Abstract:
:KARAP/DAP12 is a broadly distributed transmembrane signaling polypeptide with an immunoreceptor tyrosine-based activation motif, and is non-covalently associated with a variety of activating surface receptors. We report here the characterization of transgenic mice that overexpress KARAP/DAP12 polypeptides in both myeloid and lymphoid compartments. KARAP/DAP12-transgenic mice present, in a transgene dose-dependent manner, a complex phenotype characterized by two independent and spontaneous hematological abnormalities: (i) a severe lymphopenia and (ii) a massive inflammatory syndrome associated with neutrophilia and lung infiltration by multinucleated macrophages. These myeloid abnormalities observed in KARAP/DAP12-transgenic mice indicate that KARAP/DAP12-driven signals are critically involved in inflammation, and constitute an essential target to control the resolution of inflammatory disorders based on monocytes/macrophages and neutrophils.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Lucas M,Daniel L,Tomasello E,Guia S,Horschowski N,Aoki N,Figarella-Branger D,Gomez S,Vivier Edoi
10.1002/1521-4141(200209)32:9<2653::AID-IMMU2653>3keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
2653-63issue
9eissn
0014-2980issn
1521-4141journal_volume
32pub_type
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