当前位置： SCI文献检索 > EUROPEAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > T-follicular helper cells survive as long-term memory cells.

T-follicular helper cells survive as long-term memory cells.

Abstract：

:T-follicular helper (TFH) cells represent the subpopulation of CD4(+) T cells that provides help for antigen-specific B cells in the GC response. They are generated from naïve T cells during an immune response and are imprinted by their master transcription factor Bcl-6. It has been a long-standing question if TFH cells contribute to the CD4(+) memory pool after the GC response has been terminated. To answer this question, we sorted antigen-specific TFH and non-TFH effector cells from an ongoing GC response and transferred them into naïve mice. Without further signals via the TCR, transferred cells rapidly contracted with a small population of both TFH and non-TFH cells surviving as memory cells in peripheral lymphoid organs for at least 4 weeks in the absence of antigen. TFH cells strongly downregulated their signature genes Bcl-6, CXCR5, and PD-1 in the memory phase. Upon rechallenge with antigen they rapidly upregulated these markers again. An enhanced potential to produce IL-21, paired with higher expression of CXCR5 and lower expression of CCR7, should enable TFH memory cells to provide more efficient help for antigen-specific B cells than their non-TFH counterparts.

journal_name

Eur J Immunol

journal_title

European journal of immunology

authors

Weber JP,Fuhrmann F,Hutloff A

doi

10.1002/eji.201242540

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

1981-8

issue

8

eissn

0014-2980

issn

1521-4141

journal_volume

42

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF IMMUNOLOGY文献大全
  • Acquisition of regulatory function by human CD8(+) T cells treated with anti-CD3 antibody requires TNF.

    abstract：:Anti-CD3 mAb can modulate graft rejection and attenuate autoimmune diseases but their mechanism(s) of action remain unclear. CD8(+) T cells with regulatory function are induced in vitro by Teplizumab, a humanized anti-CD3 antibody and inhibit responses of autologous and allogeneic T cells. They inhibit CD4(+) T-cell p...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201040485

    authors： Ablamunits V,Bisikirska B,Herold KC

    更新日期：2010-10-01 00:00:00

  • Signaling through CD19, Fc receptors or transforming growth factor-beta: each inhibits the activation of resting human B cells differently.

    abstract：:To understand further the roles that negative regulatory signals may play in B cell immune responses, we compared three inhibitors of B cell proliferation: cross-linking CD19 with monoclonal antibody (mAb), signaling through Fc receptors by intact anti-mu mAb, and transforming growth factor-beta (TGF-beta). Each agent...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830200516

    authors： Barrett TB,Shu GL,Draves KE,Pezzutto A,Clark EA

    更新日期：1990-05-01 00:00:00

  • CD2 is involved in regulating cyclic AMP levels in T cells.

    abstract：:The human T lymphocyte-specific CD2 (T11) molecule, that regulates T cell activation, is capable of mediating increases of intracellular cAMP. Monoclonal antibodies directed to different epitopes of the CD2 molecule which either induce or inhibit T cell proliferation are capable of triggering an increase of cAMP compa...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830180620

    authors： Carrera AC,Rincón M,De Landázuri MO,López-Botet M

    更新日期：1988-06-01 00:00:00

  • Preferential positive selection of V alpha 2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V alpha a haplotypes: determination with a V alpha 2-specific monoclonal antibody.

    abstract：:A monoclonal antibody, B20.1, was generated by fusing spleen cells from a Lou rat immunized with a soluble alpha/beta T cell receptor (TcR; V alpha 2/V beta 2) to mouse myeloma cells. Analysis of a panel of V alpha 2 mRNA-expressing T cell lines, hybridomas and transfectants revealed that the B20.1 antibody was specif...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830220217

    authors： Pircher H,Rebaï N,Groettrup M,Grégoire C,Speiser DE,Happ MP,Palmer E,Zinkernagel RM,Hengartner H,Malissen B

    更新日期：1992-02-01 00:00:00

  • Brucella abortus nitric oxide metabolite regulates inflammasome activation and IL-1β secretion in murine macrophages.

    abstract：:NLRP3 inflammasome is a protein complex crucial to caspase-1 activation and IL-1β and IL-18 maturation. This receptor participates in innate immune responses to different pathogens, including the bacteria of genus Brucella. Our group recently demonstrated that Brucella abortus-induced IL-1β secretion involves NLRP3 in...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201848016

    authors： Campos PC,Gomes MTR,Marinho FAV,Guimarães ES,de Moura Lodi Cruz MGF,Oliveira SC

    更新日期：2019-07-01 00:00:00

  • CD4(-)c-kit(-)CD3epsilon(-)IL-2Ralpha(+) Peyer's patch cells are a novel cell subset which secrete IL-5 in response to IL-2: implications for their role in IgA production.

    abstract：:In this study, we examined which cell population contributes to IL-5 production by Peyer's patch (PP) cells. Thy1.2(-) fraction of PP cells, but not those of splenocytes, secreted IL-5 in response to IL-2. We found that CD3epsilon(-)IL-2Ralpha(+) cells purified from the Thy1.2(-)B220(-) fraction of PP cells secreted I...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200324696

    authors： Kuraoka M,Hashiguchi M,Hachimura S,Kaminogawa S

    更新日期：2004-07-01 00:00:00

  • Interleukin 2/interleukin 4-independent T helper cell generation during an in vitro antigenic stimulation of mouse spleen cells in the presence of cyclosporin A.

    abstract：:Cyclosporin A (CsA), an immunosuppressive drug which completely suppresses the humoral response to thymus-dependent antigens, does not affect the generation of T helper (Th) cells during an in vitro stimulation of murine spleen cells with sheep red blood cells. The appearance of Th cells depends on time and their deve...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830210304

    authors： Motta I,Colle JH,Shidani B,Truffa-Bachi P

    更新日期：1991-03-01 00:00:00

  • LIGHT costimulates CD40 triggering and induces immunoglobulin secretion; a novel key partner in T cell-dependent B cell terminal differentiation.

    abstract：:The T cell-dependent differentiation and function of B lymphocytes are tightly regulated by TNF ligands (L) and receptors interactions, such as CD40/CD40L, CD27/CD70 and CD134/CD314L. The LIGHT/HVEM system [homologous to lymphotoxin, inducible expression, competing for GpD of herpes virus, that binds to the herpes vir...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200425598

    authors： Duhen T,Pasero C,Mallet F,Barbarat B,Olive D,Costello RT

    更新日期：2004-12-01 00:00:00

  • Tumor-driven matrix invasion by infiltrating lymphocytes: involvement of the alpha1 integrin I-domain.

    abstract：:Here we show that tumor cells (TC) from renal cancers regulate the migratory properties of autologous tumor-infiltrating lymphocytes (TIL), enhancing their ability to invade the extracellular matrix. A similar effect is exerted by human recombinant macrophage chemotactic protein 1 (MCP-1) and IL-8, chemokines known to...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199808)28:08<2530::AID-IMM

    authors： Ferrero E,Fabbri M,Poggi A,Galati G,Bernasconi S,Zocchi MR

    更新日期：1998-08-01 00:00:00

  • Alteration of the T cell self-specificity repertoire by treatment with anti-Ia antibody during embryonic life.

    abstract：:The effect of anti-Ia antibody on the development of murine neonatal self-Ia-reactive T lymphocytes in the thymus was studied. A C57BL/6 (B6) mouse pregnant with (B6 X C3H/He)F1 (B6C3F1) embryos was injected with monoclonal anti-I-Ek (m alpha I-Ek) antibody every other day starting from the 12th day of gestation. The ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830160719

    authors： Kimoto M,Kishimoto S

    更新日期：1986-07-01 00:00:00

  • Influences on the lifespan of B cell subpopulations defined by different phenotypes.

    abstract：:The turnover of mature and immature B cells defined by a range of cell surface markers was investigated by feeding normal or bcl-2-transgenic (bcl-2-Tg) mice 5'-bromo-2-deoxyuridine (BrdUrd) for up to 6 weeks. In peripheral lymphoid tissue, B cells accumulated BrdUrd with a 50% labeling time of 4.3 weeks and a pattern...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270521

    authors： Fulcher DA,Basten A

    更新日期：1997-05-01 00:00:00

  • Massive inflammatory syndrome and lymphocytic immunodeficiency in KARAP/DAP12-transgenic mice.

    abstract：:KARAP/DAP12 is a broadly distributed transmembrane signaling polypeptide with an immunoreceptor tyrosine-based activation motif, and is non-covalently associated with a variety of activating surface receptors. We report here the characterization of transgenic mice that overexpress KARAP/DAP12 polypeptides in both myel...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/1521-4141(200209)32:9<2653::AID-IMMU2653>3

    authors： Lucas M,Daniel L,Tomasello E,Guia S,Horschowski N,Aoki N,Figarella-Branger D,Gomez S,Vivier E

    更新日期：2002-09-01 00:00:00

  • TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2.

    abstract：:TLR and complement activation ensures efficient clearance of infection. Previous studies documented synergism between TLRs and the receptor for the pro-inflammatory complement peptide C5a (C5aR/CD88), and regulation of TLR-induced pro-inflammatory responses by C5aR, suggesting crosstalk between TLRs and C5aR. However,...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.201041350

    authors： Raby AC,Holst B,Davies J,Colmont C,Laumonnier Y,Coles B,Shah S,Hall J,Topley N,Köhl J,Morgan BP,Labéta MO

    更新日期：2011-09-01 00:00:00

  • Selective inhibition of antigen-induced "step one" in cytotoxic T lymphocytes by anti-Lyt-2 antibodies.

    abstract：:Stimulation of mixed lymphocyte cultures with ultraviolet (UV)-irradiated stimulator cells leads to selective activation of Lyt-2+ cytotoxic T lymphocyte precursors (CTL-P) to acquire interleukin 2 (IL2) reactivity: (a) no proliferative response, nor IL2 production was observed in these cultures; (b) upon addition of ...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830121205

    authors： Gullberg M,Larsson EL

    更新日期：1982-12-01 00:00:00

  • Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation.

    abstract：:The pathogenesis of the decline of CD4 lymphocyte counts accompanying the typical course of HIV-1 infection is not completely defined and might be related to a differential susceptibility of naive and memory cells to HIV-1 exposure. Here, we examined the effects induced by heat-inactivated HIV-1 virions on these lymph...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/(SICI)1521-4141(199906)29:06<1879::AID-IMM

    authors： Masci AM,Paz FL,Borriello A,Cassano S,Della Pietra V,Stoiber H,Matarese G,Della Ragione F,Zappacosta S,Racioppi L

    更新日期：1999-06-01 00:00:00

  • Immunodeficient mice recover from infection with vaccinia virus expressing interferon-gamma.

    abstract：:Recombinant vaccinia viruses (VV)-encoding murine interferon-gamma (IFN-gamma) were constructed and the effect of virus-encoded IFN-gamma on the immune response towards VV in vivo investigated. In athymic nude mice and sublethally irradiated euthymic mice, IFN-gamma expression by VV enabled the mice to recover from th...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830200123

    authors： Kohonen-Corish MR,King NJ,Woodhams CE,Ramshaw IA

    更新日期：1990-01-01 00:00:00

  • Urtica dioica agglutinin, a V beta 8.3-specific superantigen, prevents the development of the systemic lupus erythematosus-like pathology of MRL lpr/lpr mice.

    abstract：:The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3+ T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline-injected MRL lpr/lpr controls, UDA-treated animals did n...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830260807

    authors： Musette P,Galelli A,Chabre H,Callard P,Peumans W,Truffa-Bachi P,Kourilsky P,Gachelin G

    更新日期：1996-08-01 00:00:00

  • Enhanced sensitivity of P-glycoprotein-positive multidrug resistant tumor cells to complement-mediated lysis.

    abstract：:The interaction of KB-V1, a multidrug resistant (MDR) variant of the KB-3-1 human oral carcinoma, with human complement was investigated. KB-V1 cells were found to be more sensitive than KB-3-1 cells to complement-mediated lysis. Detailed analysis of the capacity of KB cells to activate human complement demonstrated t...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830270913

    authors： Bomstein Y,Fishelson Z

    更新日期：1997-09-01 00:00:00

  • Expression of new idiotypes following neonatal idiotypic suppression of a dominant clone.

    abstract：:The anti-PC antibodies of BALB/c origin bear predominantly the idiotype characteristic of the phosphorylcholine (PC)-binding T15 idiotype than sera from adult mice, and, unlike the latter, they also contain detectable amounts of anti-T15 antibodies. By 2 weeks of age the anti-T15 antibodies are no longer detectable wh...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830060710

    authors： Augustin A,Cosenza H

    更新日期：1976-07-01 00:00:00

  • IL-10 promotes malignant pleural effusion by regulating TH 1 response via an miR-7116-5p/GPR55/ERK pathway in mice.

    abstract：:IL-10, produced by a wide variety of cells, is a highly pleiotropic cytokine that plays a critical role in the control of immune responses. However, its regulatory activity in tumor immunity remains poorly understood. In this study, we report that IL-10 deficiency robustly suppressed the formation of malignant pleural...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.202048574

    authors： Zhai K,Shi XY,Yi FS,Huang ZY,Wu XZ,Dong SF,Wang W,Wu MT,Shi HZ

    更新日期：2020-11-01 00:00:00

  • An age-related gamma delta T cell suppressor activity correlates with the outcome of autoimmunity in experimental Trypanosoma cruzi infection.

    abstract：:In this work the suppressive activity of splenic T cells from young and aged BALB/c mice infected with Trypanosoma cruzi were compared and correlated with the development of autoimmune myocarditis. The T cells from young adult BALB/c mice with acute T. cruzi infection exhibit suppressor activity when added to full all...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830231033

    authors： Cardillo F,Falcão RP,Rossi MA,Mengel J

    更新日期：1993-10-01 00:00:00

  • Inhibition of anti-GD3-ganglioside antibody-induced proliferation of human CD8+ T cells by CD16+ natural killer cells.

    abstract：:The ganglioside GD3 has been described as a membrane component of human T cells which is involved in T cell growth. In the present study the activating function of GD3 for human CD4+ and CD8+ T cells was analyzed by five different monoclonal antibodies (mAb) directed against the GD3 molecule. Three mAb U5, Z21 and R24...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830240530

    authors： Claus C,Schlaak J,Dittmayer M,Meyer zum Büschenfelde K,Dippold W

    更新日期：1994-05-01 00:00:00

  • CD4-positive/heat-stable antigen-positive thymocytes cause graft-versus-host disease across non-major histocompatibility complex incompatibilities.

    abstract：:Single-positive thymocytes are the immediate precursors of peripheral recent thymic emigrants (RTE) which develop into mature peripheral T cells. The functional ability of RTE is unclear but their state of differentiation may be relevant to the development of tolerance to peripheral "self" antigens. Since RTE are diff...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830240738

    authors： Charlton B,Meltzer J,Fathman CG

    更新日期：1994-07-01 00:00:00

  • Interferon-gamma activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I-A beta, tumor necrosis factor and complement component C3 in mouse macrophages.

    abstract：:The purpose of this study was to obtain additional information on the mechanism by which interferon-gamma (IFN-gamma) is able to regulate gene expression in macrophages. The expression of the genes for class II histocompatibility I-A beta, tumor necrosis factor (TNF) and complement component C3 was assayed after treat...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830190621

    authors： Celada A,Klemsz MJ,Maki RA

    更新日期：1989-06-01 00:00:00

  • Northern pig-tailed macaques (Macaca leonina) maintain superior CD4+ T-cell homeostasis during SIVmac239 infection.

    abstract：:Gradual depletion of CD4+ T cells is a typical characteristic of pathogenic SIV infection. Intriguingly, we find a spontaneous CD4+ T-cell homeostasis in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection. ...

    journal_title：European journal of immunology

    pub_type： 信件

    doi：10.1002/eji.201747284

    authors： Zhang MX,Zheng HY,Jiang J,Song JH,Chen M,Xiao Y,Lian XD,Song TZ,Tian RR,Pang W,Zheng YT

    更新日期：2018-02-01 00:00:00

  • Augmentation of major histocompatibility complex class I and ICAM-1 expression on glial cells following measles virus infection: evidence for the role of type-1 interferon.

    abstract：:An intracellular staining procedure for the cytoskeletal marker, glial fibrillary acidic protein of astrocytes, has been developed which allows flow cytometric phenotyping of astrocytes within complex mixtures of glial cells. Employing this technique, we show here that measles virus infection of rat mixed glial cell c...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830220126

    authors： Kraus E,Schneider-Schaulies S,Miyasaka M,Tamatani T,Sedgwick J

    更新日期：1992-01-01 00:00:00

  • Analysis of individual immunoglobulin lambda light chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center B cell somatic mutation.

    abstract：:Responding B cells in specific immune responses diversify their immunoglobulin genes and are selected on their variant antigen receptors in the microenvironment of the germinal center. The patterns of mutations previously reported for immunglobulin (Ig) genes have supported mechanistic hypotheses of either error-prone...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830240814

    authors： Ford JE,McHeyzer-Williams MG,Lieber MR

    更新日期：1994-08-01 00:00:00

  • Uniformity in the clonal repertoire for the immune response to phosphorylcholine in mice.

    abstract：:A comparison of the clonal nature of the immune response to phosphorylcholine (PC) was made in nine different inbred mouse strains. Quantitative idiotypic analysis showed that anti-PC antibodies from each strain were composed of antibodies bearing binding-site idiotypic determinants indistinguishable from two differen...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.1830061002

    authors： Claflin JL

    更新日期：1976-10-01 00:00:00

  • Inhibition of clonal expansion by Foxp3 expression as a mechanism of controlled T-cell responses and autoimmune disease.

    abstract：:The essential role of the transcription factor Foxp3 in the development and function of Treg has been well documented. The role of Foxp3 in non-Treg, however, is not fully understood. Emerging evidence indicates that Foxp3 expression is not confined to CD4+CD25+ Treg. The present study shows that in Foxp3 transgenic (...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200939404

    authors： Guo L,Tian J,Marinova E,Zheng B,Han S

    更新日期：2010-01-01 00:00:00

  • Immunodominant T-cell epitopes of hnRNP-A2 associated with disease activity in patients with rheumatoid arthritis.

    abstract：:The heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) has been described as an important autoantigen in rheumatoid arthritis (RA) since it is targeted by autoantibodies, autoreactive T cells, and is aberrantly expressed in synovial cells in patients. To identify hnRNP-A2-specific T-cell epitopes possibly associate...

    journal_title：European journal of immunology

    pub_type： 杂志文章

    doi：10.1002/eji.200939482

    authors： Trembleau S,Hoffmann M,Meyer B,Nell V,Radner H,Zauner W,Hammer J,Aichinger G,Fischer G,Smolen J,Steiner G

    更新日期：2010-06-01 00:00:00