CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human γδ peripheral blood lymphocytes.

abstract：:A monoclonal antibody (mAb), 2D1(IgM), was identified for its anti-proliferative effect on human T leukemia cell line, SUP-T13. The cells bound with 2D1 showed DNA ladder patterns of oligonucleosomes, demonstrating apoptosis. Peripheral mononuclear cells activated by phytohemagglutinin or OKT3 induced expression of 2D...

journal_title：European journal of immunology

authors： Takahashi S,Sato N,Takayama S,Ichimiya S,Satoh M,Hyakumachi N,Kikuchi K

更新日期：1993-08-01 00:00:00

abstract：:Tyrosine kinase 2 (Tyk2) contributes to the signals triggered by IL-12 for IFN-gamma production by NK cells and T cells. We found in this study that Tyk2-deficient (-/-) mice showed increased susceptibility at the early stage after an i.p. infection with Listeria monocytogenes, accompanied by impaired IFN-gamma produc...

journal_title：European journal of immunology

authors： Aizu K,Li W,Yajima T,Arai T,Shimoda K,Nimura Y,Yoshikai Y

更新日期：2006-11-01 00:00:00

abstract：:The production of IL-10, a potent immunosuppressive cytokine, must be strictly regulated to ensure a balanced immune response. IFN-γ, a key cytokine in multiple immune processes and pathologies, is known as an inhibitor of IL-10 production by monocytes and macrophages, but also has some regulatory functions. In the pr...

journal_title：European journal of immunology

authors： Imbrechts M,De Samblancx K,Fierens K,Brisse E,Vandenhaute J,Mitera T,Libert C,Smets I,Goris A,Wouters C,Matthys P

更新日期：2018-09-01 00:00:00

abstract：:It has been reported that, following the initial expression of the T cell receptor (TcR) alpha/beta, newly generated thymocytes pass through a developmental window characterized by ineffective coupling between the alpha/beta and CD3 components resulting in resistance to deletion (negative selection). However, we now p...

journal_title：European journal of immunology

authors： Jenkinson EJ,Kingston R,Owen JJ

更新日期：1990-11-01 00:00:00

abstract：:ME3738 is a new compound that attenuates liver disease in several models of acute and chronic liver inflammation. We used the concanavalin A (Con A) model to elucidate the molecular mechanisms of ME3738 to block liver cell damage. Pretreatment of BALB/c mice with ME3738 prior to Con A injection resulted in a significa...

journal_title：European journal of immunology

authors： Klein C,Wüstefeld T,Heinrich PC,Streetz KL,Manns MP,Trautwein C

更新日期：2003-08-01 00:00:00

abstract：:Using limiting dilution analysis, we investigated proliferative responses of UCHL1+ and UCHL1- T cell populations to compare the precursor cell frequencies following recall and alloantigen stimulation, and the complexity of cellular interactions within UCHL1+ and UCHL1- populations. We find high frequencies of recall ...

journal_title：European journal of immunology

authors： Merkenschlager M,Terry L,Edwards R,Beverley PC

更新日期：1988-11-01 00:00:00

abstract：:CD4+ helper T lymphocytes and CD8+ killer T lymphocytes are both generated in the thymus from common precursor cells expressing CD4 and CD8. The development of immature CD4 CD8+ thymocytes into mature 'single-positive' T cells requires T cell antigen-receptor (TCR)-mediated positive selection signals. Although it is k...

journal_title：European journal of immunology

authors： Takahama Y,Tokoro Y,Sugawara T,Negishi I,Nakauchi H

更新日期：1997-12-01 00:00:00

abstract：:Th17 cells are defined by their capacity to produce IL-17, and are important mediators of inflammation and autoimmunity. Human Th17 cells express high levels of the retinoic acid-related orphan receptor variant 2 (RORC2), but it is currently unclear whether expression of this transcription factor alone is sufficient t...

journal_title：European journal of immunology

authors： Crome SQ,Wang AY,Kang CY,Levings MK

更新日期：2009-06-01 00:00:00

abstract：:The pool of hematopoietic stem cells (HSCs) in the bone marrow is a mixture of resting, proliferating, and differentiating cells. Long-term repopulating HSCs (LT-HSC) are routinely enriched as Lin- Sca1+ c-Kit+ CD34- Flt3- CD150+ CD48- cells. The Flt3 ligand (Flt3L) and its receptor Flt3 are important regulators of HS...

journal_title：European journal of immunology

authors： Tornack J,Kawano Y,Garbi N,Hämmerling GJ,Melchers F,Tsuneto M

更新日期：2017-09-01 00:00:00

abstract：:The magnitude of the output of lymphocytes from Peyer's patches (PP), the morphology of the lymphocytes and their route of exit from PP has been examined in sheep. An extracorporeal perfusion system was used to selectively label a 3-4 m length of the terminal ileum of lambs at 6-10 weeks of age (the mesenteric lymph n...

journal_title：European journal of immunology

authors： Reynolds JD,Pabst R

更新日期：1984-01-01 00:00:00

abstract：:Sand fly saliva contains maxadilan, a peptide that causes vasodilation and modifies the secretion of pro-inflammatory cytokines by macrophages. We show that 1 to 10 microg maxadilan protected BALB/c mice against a lethal dose of LPS. Maxadilan reduced serum levels of TNF-alpha by approximately tenfold, while it caused...

journal_title：European journal of immunology

authors： Bozza M,Soares MB,Bozza PT,Satoskar AR,Diacovo TG,Brombacher F,Titus RG,Shoemaker CB,David JR

更新日期：1998-10-01 00:00:00

abstract：:A generalized Shwartzman reaction was found to occur in non-SPF-NMRI mice given a local injection of S. marcescens lipopolysaccharide (LPS) in the footpad, followed, with an interval of 24 h, by an i.v. injection. The reaction occurred several hours after the second injection. It was characterized by disseminated subc...

journal_title：European journal of immunology

authors： Billiau A,Heremans H,Vandekerckhove F,Dillen C

更新日期：1987-12-01 00:00:00

abstract：:Transgenic CBA (H-2k haplotype) mice expressing the H-2 Kb major histocompatibility complex (MHC) class I gene under control of transcriptional promoter elements from a milk protein gene display high-level H-2 Kb transcription in lactating mammary glands and low-level transcription in skin and thymus of male and virgi...

journal_title：European journal of immunology

authors： Husbands SD,Schönrich G,Arnold B,Chandler PR,Simpson E,Philpott KL,Tomlinson P,O'Reilly L,Cooke A,Mellor AL

更新日期：1992-10-01 00:00:00

abstract：:Beta1 integrins can provide T cell co-stimulation, but little is known concerning their downstream signaling pathways. We found that Pyk2, a focal adhesion kinase-related tyrosine kinase, is regulated by beta1 integrin signaling in human T cells. Stimulation of Jurkat T cells with the alpha4beta1 integrin ligand VCAM-...

journal_title：European journal of immunology

authors： van Seventer GA,Mullen MM,van Seventer JM

更新日期：1998-11-01 00:00:00

abstract：:Terminal differentiation of B cells into antibody-secreting cells is the foundation of humoral immune response. B-1 cells, which are different from B-2 cells, preferentially differentiate into plasma cells. CMTM7 is a MARVEL-domain-containing membrane protein predominantly expressed in B cells that plays an important ...

journal_title：European journal of immunology

authors： Liu Z,Liu Y,Li T,Wang P,Mo X,Lv P,Ma D,Han W

更新日期：2020-06-01 00:00:00

abstract：:PA28alpha/beta is a regulatory complex of the 20S proteasome which consists of two IFN-gamma inducible subunits. Both subunits, alpha and beta, contribute equally to the formation of hexa- or heptameric rings which can associate with the 20S proteasome. Previously, we have shown that overexpression of the PA28alpha su...

journal_title：European journal of immunology

authors： Schwarz K,Eggers M,Soza A,Koszinowski UH,Kloetzel PM,Groettrup M

更新日期：2000-12-01 00:00:00

abstract：:An antigen-specific T-T hybridoma was mutagenized with ethylmethane sulfonate and negatively selected by anti-Ly-6 antibody-induced growth inhibition. One of the mutants generated, M4/8, had lost surface expression of a T cell receptor (TcR) V beta 8 epitope detected on the surface of the parental cell line. However, ...

journal_title：European journal of immunology

authors： Reno TA,Ley S,Sugiyama E,Cantagrel A,Blumberg R,Bonventre J,Terhorst C,Yeh ET

更新日期：1990-07-01 00:00:00

abstract：:A fraction of activated CD8+ T cells expresses CD40 ligand (CD40L), a molecule that plays a key role in T cell-dependent B cell stimulation. CD8+ T cell clones were examined for CD40L expression and for their capacity to allow the growth and differentiation of B cells, upon activation with immobilized anti-CD3. Accord...

journal_title：European journal of immunology

authors： Hermann P,Van-Kooten C,Gaillard C,Banchereau J,Blanchard D

更新日期：1995-10-01 00:00:00

abstract：:F protein is found predominantly in the liver and is of unknown function. The protein has been of interest to immunologists in the areas of self tolerance and the immunogenetics of the anti-F protein response. In the mouse there are two alleles (F1 and F2), and although mice are completely tolerant to the self form of...

journal_title：European journal of immunology

authors： Schofield JP,Vijayakumar RK,Oliveira DB

更新日期：1991-05-01 00:00:00

abstract：:In June 2009, the National Institute of Allergy and Infectious Diseases (NIAID), Division of Allergy, Immunology and Transplantation (DAIT), sponsored a workshop entitled Mast Cells in Innate and Adaptive Immunity. International experts in mast cell biology discussed recent advances in the field and future areas of re...

journal_title：European journal of immunology

authors： Palker TJ,Dong G,Leitner WW

更新日期：2010-01-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) plays an important role in the immune response by modulating the complex interactions between leukocytes and tissue cells under inflammatory conditions. PGE(2) may possibly influence pro-inflammatory effects of chemokines and chemokine receptors that are among the main regulators of directi...

journal_title：European journal of immunology

authors： Panzer U,Uguccioni M

更新日期：2004-12-01 00:00:00

abstract：:Interleukin (IL)-7 and IL-2 are important lymphoproliferative cytokines which both use the gamma c chain as part of their respective receptors. To learn more of their signaling mechanisms a comparison was made of the patterns of intracellular tyrosine phosphorylated proteins induced by these cytokines in the murine T ...

journal_title：European journal of immunology

authors： Crawley JB,Willcocks J,Foxwell BM

更新日期：1996-11-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a potent inducer of interleukin 1 (IL 1) synthesis and release, and of tumor necrosis factor (TNF) secretion. Many signals can enhance the LPS-induced production of these cytokines. We have previously observed that addition of low amounts of normal human serum to the culture medium enhances...

journal_title：European journal of immunology

authors： Cavaillon JM,Fitting C,Haeffner-Cavaillon N

更新日期：1990-02-01 00:00:00

abstract：:Maintenance of peripheral tolerance and inactivation of autoreactive T cells is based on a delicate balance between pro-inflammatory and protective cytokines that is poorly understood. We have here addressed how the local expression of the inflammatory cytokine TNF-alpha can impair peripheral tolerance and lead to aut...

journal_title：European journal of immunology

authors： Skak K,Guerder S,Picarella DE,Brenden N,Flavell RA,Michelsen BK

更新日期：2003-05-01 00:00:00

abstract：:Plasticity and heterogeneity are hallmarks of myelomonocytic differentiation and polarized activation. Evidence published in this issue of the European Journal of Immunology, together with other recent data, add new elements and perspectives to the current understanding of mononuclear phagocyte differentiation and act...

journal_title：European journal of immunology

authors： Mantovani A,Sica A,Locati M

更新日期：2007-01-01 00:00:00

abstract：:Previously we have reported on the production of two sets of human monoclonal antibodies reacting with mouse mammary tumor virus (MMTV) and human mammary tumor virus (HuMTV) cross-reacting antigens. B11 is a monoclonal IgG generated by the human-human hybridoma technique using axillary lymph node of breast cancer pati...

journal_title：European journal of immunology

authors： Smorodinsky NI,Ghendler Y,Bakimer R,Chaitchuk S,Keydar I,Shoenfeld Y

更新日期：1988-11-01 00:00:00

abstract：:The involvement of the CD2 (T11) molecule, an alternative activation pathway for T lymphocytes, in the regulation of tumor necrosis factor (TNF)-alpha/TNF receptor system in human T lymphocytes has been investigated. It has been found that both TNF-alpha synthesis and secretion were induced after incubation of purifie...

journal_title：European journal of immunology

authors： Santis AG,Campanero MR,Alonso JL,Sánchez-Madrid F

更新日期：1992-12-01 00:00:00

abstract：:In the bone marrow, the passage of developing B cells through critical checkpoints of differentiation is associated with a reduction of specific categories of CDR3 of the Ig heavy chain (CDR-H3), particularly those with excessive hydrophobic or charged amino acids and those with a length of eight or fewer residues. To...

journal_title：European journal of immunology

authors： Schelonka RL,Tanner J,Zhuang Y,Gartland GL,Zemlin M,Schroeder HW Jr

更新日期：2007-04-01 00:00:00

abstract：:NK cells offer a first line of defense against viruses and are considered beneficial to the host during infection. Nevertheless, little is understood regarding the phenotype and function of NK cells in the lung during influenza virus infection. We found that the frequency of NK cells in mouse lung increased during inf...

journal_title：European journal of immunology

authors： Zhou G,Juang SW,Kane KP

更新日期：2013-04-01 00:00:00

abstract：:The effects of vasoactive intestinal peptide (VIP) on human IgA1 and IgA2 production were studied. In unfractionated small resting B cells stimulated with anti-CD40 monoclonal antibody (mAb), VIP induced IgA1 and IgA2 production without affecting the production of IgG1, IgG2, IgG3, IgG4, IgM, or IgE. When small B cell...

journal_title：European journal of immunology

authors： Kimata H,Fujimoto M

更新日期：1994-09-01 00:00:00