)+iono...

journal_title：European journal of immunology

authors： Moore NC,Jenkinson EJ,Owen JJ

更新日期：1992-10-01 00:00:00

abstract：:The mechanism of synergistic complement-mediated lysis of rat red cells was investigated using rat monoclonal antibodies against class I RT1Aa antigens. The increased lytic activity when using two antibodies simultaneously is due to the increase in the number of activated C1 molecules on the cell surface and this resu...

journal_title：European journal of immunology

authors： Hughes-Jones NC,Gorick BD,Howard JC

更新日期：1983-08-01 00:00:00

abstract：:Regulatory T cells (Treg) are vital in maintaining the homeostasis of immune reactions. In chronic infections, such as schistosomiasis, it remains unclear whether engagement of the TLR family is required to induce Treg activity. Thus, we performed in vivo studies using TLR2-/- mice infected with Schistosoma mansoni an...

journal_title：European journal of immunology

authors： Layland LE,Rad R,Wagner H,da Costa CU

更新日期：2007-08-01 00:00:00

abstract：:Mutations in PTEN-induced kinase 1 (PINK1), a serine/threonine kinase linked to familial early-onset Parkinsonism, compromise mitochondrial integrity and metabolism and impair AKT signaling. As the activation of a naïve T cell requires an AKT-dependent reorganization of a cell's metabolic machinery, we sought to deter...

journal_title：European journal of immunology

authors： Ellis GI,Zhi L,Akundi R,Büeler H,Marti F

更新日期：2013-12-01 00:00:00

abstract：:The involvement of Lyt-2+ T cells in the immunological control of cutaneous leishmaniasis was assessed by studying the course of the disease in mice in which the number of these cells was reduced by treatment with anti-Lyt-2 monoclonal antibody (mAb). Administration of anti-Lyt-2 mAb exacerbated Leishmania major-induc...

journal_title：European journal of immunology

authors： Titus RG,Milon G,Marchal G,Vassalli P,Cerottini JC,Louis JA

更新日期：1987-10-01 00:00:00

abstract：:While the nasal mucosa is a potentially useful site for human immunization, toxin-based nasal adjuvants are generally unsafe and less effective in humans. Safe mucosal adjuvants that activate protective immunity via mucosal administration are highly dependent on barrier antigen sampling by epithelial and DCs. Here, we...

journal_title：European journal of immunology

authors： Makidon PE,Belyakov IM,Blanco LP,Janczak KW,Landers J,Bielinska AU,Groom JV 2nd,Baker JR Jr

更新日期：2012-08-01 00:00:00

abstract：:A mouse HER2-derived peptide, HER2p63 (A) (TYLPANASL), can induce K(d)-restricted mouse cytotoxic T lymphocytes (CTL) and also function as a tumor rejection antigen in an in vivo assay. Since the anchor motif of mouse K(d) for peptide binding has much similarity to that of human HLA-A2402, we asked if human HER2p63 (T...

journal_title：European journal of immunology

authors： Okugawa T,Ikuta Y,Takahashi Y,Obata H,Tanida K,Watanabe M,Imai S,Furugen R,Nagata Y,Toyoda N,Shiku H

更新日期：2000-11-01 00:00:00

abstract：:In this report, we provide new evidence of a crosstalk between T cell activation and adhesion processes through a functional cytokeleton. We show that CD82 signaling induces long-lasting adhesion, spreading and development of membrane extensions, involving actin polymerization. Addition of various co-stimuli (phorbol ...

journal_title：European journal of immunology

authors： Lagaudrière-Gesbert C,Lebel-Binay S,Hubeau C,Fradelizi D,Conjeaud H

更新日期：1998-12-01 00:00:00

abstract：:Checkpoint blockade of CTLA-4 results in long-lasting survival benefits in metastatic cancer patients. However, patients treated with CTLA-4 blockade have suffered from immune-related adverse events, most likely due to the breadth of the induced T-cell activation. Here, we investigated the efficacy of a local low-dose...

journal_title：European journal of immunology

authors： van Hooren L,Sandin LC,Moskalev I,Ellmark P,Dimberg A,Black P,Tötterman TH,Mangsbo SM

更新日期：2017-02-01 00:00:00

abstract：:To study the control of immunoglobulin kappa light chain gene rearrangement, we generated transgenic mice carrying a germ-line human kappa minilocus (HK) containing the J kappa-proximal V gene, V kappa IV, the V-J intergenic region, the five J kappa segments and the C kappa gene. This construct includes the intronic, ...

journal_title：European journal of immunology

authors： Cavelier P,Nato F,Coquilleau I,Rolink A,Rougeon F,Goodhardt M

更新日期：1997-07-01 00:00:00

abstract：:The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model. We found that both the endothelium and epithelium of murine cor...

journal_title：European journal of immunology

authors： Fu H,Khan A,Coe D,Zaher S,Chai JG,Kropf P,Müller I,Larkin DF,George AJ

更新日期：2011-10-01 00:00:00

abstract：:Interferon regulatory factor-1 (IRF-1) is a transcription factor regulating the expression of several cytokines. Using IRF-1 knockout (KO) mice, the role of IRF-1 in the production and activity of IL-18 was evaluated. Administration of IL-12 or concanavalin A significantly increased levels of circulating IL-18 in wild...

journal_title：European journal of immunology

authors： Fantuzzi G,Reed D,Qi M,Scully S,Dinarello CA,Senaldi G

更新日期：2001-02-01 00:00:00

abstract：:Fas is a cell surface molecule that is expressed on a wide array of cell types and triggers apoptosis. While in most situations Fas ligation activates programmed cell death, on resting T lymphocytes it can co-stimulate proliferation with the T cell receptor (TCR)/CD3 complex. This incongruity suggests that Fas may eli...

journal_title：European journal of immunology

authors： Wilson DJ,Fortner KA,Lynch DH,Mattingly RR,Macara IG,Posada JA,Budd RC

更新日期：1996-05-01 00:00:00

abstract：:An immune response (Ir) gene is described which controls the ability of mice to respond to seven very closely related gallinaceous egg white lysozymes (GEL). This Ir-GEL gene locus is linked to the major histocompatibility locus of the mouse and operates at the level of the T cell. Responsiveness to the nonimmunogenic...

journal_title：European journal of immunology

authors： Hill SW,Sercarz EE

更新日期：1975-05-01 00:00:00

abstract：:Among human peripheral blood B cells we localized the precursors of two interleukin-dependent B cell activation processes: the specific response to a particulate antigen, trinitrophenylated polyacrylamide beads (TNP-PAA) and the polyclonally induced response to pokeweed mitogen. In both cases the precursors belong to ...

journal_title：European journal of immunology

authors： Richard Y,Leprince C,Treton D,Galanaud P

更新日期：1986-10-01 00:00:00

abstract：:Naturally activated T lymphocytes present in normal mouse spleen were studied for direct reactivity to interleukin 2 (IL 2) and for binding of anti-IL 2 receptor (IL 2R) antibodies or radiolabeled IL 2. The majority of large-sized splenic T lymphocytes are IL 2R-; thus, at the most one third of large L3T4+ T cells and...

journal_title：European journal of immunology

authors： Bandeira A,Larsson EL,Forni L,Pereira P,Coutinho A

更新日期：1987-07-01 00:00:00

abstract：:Impaired control of chronic pathogen replication may be associated to alterations of NK-cell function. Whether mechanisms underlying this dysfunction involve perturbations of differentiating NK cells is still unknown. We studied an "in vitro" model of differentiation from CD34(+)Lin(-) precursors growing only myelomon...

journal_title：European journal of immunology

authors： Costa P,Sivori S,Bozzano F,Martini I,Moretta A,Moretta L,De Maria A

更新日期：2009-01-01 00:00:00

abstract：:In previous studies, Saimiri sciureus boliviensis monkeys have been immunized with four recombinant proteins reproducing part of the circumsporozoite (CS) protein of Plasmodium vivax sporozoites (NS1(81) V20, rPvCS-1, rPvCS-2, rPv-CS-3), or with irradiated sporozoites of P. vivax Salvador I strain. To analyze the anti...

journal_title：European journal of immunology

authors： Millet P,Chizzolini C,Wirtz RA,Bathurst I,Broderson JR,Campbell GH,Collins WE

更新日期：1992-02-01 00:00:00

abstract：:Since signals via CD40 and the B cell receptor are known to synergize to induce B cell activation, we have analyzed the pocket protein/E2F complexes in mouse B lymphocytes following stimulation by anti-IgM, anti-CD40, alone or together. We find that E2F4 and DP1 form the predominant E2F heterodimers in the G0 and G1 p...

journal_title：European journal of immunology

authors： Lam EW,Glassford J,van der Sman J,Banerji L,Pizzey AR,Shaun N,Thomas B,Klaus GG

更新日期：1999-10-01 00:00:00

abstract：:A small dose of the IgG1 fraction of anti-idiotypic antibody (aId1) raised in guinea pigs against a strain A/J antibody specific for streptococcal Group A carbohydrate sensitizes A/J mice against Group A streptococci. This is opposed to the previously established suppressive function of anti-idiotypic antibody of the ...

journal_title：European journal of immunology

authors： Eichmann K,Rajewsky K

更新日期：1975-10-01 00:00:00