Abstract:
:Vgamma9/Vdelta2+ T cells specifically recognize Mycobacterium tuberculosis in vitro and are precociously recruited in early mycobacterial lesions. Even if gammadelta T cells are only fortuitously detected in granulomas or bronchoalveolar lavages of patients with active pulmonary tuberculosis, a role in shaping the mature alphabeta T cell response against M. tuberculosis is substantiated. Here we provide a molecular explanation for this paradox: the engagement of the gammadelta TCR by mycobacterial antigens induced the expression of CD95 ligand (CD95L) by chronically activated CD95+/CD95L- gammadelta T lymphocytes. The receptor was functional, as CD95/CD95L interaction triggered the bystander death of CD95+ cells by apoptosis. Cell death was abolished by CD95-blocking antibodies. The transient accumulation at the site of infection of CD95L+ gammadelta lymphocytes, capable of interacting with CD95+ leukocytes attracted by the response towards the pathogen, may determine the characteristics of the ensuing granulomatous disease.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Manfredi AA,Heltai S,Rovere P,Sciorati C,Paolucci C,Galati G,Rugarli C,Vaiani R,Clementi E,Ferrarini Mdoi
10.1002/(SICI)1521-4141(199806)28:06<1798::AID-IMMsubject
Has Abstractpub_date
1998-06-01 00:00:00pages
1798-806issue
6eissn
0014-2980issn
1521-4141pii
10.1002/(SICI)1521-4141(199806)28:06<1798::AID-IMMjournal_volume
28pub_type
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