Group 1 CD1-restricted T cells take center stage.

abstract：:BALB/c mice were immunized intranasally with either soluble ovalbumin (OVA) or OVA entrapped in liposomes. The effect of adding Sigma cholera toxin B subunit (sCT-B), which contained low amounts of cholera holotoxin (CT), or recombinant CT-B (rCT-B) which was free from CT, as mucosal adjuvants was also investigated. T...

journal_title：European journal of immunology

authors： Vadolas J,Davies JK,Wright PJ,Strugnell RA

更新日期：1995-04-01 00:00:00

abstract：:cDNA of the T cell receptor beta (TCRB) have been isolated from the anuran amphibian Xenopus and they show strong structural homology to TCRB sequences of other vertebrates. Ten BV families, two D segments, ten J segments, and a single C region have been defined so far. Each V family consists of one to two members per...

journal_title：European journal of immunology

authors： Chretien I,Marcuz A,Fellah J,Charlemagne J,Du Pasquier L

更新日期：1997-03-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is a cytokine which, among other properties, is a principle mediator of inflammation and septic shock. It acts upon target cells by binding to specific cell surface receptors. A10G10 is a murine monoclonal antibody which recognizes human TNF and neutralizes its activity. A rabbit polyclonal...

journal_title：European journal of immunology

authors： Galloway CJ,Madanat MS,Sarr T,Espevik T,Dumas ML,Mitra G,Ranges GE

更新日期：1992-11-01 00:00:00

abstract：:IL-7 plays many fundamental roles during murine B lineage development. One reported function is to maintain progenitors in a developmentally immature state by preventing differentiation to the surface IgM (sIgM)(+) stage. Withdrawal of IL-7 from cultures has been shown to lead to increases in mature traits such as RAG...

journal_title：European journal of immunology

authors： Milne CD,Fleming HE,Paige CJ

更新日期：2004-10-01 00:00:00

abstract：:The human butyrophilin (BTN) 3 or CD277 molecules belong to the B7 family members and are expressed in various immune cells such as T and NK cells. Here, we show that CD277 triggering considerably enhances TCR-induced cytokine production and cell proliferation, even when another co-stimulatory molecule, CD28, is engag...

journal_title：European journal of immunology

authors： Messal N,Mamessier E,Sylvain A,Celis-Gutierrez J,Thibult ML,Chetaille B,Firaguay G,Pastor S,Guillaume Y,Wang Q,Hirsch I,Nunès JA,Olive D

更新日期：2011-12-01 00:00:00

abstract：:A major feature of the immature immune system in the newborn is its inability to produce significant levels of immunoglobulins other than IgM in response to antigens. It has recently been demonstrated that interaction of the CD40 molecule on B cells with the CD40 ligand (CD40L) on activated T cells is pivotal for immu...

journal_title：European journal of immunology

authors： Brugnoni D,Airò P,Graf D,Marconi M,Lebowitz M,Plebani A,Giliani S,Malacarne F,Cattaneo R,Ugazio AG

更新日期：1994-08-01 00:00:00

abstract：:Activation of mature CD8+ T cells requires recognition, via the T cell receptor (TCR), of peptide + MHC (pMHC) complexes with an avidity that exceeds a designated threshold. Multiple indicators of T cell avidity have been described that provide unique information on the characteristics of T cell interactions. However,...

journal_title：European journal of immunology

authors： La Gruta NL,Doherty PC,Turner SJ

更新日期：2006-11-01 00:00:00

abstract：:The forkhead-family transcription factor FoxP3 is important for the development and function of CD4+CD25+ regulatory T cells. While the overall phenotypic effects of FoxP3 expression are evident, the mechanism by which FoxP3 regulates T cell activation is not well understood. CD4+ T cells from mice that express a FoxP...

journal_title：European journal of immunology

authors： Kasprowicz DJ,Droin N,Soper DM,Ramsdell F,Green DR,Ziegler SF

更新日期：2005-12-01 00:00:00

abstract：:A multiparametric analysis of the resident immune populations in the parotid, submandibular and sublingual salivary glands was done in single-cell suspensions. The incidence of T and B cells and of macrophages was assessed using phenotypic markers in immunofluorescent staining and a functional assay was used to enumer...

journal_title：European journal of immunology

authors： Oudghiri M,Seguin J,Deslauriers N

更新日期：1986-03-01 00:00:00

abstract：:The simultaneous detection of Ig and theta on the surface of mouse lymphocytes permits the detection of four cell types (Ig-theta-, Ig-theta+, Ig+theta-, and Ig+theta+) which also have distinct electrophoretic profiles. All types are present in variable proportions in all lymphoid organs studied. Results obtained in c...

journal_title：European journal of immunology

authors： Roelants GE,Loor F,von Boehmer H,Sprent J,Hägg LB,Mayor KS,Rydén A

更新日期：1975-02-01 00:00:00

abstract：:Responding B cells in specific immune responses diversify their immunoglobulin genes and are selected on their variant antigen receptors in the microenvironment of the germinal center. The patterns of mutations previously reported for immunglobulin (Ig) genes have supported mechanistic hypotheses of either error-prone...

journal_title：European journal of immunology

authors： Ford JE,McHeyzer-Williams MG,Lieber MR

更新日期：1994-08-01 00:00:00

abstract：:Splenic T cells were primed, after removal of alloreactive cells, to beef insulin on allogeneic antigen-presenting cells (APC). The fine specificity of in vitro secondary response was tested in combinations H-2b (responder) T cell-H-2k (nonresponder) APC, and vice versa, using separated chains of beef and pork insulin...

journal_title：European journal of immunology

authors： Ishii N,Klein J,Nagy ZA

更新日期：1983-08-01 00:00:00

abstract：:Auto-reactive T cells present in healthy subjects remain in a state of unresponsiveness, but may trigger autoimmunity under various situations. Although myelin oligodendrocyte glycoprotein (MOG) is a potential target antigen in multiple sclerosis (MS), MOG-reactive T cell responses are present in the blood of both hea...

journal_title：European journal of immunology

authors： Villoslada P,Abel K,Heald N,Goertsches R,Hauser SL,Genain CP

更新日期：2001-10-01 00:00:00

abstract：:T cell receptor (TCR) genes are initially activated in hematopoietic stem cells that have been committed to the T cell lineage during ontogeny. We have established cell lines derived from hematopoietic organs which express truncated TCR delta mRNA (1.3 kbp). In this study, cDNA clones of this mRNA were analyzed to cha...

journal_title：European journal of immunology

authors： Shimamura M,Ohta S

更新日期：1995-06-01 00:00:00

abstract：:New Zealand Black (NZB) mice spontaneously develop an autoimmune hemolytic anemia together with a markedly increased production of polyclonal antibodies. The spontaneous generation of anti-mouse red blood cells (MRBC), anti-bromelain-treated MRBC (BrMRBC) and anti-DNA autoantibodies was compared to the polyclonal anti...

journal_title：European journal of immunology

authors： Reininger L,Shibata T,Schurmans S,Merino R,Fossati L,Lacour M,Izui S

更新日期：1990-11-01 00:00:00

abstract：:Three molecular forms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1ra type II (IL-1ra3), have no leader sequence, thus ...

journal_title：European journal of immunology

authors： Muzio M,Polentarutti N,Facchetti F,Peri G,Doni A,Sironi M,Transidico P,Salmona M,Introna M,Mantovani A

更新日期：1999-03-01 00:00:00

abstract：:A murine monoclonal IgM antibody recognizes an antigen (Mo3e) found on the surface of human peripheral blood monocytes stimulated with phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide and muramyl dipeptide and blocks the monocyte response to migration inhibitory factor (MIF). We utilized Western blot and immu...

journal_title：European journal of immunology

authors： Liu DY,Ree JY,Trochelman RD,Todd RF 3rd

更新日期：1989-04-01 00:00:00

abstract：:Macrophage-chemotactic factor (MChF)-producing T cell hybridomas were established. These hybridomas produced MChF upon the specific antigenic stimulation with phosphorylcholine (PC)-conjugated protein in the presence of I-Ed-positive antigen-presenting cells. The hybridomas also secreted MChF after co-culture with con...

journal_title：European journal of immunology

authors： Harita S,Sugimura K,Watanabe T

更新日期：1984-08-01 00:00:00

abstract：:Neutrophils express pattern recognition receptors (PRRs) and regulate immune responses via PRR-dependent cytokine production. An emerging theme is that neutrophil PRRs often exhibit cell type-specific adaptations in their signalling pathways. This prompted us to examine inflammasome signalling by the PRR NLRP3 in muri...

journal_title：European journal of immunology

authors： Chen KW,Bezbradica JS,Groß CJ,Wall AA,Sweet MJ,Stow JL,Schroder K

更新日期：2016-04-01 00:00:00

abstract：:FTY720 is a novel immunosuppressant that improves the outcomes after solid organ and bone marrow transplantation (BMT) due to the sequestration of T cells into LN. We tested the hypothesis that the sequestration of donor T cells in LN by FTY720 would enhance their interaction with host APC, thus causing a greater degr...

journal_title：European journal of immunology

authors： Hashimoto D,Asakura S,Matsuoka K,Sakoda Y,Koyama M,Aoyama K,Tanimoto M,Teshima T

更新日期：2007-01-01 00:00:00

abstract：:A single T cell clone can be activated by many different peptides in the context of a particular HLA molecule. To quantify the number of peptides that can be recognized by a CD4(+) T cell clone, we screened a one-bead-one-peptide synthetic peptide library and a protein database for peptides that stimulate an HLA-DR3-r...

journal_title：European journal of immunology

authors： Hiemstra HS,van Veelen PA,Willemen SJ,Benckhuijsen WE,Geluk A,de Vries RR,Roep BO,Drijfhout JW

更新日期：1999-08-01 00:00:00

abstract：:Adaptive immune responses have long been considered the "territory" of antigenic proteins, whereas carbohydrates are characterized as T-cell-independent antigens that are not typically recognized by the complete adaptive machinery. The current modus operandi when searching for dominant epitopes is the use of synthetic...

journal_title：European journal of immunology

authors： Cobb BA,Kasper DL

更新日期：2005-02-01 00:00:00

abstract：:The fate of the T cell receptor (TcR)/CD3 complex was examined on a cytotoxic T lymphocyte (CTL) clone (KB5.C20) activated either via binding of an anti-TcR monoclonal antibody (mAb) or by a Ca2+ ionophore and phorbol 12-myristate 13-acetate (PMA). After binding of the anti-TcR mAb, electron microscopy revealed intern...

journal_title：European journal of immunology

authors： Boyer C,Auphan N,Luton F,Malburet JM,Barad M,Bizozzero JP,Reggio H,Schmitt-Verhulst AM

更新日期：1991-07-01 00:00:00

abstract：:Immunocompetent adult mice infected with lymphocytic choriomeningitis virus (LCMV) generate a strong antiviral cytotoxic T cell response that clears virus from all organs. Although there is good evidence that immune cytotoxic T lymphocytes (CTL) kill target cells in vitro, in vivo it is debated whether antiviral activ...

journal_title：European journal of immunology

authors： Kyburz D,Speiser DE,Battegay M,Hengartner H,Zinkernagel RM

更新日期：1993-07-01 00:00:00

abstract：:The TORC1 pathway is necessary for ribosomal biogenesis and initiation of protein translation. Furthermore, the differentiation of Th1 and Th17 cells requires TORC1 activity. To investigate the role of the TORC1 pathway in the differentiation of Th1 and/or Th17 cells in more detail, we compared the differentiation cap...

journal_title：European journal of immunology

authors： Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P

更新日期：2016-01-01 00:00:00

abstract：:The expression of an X-linked defect in the CBA/N strain of mice has been found to result in a number of immune abnormalities. These include low responsiveness to antigens and a greatly reduced ability to respond to many of the common B cell mitogens. An in vitro manifestation of this condition is the virtual inabilit...

journal_title：European journal of immunology

authors： Narendran A,Cumano A,Dorshkind K,Paige CJ

更新日期：1992-04-01 00:00:00

abstract：:A number of applications of antibodies in diagnosis and therapy require multivalent reagents either because of the polymeric nature of the antigens or because biological activity depends on an effect on the formation of homodimeric species. Here, we report a procedure for mass screening of phage-derived monomeric anti...

journal_title：European journal of immunology

authors： Zaccolo M,Griffiths AP,Prospero TD,Winter G,Gherardi E

更新日期：1997-03-01 00:00:00

abstract：:The effect of Trypanosoma brucei infections on parasite-specific antibody responses was examined by immunization of infected mice with radio-attenuated trypanosomes of a noncross-reacting clone. Antibody titers (total Ig) against variant surface antigen were determined by indirect immunofluorescence. The suppression r...

journal_title：European journal of immunology

authors： Sacks DL,Askonas BA

更新日期：1980-12-01 00:00:00

abstract：:Autoantibodies in the form of immune complexes are known to be crucial mediators in initiating inflammation in a variety of autoimmune diseases. This has been well documented in the anti-collagen II antibody-induced arthritis animal model for a long time now. Recently, in the K/B x N mouse model (the F1 of the TCR-tra...

journal_title：European journal of immunology

authors： Solomon S,Rajasekaran N,Jeisy-Walder E,Snapper SB,Illges H

更新日期：2005-10-01 00:00:00

abstract：:Neurotropic coronavirus infection of mice results in acute encephalomyelitis followed by viral persistence. Whereas cellular immunity controls acute infection, humoral immunity regulates central nervous system (CNS) persistence. Maintenance of serum Ab was correlated with tissue distribution of virus-specific Ab-secre...

journal_title：European journal of immunology

authors： Tschen SI,Stohlman SA,Ramakrishna C,Hinton DR,Atkinson RD,Bergmann CC

更新日期：2006-03-01 00:00:00