Abstract:
:Previously, we have shown that the intravenous (i.v.) injection of allogeneic lymphocytes across an H-2 class I-mutant disparity leads to specific skin allograft tolerance caused by irradiation-sensitive donor T cells, which function as veto cells. In the present study, we show that the i.v. injection of H-2 class II-incompatible spleen cells also results in specific skin allograft tolerance. However, tolerance induction depends on the presence of irradiation-resistant non-T cells in the donor cell inoculum. Thus, different mechanisms operate in tolerance induction across an H-2 class I vs. H-2 class II mismatch. I.v. injection of allogeneic spleen cells across an H-2 class I plus class II disparity does not result in skin allograft tolerance. Finally, our data show that transfusion-induced suppression of the delayed-type hypersensitivity response against alloantigens does not correlate with skin allograft tolerance induced by i.v. injected allogeneic lymphocytes. In conclusion, the type of H-2 mismatch between transfusion donor and recipient not only determines the occurrence of allograft tolerance but also the mechanism leading to tolerization.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
van Twuyver E,Kast WM,Mooijaart RJ,Melief CJ,De Waal LPdoi
10.1002/eji.1830200232subject
Has Abstractpub_date
1990-02-01 00:00:00pages
441-4issue
2eissn
0014-2980issn
1521-4141journal_volume
20pub_type
杂志文章abstract::The molecular mechanism of the interleukin (IL) 2-induced differentiation of human B cells has been investigated. The experimental results show that Staphylococcus aureus Cowan strain I (SAC) activation alone induces IL6 secretion from B cells. When B cells were activated by SAC, there was an increased transcription o...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830191215
更新日期:1989-12-01 00:00:00
abstract::Spleen cells from trypanosome-infected mice strongly suppressed lymphocyte stimulation induced in normal spleen cell populations by lipopolysaccharide, concanavalin A or allogeneic (H-2-different) stimulator cells. This suppression was not H-2-restricted, as responses of spleen lymphocytes both allogeneic and syngenei...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830090306
更新日期:1979-03-01 00:00:00
abstract::Anti-HLA donor-specific antibodies are deleterious for organ transplant survival. Class I HLA donor-specific antibodies are identified by using the Luminex single antigen beads (LSAB) assay, which also detects anti-denatured HLA antibodies (anti-dHLAs). Anti-dHLAs are thought to be unable to recognize native HLA (nHLA...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201445340
更新日期:2015-07-01 00:00:00
abstract::T and B cells continually migrate around the body by recirculating between blood and lymph via lymphoid tissues. This is an important way of fostering the cell-cell interactions required for the initiation of an immune response. Data from previous studies of T and B cell recirculation, based on relatively complex appr...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830180602
更新日期:1988-06-01 00:00:00
abstract::Tumor-associated macrophages (TAMs) are key components of the tumor macroenvironment. Cancer- and host cell-derived signals generally drive the functions of TAMs towards an M2-like polarized, tumor-propelling mode; however, when appropriately re-educated. TAMs also have the potential to elicit tumor destructive reacti...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.201141894
更新日期:2011-09-01 00:00:00
abstract::Mouse peritoneal macrophages were charged with IgG molecules in monomeric (mIgG), heat-aggregated (agIgG) or antigen-complexed (acIgG) form. Upon exposure to 37 degrees C, all bound IgG ligand types are redistributed on the cell surface due to the mobilization of their corresponding Fc receptor (FcR). The major findin...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830091213
更新日期:1979-12-01 00:00:00
abstract::To investigate the role of TCR-pMHC interaction in regulating lung CD8 tissue-resident T cell (TR ) differentiation, polyclonal responses were compared against NP366-374 /Db and PA224-233 /Db , two immunodominant epitopes that arise during influenza A infection in mice. Memory niches distinct from iBALTs develop withi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201747174
更新日期:2018-01-01 00:00:00
abstract::Transcription factors (TFs) regulate cell-type-specific gene expression programs by combinatorial binding to cis-genomic elements, particularly enhancers, subsequently leading to the recruitment of cofactors, and the general transcriptional machinery to target genes. Using data integration of genome-wide TF binding pr...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201545713
更新日期:2015-11-01 00:00:00
abstract::The developmental stages and the role of protein tyrosine kinases (PTK) in the maturation of CD3+CD8 alpha alpha+ intraepithelial lymphocytes (IEL) have not been extensively characterized. However, comparisons of thymic and extrathymic T cell development indicate that these processes involve some distinct signaling an...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830270229
更新日期:1997-02-01 00:00:00
abstract::The inflammatory process that underlies allergic diseases such as asthma is characterized by tissue infiltration of eosinophils and T cells. We have used the Stamper-Woodruff frozen-section assay to characterize the receptors involved in adhesion of human peripheral blood T cells to nasal polyp endothelium (NPE) as a ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199904)29:04<1324::AID-IMM
更新日期:1999-04-01 00:00:00
abstract::Human immunodeficiency virus binds to CD4 T lymphocytes by interaction between its envelope glycoprotein gp120 and the CD4 molecule. The latter is non-covalently associated with a src-related tyrosine kinase, p56lck. CD4 cross-linking increases the activity of p56lck, leading to phosphorylation of several cellular sub...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230303
更新日期:1993-03-01 00:00:00
abstract::Cytotoxic T lymphocytes (CTL) recognize antigenic peptides presented by major histocompatibility complex class I (MHC-I) molecules on the surface of target cells. Optimal induction of CD8+ CTL depends on the amount of relevant peptide/MHC-I complexes and the presence of co-stimulatory molecules on antigen-presenting c...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830241118
更新日期:1994-11-01 00:00:00
abstract::The antagonistic effects of macrophage (M phi)-derived interleukin 1 (IL 1) and prostaglandin E2 (PGE2) on thymocyte proliferation were uncoupled and studied. Elimination of PGE2 from the culture medium of prostaglandin E2-stimulated M phi was achieved by dialysis of the media or by indomethacin treatment of the M phi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830150109
更新日期:1985-01-01 00:00:00
abstract::Two out of five murine IgG3 anti-trinitrophenyl (TNP) monoclonal antibodies (mAb) obtained either by immunization with TNP-keyhole limpet hemocyanin (KLH) (CB1, CB5, CB6 and 4H10) or with dinitrophenyl-lipopolysaccharide (9A6), exhibited anti-IgG rheumatoid factor (RF) activity (CB6 and 4H10). The anti-IgG activity of...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830191123
更新日期:1989-11-01 00:00:00
abstract::Hypoxia and glucose deprivation are often observed in the microenvironment surrounding solid tumors in vivo. However, how they interfere with MHC class I antigen processing and CD8(+) T-cell responses remains unclear. In this study, we analyzed the production of antigenic peptides presented by classical MHC class I in...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201545835
更新日期:2016-04-01 00:00:00
abstract::Protein kinase C (PKC) has been implicated in the signaling of a number of cellular responses including activation of T cells. In the present report we have evaluated the effect of increased cAMP levels on PKC activation after stimulation of two distinct receptor systems on normal human T cells. PKC substrate phosphor...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190622
更新日期:1989-06-01 00:00:00
abstract::MPhi and DC are key elements in the control of tissue homeostasis and response to insult. In this work, we demonstrate that MPhi and DC are the major producers of the phenylalanine catabolizing enzyme IL-4-induced gene 1 (IL4I1) under inflammatory conditions. IL4I1 was first described in B cells, which indeed can prod...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201040428
更新日期:2010-09-01 00:00:00
abstract::IL-6-specific autoantibodies (aAb-IL-6) have been reported in diseased and healthy individuals. We recently established a model for aAb-IL-6 in different mouse strains, based on vaccination with immunogenic IL-6 analogues, in which titers of aAb-IL-6 above 1,000 resulted in an in vivo IL-6 deficiency. Here, we examine...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425268
更新日期:2004-11-01 00:00:00
abstract::Chemokine receptors are important for recruiting leukocytes to sites of infection and may contribute to immune cell activation. The present study investigated the role of the chemokine receptor CCR2 in polymicrobial septic peritonitis. The results showed that peritoneal production of the CCR2 ligands CCL2 and CCL12 in...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425294
更新日期:2004-12-01 00:00:00
abstract::There is an antigen presenting cell (APC) in the lymphoid organs capable of presenting exogenous antigen (Ag) with major histocompatibility complex (MHC) class I molecules. This study was initiated to isolate clones of these APC to definitively establish their phenotype and to further study their properties. Murine bo...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830241024
更新日期:1994-10-01 00:00:00
abstract::Mycoplasma arthritidis produces an as yet undefined soluble molecule (MAS) that has a potent mitogenic effect on T cells of several species. We have used cloned human cytotoxic and proliferative T lymphocytes to dissect the molecular mechanism of T cell activation by this mitogen. Reactivity to MAS is clonally express...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830181112
更新日期:1988-11-01 00:00:00
abstract::CD5 is expressed on T cells and a subset of B cells (B1a). It can attenuate TCR signalling and impair CTL activation and is a therapeutic targetable tumour antigen expressed on leukemic T and B cells. However, the potential therapeutic effect of functionally blocking CD5 to increase T cell anti-tumour activity against...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201948309
更新日期:2020-05-01 00:00:00
abstract::In experimental autoimmune encephalomyelitis (EAE), intravenous transfer of activated CD4(+) myelin-specific T cells is sufficient to induce disease. Transferred T cells access the CNS parenchyma by trafficking across the blood brain barrier (BBB) vascular endothelium into the perivascular space, and then across the g...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200425864
更新日期:2005-04-01 00:00:00
abstract::HSP gp96-based vaccines have been trialled in rodent models and, more recently, in humans. Better understanding of gp96's immunomodulatory role will help with the design of more effective strategies for treatment of cancer and infectious diseases. In this study, we monitored the activities of T cells and activation of...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200939593
更新日期:2009-11-01 00:00:00
abstract::B cells and regulatory T (Treg) cells can both facilitate remission from experimental auto immune encephalomyelitis (EAE), a disease of the central nervous system (CNS) used as a model for multiple sclerosis (MS). Considering that B-cell-depletion therapy (BCDT) is used to treat MS patients, we asked whether Treg-cell...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142242
更新日期:2012-05-01 00:00:00
abstract::We have earlier described (Cardell, S. and Sander, B., Eur. J. Immunol. 1990. 20:389) mitogen-induced production of interleukin (IL)2, IL4 and IL5 mRNA by murine spleen cells, analyzed by in situ hybridization. In the present study we have investigated the potential of CD8 T cells to produce these interleukins, normal...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830211028
更新日期:1991-10-01 00:00:00
abstract::The lymph node cells (LNC) activated in vivo by liver regeneration following partial hepatectomy of mice (primed lymph node cells) respond to regenerating liver cells in vitro with typical secondary immune response characteristics (Miyahara, S. et al., Eur. J. Immunol. 1983. 13: 878). These LNC activated in vivo suppr...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830131105
更新日期:1983-11-01 00:00:00
abstract::Deficiencies in terminal complement components, including the component C7, are uncommon and associated with an increased risk of recurrent systemic neisserial infection. A total of 22 molecular defects have been reported in the C7 gene with both complete (C7Q0) and subtotal (C7SD) C7 deficiencies. In this study we re...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200636812
更新日期:2007-05-01 00:00:00
abstract::Empty major histocompatibility complex (MHC) class I molecules present on the surface of RMA-S (26 degrees C) cells were loaded with the iodinated peptides APGNYPAL, FAPGNYPAL (SEV-9) and RGYVYQGL (VSV-8), respectively. The thermostability of these peptide-loaded MHC class I molecules was assessed using temperature gr...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230847
更新日期:1993-08-01 00:00:00
abstract::Memory T cells can now be defined with various monoclonal antibodies but little is known about the functional properties of these cells as compared to virgin T cells. We have studied Ca2+ mobilization and proliferation of memory and virgin cells in both the CD4 and CD8 subsets in response to phytohemagglutin-in. Using...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200913
更新日期:1990-09-01 00:00:00