A new surface marker on mouse natural killer cells: receptors for Helix pomatia A hemagglutinin.

abstract：:Previously, we have shown that the intravenous (i.v.) injection of allogeneic lymphocytes across an H-2 class I-mutant disparity leads to specific skin allograft tolerance caused by irradiation-sensitive donor T cells, which function as veto cells. In the present study, we show that the i.v. injection of H-2 class II-...

journal_title：European journal of immunology

authors： van Twuyver E,Kast WM,Mooijaart RJ,Melief CJ,De Waal LP

更新日期：1990-02-01 00:00:00

abstract：:Adenosine triphosphate has previously been shown to induce semi-mature human monocyte-derived dendritic cells (DC). These are characterized by the up-regulation of co-stimulatory molecules, the inhibition of IL-12 and the up-regulation of some genes involved in immune tolerance, such as thrombospondin-1 and indoleamin...

journal_title：European journal of immunology

authors： Ben Addi A,Lefort A,Hua X,Libert F,Communi D,Ledent C,Macours P,Tilley SL,Boeynaems JM,Robaye B

更新日期：2008-06-01 00:00:00

abstract：:Interleukin (IL)-7 and IL-2 are important lymphoproliferative cytokines which both use the gamma c chain as part of their respective receptors. To learn more of their signaling mechanisms a comparison was made of the patterns of intracellular tyrosine phosphorylated proteins induced by these cytokines in the murine T ...

journal_title：European journal of immunology

authors： Crawley JB,Willcocks J,Foxwell BM

更新日期：1996-11-01 00:00:00

abstract：:X-linked agammaglobulinemia (XLA) is a primary immunodeficiency of the B-cell compartment caused by a defective gene encoding for the tyrosine kinase (btk) essential for B cell differentiation. Affected males undergo recurrent pyogenic infections and deficient immunoglobulin production. Peripheral blood T cells from 6...

journal_title：European journal of immunology

authors： Amedei A,Romagnani C,Benagiano M,Azzurri A,Fomia F,Torrente F,Plebani A,D'Elios MM,Del Prete G

更新日期：2001-06-01 00:00:00

abstract：:The scavenger receptor-A I/II (SR-A) and macrophage receptor with collagenous domain (MARCO) share a common domain organisation and ligand repertoire, including selected polyanions and gram-positive and -negative organisms, but differ in fine specificity of ligand binding, tissue distribution and regulation. Neisseria...

journal_title：European journal of immunology

authors： Mukhopadhyay S,Chen Y,Sankala M,Peiser L,Pikkarainen T,Kraal G,Tryggvason K,Gordon S

更新日期：2006-04-01 00:00:00

abstract：:An atypical guanine exchange factor, Dock2 is specifically expressed in hematopoietic cells and regulates activation and migration of immune cells through activating Ras-related C3 botulinum toxin substrate (Rac). Dock2 was shown to be critical in the development of various inflammatory diseases, including allergic di...

journal_title：European journal of immunology

authors： Chen Y,Meng F,Wang B,He L,Liu Y,Liu Z

更新日期：2018-06-01 00:00:00

abstract：:Both interleukin-7 (IL-7) and IL-7 receptor (R) gene knockout (IL-7-/- and IL-7R-/-) mice were employed in order to directly investigate the importance of the IL-7 and IL-7R signaling pathway for the development of intestinal intraepithelial lymphocytes (IEL). Loss of the IL-7R-specific gene resulted in complete defic...

journal_title：European journal of immunology

authors： Fujihashi K,McGhee JR,Yamamoto M,Peschon JJ,Kiyono H

更新日期：1997-09-01 00:00:00

abstract：:Many pathogens are initially encountered in the gut, where the decision is made to mount an immune response or induce tolerance. The mesentric lymph node (mLN) has been shown to be involved in immune response and much more in oral tolerance induction. Furthermore, using an in vivo transplantation model, we showed rece...

journal_title：European journal of immunology

authors： Buettner M,Pabst R,Bode U

更新日期：2011-03-01 00:00:00

abstract：:Upon transplantation of T cells from a CD28 superagonist (CD28-SA) treated donor into an irradiated allogeneic host, the CD28-SA-induced activation and expansion of Treg cells inhibits acute graft versus host disease (aGvHD), while not abrogating the desired graft versus tumor effect. Human peripheral blood CD4(+) T c...

journal_title：European journal of immunology

authors： Beyersdorf N,Werner S,Wolf N,Hünig T,Kerkau T

更新日期：2015-07-01 00:00:00

abstract：:The internalization and intracellular processing of monoclonal antibody to immunoglobulin mu heavy chain (Mamu) have been investigated in two human Burkitt lymphoma cell lines (Ramos and Raji), in a human B cell lymphoma and in normal human peripheral blood B cells. In addition to the degradation of 125I-labeled Mamu ...

journal_title：European journal of immunology

authors： Ruud E,Blomhoff HK,Funderud S,Godal T

更新日期：1986-03-01 00:00:00

abstract：:During the course of many human autoimmune diseases, antibodies which recognize negatively charged epitopes on self antigens are detected. Trypanosoma cruzi, an intracellular protozoan parasite capable of infecting a wide variety of vertebrates, is the cause of Chagas disease in humans. Infection with the parasite fre...

journal_title：European journal of immunology

authors： Kahn S,Kahn M,Eisen H

更新日期：1992-12-01 00:00:00

abstract：:Type B T cells recognize peptide-MHC class II (pMHCII) isoforms that are structurally distinct from those recognized by conventional type A T cells. These alternative type B conformers result from peptide loading in the absence of HLA-DM. Type A conformers are more stable than type B pMHCII conformers but bind the sam...

journal_title：European journal of immunology

authors： Jackson N,Compton E,Trowsdale J,Kelly AP

更新日期：2014-04-01 00:00:00

abstract：:Indirect immunofluorescence performed with 2 polyclonal and 4 monoclonal antibodies directed against human beta 2-microglobulin (beta 2m) revealed the presence of a beta 2m-like determinant on the membrane of a subpopulation of earthworm leukocytes classified as weakly adherent acidophils. Two out of the 4 monoclonal ...

journal_title：European journal of immunology

authors： Roch P,Cooper EL,Eskinazi DP

更新日期：1983-12-01 00:00:00

abstract：:We have demonstrated that analogues of alpha-mannosyl ceramide (alpha-ManCer) consisting of a series of immunosuppressive 2-aminoalcohol derivatives in place of sphingosine promote a greater immune response from mouse invariant Valpha19-Jalpha26 (AV19-AJ33) TCR-bearing NKT (Valpha19 NKT) cells than alpha-ManCer itself...

journal_title：European journal of immunology

authors： Shimamura M,Huang YY,Okamoto N,Suzuki N,Yasuoka J,Morita K,Nishiyama A,Amano Y,Mishina T

更新日期：2007-07-01 00:00:00

abstract：:A multiparametric analysis of the resident immune populations in the parotid, submandibular and sublingual salivary glands was done in single-cell suspensions. The incidence of T and B cells and of macrophages was assessed using phenotypic markers in immunofluorescent staining and a functional assay was used to enumer...

journal_title：European journal of immunology

authors： Oudghiri M,Seguin J,Deslauriers N

更新日期：1986-03-01 00:00:00

abstract：:We have previously identified a molecule on the T cell surface, which, in addition to CD2 is involved in the rosette phenomenon. This is a 32-kDa single polypeptide chain which we have termed E2. The studies reported here show striking patterns on the glycosylation status of E2. It is a heavily sialylated and glycosyl...

journal_title：European journal of immunology

authors： Aubrit F,Gelin C,Pham D,Raynal B,Bernard A

更新日期：1989-08-01 00:00:00

abstract：:Among 15 anti-DNA antibody-producing hybridomas derived from a single NZB X NZW F1 mouse, an IgM and an IgG were shown to use the same VH gene of the Q52 family. Using a combination of two primers both consisting of a mixture of oligonucleotides (one complementary to the 5' end of VH segment and one to the 3' end of V...

journal_title：European journal of immunology

authors： Taki S,Hirose S,Kinoshita K,Nishimura H,Shimamura T,Hamuro J,Shirai T

更新日期：1992-04-01 00:00:00

abstract：:The lectin leucoagglutinin has been used to induce reactivity to interleukin 2 (IL2) in unseparated spleen cells and in highly purified Lyt-2+ lymph node T cells. Recombinant human IL2 and various other IL2-containing preparations, including concanavalin A-induced spleen cell supernatant, were compared for their capac...

journal_title：European journal of immunology

authors： Vohr HW,Hünig T

更新日期：1985-04-01 00:00:00

abstract：:Two out of 25 monoclonal anti-DNA autoantibodies that were produced by human-human hybridoma were found to have lymphocytotoxic activity. The antibodies reacted with normal B and T lymphocytes at cold (4 degrees C) as well as at warm (37 degrees C) temperatures. The lymphocytotoxic activity of the monoclonal anti-DNA ...

journal_title：European journal of immunology

authors： Shoenfeld Y,Zamir R,Joshua H,Lavie G,Pinkhas J

更新日期：1985-10-01 00:00:00

abstract：:The immaturity of the neonatal immune system in mice is associated with defective IFN-gamma production and Th2-biased immune responses. In this study, infants vaccinated at birth with BCG produced similar concentrations of IFN-gamma in response to PPD and showed similar frequencies of IFN-gamma-producing lymphocytes a...

journal_title：European journal of immunology

authors： Vekemans J,Amedei A,Ota MO,D'Elios MM,Goetghebuer T,Ismaili J,Newport MJ,Del Prete G,Goldman M,McAdam KP,Marchant A

更新日期：2001-05-01 00:00:00

abstract：:Mycoplasma arthritidis produces in culture a polyclonal mitogen which is active for murine and human T lymphocytes in the presence of accessory cells (AC). We studied the requirements for processing and presentation by AC of Mycoplasma arthritidis supernatant (MAS) mitogen to human T cells. As inhibitors of AC process...

journal_title：European journal of immunology

authors： Bauer A,Rutenfranz I,Kirchner H

更新日期：1988-12-01 00:00:00

abstract：:We have previously shown, through transfection experiments, that the murine B7 (mB7) molecule, a ligand for the CD28 and CTLA-4 receptors, is a sufficient costimulatory signal for the antigen-specific and major histocompatibility complex (MHC)-restricted activation of murine CD4+ T lymphocytes. In addition to mB7, ano...

journal_title：European journal of immunology

authors： Razi-Wolf Z,Falo LD Jr,Reiser H

更新日期：1994-04-01 00:00:00

abstract：:IFN-γ-activated keratinocytes are key contributors to the pathogenetic mechanisms leading to type-1 immune-mediated skin disorders. In these epidermal cells, SOCS1 negatively regulates the molecular cascades triggered by IFN-γ by disabling JAK2 phosphorylation through its kinase inhibitory region (KIR). Aimed at poten...

journal_title：European journal of immunology

authors： Madonna S,Scarponi C,Doti N,Carbone T,Cavani A,Scognamiglio PL,Marasco D,Albanesi C

更新日期：2013-07-01 00:00:00

abstract：:Lipoproteins or lipopeptides (LP) are bacterial cell wall components detected by the innate immune system. For LP, it has been shown that TLR2 is the essential receptor in cellular activation. However, molecular mechanisms of LP recognition are not yet clear. We used a FLAG-labeled derivative of the synthetic lipopept...

journal_title：European journal of immunology

authors： Manukyan M,Triantafilou K,Triantafilou M,Mackie A,Nilsen N,Espevik T,Wiesmüller KH,Ulmer AJ,Heine H

更新日期：2005-03-01 00:00:00

abstract：:In humans infected with lymphatic filariasis, microfilaraemia [the presence of microfilariae (Mf) in the blood] is generally associated with both poor antigen (Ag)-specific proliferative responses and with protection from severe disease. Clonal deletion has been suggested as one possible mechanism by which parasite-re...

journal_title：European journal of immunology

authors： Jenson JS,O'Connor R,Osborne J,Devaney E

更新日期：2002-03-01 00:00:00

abstract：:The effect of cyclosporin A (CsA) on the delayed-type hypersensitivity (DTH) elicited in mice by sheep red blood cells was investigated. Evidence is presented that a single injection of CsA adversely affects the inflammatory reaction. Sensitized T lymphocytes initiate the DTH reaction by their recruiting activity on p...

journal_title：European journal of immunology

authors： Shidani B,Milon G,Marchal G,Truffa-Bachi P

更新日期：1984-04-01 00:00:00

abstract：:At least two subsets of CD4+ T helper cell lymphocytes termed Th1 and Th2 exist in the mouse and probably in humans. They are characterized by the secretion of different lymphokines and by their functional behavior. Dysregulated expansion of one or the other subset may be one reason for the development of certain dise...

journal_title：European journal of immunology

authors： Germann T,Gately MK,Schoenhaut DS,Lohoff M,Mattner F,Fischer S,Jin SC,Schmitt E,Rüde E

更新日期：1993-08-01 00:00:00

abstract：:CD40 ligand (CD40L) and IL-4 are sufficient to induce resting murine B cells to divide and switch isotypes from IgM and IgD to IgG1 and IgE. Tracking of cell division following (5- and 6) carboxyfluorescein diacetate succinimidyl ester (CFSE) labeling revealed that B cells expressed IgG1 after three cell divisions, an...

journal_title：European journal of immunology

authors： Hasbold J,Lyons AB,Kehry MR,Hodgkin PD

更新日期：1998-03-01 00:00:00

abstract：:The ganglioside GD3 has been described as a membrane component of human T cells which is involved in T cell growth. In the present study the activating function of GD3 for human CD4+ and CD8+ T cells was analyzed by five different monoclonal antibodies (mAb) directed against the GD3 molecule. Three mAb U5, Z21 and R24...

journal_title：European journal of immunology

authors： Claus C,Schlaak J,Dittmayer M,Meyer zum Büschenfelde K,Dippold W

更新日期：1994-05-01 00:00:00

abstract：:Hypoxia and glucose deprivation are often observed in the microenvironment surrounding solid tumors in vivo. However, how they interfere with MHC class I antigen processing and CD8(+) T-cell responses remains unclear. In this study, we analyzed the production of antigenic peptides presented by classical MHC class I in...

journal_title：European journal of immunology

authors： Sasaki T,Kanaseki T,Shionoya Y,Tokita S,Miyamoto S,Saka E,Kochin V,Takasawa A,Hirohashi Y,Tamura Y,Miyazaki A,Torigoe T,Hiratsuka H,Sato N

更新日期：2016-04-01 00:00:00