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CtIP: A DNA damage response protein at the intersection of DNA metabolism.

Abstract：

:The mammalian CtIP protein and its orthologs in other eukaryotes promote the resection of DNA double-strand breaks and are essential for meiotic recombination. Here we review the current literature supporting the role of CtIP in DNA end processing and the importance of CtIP endonuclease activity in DNA repair. We also examine the regulation of CtIP function by post-translational modifications, and its involvement in transcription- and replication-dependent functions through association with other protein complexes. The tumor suppressor function of CtIP likely is dependent on a combination of these roles in many aspects of DNA metabolism.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Makharashvili N,Paull TT

doi

10.1016/j.dnarep.2015.04.016

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

75-81

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(15)00108-1

journal_volume

32

pub_type

杂志文章,评审

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