Abstract:
:Normal BALB/c spleen cells incubated for 2 days with Streptococcus pneumoniae R 36 a (Pn) vaccine in vitro acquired the specific ability to inhibit the T-independent anti-Pn response of fresh lymphocytes. The activated suppressor cells were susceptible to cytotoxic treatment with mouse anti-theta serum plus complement, and they inhibited the anti-Pn response of B lymphocytes deprived of T cells. The suppressive effect was eliminated by adsorbtion of cells on dishes coated with the C polysaccharide from Pn, and treatment of the suppressor cells with a rabbit antibody specific for TEPC-15 myeloma protein, in the presence of complement, abolished the suppressive effect. The results indicate that stimulation of lymphocytes with a T-independent antigen in vitro activates suppressor T cells bearing a specific antigen receptor that may express the idiotype(s) characteristic of anti-Pn antibody, and that these cells inhibit the Pn-reactive B cells directly.
journal_name
Eur J Immunoljournal_title
European journal of immunologyauthors
Cerny J,Caulfield MJ,Siat Mdoi
10.1002/eji.1830100902subject
Has Abstractpub_date
1980-09-01 00:00:00pages
661-4issue
9eissn
0014-2980issn
1521-4141journal_volume
10pub_type
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