Serological analysis of antigen-specific helper factors specific for poly-L(Tyr, Glu)-poly-DLAla--poly-LLys [(T, G)-A--L] and L Glu60-LAla30-LTyr10 (GAT).

abstract：:Recent experimental studies have greatly clarified the function of cell surface molecules in the induction and modulation of T cell responses by antigen-presenting cells (APC). However, the differences in ability to stimulate T cells evident for different types and subpopulations of the same APC, such as dendritic cel...

journal_title：European journal of immunology

authors： Brooke GP,Parsons KR,Howard CJ

更新日期：1998-01-01 00:00:00

abstract：:Chloride intracellular channel (CLIC) 4 has diverse functions in membrane trafficking, apoptosis, angiogenesis and cell differentiation. CLIC4 is abundantly expressed in macrophages, but its role in innate immune functions is unclear. Here, we show that primary murine macrophages express increased amounts of CLIC4 aft...

journal_title：European journal of immunology

authors： He G,Ma Y,Chou SY,Li H,Yang C,Chuang JZ,Sung CH,Ding A

更新日期：2011-05-01 00:00:00

abstract：:TCR degeneracy may facilitate self-reactive T cell activation and the initiation of an autoimmune response in multiple sclerosis (MS). MHC class II alleles of the DR2 haplotype DR2a (DRB5*0101) and DR2b (DRB1*1501) are associated with an increased risk for MS in Caucasian populations. In order to selectively expand an...

journal_title：European journal of immunology

authors： Zhang X,Tang Y,Sujkowska D,Wang J,Ramgolam V,Sospedra M,Adams J,Martin R,Pinilla C,Markovic-Plese S

更新日期：2008-05-01 00:00:00

abstract：:BALB/c mice were repeatedly immunized with microgram doses of benzylpenicilloylated Ascaris protein(s) (BPO9Asc) in alum. At different stages of the immune response, BPO21 eicosa-L-lysine or two analogs containing one or two hydrophobic p-oxymethylbenzyl-3 beta-cholestanyl succinate (OSuco) groups were injected. When ...

journal_title：European journal of immunology

authors： Lüscher IF,Weber E,de Weck AL

更新日期：1984-01-01 00:00:00

abstract：:It has been reported that the 45-kDa low-affinity Fc epsilon receptor (Fc epsilon RII) on B cells is cleaved spontaneously from the cell surface to release soluble fragments. This study demonstrates an additional fate of the Fc epsilon RII. 125I-labeled CD23+ B cells were cultured for 24 h at 37 degrees C. After lysis...

journal_title：European journal of immunology

authors： Grenier-Brossette N,Bourget I,Akoundi C,Bonnefoy JY,Cousin JL

更新日期：1992-06-01 00:00:00

abstract：:CBA/N mice have an X-linked immune defect in B lymphocyte function which leads to their inability to respond to several thymus-independent antigens. We report here that these mice and immunologically defective F1 male (CBA/N X DBA/2N) mice can respond to Brucella abortus and to 2,4,6-trinitrophenyl derivatives of Bruc...

journal_title：European journal of immunology

authors： Mond JJ,Scher I,Mosier DE,Baese M,Paul WE

更新日期：1978-07-01 00:00:00

abstract：:Mismatch repair contributes to hypermutation in B lymphocytes, both by increasing the frequency of mutations and by changing the mutational patterns. In this paper, we investigated whether or not mismatch repair influences activation-induced cytidine deaminase (AID)-mediated hypermutation in a non-B lymphocyte line. W...

journal_title：European journal of immunology

authors： Klasen M,Spillmann FJ,Marra G,Cejka P,Wabl M

更新日期：2005-07-01 00:00:00

abstract：:The semi-public T-cell response towards the gluten epitope DQ2.5-glia-α2 uses a prototypic TCR encoded by the germline segments TRAV26-1 and TRBV7-2. Through mutagenesis experiments, we show that a TRAV26-1encoded recognition motif contacts the MHC β-chain and the TCR CDR3β loop underpinning this conserved T-cell resp...

journal_title：European journal of immunology

authors： Frick R,Gunnarsen KS,Dahal-Koirala S,Risnes LF,Sollid LM,Sandlie I,Høydahl LS,Løset GÅ

更新日期：2020-01-01 00:00:00

abstract：:Vaccination of mice with irradiated Schistosoma mansoni larvae confers high levels of immunity which is mediated by Th1-type lymphocytes. To investigate a possible role for IL-12 in the induction of protection, we have compared the immune response of IL-12 p40-deficient (KO) mice and their C57BL/6 (WT) counterparts fo...

journal_title：European journal of immunology

authors： Anderson S,Shires VL,Wilson RA,Mountford AP

更新日期：1998-09-01 00:00:00

abstract：:NKR-P1 is a type II transmembrane protein which acts as an activation receptor on natural killer (NK) cells. The cytoplasmic domains of the CD4, CD8 and 4-1BB receptors contain the sequence Cys-X-Cys-Pro which is directly involved in coupling to another pair of cysteines in the N-terminal domain of the src family tyro...

journal_title：European journal of immunology

authors： Campbell KS,Giorda R

更新日期：1997-01-01 00:00:00

abstract：:Delivery of foreign antigens to mucosal surfaces, such as the pulmonary airways, has been shown to preferentially induce Th2-mediated responses in humans and in mice. What is not clear from these studies is whether this preferential skewing in responses is the result of the limited types of antigen being administered ...

journal_title：European journal of immunology

authors： Constant SL,Lee KS,Bottomly K

更新日期：2000-03-01 00:00:00

abstract：:Intravenous immunoglobulin G (IVIg) therapy is widely used to treat autoimmune and inflammatory diseases. Recent evidence suggests that in mice, splenic resident cells might be important for the anti-inflammatory activity of IVIg in a model of serum transfer arthritis. Splenectomized human immunothrombocytopenia (ITP)...

journal_title：European journal of immunology

authors： Schwab I,Biburger M,Krönke G,Schett G,Nimmerjahn F

更新日期：2012-04-01 00:00:00

abstract：:We have analyzed the relationship between the signaling pathways coupled to surface immunoglobulin and interleukin (IL)-4 receptors in human B cells from the patterns of expression of a panel of phorbol ester-inducible early response genes (ERG) activated by anti-IgM and IL-4 stimulation in vitro. Anti-IgM stimulation...

journal_title：European journal of immunology

authors： Murphy JJ,Norton JD

更新日期：1993-11-01 00:00:00

abstract：:The in vitro recognition of acetylsalicilyl ovalbumin, penicilloylated bovine IgG (BPO-BGG) and the multichain copolymer poly-L-(Tyr, Glu)-poly-D L-Alapoly-L-Lys [(T, G)-A-L] by primed (2 x 13) F1 cells could be markedly and specifically blocked by alloantisera directed against "receptors" (R) or recognition structure...

journal_title：European journal of immunology

authors： Geczy AF,Geczy CL,de Weck AL

更新日期：1975-10-01 00:00:00

abstract：:IL-7 is a major regulator of lymphocyte homeostasis; however, little is known about the mechanisms that regulate IL-7 production. To study Il7 gene regulation in vivo, we generated a novel IL-7-reporter mouse, which allows the non-invasive quantification of Il7 gene activity in live mice and, additionally, the simulta...

journal_title：European journal of immunology

authors： Shalapour S,Deiser K,Sercan O,Tuckermann J,Minnich K,Willimsky G,Blankenstein T,Hämmerling GJ,Arnold B,Schüler T

更新日期：2010-09-01 00:00:00

abstract：:It has long been recognized that T cells in the cerebrospinal fluid (CSF) and other inflammatory compartments cannot be stimulated by mitogen and the reason for this has remained unknown. This question was investigated using mononuclear cells (MNC) isolated from the CSF of subjects with multiple sclerosis and other in...

journal_title：European journal of immunology

authors： Chofflon M,González V,Weiner HL,Hafler DA

更新日期：1989-10-01 00:00:00

abstract：:Analysis of mice transgenic for immunoglobulin genes should allow definition of the cis-acting DNA sequences required to target somatic mutation to antibody V genes. We have looked for mutations in a chimeric kappa transgene encoding a V region specific for the hapten 2-phenyloxazolone (phOx) linked to a rat C kappa g...

journal_title：European journal of immunology

authors： Sharpe MJ,Neuberger M,Pannell R,Surani MA,Milstein C

更新日期：1990-06-01 00:00:00

abstract：:Dendritic cells (DC) are the main orchestrators of specific immune responses. Depending on microbial information they encounter in peripheral tissues, they promote the development of Th1, Th2 or unpolarized Th cell responses. In this study we have investigated the immunomodulatory effect of non-pathogenic intestinal G...

journal_title：European journal of immunology

authors： Smits HH,van Beelen AJ,Hessle C,Westland R,de Jong E,Soeteman E,Wold A,Wierenga EA,Kapsenberg ML

更新日期：2004-05-01 00:00:00

abstract：:Antisera were prepared in rabbits against the idiotypic (Id) determinants of antiallergen antibodies. These antibodies were isolated from the plasma of 10 unrelated patients by immunoabsorption. Three major allergens isolated from the house dust mite, Dermatophagoides pteronyssinus (DPT), were used. The anti-Id antise...

journal_title：European journal of immunology

authors： Saint-Remy JM,Lebrun PM,Lebecque SJ,Masson PL

更新日期：1986-05-01 00:00:00

abstract：:Pre-B cells which show a delayed development of responsiveness to the B cell mitogen lipopolysaccharide (LPS) are found in murine embryonic blood between day 10 and 14 of gestation. The highest frequency of pre-B cells in embryonic blood is found at day 12 of gestation. All pre-B cells of embryonic blood, isolated at ...

journal_title：European journal of immunology

authors： Melchers F,Abramczuk J

更新日期：1980-10-01 00:00:00

abstract：:We investigated here the potential role of Toll-like receptors (TLR) and the adaptor protein MyD88 in innate immunity responses to Cryptococcus neoformans, a pathogenic encapsulated yeast. Peritoneal macrophages from MyD88(-/-) or TLR2(-/-) mice released significantly less TNF-alpha, compared with wild-type controls, ...

journal_title：European journal of immunology

authors： Biondo C,Midiri A,Messina L,Tomasello F,Garufi G,Catania MR,Bombaci M,Beninati C,Teti G,Mancuso G

更新日期：2005-03-01 00:00:00

abstract：:The cytokine interleukin 1 (IL 1) plays an important role in the induction of IL 2 secretion and high-affinity IL 2 receptor (IL 2R) expression by T cells. The events that follow binding of IL 1 to IL 1R, however, are still unknown. In this study we describe two variants of the murine thymoma EL4 (5D3 and D6/76) that ...

journal_title：European journal of immunology

authors： Von Hoegen I,Falk W,Kojouharoff G,Krammer PH

更新日期：1989-02-01 00:00:00

abstract：:Soluble anti-immunoglobulin (Ig) antibodies have been generally found to inhibit Ig secretion in B cells, via largely unknown mechanisms. To investigate this phenomenon further a two-step culture system was used in which B cells are primed for 24-72 h with various soluble monoclonal or polyclonal anti-Ig antibodies: a...

journal_title：European journal of immunology

authors： Phillips C,Klaus GG

更新日期：1992-06-01 00:00:00

abstract：:B cell-activating factor belonging to the TNF family (BAFF) and its receptor BAFF-R play critical roles in the maturation and survival of conventional peripheral B cells. However, they appeared to be dispensable for the generation and maintenance of CD5(+) B-1 cells as BAFF(-/-) and BAFF-R(-/-) mice have normal B-1 ce...

journal_title：European journal of immunology

authors： Ng LG,Ng CH,Woehl B,Sutherland AP,Huo J,Xu S,Mackay F,Lam KP

更新日期：2006-07-01 00:00:00

abstract：:Recent studies have shown that in humans the germinal center reactions produce three types of V(D)J mutated B cells in similar proportions, i.e. Ig-switched, IgD-IgM+ (IgM-only) and IgD+IgM+ cells, and that together they form the CD27+ compartment of recirculating B cells. We investigated the Ig isotype switch capacit...

journal_title：European journal of immunology

authors： Werner-Favre C,Bovia F,Schneider P,Holler N,Barnet M,Kindler V,Tschopp J,Zubler RH

更新日期：2001-01-01 00:00:00

abstract：:To investigate the role of membrane lymphotoxin (LT)alpha1 / beta2 and its LTbeta receptor (LTbetaR) in the protective immune response to Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection, we have used a soluble fusion molecule (LTbetaR-IgG1). LTbetaR-Ig treatment interferes with granuloma formation mainly ...

journal_title：European journal of immunology

authors： Lucas R,Tacchini-Cottier F,Guler R,Vesin D,Jemelin S,Olleros ML,Marchal G,Browning JL,Vassalli P,Garcia I

更新日期：1999-12-01 00:00:00

abstract：:We have previously reported the development of a two-step culture system in which soluble anti-mu monoclonal antibodies prime small resting murine B cells to secrete immunoglobulin (Ig) in response to restimulation with a mixture of interleukin-4 (IL-4) and IL-5. Here we have extended these studies to investigate the ...

journal_title：European journal of immunology

authors： Phillips C,Klaus GG

更新日期：1993-02-01 00:00:00

abstract：:We have established IgG rheumatoid factor (RF)-secreting hybridoma cell lines from the synovial tissues of three patients from whom we have previously characterized several IgM RF. The IgG RF bind human and rabbit IgG and form intracellular complement-fixing complexes indicative of a self association process in vivo. ...

journal_title：European journal of immunology

authors： Randen I,Pascual V,Victor K,Thompson KM,Førre O,Capra JD,Natvig JB

更新日期：1993-06-01 00:00:00

abstract：:The murine X-linked lymphoproliferative disease scurfy is similar to the Wiskott-Aldrich syndrome in humans. Disease in scurfy (sf) mice is mediated by CD4+ T cells. Based on similarities in scurfy mice and transgenic mice that overexpress specific cytokine genes, we evaluated the expression of cytokines in the lesion...

journal_title：European journal of immunology

authors： Kanangat S,Blair P,Reddy R,Daheshia M,Godfrey V,Rouse BT,Wilkinson E

更新日期：1996-01-01 00:00:00

abstract：:Glucopyranosyl lipid adjuvant-stable emulsion (GLA-SE) is a synthetic adjuvant TLR4 agonist that promotes potent poly-functional T(H)1 responses. Different TLR4 agonists may preferentially signal via MyD88 or TIR-domain-containing adapter inducing IFN-beta (TRIF) to exert adjuvant effects; however, the contribution of...

journal_title：European journal of immunology

authors： Orr MT,Duthie MS,Windish HP,Lucas EA,Guderian JA,Hudson TE,Shaverdian N,O'Donnell J,Desbien AL,Reed SG,Coler RN

更新日期：2013-09-01 00:00:00