Leukocyte attraction through the CCR5 receptor controls progress from insulitis to diabetes in non-obese diabetic mice.

abstract：:Several groups have described that a low percentage of in vitro cultured T cell receptor (TcR) gamma/delta cells express CD8. Contrary to TcR alpha/beta cells, however, CD8 on these TcR gamma/delta cells was shown to be a CD8 alpha homodimer. We describe here that addition of interleukin-7 (IL-7) to a short-term in vi...

journal_title：European journal of immunology

authors： Leclercq G,De Smedt M,Plum J

更新日期：1992-09-01 00:00:00

abstract：:Peptide ligands presented by MHC class I molecules are generated in a cascade of proteolytic events starting with the proteasome in the cytosol and frequently terminating with trimming aminopeptidases in the endoplasmic reticulum. Several cytosolic proteases can carry out intermediate proteolytic steps between these s...

journal_title：European journal of immunology

authors： Endert Pv

更新日期：2008-03-01 00:00:00

abstract：:The transferrin receptor (TfR) was recently proposed as putative natural killer (NK) cell target structure. Here data are presented against this hypothesis and it is shown that low TfR expression and high NK sensitivity can occur concommitantly . K562 cells were studied at various stages of cell proliferation. No chan...

journal_title：European journal of immunology

authors： Dokhélar MC,Garson D,Testa U,Tursz T

更新日期：1984-04-01 00:00:00

abstract：:The immune system has developed several regulatory mechanisms to maintain homeostasis of adaptive immune responses. T-cell programmed death (PD)-1 recognition of B7-H1 (PD-L1) expressed on APC and non-lymphoid tissue regulates T-cell activation. We show that B7-H1(-/-) mice exhibit exacerbated proteoglycan (PG)-induce...

journal_title：European journal of immunology

authors： Hamel KM,Cao Y,Wang Y,Rodeghero R,Kobezda T,Chen L,Finnegan A

更新日期：2010-11-01 00:00:00

abstract：:Self-glycosphingolipids bind to surface CD1 molecules and are readily displaced by other CD1 ligands. This capacity to exchange antigens at the cell surface is not common to other antigen-presenting molecules and its physiological importance is unclear. Here we show that a large pool of cell-surface CD1a, but not CD1b...

journal_title：European journal of immunology

authors： Manolova V,Kistowska M,Paoletti S,Baltariu GM,Bausinger H,Hanau D,Mori L,De Libero G

更新日期：2006-05-01 00:00:00

abstract：:We have established idiotope (Id)-specific T cell lines and clones derived from at least 4 different BALB/c mice immunized with the light chain (lambda 2(315] of the BALB/c myeloma protein M315 (alpha, lambda 2). Independently derived clones were indistinguishable in that they reacted to V lambda 2(315), one or more o...

journal_title：European journal of immunology

authors： Bogen B,Malissen B,Haas W

更新日期：1986-11-01 00:00:00

abstract：:CD72 has been reported to regulate BCR-mediated signals both positively and negatively. SHP-1 and Grb2 bind, respectively, to ITIM1 and ITIM2 of CD72. We generated transformed B cell lines with an immature phenotype following J2 virus infection of splenocytes from CD72(-/-) and wild-type (Wt) mice. The transformed lin...

journal_title：European journal of immunology

authors： Baba T,Fusaki N,Aoyama A,Li DH,Okamura RM,Parnes JR,Hozumi N

更新日期：2005-05-01 00:00:00

abstract：:The CD45RO phenotype of peripheral blood CD4+ and CD8+ lymphocytes were determined in physically active males (n = 171) and females (n = 70) ranging in age from 15-68 years. Direct immunofluorescence and dual color flow cytometry was performed for analysis. Absolute cell numbers (r = 0.473) and percentages of CD4+ CD4...

journal_title：European journal of immunology

authors： Gabriel H,Schmitt B,Kindermann W

更新日期：1993-10-01 00:00:00

abstract：:The role of CD8(+) T cells in the development of allergic airway disease is controversial. On the one hand, CD8(+) T cells are known to inhibit the development of airway hyperreactivity (AHR) in murine models of asthma. In humans, IL-10-producing CD8(+) T cells were shown to act as regulatory cells, inhibiting both pr...

journal_title：European journal of immunology

authors： Stock P,Kallinich T,Akbari O,Quarcoo D,Gerhold K,Wahn U,Umetsu DT,Hamelmann E

更新日期：2004-07-01 00:00:00

abstract：:The effect of fractionated total lymphoid irradiation (TLI) on the maturation of B cells was examined in mice. At various times after irradiation of the mice, their spleen cells were tested for the mitogenic responses to dextran sulfate and lipopolysaccharide. In parallel the cells were stained with fluorescent anti-T...

journal_title：European journal of immunology

authors： Zan-Bar I

更新日期：1983-01-01 00:00:00

abstract：:IL-10 is a potent anti-inflammatory molecule, which regulates TNF-alpha at multiple levels. We investigated whether IL-10 also modulated the activity of the TNF-alpha-converting enzyme (TACE). Using an ex vivo fluorogenic assay we observed that LPS rapidly induced TACE activity in monocytes coinciding with release of ...

journal_title：European journal of immunology

authors： Brennan FM,Green P,Amjadi P,Robertshaw HJ,Alvarez-Iglesias M,Takata M

更新日期：2008-04-01 00:00:00

abstract：:A considerable fraction of T cells express two distinct T cell receptors (TCR), mainly due to expression of two TCR alpha chains. It has been suggested that such dual-TCR cells could have a role in autoimmunity. However, as such cells express less of each TCR, they could be less sensitive to their physiological ligand...

journal_title：European journal of immunology

authors： Blichfeldt E,Munthe LA,Røtnes JS,Bogen B

更新日期：1996-12-01 00:00:00

abstract：:Previous studies have shown that the fecal flora of patients with Crohn's disease (CD) differed from the flora of healthy subjects by a higher number of anaerobic gram-positive coccoid rods. Sera from patients with CD agglutinated four strains of coccoid rods (Me44, C18, Me46 and Me47) more frequently and stronger tha...

journal_title：European journal of immunology

authors： Van de Merwe JP,Stegeman JH

更新日期：1985-08-01 00:00:00

abstract：:Large-scale extravasation of lymphocytes takes place in vivo under physiological conditions in lymph nodes at very specialized vascular segments called high endothelial venules (HEV). When circulating lymphocytes leave the blood, they first bind to endothelial cells of HEV (HE cells) and subsequently enter lymph nodes...

journal_title：European journal of immunology

authors： Ise Y,Yamaguchi K,Sato K,Yamamura Y,Kitamura F,Tamatani T,Miyasaka M

更新日期：1988-08-01 00:00:00

abstract：:To investigate the role of interferon-gamma (IFN-gamma) in experimental autoimmune thyroidits (EAT), H-2k mice with a disrupted IFN-gamma receptor (IFN-gamma R) gene were immunized with porcine thyroglobulin (pTg). We observed that EAT occurred on day 19 and remitted on day 35 in IFN-gamma R-deficient (IFN-gamma R(0/0...

journal_title：European journal of immunology

authors： Alimi E,Huang S,Brazillet MP,Charreire J

更新日期：1998-01-01 00:00:00

abstract：:The immunosuppressor sanglifehrin A (SfA) is a member of a family of immunophilin cyclophilin A-binding molecules and does not inhibit calcineurin activity. Sanglifehrin A inhibits M-CSF-dependent macrophage proliferation by arresting the G1 phase of the cell cycle but does not affect cell viability. This immunosuppre...

journal_title：European journal of immunology

authors： Sànchez-Tilló E,Wojciechowska M,Comalada M,Farrera C,Lloberas J,Celada A

更新日期：2006-09-01 00:00:00

abstract：:Patients undergoing allogeneic bone marrow transplantation offer a unique system to analyze NK cell development in vivo. We analyzed NK cells from 23 such patients to assess the acquisition of activating receptors. Four patients displayed an immature NK cell surface phenotype at engraftment, as their cells were CD16(-...

journal_title：European journal of immunology

authors： Vitale C,Chiossone L,Morreale G,Lanino E,Cottalasso F,Moretti S,Dini G,Moretta L,Mingari MC

更新日期：2004-02-01 00:00:00

abstract：:Sporozoite surface protein 2 has been identified as a target of malaria vaccines designed to produce protective CD8+ cytotoxic T lymphocytes (CTL) because mice immunized with mastocytoma cells expressing a fragment of Plasmodium yoelii sporozoite surface protein 2 (PySSP2) are protected against malaria by an immune re...

journal_title：European journal of immunology

authors： Wizel B,Rogers WO,Houghten RA,Lanar DE,Tine JA,Hoffman SL

更新日期：1994-07-01 00:00:00

abstract：:The killer cell lectin-like receptor G1 (KLRG1) is a cadherin-binding inhibitory receptor expressed by NK cells and differentiated T cells. Here, we surprisingly found that a fraction of KLRG1 molecules expressed in the murine A5 T-cell line and in IL-2-activated NK cells forms disulfide-linked heteromers with the tra...

journal_title：European journal of immunology

authors： Schweier O,Hofmann M,Pircher H

更新日期：2014-06-01 00:00:00

abstract：:BALB/c mice were repeatedly immunized with microgram doses of benzylpenicilloylated Ascaris protein(s) (BPO9Asc) in alum. At different stages of the immune response, BPO21 eicosa-L-lysine or two analogs containing one or two hydrophobic p-oxymethylbenzyl-3 beta-cholestanyl succinate (OSuco) groups were injected. When ...

journal_title：European journal of immunology

authors： Lüscher IF,Weber E,de Weck AL

更新日期：1984-01-01 00:00:00

abstract：:The relationship between immunogenicity of Shigella paradysenteriae, the branched synthetic polypeptide poly-L (Tyr, Glu)-polylpro-polyllys [(T, G)-Pro--L] and human albumin (HSA) interacting with macrophages and kinetics of antigen degradation and degree of binding to the cell surface was studied. Following thioglyco...

journal_title：European journal of immunology

authors： Gallily R,Bar-Eli M

更新日期：1976-11-01 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by congenital thrombocytopenia and progressive deterioration of the immune function. Dendritic cells (DC) are key effectors in the induction of specific immunity and are highly specialized in antigen uptake and subsequent migration to draining lymph ...

journal_title：European journal of immunology

authors： Allavena P,Badolato R,Facchetti F,Vermi W,Paganin C,Luini W,Giliani S,Mazza C,Bolzern U,Chiesa I,Notarangelo L,Mantovani A,Sozzani S

更新日期：2001-12-01 00:00:00

abstract：:Limited studies have addressed the ability of gammadelta T cells to become memory populations. We previously demonstrated that WC1.1(+) gammadelta T cells from ruminants vaccinated with killed Leptospira borgpetersenii proliferate and produce IFN-gamma in recall responses. Here we show that this response is dependent ...

journal_title：European journal of immunology

authors： Blumerman SL,Herzig CT,Baldwin CL

更新日期：2007-05-01 00:00:00

abstract：:The adoptive transfer of CD4(+)CD25(+) natural regulatory T cells (Treg) is a promising strategy for the treatment of autoimmune diseases and the prevention of alloresponses after transplantation. Clinical trials exploring this strategy require efficient in vitro expansion of this rare cell population. Protocols devel...

journal_title：European journal of immunology

authors： Hoffmann P,Boeld TJ,Eder R,Huehn J,Floess S,Wieczorek G,Olek S,Dietmaier W,Andreesen R,Edinger M

更新日期：2009-04-01 00:00:00

abstract：:Tissue distribution and expression on mitogen and virally stimulated lymphocytes render the ACT35 molecule a human lymphocyte activation antigen which as yet could not be clustered. Expression cloning of the ACT35 antigen from a pCDM8 library of the HUT-102 cell line revealed strong homology of the cDNA and its encode...

journal_title：European journal of immunology

authors： Latza U,Dürkop H,Schnittger S,Ringeling J,Eitelbach F,Hummel M,Fonatsch C,Stein H

更新日期：1994-03-01 00:00:00

abstract：:Pulmonary mucosal immune response is critical for preventing opportunistic Aspergillus fumigatus infections. Although fungus-specific CD4+ T cells in blood are described to reflect the actual host-pathogen interaction status, little is known about Aspergillus-specific pulmonary T-cell responses. Here, we exploit the d...

journal_title：European journal of immunology

authors： Schmidt S,Ebner F,Rosen K,Kniemeyer O,Brakhage AA,Löffler J,Seif M,Springer J,Schlosser J,Scharek-Tedin L,Scheffold A,Bacher P,Kühl AA,Rösler U,Hartmann S

更新日期：2020-11-01 00:00:00

abstract：:In asymptomatic human immunodeficiency virus-1 infection T cells respond normally to allogeneic dendritic cells (DC), but DC show reduced stimulatory capacity. By contrast in HTLV-1 infection no significant changes in allogeneic stimulation were seen but DC-stimulated activity of autologous T cells. In seeking animal ...

journal_title：European journal of immunology

authors： Gabrilovich DI,Roberts MS,Harvey JJ,Botcherby M,Bedford PA,Knight SC

更新日期：1993-11-01 00:00:00

abstract：:CD23-deficient and anti-CD23 monoclonal antibody-treated mice were used to investigate the role of the low-affinity receptor for IgE (CD23) in allergic airway inflammation and airway hyperresponsiveness (AHR). While there were no significant differences in ovalbumin (OVA)-specific IgE titers and tissue eosinophilia, e...

journal_title：European journal of immunology

authors： Dasic G,Juillard P,Graber P,Herren S,Angell T,Knowles R,Bonnefoy JY,Kosco-Vilbois MH,Chvatchko Y

更新日期：1999-09-01 00:00:00

abstract：:While c-myc often contributes to the generation of B cell transformation, its transgenic overexpression alone does not lead to full transformation of B-lineage cells. Synergistically acting second genes must cooperate. Here, we constructed doxycycline-inducible cDNA-libraries from pre-B cell mRNA. These libraries were...

journal_title：European journal of immunology

authors： Wolf I,Bouquet C,Melchers F

更新日期：2016-11-01 00:00:00

abstract：:The essential role of the transcription factor Foxp3 in the development and function of Treg has been well documented. The role of Foxp3 in non-Treg, however, is not fully understood. Emerging evidence indicates that Foxp3 expression is not confined to CD4+CD25+ Treg. The present study shows that in Foxp3 transgenic (...

journal_title：European journal of immunology

authors： Guo L,Tian J,Marinova E,Zheng B,Han S

更新日期：2010-01-01 00:00:00