当前位置： SCI文献检索 > DNA REPAIR期刊下所有文献 > Regulation of GLI1 by cis DNA elements and epigenetic marks.

Regulation of GLI1 by cis DNA elements and epigenetic marks.

Abstract：

:GLI1 is one of three transcription factors (GLI1, GLI2 and GLI3) that mediate the Hedgehog signal transduction pathway and play important roles in normal development. GLI1 and GLI2 form a positive-feedback loop and function as human oncogenes. The mouse and human GLI1 genes have untranslated 5' exons and large introns 5' of the translational start. Here we show that Sonic Hedgehog (SHH) stimulates occupancy in the introns by H3K27ac, H3K4me3 and the histone reader protein BRD4. H3K27ac and H3K4me3 occupancy is not significantly changed by removing BRD4 from the human intron and transcription start site (TSS) region. We identified six GLI binding sites (GBS) in the first intron of the human GLI1 gene that are in regions of high sequence conservation among mammals. GLI1 and GLI2 bind all of the GBS in vitro. Elimination of GBS1 and 4 attenuates transcriptional activation by GLI1. Elimination of GBS1, 2, and 4 attenuates transcriptional activation by GLI2. Eliminating all sites essentially eliminates reporter gene activation. Further, GLI1 binds the histone variant H2A.Z. These results suggest that GLI1 and GLI2 can regulate GLI1 expression through protein-protein interactions involving complexes of transcription factors, histone variants, and reader proteins in the regulatory intron of the GLI1 gene. GLI1 acting in trans on the GLI1 intron provides a mechanism for GLI1 positive feedback and auto-regulation. Understanding the combinatorial protein landscape in this locus will be important to interrupting the GLI positive feedback loop and providing new therapeutic approaches to cancers associated with GLI1 overexpression.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Taylor R,Long J,Yoon JW,Childs R,Sylvestersen KB,Nielsen ML,Leong KF,Iannaccone S,Walterhouse DO,Robbins DJ,Iannaccone P

doi

10.1016/j.dnarep.2019.04.011

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

10-21

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(18)30334-3

journal_volume

79

pub_type

杂志文章

相关文献

DNA REPAIR文献大全
  • Pyrosequencing for the quantitative assessment of 8-oxodG bypass DNA synthesis.

    abstract：:Translesion synthesis (TLS) with specialized DNA polymerases allows dealing with a base lesion on the template strand during DNA replication; a base is inserted opposite the lesion, correctly or incorrectly, depending on the lesion, the involved DNA polymerase(s) and the sequence context. The major oxidized DNA base 8...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2014.08.002

    authors： Nachtergael A,Belayew A,Duez P

    更新日期：2014-10-01 00:00:00

  • Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development.

    abstract：:DNA replication is a prerequisite for cell proliferation, yet it can be increasingly challenging for a eukaryotic cell to faithfully duplicate its genome as its size and complexity expands. Dormant origins now emerge as a key component for cells to successfully accomplish such a demanding but essential task. In this p...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2017.06.019

    authors： Shima N,Pederson KD

    更新日期：2017-08-01 00:00:00

  • Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast.

    abstract：:Non-B DNA structures are a major contributor to the genomic instability associated with repetitive sequences. Immunoglobulin switch Mu (Sμ) region sequence is comprised of guanine-rich repeats and has high potential for forming G4 DNA, in which one strand of DNA folds into an array of guanine quartets. Taking advantag...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2011.07.002

    authors： Kim N,Jinks-Robertson S

    更新日期：2011-09-05 00:00:00

  • Polk mutant mice have a spontaneous mutator phenotype.

    abstract：:Mice defective for the Polk gene, which encodes DNA polymerase kappa, are viable and do not manifest obvious phenotypes. The present studies document a spontaneous mutator phenotype in Polk(-/-) mice. The initial indication of enhanced spontaneous mutations in these mice came from the serendipitous observation of a po...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2009.09.003

    authors： Stancel JN,McDaniel LD,Velasco S,Richardson J,Guo C,Friedberg EC

    更新日期：2009-12-03 00:00:00

  • Unraveling secrets of telomeres: one molecule at a time.

    abstract：:Telomeres play important roles in maintaining the stability of linear chromosomes. Telomere maintenance involves dynamic actions of multiple proteins interacting with long repetitive sequences and complex dynamic DNA structures, such as G-quadruplexes, T-loops and t-circles. Given the heterogeneity and complexity of t...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2014.01.012

    authors： Lin J,Kaur P,Countryman P,Opresko PL,Wang H

    更新日期：2014-08-01 00:00:00

  • Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2.

    abstract：:In higher eukaryotes DNA double strand breaks (DSBs) are repaired by homologous recombination (HRR) or non-homologous end joining (NHEJ). In addition to the DNA-PK dependent pathway of NHEJ (D-NHEJ), cells employ a backup pathway (B-NHEJ) utilizing Ligase III and PARP-1. The cell cycle dependence and coordination of t...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2007.11.008

    authors： Wu W,Wang M,Wu W,Singh SK,Mussfeldt T,Iliakis G

    更新日期：2008-02-01 00:00:00

  • A PIAS-ed view of DNA double strand break repair focuses on SUMO.

    abstract：:Through the action of multiple sensors, mediators, and effectors, the DNA damage response (DDR) orchestrates the repair of DNA damage to ensure maintenance of genomic integrity. Recently, in addition to phosphorylation, other post-translational modifications such as ubiquitylation and SUMOylation have emerged as impor...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2010.02.003

    authors： Zlatanou A,Stewart GS

    更新日期：2010-05-04 00:00:00

  • Replication stalling and heteroduplex formation within CAG/CTG trinucleotide repeats by mismatch repair.

    abstract：:Trinucleotide repeat expansions are responsible for at least two dozen neurological disorders. Mechanisms leading to these large expansions of repeated DNA are still poorly understood. It was proposed that transient stalling of the replication fork by the repeat tract might trigger slippage of the newly-synthesized st...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2016.03.002

    authors： Viterbo D,Michoud G,Mosbach V,Dujon B,Richard GF

    更新日期：2016-06-01 00:00:00

  • Ultra-violet light induced changes in DNA dynamics may enhance TT-dimer recognition.

    abstract：:Short-wave ultra-violet light promotes the formation of DNA dimers between adjacent thymine bases, and if unrepaired these dimers may induce skin cancer. Living cells have a very robust repair system capable of repairing hundreds of lesions every day. Although many of the details of the dimer repair mechanism are know...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2006.04.007

    authors： Blagoev KB,Alexandrov BS,Goodwin EH,Bishop AR

    更新日期：2006-07-13 00:00:00

  • Rothmund-Thomson syndrome helicase, RECQ4: on the crossroad between DNA replication and repair.

    abstract：:RECQ proteins are conserved DNA helicases in both prokaryotes and eukaryotes. The importance of the RECQ family helicases in human health is demonstrated by their roles as cancer suppressors that are vital for preserving genome integrity. Mutations in one of the RECQ family proteins, RECQ4, not only result in developm...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2010.01.006

    authors： Liu Y

    更新日期：2010-03-02 00:00:00

  • Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes.

    abstract：:Multiple DNA polymerases participate in somatic hypermutation of immunoglobulin (Ig) genes. Mutations at A/T are largely dependent on DNA polymerase eta (POLH) whereas mutations at C/G appear to be generated by several DNA polymerases. We have previously shown that mice expressing a catalytically inactive POLQ (Polq-i...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2006.06.006

    authors： Masuda K,Ouchida R,Hikida M,Nakayama M,Ohara O,Kurosaki T,O-Wang J

    更新日期：2006-11-08 00:00:00

  • Poetry in motion: Increased chromosomal mobility after DNA damage.

    abstract：:Double-strand breaks (DSBs) are among the most lethal DNA lesions, and a variety of pathways have evolved to manage their repair in a timely fashion. One such pathway is homologous recombination (HR), in which information from an undamaged donor site is used as a template for repair. Although many of the biochemical s...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2017.06.012

    authors： Smith MJ,Rothstein R

    更新日期：2017-08-01 00:00:00

  • CtIP: A DNA damage response protein at the intersection of DNA metabolism.

    abstract：:The mammalian CtIP protein and its orthologs in other eukaryotes promote the resection of DNA double-strand breaks and are essential for meiotic recombination. Here we review the current literature supporting the role of CtIP in DNA end processing and the importance of CtIP endonuclease activity in DNA repair. We also...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2015.04.016

    authors： Makharashvili N,Paull TT

    更新日期：2015-08-01 00:00:00

  • Mutations, protein homeostasis, and epigenetic control of genome integrity.

    abstract：:From bacteria to humans, ancient stress responses enable organisms to contend with damage to both the genome and the proteome. These pathways have long been viewed as fundamentally separate responses. Yet recent discoveries from multiple fields have revealed surprising links between the two. Many DNA-damaging agents a...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2018.08.004

    authors： Xie JL,Jarosz DF

    更新日期：2018-11-01 00:00:00

  • Current role of mammalian sirtuins in DNA repair.

    abstract：:Cellular DNA is constantly challenged by damage-inducing factors derived from exogenous or endogenous sources. Thus, to protect against DNA damage, cells have evolved complex and finely regulated mechanisms collectively known as DNA-damage response (DDR). However, DNA repair in eukaryotes does not occur merely in nake...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2019.06.009

    authors： Lagunas-Rangel FA

    更新日期：2019-08-01 00:00:00

  • Recruitment and retention dynamics of RECQL5 at DNA double strand break sites.

    abstract：:RECQL5 is one of the five human RecQ helicases, involved in the maintenance of genomic integrity. While much insight has been gained into the function of the Werner (WRN) and Bloom syndrome proteins (BLM), little is known about RECQL5. We have analyzed the recruitment and retention dynamics of RECQL5 at laser-induced ...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2012.05.001

    authors： Popuri V,Ramamoorthy M,Tadokoro T,Singh DK,Karmakar P,Croteau DL,Bohr VA

    更新日期：2012-07-01 00:00:00

  • MGMT inhibitors--The Trinity College-Paterson Institute experience, a chemist's perception.

    abstract：:The DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase (MGMT) can confer resistance to the cancer chemotherapeutic effects of the class of DNA damaging drugs generally referred to as the O(6)-alkylating agents. Inactivation of MGMT is thus a practical approach to improving the efficacy of such agents. An accou...

    journal_title：DNA repair

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.dnarep.2007.03.015

    authors： McMurry TB

    更新日期：2007-08-01 00:00:00

  • Apex1 can cleave complex clustered DNA lesions in cells.

    abstract：:Current data indicate that clustered DNA damage generated by ionizing radiation contains 2-5 damages within 20 bps. The complexity of clustered damage is also believed to increase as the linear energy transfer of the radiation increases. Complex lesions are therefore biologically relevant especially with the use of ca...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2009.08.008

    authors： Malyarchuk S,Castore R,Harrison L

    更新日期：2009-12-03 00:00:00

  • Biochemical mapping of human NEIL1 DNA glycosylase and AP lyase activities.

    abstract：:Base excision repair of oxidized DNA in human cells is initiated by several DNA glycosylases with overlapping substrate specificity. The human endonuclease VIII homologue NEIL1 removes a broad spectrum of oxidized pyrimidine and purine lesions. In this study of NEIL1 we have identified several key residues, located in...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2012.07.002

    authors： Vik ES,Alseth I,Forsbring M,Helle IH,Morland I,Luna L,Bjørås M,Dalhus B

    更新日期：2012-09-01 00:00:00

  • Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1.

    abstract：:In male germ cells the repair of DNA double strand breaks (DSBs) differs from that described for somatic cell lines. Irradiation induced immunofluorescent foci (IRIF's) signifying a double strand DNA breaks, were followed in spermatogenic cells up to 16 h after the insult. Foci were characterised for Mdc1, 53BP1 and R...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2007.02.011

    authors： Ahmed EA,van der Vaart A,Barten A,Kal HB,Chen J,Lou Z,Minter-Dykhouse K,Bartkova J,Bartek J,de Boer P,de Rooij DG

    更新日期：2007-09-01 00:00:00

  • Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase.

    abstract：:Thymidylate deprivation brings about "thymineless death" in prokaryotes and eukaryotes. Although the precise mechanism for thymineless death has remained elusive, inhibition of the enzyme thymidylate synthase (TS), which catalyzes the de novo synthesis of TMP, has served for many years as a basis for chemotherapeutic ...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2008.06.006

    authors： Waldman BC,Wang Y,Kilaru K,Yang Z,Bhasin A,Wyatt MD,Waldman AS

    更新日期：2008-10-01 00:00:00

  • RAD51D protects against MLH1-dependent cytotoxic responses to O(6)-methylguanine.

    abstract：:S(N)1-type methylating agents generate O(6)-methyl guanine (O(6)-meG), which is a potently mutagenic, toxic, and recombinogenic DNA adduct. Recognition of O(6)-meG:T mismatches by mismatch repair (MMR) causes sister chromatid exchanges, which are representative of homologous recombination (HR) events. Although the MMR...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2010.01.009

    authors： Rajesh P,Rajesh C,Wyatt MD,Pittman DL

    更新日期：2010-04-04 00:00:00

  • The involvement of key DNA repair pathways in the formation of chromosome rearrangements in embryonic stem cells.

    abstract：:It is vital that embryonic stem (ES) cells, which give rise to the diverse tissues of the mature organism, maintain genetic stability. To understand mechanisms for the prevention and causation of chromosomal instability, we have used spectral karyotyping (SKY) to analyse ES cells from wild-type and repair-gene knockou...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2005.05.005

    authors： Griffin C,Waard Hd,Deans B,Thacker J

    更新日期：2005-08-15 00:00:00

  • Constitutive and regulated expression of the mouse Dinb (Polkappa) gene encoding DNA polymerase kappa.

    abstract：:A recently discovered group of novel polymerases are characterized by significantly reduced fidelity of DNA synthesis in vitro. This feature is consistent with the relaxed fidelity required for the replicative bypass of various types of base damage that frequently block high fidelity replicative polymerases. The prese...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/s1568-7864(02)00189-1

    authors： Velasco-Miguel S,Richardson JA,Gerlach VL,Lai WC,Gao T,Russell LD,Hladik CL,White CL,Friedberg EC

    更新日期：2003-01-02 00:00:00

  • Developmental retinal apoptosis in Ku86-/- mice.

    abstract：:The nonhomologous DNA end-joining pathway (NHEJ), a major pathway for repairing DNA double-strand breaks (DSBs), is essential for maintaining genomic stability. Knockout animals for components in this pathway demonstrate a distinct pattern of cell death in the developing brain. Here we demonstrate that cell death is a...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2003.08.011

    authors： Karanjawala ZE,Hinton DR,Oh E,Hsieh CL,Lieber MR

    更新日期：2003-12-09 00:00:00

  • Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation.

    abstract：:In budding yeast, the Rad9 protein is an important player in the maintenance of genomic integrity and has a well-characterised role in DNA damage checkpoint activation. Recently, roles for different post-translational histone modifications in the DNA damage response, including H2A serine 129 phosphorylation and H3 lys...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2006.03.005

    authors： Toh GW,O'Shaughnessy AM,Jimeno S,Dobbie IM,Grenon M,Maffini S,O'Rorke A,Lowndes NF

    更新日期：2006-06-10 00:00:00

  • The splicing component ISY1 regulates APE1 in base excision repair.

    abstract：:The integrity of cellular genome is continuously challenged by endogenous and exogenous DNA damaging agents. If DNA damage is not removed in a timely fashion the replisome may stall at DNA lesions, causing fork collapse and genetic instability. Base excision DNA repair (BER) is the most important pathway for the remov...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2019.102769

    authors： Jaiswal AS,Williamson EA,Srinivasan G,Kong K,Lomelino CL,McKenna R,Walter C,Sung P,Narayan S,Hromas R

    更新日期：2020-02-01 00:00:00

  • Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ.

    abstract：:Lagging strand DNA replication requires the concerted actions of DNA polymerase δ, Fen1 and DNA ligase I for the removal of the RNA/DNA primers before ligation of Okazaki fragments. To better understand this process in human cells, we have reconstituted Okazaki fragment processing by the short flap pathway in vitro wi...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2013.08.008

    authors： Lin SH,Wang X,Zhang S,Zhang Z,Lee EY,Lee MY

    更新日期：2013-11-01 00:00:00

  • The involvement of non-B DNA structures in gross chromosomal rearrangements.

    abstract：:Non-B DNA conformations adopted by certain types of DNA sequences promote genetic instabilities, especially gross rearrangements including translocations. We conclude the following: (a) slipped (hairpin) structures, cruciforms, triplexes, tetraplexes and i-motifs, and left-handed Z-DNA are formed in chromosomes and el...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2006.05.032

    authors： Bacolla A,Wojciechowska M,Kosmider B,Larson JE,Wells RD

    更新日期：2006-09-08 00:00:00

  • DNA decay and limited Rad53 activation after liquid holding of UV-treated nucleotide excision repair deficient S. cerevisiae cells.

    abstract：:The DNA damage checkpoint is a surveillance mechanism activated by DNA lesions and devoted to the maintenance of genome stability. It is considered as a signal transduction cascade, involving a sensing step, the activation of a set of protein kinases and the transmission and amplification of the damage signal through ...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2004.06.019

    authors： Giannattasio M,Lazzaro F,Siede W,Nunes E,Plevani P,Muzi-Falconi M

    更新日期：2004-12-02 00:00:00