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Biochemical reconstitution and genetic characterization of the major oxidative damage base excision DNA repair pathway in Thermococcus kodakarensis.

Abstract：

:Reactive oxygen species drive the oxidation of guanine to 8-oxoguanine (8oxoG), which threatens genome integrity. The repair of 8oxoG is carried out by base excision repair enzymes in Bacteria and Eukarya, however, little is known about archaeal 8oxoG repair. This study identifies a member of the Ogg-subfamily archaeal GO glycosylase (AGOG) in Thermococcus kodakarensis, an anaerobic, hyperthermophilic archaeon, and delineates its mechanism, kinetics, and substrate specificity. TkoAGOG is the major 8oxoG glycosylase in T. kodakarensis, but is non-essential. In addition to TkoAGOG, the major apurinic/apyrimidinic (AP) endonuclease (TkoEndoIV) required for archaeal base excision repair and cell viability was identified and characterized. Enzymes required for the archaeal oxidative damage base excision repair pathway were identified and the complete pathway was reconstituted. This study illustrates the conservation of oxidative damage repair across all Domains of life.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Gehring AM,Zatopek KM,Burkhart BW,Potapov V,Santangelo TJ,Gardner AF

doi

10.1016/j.dnarep.2019.102767

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

102767

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(19)30300-3

journal_volume

86

pub_type

杂志文章

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