Human CD8+ T cell blasts are more sensitive than CD4+ T cell blasts to regulation by APO2L/TRAIL.

abstract：:The in vitro recognition of acetylsalicilyl ovalbumin, penicilloylated bovine IgG (BPO-BGG) and the multichain copolymer poly-L-(Tyr, Glu)-poly-D L-Alapoly-L-Lys [(T, G)-A-L] by primed (2 x 13) F1 cells could be markedly and specifically blocked by alloantisera directed against "receptors" (R) or recognition structure...

journal_title：European journal of immunology

authors： Geczy AF,Geczy CL,de Weck AL

更新日期：1975-10-01 00:00:00

abstract：:Maintenance of homeostasis at body barriers that are constantly challenged by microbes, toxins and potentially bioactive (macro)molecules requires complex, highly orchestrated mechanisms of protection. Recent discoveries in respiratory research have shed light on the unprecedented role of airway epithelial cells (AEC)...

journal_title：European journal of immunology

authors： Smole U,Kratzer B,Pickl WF

更新日期：2020-05-01 00:00:00

abstract：:To evaluate a long peptide-based allergy vaccine in a murine model, CBA/J mice were sensitized with low dose alum-adsorbed phospholipase A2 (PLA2), a major bee venom allergen. Presensitized mice were treated by daily i.p. injections of a mixture of three long overlapping peptides (44- to 60-mer) spanning the entire PL...

journal_title：European journal of immunology

authors： von Garnier C,Astori M,Kettner A,Dufour N,Heusser C,Corradin G,Spertini F

更新日期：2000-06-01 00:00:00

abstract：:Allogeneic bone marrow transplantation in the neonate is an effective way of inducing permanent tolerance to donor tissue. To do the same in the immunocompetent adult requires immunosuppression to counter host-versus-graft alloreactivity. Conditioning with monoclonal antibodies (mAb) to CD4 and CD8 has been sufficient...

journal_title：European journal of immunology

authors： Leong LY,Qin S,Cobbold SP,Waldmann H

更新日期：1992-11-01 00:00:00

abstract：:The effects of vasoactive intestinal peptide (VIP) on human IgA1 and IgA2 production were studied. In unfractionated small resting B cells stimulated with anti-CD40 monoclonal antibody (mAb), VIP induced IgA1 and IgA2 production without affecting the production of IgG1, IgG2, IgG3, IgG4, IgM, or IgE. When small B cell...

journal_title：European journal of immunology

authors： Kimata H,Fujimoto M

更新日期：1994-09-01 00:00:00

abstract：:By stimulating peripheral blood mononuclear cells of four healthy donors with a mixture of overlapping peptides representing the core domain of p53, we established two CD4+ alphabeta T cell clones and four lines that recognized wild-type and mutant p53 proteins as well as p53 self peptides in an HLA class II-restricte...

journal_title：European journal of immunology

authors： Fujita H,Senju S,Yokomizo H,Saya H,Ogawa M,Matsushita S,Nishimura Y

更新日期：1998-01-01 00:00:00

abstract：:Both interleukin-7 (IL-7) and IL-7 receptor (R) gene knockout (IL-7-/- and IL-7R-/-) mice were employed in order to directly investigate the importance of the IL-7 and IL-7R signaling pathway for the development of intestinal intraepithelial lymphocytes (IEL). Loss of the IL-7R-specific gene resulted in complete defic...

journal_title：European journal of immunology

authors： Fujihashi K,McGhee JR,Yamamoto M,Peschon JJ,Kiyono H

更新日期：1997-09-01 00:00:00

abstract：:Antioxidant systems maintain cellular redox homeostasis. The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance. In fact, T lymphocytes critically rely on reducing equivalents from the Trx1 system for DNA biosynthesis during metabolic repr...

journal_title：European journal of immunology

authors： Muri J,Thut H,Heer S,Krueger CC,Bornkamm GW,Bachmann MF,Kopf M

更新日期：2019-05-01 00:00:00

abstract：:We isolated immunoglobulin (Ig) VH4 genes that were rearranged in the genomic DNA of 160 day human fetal spleen. Productively rearranged VH 4-21 genes were cloned into pRTM1, a human IgM expression vector. This allowed us to generate IgM kappa-expressing transfectomas by co-transfecting each of these constructs with p...

journal_title：European journal of immunology

authors： Parr TB,Johnson TA,Silberstein LE,Kipps TJ

更新日期：1994-12-01 00:00:00

abstract：:ME3738 is a new compound that attenuates liver disease in several models of acute and chronic liver inflammation. We used the concanavalin A (Con A) model to elucidate the molecular mechanisms of ME3738 to block liver cell damage. Pretreatment of BALB/c mice with ME3738 prior to Con A injection resulted in a significa...

journal_title：European journal of immunology

authors： Klein C,Wüstefeld T,Heinrich PC,Streetz KL,Manns MP,Trautwein C

更新日期：2003-08-01 00:00:00

abstract：:Monocytes differentiate into dendritic cells (DC) in response to GM-CSF combined with other cytokines including IL-4 and IL-15. Here, we show that IL15-DC are efficient in priming naive CD8+ T cells to differentiate into melanoma antigen-specific cytotoxic T lymphocytes (CTL). While both melanoma peptide-pulsed IL15-D...

journal_title：European journal of immunology

authors： Dubsky P,Saito H,Leogier M,Dantin C,Connolly JE,Banchereau J,Palucka AK

更新日期：2007-06-01 00:00:00

abstract：:A murine monoclonal IgM antibody recognizes an antigen (Mo3e) found on the surface of human peripheral blood monocytes stimulated with phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide and muramyl dipeptide and blocks the monocyte response to migration inhibitory factor (MIF). We utilized Western blot and immu...

journal_title：European journal of immunology

authors： Liu DY,Ree JY,Trochelman RD,Todd RF 3rd

更新日期：1989-04-01 00:00:00

abstract：:Ligand binding to beta1-integrins exerts multiple effects on cells of the immune system including adhesion, spreading, haptotaxis and costimulation of T cells activated by anti-CD3. Here we show that a high-affinity ligand for beta1-integrins, the invasin (Inv) protein of Yersinia pseudotuberculosis, can induce cell d...

journal_title：European journal of immunology

authors： Arencibia I,Frankel G,Sundqvist KG

更新日期：2002-04-01 00:00:00

abstract：:Rapid IgE desensitization provides temporary tolerization for patients who have presented severe hypersensitivity reactions to food and drugs, protecting them from anaphylaxis, but the underlying mechanisms are still incompletely understood. Thus, here we develop an effective and reproducible in vitro model of rapid I...

journal_title：European journal of immunology

authors： Sancho-Serra Mdel C,Simarro M,Castells M

更新日期：2011-04-01 00:00:00

abstract：:Because of their plasticity and central role in orchestrating immunity and tolerance, DCs can respond to pregnancy-specific signals, thus promoting the appropriate immune response in order to support pregnancy. Here, we show that pregnancy-specific glycoprotein (PSG1a), the major variant of PSG released into the circu...

journal_title：European journal of immunology

authors： Martínez FF,Knubel CP,Sánchez MC,Cervi L,Motrán CC

更新日期：2012-06-01 00:00:00

abstract：:Since the discovery of antibody-producing B cells in chickens six decades ago, chickens have been a model for B-cell development in gut-associated lymphoid tissue species. Here we describe targeting of the immunoglobulin light chain locus by homologous recombination in chicken primordial germ cells (PGCs) and generati...

journal_title：European journal of immunology

authors： Schusser B,Collarini EJ,Pedersen D,Yi H,Ching K,Izquierdo S,Thoma T,Lettmann S,Kaspers B,Etches RJ,van de Lavoir MC,Harriman W,Leighton PA

更新日期：2016-09-01 00:00:00

abstract：:The transfer of maternal antibodies to the offspring and their inhibitory effects on active infant immunization is an important factor hampering the use of certain vaccines, such as measles or respiratory syncytial virus vaccine, in early infancy. The resulting delay in protection by conventional or novel vaccines may...

journal_title：European journal of immunology

authors： Siegrist CA,Barrios C,Martinez X,Brandt C,Berney M,Córdova M,Kovarik J,Lambert PH

更新日期：1998-12-01 00:00:00

abstract：:Acute P. falciparum malaria is associated with loss of in vitro T cell responsiveness to antigenic stimulation, and with high plasma levels of soluble interleukin 2 receptor (IL 2R). In the present study peripheral T cells from acute P. falciparum malaria patients from a malaria-endemic area of Sudan were analyzed for...

journal_title：European journal of immunology

authors： Hviid L,Theander TG,Abdulhadi NH,Abu-Zeid YA,Bayoumi RA,Jensen JB

更新日期：1991-05-01 00:00:00

abstract：:Plasmid cassette-transfer vectors pBHuC chi and pBHuC gamma l have been designed which enable the construction of recombinant baculoviruses directing the co-expression of complete immunoglobulin in insect cells. We describe the application of these vectors for the expression of a human/mouse chimeric monoclonal antibo...

journal_title：European journal of immunology

authors： Poul MA,Cerutti M,Chaabihi H,Ticchioni M,Deramoudt FX,Bernard A,Devauchelle G,Kaczorek M,Lefranc MP

更新日期：1995-07-01 00:00:00

abstract：:Dendritic cells (DC) play an essential role in the induction of primary immune responses; however, very little information is available on cytokine production by DC. Here we determined the cytokine gene expression profile of two immortalized DC clones, CB1 and D2SC/1, both generated from mouse spleen but differing in ...

journal_title：European journal of immunology

authors： Granucci F,Girolomoni G,Lutz MB,Foti M,Marconi G,Gnocchi P,Nolli L,Ricciardi-Castagnoli P

更新日期：1994-10-01 00:00:00

abstract：:The activation requirements for antigen-dependent proliferation of CD4+ T cells are well documented, while the events leading to the inactivation phase are poorly understood. Here, we tested the hypothesis that the lymphocyte-activation gene 3 (LAG-3), a second major histocompatibility complex (MHC) class II ligand, p...

journal_title：European journal of immunology

authors： Huard B,Tournier M,Hercend T,Triebel F,Faure F

更新日期：1994-12-01 00:00:00

abstract：:Humanized BALB/c mice (termed trimera mice) conditioned by lethal total body irradiation and bone marrow transplantation from SCID mice have been described to support rapid engraftment of human peripheral blood mononuclear cells (PBMC) and the induction of strong B and T cell responses after immunization in vivo. More...

journal_title：European journal of immunology

authors： Böcher WO,Dekel B,Schwerin W,Geissler M,Hoffmann S,Rohwer A,Arditti F,Cooper A,Bernhard H,Berrebi A,Rose-John S,Shaul Y,Galle PR,Löhr HF,Reisner Y

更新日期：2001-07-01 00:00:00

abstract：:Heterologous adenovirus-based vectors hold promise as preventative HIV vaccines but their capacity to induce effective T-cell immunity in established infection has not been explored. We vaccinated rhesus macaques chronically infected with SIVmac251 and undergoing antiretroviral therapy (ART) with human adenovirus sero...

journal_title：European journal of immunology

authors： Soloff AC,Liu X,Gao W,Day RD,Gambotto A,Barratt-Boyes SM

更新日期：2009-09-01 00:00:00

abstract：:X-linked agammaglobulinemia (XLA) is a primary immunodeficiency of the B-cell compartment caused by a defective gene encoding for the tyrosine kinase (btk) essential for B cell differentiation. Affected males undergo recurrent pyogenic infections and deficient immunoglobulin production. Peripheral blood T cells from 6...

journal_title：European journal of immunology

authors： Amedei A,Romagnani C,Benagiano M,Azzurri A,Fomia F,Torrente F,Plebani A,D'Elios MM,Del Prete G

更新日期：2001-06-01 00:00:00

abstract：:Double-negative (DN) thymocyte subsets were examined in mice deficient in the CD3 zeta chain (zeta-/-). The HSA+CD44-CD25- subset was found to be missing, and DN thymocytes seemed to differentiate directly from HSA+CD25+CD44- cells to double-positive (DP) cells. When fetal thymic ontogeny was examined, we found a mark...

journal_title：European journal of immunology

authors： Crompton T,Moore M,MacDonald HR,Malissen B

更新日期：1994-08-01 00:00:00

abstract：:The murine monoclonal antibody F23.1 reacts with an allotypic determinant on the beta chain of the T cell receptor expressed by approximately 20% of T helper and cytotoxic T lymphocytes of most common mouse strains. This IgG2a antibody, either in soluble form or covalently coupled to Sepharose beads, can activate rest...

journal_title：European journal of immunology

authors： Staerz UD,Bevan MJ

更新日期：1986-03-01 00:00:00

abstract：:We have studied the role of murine eosinophils as antigen-presenting cells (APC). Eosinophils have several characteristics that support the hypothesis of its function as potential APC: they have phagocytic capacity, express adhesion molecules and major histocompatibility complex (MHC) class II antigens and can produce...

journal_title：European journal of immunology

authors： Del Pozo V,De Andrés B,Martín E,Cárdaba B,Fernández JC,Gallardo S,Tramón P,Leyva-Cobian F,Palomino P,Lahoz C

更新日期：1992-07-01 00:00:00

abstract：:We previously demonstrated that cholera toxin (CT) is highly efficient as a combined carrier and adjuvant for dendritic cell (DC) vaccination, inducing strong Th1-dominated B cell and CD4(+) T cell responses. In this study we show that vaccination with DC pre-pulsed ex vivo with CT-conjugated OVA (OVA-CT) gives rise t...

journal_title：European journal of immunology

authors： Eriksson K,Sun JB,Nordström I,Fredriksson M,Lindblad M,Li BL,Holmgren J

更新日期：2004-05-01 00:00:00

abstract：:In this report, we demonstrate that gp40, a molecule previously shown to be expressed by thymic epithelial cell lines in vitro and by thymic epithelial cells in vivo, is the murine homolog of human Ep-CAM, a calcium-independent homotypic adhesion molecule. gp40 is also expressed at low levels by thymocytes and periphe...

journal_title：European journal of immunology

authors： Nelson AJ,Dunn RJ,Peach R,Aruffo A,Farr AG

更新日期：1996-02-01 00:00:00

abstract：:Interleukin-5 (IL-5) plays a critical role in the pathogenesis of eosinophil-associated allergic disorders, such as asthma. IL-5 may also play a major role in the development of eosinophilia-associated lymphoproliferative disorders caused by human T lymphotropic virus type I (HTLV-I). In this study, we have investigat...

journal_title：European journal of immunology

authors： Li-Weber M,Giaisi M,Krammer PH

更新日期：2001-12-01 00:00:00