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A dynamic immunological synapse mediates homeostatic TCR-dependent and -independent signaling.

Abstract：

:For homeostasis, T cells integrate non-cognate TCR-dependent and -independent signals to survive and weakly proliferate. In contrast to antigen-specific, stable, and long-lived contacts, signaling in short-lived homeostatic interactions depends upon the coordination of ongoing T-cell migration on the surface of DC and signaling at the cell-cell junction. To mimic peripheral tissues and analyze how T-cell migration and cell-cell signaling are integrated, we used live-cell imaging and 3-D reconstruction of fixed conjugates between DO11.10 T cells and DC in 3-D low-density collagen matrices. T cells simultaneously maintained amoeboid migration and polarized towards the DC, leading to a fully dynamic interaction plane that delivered signals for homeostatic T-cell survival and proliferation. The contact plane comprised three zones, the actin-rich leading edge poor in signal but driving migration, a mid-zone mediating TCR/MHC-induced signal associated with proliferation, and the rear uropod mediating predominantly MHC-independent signals. Thus a dynamic immunological synapse with distinct signaling sectors enables moving T cells to serially sample resident tissue cells and acquire molecular information "en passant".

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Storim J,Bröcker EB,Friedl P

doi

10.1002/eji.201040575

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

2741-50

issue

10

eissn

0014-2980

issn

1521-4141

journal_volume

40

pub_type

杂志文章

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