The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen.

Abstract:

:Tissue distribution and expression on mitogen and virally stimulated lymphocytes render the ACT35 molecule a human lymphocyte activation antigen which as yet could not be clustered. Expression cloning of the ACT35 antigen from a pCDM8 library of the HUT-102 cell line revealed strong homology of the cDNA and its encoded protein sequence with the formerly described rat OX40 antigen. The 1.4-kb nucleotide sequence and the deduced 277-amino acid sequence of the single transmembrane protein were 65% and 63% identical, in human and in rat, respectively. Conservation included one N-linked glycosylation site and one protein kinase C phosphorylation site. When expressed in COS-1 cells, the cDNA presented properties comparable to the native ACT35 antigen and the rat OX40 molecule (relative molecular mass 48,000). Thus, the ACT35 protein corresponds to the hitherto unknown human OX40 antigen and is, therefore, another member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. After applying fluorescence in situ hybridization, the human ACT35/OX40 gene could be mapped to chromosome band 1p36 and is, thus, linked to the genes for TNFR II and CD30.

journal_name

Eur J Immunol

authors

Latza U,Dürkop H,Schnittger S,Ringeling J,Eitelbach F,Hummel M,Fonatsch C,Stein H

doi

10.1002/eji.1830240329

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

677-83

issue

3

eissn

0014-2980

issn

1521-4141

journal_volume

24

pub_type

杂志文章
  • Requirement of secondary lymphoid tissues for the induction of primary and secondary T cell responses against Listeria monocytogenes.

    abstract::Activation of naive T cells is tightly controlled and depends on cognate interactions with professional antigen-presenting cells. We analyzed dependency on secondary lymphoid tissues for the activation of naive and memory CD4(+) and CD8(+) T cells following primary and secondary Listeria monocytogenes infection, respe...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200737142

    authors: Kursar M,Jänner N,Pfeffer K,Brinkmann V,Kaufmann SH,Mittrücker HW

    更新日期:2008-01-01 00:00:00

  • Isolation of antigen-specific T cell clones from nonresponder mice.

    abstract::The mechanisms responsible for major histocompatibility complex (MHC)-linked unresponsiveness are still poorly understood. Here we examine the cellular events that follow when B10. A mice are immunized with cow insulin, an antigen to which they make no apparent immunologic response. Despite the fact that there is no d...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830180122

    authors: Abromson-Leeman S,Laning J,Cantor H,Dorf ME

    更新日期:1988-01-01 00:00:00

  • Oxidized phospholipids induce anergy in human peripheral blood T cells.

    abstract::Lipids are key regulators of immune responses. In this study we investigated the direct impact of oxidized phospholipids (ox-PL) on T cell activation and function. We could demonstrate that ox-PL strongly inhibit proliferation of purified human T cells induced with anti-CD3/CD28 or anti-CD3/CD63 mAb, whereas prolifera...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200737619

    authors: Seyerl M,Blüml S,Kirchberger S,Bochkov VN,Oskolkova O,Majdic O,Stöckl J

    更新日期:2008-03-01 00:00:00

  • Purified lymphocyte function-associated antigen-3 and T11 target structure are active in CD2-mediated T cell stimulation.

    abstract::In this study we have used cells expressing LFA-3 or T11TS, the human and sheep forms of the ligand of CD2, as well as the purified LFA-3 and T11TS molecules themselves to study their effects on T cell activation via the CD2-mediated "alternative pathway". Sheep red blood cells, which bind to CD2 via T11TS in E-rosett...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830171227

    authors: Tiefenthaler G,Hünig T,Dustin ML,Springer TA,Meuer SC

    更新日期:1987-12-01 00:00:00

  • HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin.

    abstract::Tapasin is a 48-kDa endoplasmic reticulum (ER)-resident glycoprotein that binds to the transporter associated with antigen processing (TAP) and mediates an interaction between TAP and newly synthesized MHC class I molecules. It is also essential for the proper antigen presenting function of HLA-A*0101 (HLA-A1), HLA-A*...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1521-4141(199810)28:10<3214::AID-IMM

    authors: Lewis JW,Sewell A,Price D,Elliott T

    更新日期:1998-10-01 00:00:00

  • Spontaneous apoptosis of dendritic cells is efficiently inhibited by TRAP (CD40-ligand) and TNF-alpha, but strongly enhanced by interleukin-10.

    abstract::In the lymphoid tissues, adaptive immune responses are initiated by the interaction of interdigitating dendritic cells (IDC) with naive T cells. To understand this interplay better, we used mature Langerhans cells (mLC), migrating from human epidermis, as the correlate of IDC ex vivo to evaluate the different effects ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830250722

    authors: Ludewig B,Graf D,Gelderblom HR,Becker Y,Kroczek RA,Pauli G

    更新日期:1995-07-01 00:00:00

  • Linomide inhibits programmed cell death of peripheral T cells in vivo.

    abstract::Programmed cell death (PCD) is involved in the physiological regulation of lymphocyte turnover, as well in the antigen-driven selection of T and B cells. Here it is shown that the immunomodulator linomide (quinoline-3-carboxamide) inhibits the apoptotic decay of peripheral T lymphocytes in response to three different ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830240108

    authors: Gonzalo JA,González-García A,Kalland T,Hedlung G,Martínez C,Kroemer G

    更新日期:1994-01-01 00:00:00

  • Therapeutic targeting of alpha 4-integrins in chronic inflammatory diseases: tipping the scales of risk towards benefit?

    abstract::Inhibition of leukocyte trafficking via alpha4-integrin antibody blockade has recently become a validated therapeutic approach for several inflammatory diseases, including multiple sclerosis, ulcerative colitis and Crohn's disease. In the midst of this recent success, 3 patients receiving chronic treatment with the an...

    journal_title:European journal of immunology

    pub_type: 杂志文章,评审

    doi:10.1002/eji.200535195

    authors: Engelhardt B,Briskin MJ

    更新日期:2005-08-01 00:00:00

  • N-terminal elongation of a peptide determinant beyond the first primary anchor improves binding to H-2 I-Ad and HLA-DR1 by backbone-dependent and aromatic side chain-dependent interactions, respectively.

    abstract::The IgG2a(b) heavy chain allopeptide determinant gamma2a(b) 436-451 (Kabat numbering) presented by the major histocompatibility complex (MHC) class II molecule I-Ad is recognized by T cells which cross-react with a corneal self antigen and with the UL6 protein of the herpes simplex virus which induce autoimmune kerati...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1521-4141(199901)29:01<189::AID-IMMU

    authors: Bartnes K,Leon F,Briand JP,Travers PJ,Hannestad K

    更新日期:1999-01-01 00:00:00

  • Cell death and thymic export during fetal life.

    abstract::In the fetus the peripheral T cell pool expands as the fetus grows, but the mechanisms that regulate T cell homeostasis during fetal life are unknown. Here, we show that the peripheral T cell pool in the sheep fetus is established by the export from the fetal thymus of twice as many CD8+ as CD4+ thymic emigrants every...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.200636096

    authors: Holder JE,Washington EA,Cunningham CP,Cahill RN,Kimpton WG

    更新日期:2006-10-01 00:00:00

  • Division of human helper T cells into two sets on the basis of the induction of anti-tumor cytotoxicity by phorbol ester and calcium ionophore.

    abstract::Fourteen noncytotoxic human helper T cell clones were examined for autocrine proliferative responses and cytotoxicity to tumor cells after stimulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) and ionomycin (Io). Although all clones responded to alloantigen, they could be divided into two groups based on their p...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830180729

    authors: Pawelec G,Busch F,Reinhold U,Rehbein A,Balko I,Bühring HJ

    更新日期:1988-07-01 00:00:00

  • IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis.

    abstract::Glomerular crescent formation characterizes severe glomerulonephritis (GN). Evidence suggests that crescent formation results from a delayed-type hypersensitivity-like Th1 response. As IL-12 directs Th1 responses, we tested the hypothesis that IL-12 is important in crescentic GN. Neutralization of IL-12 attenuated cre...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1521-4141(199901)29:01<1::AID-IMMU1>

    authors: Kitching AR,Tipping PG,Holdsworth SR

    更新日期:1999-01-01 00:00:00

  • Immunologically discrete conformation isomers of I-A locus-equivalent class II molecules detected in Lewis rats.

    abstract::Monoclonal antibodies MRC-OX6 and MRC-OX3 were used to define biosynthetically inter-related subsets of I-A-equivalent class II molecules from Lewis rat spleen cells. MRC-OX6 was shown to recognize specifically multiple forms of the class II molecule arising along its maturation pathway from the origin of polypeptide ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830151216

    authors: Reske K,Weitzel R

    更新日期:1985-12-01 00:00:00

  • Spontaneous production of anti-mouse red blood cell autoantibodies is independent of the polyclonal activation in NZB mice.

    abstract::New Zealand Black (NZB) mice spontaneously develop an autoimmune hemolytic anemia together with a markedly increased production of polyclonal antibodies. The spontaneous generation of anti-mouse red blood cells (MRBC), anti-bromelain-treated MRBC (BrMRBC) and anti-DNA autoantibodies was compared to the polyclonal anti...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830201107

    authors: Reininger L,Shibata T,Schurmans S,Merino R,Fossati L,Lacour M,Izui S

    更新日期:1990-11-01 00:00:00

  • An HLA-B35-restricted epitope modified at an anchor residue results in an antagonist peptide.

    abstract::Peptides associated with HLA-B35 commonly have a proline or occasionally a serine residue in the P2 anchor position of the peptide, with a tyrosine at the C terminus. Based on this motif, we identified an octamer epitope from influenza A matrix protein which is presented by HLA-B35. The requirements for MHC binding an...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830260210

    authors: Dong T,Boyd D,Rosenberg W,Alp N,Takiguchi M,McMichael A,Rowland-Jones S

    更新日期:1996-02-01 00:00:00

  • Lysis of infected cells in vivo by antiviral cytolytic T cells demonstrated by release of cell internal viral proteins.

    abstract::Immunocompetent adult mice infected with lymphocytic choriomeningitis virus (LCMV) generate a strong antiviral cytotoxic T cell response that clears virus from all organs. Although there is good evidence that immune cytotoxic T lymphocytes (CTL) kill target cells in vitro, in vivo it is debated whether antiviral activ...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830230722

    authors: Kyburz D,Speiser DE,Battegay M,Hengartner H,Zinkernagel RM

    更新日期:1993-07-01 00:00:00

  • Induction of interferon-gamma production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation.

    abstract::IFN-gamma produced by CD4+ T helper 1 (Th1) cells promotes protection against intracellular pathogens. Antigen activation of Th1 cells is an important mode of IFN-gamma induction, but here we analyze a second, antigen-nonspecific pathway capable of inducing full IFN-gamma transcription. IL-12 or IL-18 alone do not ind...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1521-4141(199902)29:02<548::AID-IMMU

    authors: Yang J,Murphy TL,Ouyang W,Murphy KM

    更新日期:1999-02-01 00:00:00

  • Tumor-specific CD4+ T cells maintain effector and memory tumor-specific CD8+ T cells.

    abstract::Immunotherapies that augment antitumor T cells have had recent success for treating patients with cancer. Here we examined whether tumor-specific CD4(+) T cells enhance CD8(+) T-cell adoptive immunotherapy in a lymphopenic environment. Our model employed physiological doses of tyrosinase-related protein 1-specific CD4...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201343718

    authors: Church SE,Jensen SM,Antony PA,Restifo NP,Fox BA

    更新日期:2014-01-01 00:00:00

  • The enumeration of mouse IgE-secreting cells using plaque-forming cell assays.

    abstract::With the aid of a specific rabbit antibody preparation to purified monoclonal murine IgE, two plaque-forming cell (PFC) assays have been developed for the detection and enumeration of mouse IgE-secreting cells. The first assay, utilizing protein A-coated sheep red cells (protein A-SRC), detected antibody-secreting cel...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830101210

    authors: Rector ES,Lang GM,Carter BG,Kelly KA,Bundesen PG,Böttcher I,Sehon AH

    更新日期:1980-12-01 00:00:00

  • The multifaceted Foxp3fgfp allele enhances spontaneous and therapeutic immune surveillance of cancer in mice.

    abstract::It is well established that therapeutic impairment of Foxp3+ Treg in mice and humans favors immune rejection of solid tumors. Less explored is the impact Foxp3 allelic variants may have on tumor incidence, progression and therapy. In this work, we tested and demonstrate that the Foxp3fgfp reporter allele, found previo...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201948251

    authors: Almeida-Santos J,Bergman ML,Amendoeira Cabral I,Correia V,Caramalho Í,Demengeot J

    更新日期:2020-03-01 00:00:00

  • Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation.

    abstract::The pathogenesis of the decline of CD4 lymphocyte counts accompanying the typical course of HIV-1 infection is not completely defined and might be related to a differential susceptibility of naive and memory cells to HIV-1 exposure. Here, we examined the effects induced by heat-inactivated HIV-1 virions on these lymph...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1521-4141(199906)29:06<1879::AID-IMM

    authors: Masci AM,Paz FL,Borriello A,Cassano S,Della Pietra V,Stoiber H,Matarese G,Della Ragione F,Zappacosta S,Racioppi L

    更新日期:1999-06-01 00:00:00

  • Acute rejection of allogeneic hemopoietic progenitors by genetically resistant mice.

    abstract::Natural resistance to hemopoietic allograft results in functional elimination of the graft from the host within 24 to 48 h. The resistance is specific and is directed to the cell surface target structures of an unidentified nature. These determinants are controlled by the major histocompatibility complex-linked hemopo...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830190702

    authors: Shimamura K,Kaminsky SG,Nakamura I

    更新日期:1989-07-01 00:00:00

  • Differential induction of helper and killer T cells from isolated CD4+CD8+ thymocytes in suspension culture.

    abstract::Thymocytes of T cell receptor transgenic mice with nonselecting and RAG-2 -/- backgrounds were developmentally arrested at the CD4+CD8+ stage before positive selection. These thymocytes underwent lineage commitment upon transient stimulation with a combination of ionomycin, a calcium ionophore, and phorbol 12-myristat...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830260918

    authors: Iwata M,Kuwata T,Mukai M,Tozawa Y,Yokoyama M

    更新日期:1996-09-01 00:00:00

  • Comparison of three different forms of HLA-DR4Dw4 proteins.

    abstract::The biochemical behavior and peptide binding properties of a soluble form of the human class II DR4Dw4 molecule (PI-DR4Dw4) were compared to DR4Dw4 molecules containing the transmembrane and cytoplasmic domains that were purified both from B and transfected chinese hamster ovary cells. Recombinant and B cell-derived D...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830230112

    authors: Buelow R,Paborsky LR,van Schooten WC,Kummerehl TJ,Schreifels R,Marshall K,Mayer J,Rothbard JB

    更新日期:1993-01-01 00:00:00

  • Protein tyrosine phosphorylation is mandatory for CD40-mediated rescue of germinal center B cells from apoptosis.

    abstract::Spontaneous apoptosis in germinal center (GC) B cells can be arrested either by engaging cell surface immunoglobulin (Ig) with immobilized ligand or, more effectively, by treatment with soluble monoclonal antibody (mAb) directed against CD40. The present study examines the intracellular signal transduction pathways th...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830231030

    authors: Knox KA,Gordon J

    更新日期:1993-10-01 00:00:00

  • The B cell receptor, but not the pre-B cell receptor, mediates arrest of B cell differentiation.

    abstract::B cell development in organ cultures of fetal liver from mice at day 14 of gestation resembles in kinetics and cell numbers generated the one observed in vivo. This development in vitro can be blocked by an IL-7 receptor-specific monoclonal antibody. Monoclonal antibodies specific for the pre-B cell receptor, i. e. fo...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/1521-4141(200003)30:3<759::AID-IMMU759>3.0

    authors: Ceredig R,Rolink AG,Melchers F,Andersson J

    更新日期:2000-03-01 00:00:00

  • Preferential positive selection of V alpha 2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V alpha a haplotypes: determination with a V alpha 2-specific monoclonal antibody.

    abstract::A monoclonal antibody, B20.1, was generated by fusing spleen cells from a Lou rat immunized with a soluble alpha/beta T cell receptor (TcR; V alpha 2/V beta 2) to mouse myeloma cells. Analysis of a panel of V alpha 2 mRNA-expressing T cell lines, hybridomas and transfectants revealed that the B20.1 antibody was specif...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830220217

    authors: Pircher H,Rebaï N,Groettrup M,Grégoire C,Speiser DE,Happ MP,Palmer E,Zinkernagel RM,Hengartner H,Malissen B

    更新日期:1992-02-01 00:00:00

  • Peptide recognition, T cell receptor usage and HLA restriction elements of human heat-shock protein (hsp) 60 and mycobacterial 65-kDa hsp-reactive T cell clones from rheumatoid synovial fluid.

    abstract::A commonly held postulate regarding the etiology of rheumatoid arthritis (RA) is that of antigenic mimicry. Recent interest has focused on the mycobacterial 65-kDa heat-shock protein (hsp) as a putative causal agent. The 65-kDa hsp has over 40% sequence homology with the human hsp 60, and elevated synovial T cell resp...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830220529

    authors: Quayle AJ,Wilson KB,Li SG,Kjeldsen-Kragh J,Oftung F,Shinnick T,Sioud M,Førre O,Capra JD,Natvig JB

    更新日期:1992-05-01 00:00:00

  • Genetic differences in the T cell receptor alleles of LEW rats and their encephalomyelitis-resistant derivative, LER, and their impact on the inheritance of EAE resistance.

    abstract::Experimental allergic encephalomyelitis (EAE) is an animal model for the human disease, multiple sclerosis. The LEW rat strain is very susceptible to induction of EAE, whereas the closely related, major histocompatibility complex (MHC)-identical, inbred strain LER is resistant. In this report, the two rat strains have...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.1830210910

    authors: Blankenhorn EP,Stranford SA,Smith PD,Hickey WF

    更新日期:1991-09-01 00:00:00

  • The thioredoxin-1 and glutathione/glutaredoxin-1 systems redundantly fuel murine B-cell development and responses.

    abstract::Antioxidant systems maintain cellular redox homeostasis. The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance. In fact, T lymphocytes critically rely on reducing equivalents from the Trx1 system for DNA biosynthesis during metabolic repr...

    journal_title:European journal of immunology

    pub_type: 杂志文章

    doi:10.1002/eji.201848044

    authors: Muri J,Thut H,Heer S,Krueger CC,Bornkamm GW,Bachmann MF,Kopf M

    更新日期:2019-05-01 00:00:00