Pyk2 is differentially regulated by beta1 integrin- and CD28-mediated co-stimulation in human CD4+ T lymphocytes.

abstract：:We examined T cell development and T cell repertoire in transgenic mice expressing a single T cell receptor (TCR) alpha chain derived from the H-2Db-lymphocytic choriomeningitis virus (LCMV)-specific cytolytic T lymphocyte (CTL) clone P14. To generate these alpha P14 mice, mice transgenic for the P14 TCR alpha chain w...

journal_title：European journal of immunology

authors： Brändle D,Brduscha-Riem K,Hayday AC,Owen MJ,Hengartner H,Pircher H

更新日期：1995-09-01 00:00:00

abstract：:Psoriasis is an inflammatory disease of the skin affecting 2-3% of the population, characterized by a thickening of the epidermis and immune infiltrates throughout the dermis and epidermis, causing skin lesions that can seriously affect quality of life. The study of psoriasis has historically been hampered by the lack...

journal_title：European journal of immunology

authors： Flutter B,Nestle FO

更新日期：2013-12-01 00:00:00

abstract：:Fever is associated with improved survival during infection in endothermic and ectothermic species although the protective mechanisms are largely undefined. Previous studies indicate that fever-range thermal stress increases the binding activity of the L-selectin homing receptor in human or mouse leukocytes, thereby p...

journal_title：European journal of immunology

authors： Appenheimer MM,Girard RA,Chen Q,Wang WC,Bankert KC,Hardison J,Bain MD,Ridgley F,Sarcione EJ,Buitrago S,Kothlow S,Kaspers B,Robert J,Rose-John S,Baumann H,Evans SS

更新日期：2007-10-01 00:00:00

abstract：:Macrophage-chemotactic factor (MChF)-producing T cell hybridomas were established. These hybridomas produced MChF upon the specific antigenic stimulation with phosphorylcholine (PC)-conjugated protein in the presence of I-Ed-positive antigen-presenting cells. The hybridomas also secreted MChF after co-culture with con...

journal_title：European journal of immunology

authors： Harita S,Sugimura K,Watanabe T

更新日期：1984-08-01 00:00:00

abstract：:Alymphoplasia mice (aly/aly) have been shown to be deficient for a nuclear factor-kappaB-inducing kinase involved in signal transduction of lymphotoxin beta receptor (LT-betaR) and of CD40, resulting in structural defects of secondary lymphoid organs and highly increased susceptibility to viral infections. We analyzed...

journal_title：European journal of immunology

authors： Karrer U,Althage A,Odermatt B,Hengartner H,Zinkernagel RM

更新日期：2000-10-01 00:00:00

abstract：:To study the biological consequences of cytokine production and apoptosis by intraepithelial lymphocytes (IEL), we have studied these characteristics in both the high and low density CD3+ IEL populations. Stimulation of low- or high-density CD3+ IEL via the T cell receptor (TCR)-CD3 complex using monoclonal anti-CD3, ...

journal_title：European journal of immunology

authors： Yamamoto M,Fujihashi K,Amano M,McGhee JR,Beagley KW,Kiyono H

更新日期：1994-06-01 00:00:00

abstract：:The receptor for the inflammatory peptide C3a has scarcely been examined on human cells. This work demonstrates that human tumor-derived basophilic granulocytes express C3a receptors, and presents parts of the hitherto unknown C3a-signal transduction. When incubated with IL-3, these cells specifically liberated histam...

journal_title：European journal of immunology

authors： Kretzschmar T,Jeromin A,Gietz C,Bautsch W,Klos A,Köhl J,Rechkemmer G,Bitter-Suermann D

更新日期：1993-02-01 00:00:00

abstract：:A rapidly-growing, HAT-sensitive cell line LICR-LON-HMy2 has been derived from the ARH-77 human plasma cell leukemia-derived line. It lacks the enzyme hypoxanthine phosphoribosyltransferase (EC 2.4.2.8). Hybrids have been reproducibly made for more than a year and in independent laboratories with lymphocytes from tons...

journal_title：European journal of immunology

authors： Edwards PA,Smith CM,Neville AM,O'Hare MJ

更新日期：1982-08-01 00:00:00

abstract：:Twenty-seven B cell hybridomas derived from spleen cells of nonimmunized, 6-day-old BALB/c mice and previously characterized serologically were screened for VH-gene expression: hybridomas expressing the two most D-proximal VH-gene families, 7183 and QUPC 52 were over-represented in this sample. Strikingly, clones sero...

journal_title：European journal of immunology

authors： Holmberg D

更新日期：1987-03-01 00:00:00

abstract：:We have utilized the sensitive polymerase chain reaction (PCR) to determine whether cytotoxic T lymphocyte (CTL) hybridomas generated from peritoneal exudate lymphocytes (PEL) and mixed lymphocyte cultures (MLC) express transcripts for perforin and the cytotoxic cell proteinases CCP1 to CCP5. We could readily detect l...

journal_title：European journal of immunology

authors： Helgason CD,Prendergast JA,Berke G,Bleackley RC

更新日期：1992-12-01 00:00:00

abstract：:The involvement of rheumatoid factor (RF)-secreting cells in normal immune responses was examined by screening hybridomas derived from 129/Sv mice during primary and secondary immune responses against foreign proteins. No RF-secreting cells were detected during primary responses, but up to 10% of the total number of c...

journal_title：European journal of immunology

authors： Van Snick J,Coulie P

更新日期：1983-11-01 00:00:00

abstract：:Elucidating the signaling events that promote T-cell tolerance versus activation provides important insights for manipulating immunity in vivo. Previous studies have suggested that the absence of PKCtheta results in the induction of anergy and that the balance between the induction of the transcription factors NFAT, A...

journal_title：European journal of immunology

authors： Deenick EK,Po L,Chapatte L,Murakami K,Lu YC,Elford AR,Saibil SD,Ruland J,Gerondakis S,Mak TW,Ohashi PS

更新日期：2010-03-01 00:00:00

abstract：:Developing T cells undergo distinct selection processes that determine the T cell receptor (TcR) repertoire. One of these processes is positive selection. Positive selection involves the differentiation to mature T cells of thymocytes bearing TcR capable of recognizing antigens in the context of self-major histocompat...

journal_title：European journal of immunology

authors： Carrera AC,Baker C,Roberts TM,Pardoll DM

更新日期：1992-09-01 00:00:00

abstract：:To further define DNA immunization as a model for anti-DNA production, we investigated the cellular requirements for this response in mice immunized with single-stranded DNA from E. coli. The anti-DNA responses of genetically immune-deficient mice and congenic controls were measured by ELISA after immunization with E....

journal_title：European journal of immunology

authors： Gilkeson GS,Pritchard AJ,Pisetsky DS

更新日期：1990-08-01 00:00:00

abstract：:Postganglionic sympathetic neurons innervate secondary lymphoid organs and secrete norepinephrine (NE) as the primary neurotransmitter. NE binds and signals through five distinct members of the adrenergic receptor family. In this study, we show elevated expression of the β2-adrenergic receptor (ADRB2) on primary human...

journal_title：European journal of immunology

authors： Estrada LD,Ağaç D,Farrar JD

更新日期：2016-08-01 00:00:00

abstract：:Human B lymphocytes transformed by infection with the Epstein-Barr virus (EBV) express a new membrane protein of 63 kDa (latent membrane protein, LMP) encoded by the virus. The function of this protein in the virus-cell interaction is not known. In this work we have identified in EBV- human and mouse cell molecules wh...

journal_title：European journal of immunology

authors： Hatzubai A,Lerner RA,Klein G,Sulitzeanu D

更新日期：1988-08-01 00:00:00

abstract：:The MOPC460 idiotype is expressed in mice with the IghCa allotypic haplotype after anti-2,4-dinitrophenyl (DNP) immunization. We have previously shown that two monoclonal syngeneic anti-idiotypic antibodies (IDM 92-13 and IDM 41-27) define two distinct idiotopes (the 460.92 and the 460.41) on the M460 idiotype. The cu...

journal_title：European journal of immunology

authors： Sanchez P,Juy D,Cazenave PA

更新日期：1983-12-01 00:00:00

abstract：:During the chronic phase of infection with the parasite Trypanosoma cruzi, mice develop inflammatory lesions in the heart and skeletal muscles, as well as in peripheral nerves and the liver. We demonstrated the presence, in the blood of chronically infected mice, of L3T4+ T cells able to transfer a specific T. cruzi d...

journal_title：European journal of immunology

authors： Hontebeyrie-Joskowicz M,Said G,Milon G,Marchal G,Eisen H

更新日期：1987-07-01 00:00:00

abstract：:The poxvirus A39R protein is a member of the semaphorin family that binds to Plexin C1, a molecule expressed on neutrophils and dendritic cells (DC). We previously showed that binding of A39R to Plexin C1 induces local rearrangement of the actin cytoskeleton and inhibits integrin-mediated adhesion, leading to cell ret...

journal_title：European journal of immunology

authors： Walzer T,Galibert L,De Smedt T

更新日期：2005-02-01 00:00:00

abstract：:Auto-reactive T cells present in healthy subjects remain in a state of unresponsiveness, but may trigger autoimmunity under various situations. Although myelin oligodendrocyte glycoprotein (MOG) is a potential target antigen in multiple sclerosis (MS), MOG-reactive T cell responses are present in the blood of both hea...

journal_title：European journal of immunology

authors： Villoslada P,Abel K,Heald N,Goertsches R,Hauser SL,Genain CP

更新日期：2001-10-01 00:00:00

abstract：:The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3+ T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline-injected MRL lpr/lpr controls, UDA-treated animals did n...

journal_title：European journal of immunology

authors： Musette P,Galelli A,Chabre H,Callard P,Peumans W,Truffa-Bachi P,Kourilsky P,Gachelin G

更新日期：1996-08-01 00:00:00

abstract：:Muramyl peptides are the building blocks of bacterial peptidoglycan, and their biological functions in mammals have been extensively studied. In particular, muramyl peptides trigger inflammation, contribute to host defense against microbial infections, and modulate the adaptive immune response to antigens. These bacte...

journal_title：European journal of immunology

authors： Magalhaes JG,Lee J,Geddes K,Rubino S,Philpott DJ,Girardin SE

更新日期：2011-05-01 00:00:00

abstract：:Regulatory T (T(reg)) cells play a key role in the maintenance of the immune system homeostasis. T(reg) cells can be generated in the periphery under control of TGF-beta, a cytokine involved in the negative control of the immune system. However, TGF-beta cooperates with IL-6 in the generation of Th17 cells, a novel cl...

journal_title：European journal of immunology

authors： Fantini MC,Rizzo A,Fina D,Caruso R,Becker C,Neurath MF,Macdonald TT,Pallone F,Monteleone G

更新日期：2007-11-01 00:00:00

abstract：:Once generated during an infection, memory CD8+ T cells can provide long-lasting protection against reinfection with an intracellular pathogen, but the longevity of this defense depends on the ability of these pathogen-specific memory cells to be maintained. It is generally believed that the bone marrow plays an impor...

journal_title：European journal of immunology

authors： Nolte MA,Goedhart M,Geginat J

更新日期：2017-11-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells elaborate a cytolytic protein named perforin or cytolysin. It was widely held that, in vivo, high quantities of perforin are not present in resting lymphocytes and are usually produced only by activated lymphocytes found under pathological conditions. Until n...

journal_title：European journal of immunology

authors： Zheng LM,Ojcius DM,Young JD

更新日期：1993-09-01 00:00:00

abstract：:Plasma cells secreting IgG, M, and A abound in the synovium of patients with rheumatoid arthritis, yet their immunoglobulin repertoire and clonal relationship remain to be elucidated. Locally synthesized immunoglobulins probably contribute to the chronic joint inflammatory processes which are characteristic of these p...

journal_title：European journal of immunology

authors： Williams DG,Taylor PC

更新日期：1997-02-01 00:00:00

abstract：:Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1) is a critical component of the NF-kappaB signaling cascade mediated by TCR engagement. In addition to activation of naïve T cells, TCR signaling is important for the development of agonist-selected T-cell subsets such as Treg...

journal_title：European journal of immunology

authors： Medoff BD,Sandall BP,Landry A,Nagahama K,Mizoguchi A,Luster AD,Xavier RJ

更新日期：2009-01-01 00:00:00

abstract：:B cells from bursa of Fabricius of newly hatched chickens are able to reconstitute the B cell compartment of chemically bursectomized chickens. The resulting B cell chimerism can be detected with monoclonal antibodies against donor B cell alloantigen. Chimeric chickens accept donor-type skin grafts and are unresponsiv...

journal_title：European journal of immunology

authors： Lehtonen L,Vainio O,Veromaa T,Toivanen P

更新日期：1989-03-01 00:00:00

abstract：:Biochemical and functional studies have demonstrated major histocompatibility complex (MHC) class II-restricted presentation of peptides derived from cytosolic proteins, but the underlying processing and presentation pathways have remained elusive. Here we show that endogenous presentation of an epitope derived from t...

journal_title：European journal of immunology

authors： Nimmerjahn F,Milosevic S,Behrends U,Jaffee EM,Pardoll DM,Bornkamm GW,Mautner J

更新日期：2003-05-01 00:00:00

abstract：:Dendritic cells expanded from mouse bone marrow (BMDC) with granulocyte/macrophage-colony-stimulating factor have potent T cell-stimulatory properties both in vitro and in vivo. This has been well documented for major histocompatibility complex (MHC) class II-restricted responses, and more recently using peptide-loade...

journal_title：European journal of immunology

authors： Norbury CC,Chambers BJ,Prescott AR,Ljunggren HG,Watts C

更新日期：1997-01-01 00:00:00