The Rad52-Rad59 complex interacts with Rad51 and replication protein A.

abstract：:DNA replication is a prerequisite for cell proliferation, yet it can be increasingly challenging for a eukaryotic cell to faithfully duplicate its genome as its size and complexity expands. Dormant origins now emerge as a key component for cells to successfully accomplish such a demanding but essential task. In this p...

journal_title：DNA repair

authors： Shima N,Pederson KD

更新日期：2017-08-01 00:00:00

abstract：:In eukaryotic cells, DNA associates with histones and exists in the form of a chromatin hierarchy. Thus, it is generally believed that many eukaryotic cellular DNA processing events such as replication, transcription, recombination and DNA repair are influenced by the packaging of DNA into chromatin. This mini-review ...

journal_title：DNA repair

authors： Liu X

更新日期：2015-12-01 00:00:00

abstract：:Regulation of the vertebrate checkpoint kinase Chk1 involves several protein complexes including the recently identified protein Claspin. Claspin associates with Chk1 upon replication stress and DNA damage and is required for Chk1 activation in both Xenopus and human systems. More importantly, Claspin is involved in r...

journal_title：DNA repair

authors： Chini CC,Chen J

更新日期：2004-08-01 00:00:00

abstract：:Nucleotide excision repair (NER) acts on a variety of DNA lesions, including damage induced by many chemotherapeutic drugs. Cancer therapy with such drugs might be improved by reducing the NER capacity of tumors. It is not known, however to what extent any individual NER protein is rate-limiting for any step of the re...

journal_title：DNA repair

authors： Köberle B,Roginskaya V,Wood RD

更新日期：2006-05-10 00:00:00

abstract：:Cells carrying deletions of genes encoding H-class ribonucleases display elevated rates of chromosome instability. The role of these enzymes is to remove RNA-DNA associations including persistent mRNA-DNA hybrids (R-loops) formed during transcription, and ribonucleotides incorporated into DNA during replication. RNase...

journal_title：DNA repair

authors： Cornelio DA,Sedam HN,Ferrarezi JA,Sampaio NM,Argueso JL

更新日期：2017-04-01 00:00:00

abstract：:Prediabetes is the preclinical stage of type 2 diabetes mellitus (T2DM) with intermediate state of hyperglycemia. Hyperglycemia results in a state of oxidative stress, which may contribute to the production of insulin resistance, β-cell dysfunction and long-term complications of diabetes. Novel approaches are required...

journal_title：DNA repair

authors： Kant M,Akış M,Çalan M,Arkan T,Bayraktar F,Dizdaroglu M,İşlekel H

更新日期：2016-12-01 00:00:00

abstract：:The proximity of the mitochondrial genome to the respiratory chain, a major source of ROS (radical oxygen species), makes mtDNA more vulnerable to oxidative damage than nuclear DNA. Mitochondrial BER (base excision repair) is generally considered to be the main pathway involved in the prevention of oxidative lesion-in...

journal_title：DNA repair

authors： Kaniak A,Dzierzbicki P,Rogowska AT,Malc E,Fikus M,Ciesla Z

更新日期：2009-03-01 00:00:00

abstract：:Translesion synthesis (TLS) with specialized DNA polymerases allows dealing with a base lesion on the template strand during DNA replication; a base is inserted opposite the lesion, correctly or incorrectly, depending on the lesion, the involved DNA polymerase(s) and the sequence context. The major oxidized DNA base 8...

journal_title：DNA repair

authors： Nachtergael A,Belayew A,Duez P

更新日期：2014-10-01 00:00:00

abstract：:The RecQ family of helicases are traditionally viewed as recombination factors, important for maintaining genome stability. RECQL5 is unique among these proteins in being associated with RNA polymerase II, the enzyme responsible for transcribing all protein-encoding genes in eukaryotes. Here, we describe the possible ...

journal_title：DNA repair

authors： Aygün O,Svejstrup JQ

更新日期：2010-03-02 00:00:00

abstract：:In both Schizosaccharomyces pombe and Saccharomyces cerevisiae, Mms22 and Mms1 form a complex with important functions in the response to DNA damage, loss of which leads to perturbations during replication. Furthermore, in S. cerevisiae, Mms1 has been suggested to function in concert with a Cullin-like protein, Rtt101...

journal_title：DNA repair

authors： Vejrup-Hansen R,Mizuno K,Miyabe I,Fleck O,Holmberg C,Murray JM,Carr AM,Nielsen O

更新日期：2011-03-07 00:00:00

abstract：:Pyridine nucleotides are essential coenzymes in many cellular redox reactions in all living systems. In addition to functioning as a redox carrier, NAD(+) is also a required co-substrate for the conserved sirtuin deacetylases. Sirtuins regulate transcription, genome maintenance and metabolism and function as molecular...

journal_title：DNA repair

authors： Kato M,Lin SJ

更新日期：2014-11-01 00:00:00

abstract：:UVB radiation results in the formation of potentially mutagenic photoproducts in the DNA of epidermal skin cells. In vitro approaches have demonstrated that the nucleotide excision repair (NER) machinery removes UV photoproducts from DNA in the form of small (∼30-nt-long), excised, damage-containing DNA oligonucleotid...

journal_title：DNA repair

authors： Choi JH,Han S,Kemp MG

更新日期：2020-02-01 00:00:00

abstract：:Ubiquitin conjugation plays critical roles in virtually all DNA repair pathways. This review provides an overview of the known multi-domain RING/Ubox E3 ligases and their domain structures. An analysis of known RING/Ubox X-ray and NMR structures leads to a discussion of the effects of dimerization. Structural and mech...

journal_title：DNA repair

authors： Hibbert RG,Mattiroli F,Sixma TK

更新日期：2009-04-05 00:00:00

abstract：:Oxidative DNA damage is implicated in brain aging, neurodegeneration and neurological diseases. Damage can be created by normal cellular metabolism, which accumulates with age, or by acute cellular stress conditions which create bursts of oxidative damage. Brain cells have a particularly high basal level of metabolic ...

journal_title：DNA repair

authors： Canugovi C,Misiak M,Ferrarelli LK,Croteau DL,Bohr VA

更新日期：2013-08-01 00:00:00

abstract：:Mammalian cells have evolved sophisticated DNA repair systems to correct mispaired or damaged bases and extrahelical loops. Emerging evidence suggests that, in some cases, the normal DNA repair machinery is "hijacked" to become a causative factor in mutation and disease, rather than act as a safeguard of genomic integ...

journal_title：DNA repair

authors： McMurray CT

更新日期：2008-07-01 00:00:00

abstract：:Xeroderma pigmentosum (XP) is a genetic disorder associated with defects in nucleotide excision repair, a pathway that eliminates a wide variety of helix-distorting DNA lesions, including ultraviolet-induced pyrimidine dimers. In addition to skin diseases in sun-exposed areas, approximately 25% of XP patients develop ...

journal_title：DNA repair

authors： Mori T,Nakane H,Iwamoto T,Krokidis MG,Chatgilialoglu C,Tanaka K,Kaidoh T,Hasegawa M,Sugiura S

更新日期：2019-08-01 00:00:00

abstract：:By combining mutations in DNA repair genes, important and unexpected interactions between different repair pathways can be discovered. In this study, we identified a novel link between mismatch repair (MMR) genes and postreplication repair (PRR) in Saccharomyces cerevisiae. Strains lacking Rad5 (HLTF in mammals), a pr...

journal_title：DNA repair

authors： Berg IL,Persson JO,Åström SU

更新日期：2020-01-01 00:00:00

abstract：:Srs2 is a 3'-5' DNA helicase that regulates many aspects of DNA metabolism in Saccharomyces cerevisiae. It is best known for its ability to counteract homologous recombination by dismantling Rad51 filaments, but is also involved in checkpoint activation, adaptation and recovery, and in resolution of late recombination...

journal_title：DNA repair

authors： León Ortiz AM,Reid RJ,Dittmar JC,Rothstein R,Nicolas A

更新日期：2011-05-05 00:00:00

abstract：:I was born in January, 1921 and was fortunate in working for a research organization that had no fixed retirement age. I was permitted to continue Science as long as there were some resources to support research that had some relevance to the organization's goals. A number of projects on which I worked were continuati...

journal_title：DNA repair

authors： Setlow RB

更新日期：2004-04-01 00:00:00

abstract：:Among different DNA repair processes that cells use to face with DNA damage, nucleotide excision repair (NER) is particularly important for the removal of a high variety of lesions, including those generated by some antitumor drugs. A number of factors participating in NER, such as the TFIIH complex and the endonuclea...

journal_title：DNA repair

authors： Dutto I,Cazzalini O,Stivala LA,Prosperi E

更新日期：2017-03-01 00:00:00

abstract：:The majority of the cells in the body, including stem cells, exist in a quiescent state, so it is in quiescent cells where most DNA damage occurs. It has been uncertain whether or not this damage is repaired or fixed into mutations during quiescence or if proliferation is required for both. Prior to the development of...

journal_title：DNA repair

authors： Bielas JH,Heddle JA

更新日期：2004-07-02 00:00:00

abstract：:The human gene that encodes XRCC1 was cloned nearly thirty years ago but experimental analysis of this fascinating protein is still unveiling new insights into the DNA damage response. XRCC1 is a molecular scaffold protein that interacts with multiple enzymatic components of DNA single-strand break repair (SSBR) inclu...

journal_title：DNA repair

authors： Caldecott KW

更新日期：2019-09-01 00:00:00

abstract：:The efficiency and fidelity of nucleotide incorporation and next-base extension by DNA polymerase (pol) κ past N(2)-ethyl-Gua were measured using steady-state and rapid kinetic analyses. DNA pol κ incorporated nucleotides and extended 3' termini opposite N(2)-ethyl-Gua with measured efficiencies and fidelities similar...

journal_title：DNA repair

authors： Pence MG,Blans P,Zink CN,Fishbein JC,Perrino FW

更新日期：2011-01-02 00:00:00

abstract：:We studied how DNA divergence between recombining DNAs and the mismatch repair system modulate the SOS response in Escherichia coli. The observed positive log-linear correlation between SOS induction and DNA divergence, and the negative correlation between SOS induction and frequency of recombination, suggest that the...

journal_title：DNA repair

authors： Delmas S,Matic I

更新日期：2005-02-03 00:00:00

abstract：:Structure-prone DNA repeats are common components of genomic DNA in all kingdoms of life. In humans, these repeats are linked to genomic instabilities that result in various hereditary disorders, including many cancers. It has long been known that DNA repeats are not only highly polymorphic in length but can also caus...

journal_title：DNA repair

authors： Shah KA,Mirkin SM

更新日期：2015-08-01 00:00:00

abstract：:Mitochondria are membrane-bound organelles found in eukaryotic cells where they generate energy through the respiratory chain. They contain their own genome that encodes genes critical to the mitochondrial function, but most of their protein content is synthetized from nuclear encoded genes. Damages to the mtDNA can c...

journal_title：DNA repair

authors： Bernal M,Yang X,Lisby M,Mazón G

更新日期：2019-10-01 00:00:00

abstract：:The nonhomologous DNA end-joining pathway (NHEJ), a major pathway for repairing DNA double-strand breaks (DSBs), is essential for maintaining genomic stability. Knockout animals for components in this pathway demonstrate a distinct pattern of cell death in the developing brain. Here we demonstrate that cell death is a...

journal_title：DNA repair

authors： Karanjawala ZE,Hinton DR,Oh E,Hsieh CL,Lieber MR

更新日期：2003-12-09 00:00:00

abstract：:The repair of DNA double strand breaks is essential for cell survival and several conserved pathways have evolved to ensure their rapid and efficient repair. The non-homologous end joining pathway is initiated when Ku binds to the DNA break site. Ku is an abundant nuclear heterodimer of Ku70 and Ku80 with a toroidal s...

journal_title：DNA repair

authors： Grundy GJ,Moulding HA,Caldecott KW,Rulten SL

更新日期：2014-05-01 00:00:00

abstract：:The MutS2 homologues have been found widespread in most prokaryotes, which are involved in DNA repair and reactive oxygen species detoxification. The C-terminal small mutS-related (Smr) domain is critical for its endonucleolytic activity. However, the detailed catalytic mechanism is still unclear. In this study, we fi...

journal_title：DNA repair

authors： Zhang H,Xu Q,Lu M,Xu X,Wang Y,Wang L,Zhao Y,Hua Y

更新日期：2014-09-01 00:00:00

abstract：:Cancer-prone diseases ataxia-telangiectasia (AT), Nijmegen breakage syndrome (NBS) and ataxia-telangiectasia-like disorder (ATLD) are defective in the repair of DNA double-stranded break (DSB). On the other hand, arsenic (As) has been reported to cause DSB and to be involved in the occurrence of skin, lung and bladder...

journal_title：DNA repair

authors： Yuan SS,Su JH,Hou MF,Yang FW,Zhao S,Lee EY

更新日期：2002-02-28 00:00:00