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The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression.

Abstract：

:The DNA damage response (DDR) pathway's primary purpose is to maintain the genome structure's integrity and stability. A great deal of effort has done to understand the exact molecular mechanisms of non-coding RNAs, such as lncRNA, miRNAs, and circRNAs, in distinct cellular and genomic processes and cancer progression. In this regard, the ncRNAs possible regulatory role in DDR via modulation of key components expression and controlling repair signaling pathway activation is validated. Therefore, in this article, we will discuss the latest developments of ncRNAs contribution in different aspects of DNA repair through regulation of ATM-ATR, P53, and other regulatory signaling pathways.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Malakoti F,Alemi F,Younesi S,Majidinia M,Yousefi B,Morovat P,Khelghati N,Maleki M,Karimian A,Asemi Z

doi

10.1016/j.dnarep.2020.103036

subject

Has Abstract

pub_date

2021-01-07 00:00:00

pages

103036

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(20)30296-2

journal_volume

98

pub_type

杂志文章

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