Abstract:
:Chemokines are proinflammatory mediators that regulate leukocyte trafficking at different steps of the leukocyte recruitment cascade. Studies using new imaging approaches and new mouse models are giving new insights into the role of chemokines in neutrophil migration at sites of inflammation. Conventional rolling and adhesion paradigms as well as previously unappreciated functions of signaling pathways triggering leukocyte adhesion, intralumenal crawling and transendothelial migration are compiled and described here. In this review we will summarize recent work in this field, highlighting in vivo imaging studies that examine the behavior of neutrophils in response to chemokines.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Sanz MJ,Kubes Pdoi
10.1002/eji.201142231subject
Has Abstractpub_date
2012-02-01 00:00:00pages
278-83issue
2eissn
0014-2980issn
1521-4141journal_volume
42pub_type
杂志文章,评审abstract::Recent studies have shown that in humans the germinal center reactions produce three types of V(D)J mutated B cells in similar proportions, i.e. Ig-switched, IgD-IgM+ (IgM-only) and IgD+IgM+ cells, and that together they form the CD27+ compartment of recirculating B cells. We investigated the Ig isotype switch capacit...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200101)31:1<243::AID-IMMU243>3.0
更新日期:2001-01-01 00:00:00
abstract::Mature T cells may be produced in the thymus, or by expansion in the periphery. While thymus output of virgin cells ensures repertoire diversity, peripheral expansion increases the size of rare clones, and thus the efficiency of immune responses. We studied the role of both phenomena in the generation of the CD8+ T ce...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830250802
更新日期:1995-08-01 00:00:00
abstract::The atypical chemokine receptor CXCR7 binds the chemokines CXCL12 and CXCL11. The receptor is widely expressed and was shown to tune CXCR12-induced responses of CXCR4. Here, the function of CXCR7 was examined at late stages of human B-cell maturation, when B cells differentiate into Ab-secreting plasmablasts. We ident...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201343907
更新日期:2014-03-01 00:00:00
abstract::Mice carrying the H-2b haplotype (e.g., inbred strains C57BL/6 and C57BL/10) are low responders to sperm whale myoglobin when tested in the T cell proliferation assay. Their response is improved by the removal of the Ly-2+ cells from the lymph node population, but it still remains significantly lower than that of cell...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830180905
更新日期:1988-09-01 00:00:00
abstract::Recently, it has been shown that cloned L1/1 T helper cells of type 2 (TH2-cells), when stimulated with antigen, are able to induce polyclonal B cell proliferation. Here we present evidence that this process is dependent on direct cell-cell interaction between T and B cells, which in the effector phase, i.e., during s...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830190113
更新日期:1989-01-01 00:00:00
abstract::The C-terminal fragment of merozoite surface protein-1 (MSP-1) of the mouse malaria parasite Plasmodium chabaudi chabaudi (AS) stimulates a weak CD4 T cell response when compared to the response to a more structurally simple region of the molecule. The tertiary structure of the C-terminal region of MSP-1 is maintained...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200101)31:1<72::aid-immu72
更新日期:2001-01-01 00:00:00
abstract::Macrophage precursor cells were cultured from the bone marrow of mice in a liquid culture system in the presence of conditioned medium. To separate their different maturation stages, they were passed through a discontinuous Ficoll density gradient, treated with iron plus magnet or passed through glass bead columns. Th...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830090404
更新日期:1979-04-01 00:00:00
abstract::Pre-B cells which show a delayed development of responsiveness to the B cell mitogen lipopolysaccharide (LPS) are found in murine embryonic blood between day 10 and 14 of gestation. The highest frequency of pre-B cells in embryonic blood is found at day 12 of gestation. All pre-B cells of embryonic blood, isolated at ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830101007
更新日期:1980-10-01 00:00:00
abstract::The infiltration and activation of monocytes is a hallmark of chronic inflammation, including that associated with a variety of disease states such as rheumatoid arthritis, atherosclerosis, and various autoimmune conditions. Recently, a family of small molecular mass proteins has been described which appear to have in...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830220621
更新日期:1992-06-01 00:00:00
abstract::Rabbit antibodies to Atlantic cod (Gadus morhua L.) immunoglobulin were affinity purified and used to screen cDNA libraries from spleen and head kidney mRNA. cDNA clones for both the secretory and membrane-bound heavy (H) chain were isolated, the nucleotide and deduced amino acid sequences of which are reported here. ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830211219
更新日期:1991-12-01 00:00:00
abstract::The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model. We found that both the endothelium and epithelium of murine cor...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201141683
更新日期:2011-10-01 00:00:00
abstract::A majority of immunodominant epitopes of mycobacterial antigens are known to be recognized by murine T cells in the context of several H-2 haplotypes. In this study, we established the frequency of T cells able to recognize these peptides promiscuously, i.e. in the context of allogeneic antigen-presenting cells, using...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830251009
更新日期:1995-10-01 00:00:00
abstract::Riboflavin, also known as vitamin B2 , is converted by riboflavin kinase (RFK) into flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are essential cofactors of dehydrogenases, reductases, and oxidases including the phagocytic NADPH oxidase 2 (Nox2). Riboflavin deficiency is common in young adul...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201343940
更新日期:2014-03-01 00:00:00
abstract::We have followed the fate of mature CD8+ T cells with a male-specific transgenic T cell receptor after antigenic stimulation with hemopoietic cells in the absence or presence of help. Our data show that mature CD8+ T cells can be deleted after a 3-week period of transient activation and that help, e.g. in the form of ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830230835
更新日期:1993-08-01 00:00:00
abstract::A cDNA encoding the human beta Fc gamma receptor II (FcRII) was isolated from a placental cDNA library. Analysis of the predicted amino acid sequence indicates that this receptor is synthesized with a 42-amino acid leader sequence. The mature protein consists of 249 amino acids. The leader sequence and the cytoplasmic...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200624
更新日期:1990-06-01 00:00:00
abstract::The active role of chemokines in the central nervous system (CNS) during the pathogenesis of experimental autoimmune encephalomyelitis (EAE) has been clearly established. In this study the expression pattern of several chemokines and cytokines was elucidated using reverse transcription-PCR and immunohistochemistry in ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/1521-4141(200007)30:7<1911::AID-IMMU1911>3
更新日期:2000-07-01 00:00:00
abstract::The MRC OX-47 monoclonal antibody recognizes a membrane antigen present at low levels on many lymphocytes but whose expression is markedly increased on activation with mitogens. cDNA clones for the OX-47 antigen were isolated from an expression library and the protein sequence deduced. It contains a leader sequence gi...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830210320
更新日期:1991-03-01 00:00:00
abstract::The molecular mimicry represented by cross-recognition of determinants shared by unrelated antigens by antibodies or T cells is of broad immunological interest. In this study, we analyzed the cross-recognition by CD4+ T cells of a peptide epitope shared by two mycobacterial proteins of diverse sequence, represented by...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830251128
更新日期:1995-11-01 00:00:00
abstract::Myeloid leukocytes form actin-based plasma membrane protrusions, called podosomes, that are implicated in myeloid cell recruitment into tissues and cell migration within the interstitium. In this study, we show that tyrosine kinases of the Abl family are present in podosomes formed by murine and human macrophages. Sil...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201142270
更新日期:2012-10-01 00:00:00
abstract::Pulmonary mucosal immune response is critical for preventing opportunistic Aspergillus fumigatus infections. Although fungus-specific CD4+ T cells in blood are described to reflect the actual host-pathogen interaction status, little is known about Aspergillus-specific pulmonary T-cell responses. Here, we exploit the d...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.201948524
更新日期:2020-11-01 00:00:00
abstract::Memory T cells can now be defined with various monoclonal antibodies but little is known about the functional properties of these cells as compared to virgin T cells. We have studied Ca2+ mobilization and proliferation of memory and virgin cells in both the CD4 and CD8 subsets in response to phytohemagglutin-in. Using...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830200913
更新日期:1990-09-01 00:00:00
abstract::Anti-idiotypes produced against monoclonal anti-H-2 antibodies have been used to examine idiotope sharing among a panel of anti-major histocompatibility complex (MHC) antibodies detecting the same and different specificities. Both xenogeneic anti-100-30 and anti-3-83, which did not react with predominant idiotypes in ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830130611
更新日期:1983-06-01 00:00:00
abstract::The expression of interferon (IFN) β is highly induced in immune and nonimmune cells in response to virus infection. This upregulation is mediated at both transcriptional and posttranscriptional levels. Whereas the signaling pathways triggered by innate virus receptors leading to transcription factor activation have b...
journal_title:European journal of immunology
pub_type: 评论,杂志文章
doi:10.1002/eji.201545616
更新日期:2015-05-01 00:00:00
abstract::Recent years have seen a dramatic increase in the range of applications of virus-like nanoparticle (VNP)- and liposome-based antigen delivery systems for the treatment of allergies. These platforms rely on a growing number of inert virus-backbones or distinct lipid formulations and intend to engage the host's innate a...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.201847810
更新日期:2020-01-01 00:00:00
abstract::NK cells and cytotoxic T lymphocytes can induce apoptosis in virus-infected and transformed target cells via the granule exocytosis pathway. The key components of the cytolytic granules are perforin and several serine esterases, termed granzymes. While the cellular distribution of human granzymes A (GrA) and B (GrB) h...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.200526122
更新日期:2005-09-01 00:00:00
abstract::Changes in the migration pattern of lymphocytes represent a key event in the evolution of an immune response since they enable lymphocytes to gain access to infected tissues. We studied the location of virus-specific CD8 T cells in various splenic compartments in response to infection with lymphocytic choriomeningitis...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/(SICI)1521-4141(199911)29:11<3562::AID-IMM
更新日期:1999-11-01 00:00:00
abstract::The thymus is the primary organ for T-cell differentiation and maturation. Unlike other major organs, the thymus is highly dynamic, capable of undergoing multiple rounds of almost complete atrophy followed by rapid restoration. The process of thymic atrophy, or involution, results in decreased thymopoiesis and emigrat...
journal_title:European journal of immunology
pub_type: 杂志文章,评审
doi:10.1002/eji.201142305
更新日期:2012-05-01 00:00:00
abstract::Plasmodium falciparum stimulates peripheral blood gamma delta + T cells from unexposed donors. The responding cells bear V gamma 9+ chains of the T cell receptor, the majority of which, but not all, are associated with V delta 2 chains. We have analyzed whether the precursor frequency of these V gamma 9+ cells approac...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830221045
更新日期:1992-10-01 00:00:00
abstract::Programmed cell death (PCD) is involved in the physiological regulation of lymphocyte turnover, as well in the antigen-driven selection of T and B cells. Here it is shown that the immunomodulator linomide (quinoline-3-carboxamide) inhibits the apoptotic decay of peripheral T lymphocytes in response to three different ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830240108
更新日期:1994-01-01 00:00:00
abstract::Two out of 25 monoclonal anti-DNA autoantibodies that were produced by human-human hybridoma were found to have lymphocytotoxic activity. The antibodies reacted with normal B and T lymphocytes at cold (4 degrees C) as well as at warm (37 degrees C) temperatures. The lymphocytotoxic activity of the monoclonal anti-DNA ...
journal_title:European journal of immunology
pub_type: 杂志文章
doi:10.1002/eji.1830151012
更新日期:1985-10-01 00:00:00