Abstract：
:We studied how DNA divergence between recombining DNAs and the mismatch repair system modulate the SOS response in Escherichia coli. The observed positive log-linear correlation between SOS induction and DNA divergence, and the negative correlation between SOS induction and frequency of recombination, suggest that the level of SOS induction precisely reflects the difficulty of RecA protein to initiate a productive strand exchange process. Our results suggest that the mismatch repair system could contribute to this SOS induction more by affecting the RecA-catalyzed homology search than by acting on mismatched recombination intermediates. The propensity of the recombination machinery to promote recombination between the blocks of sequences with the highest identity results in the increasing ratios of merodiploids (partial diploids) over genuine recombinants (homologous replacements) with increasing DNA divergence. We discuss the role of molecular mechanisms involved in the control of the recombination between diverged DNA sequences in the maintenance of genomic stability and genome evolution.
journal_name
DNA Repair (Amst)journal_title
DNA repairauthors
Delmas S,Matic Idoi
10.1016/j.dnarep.2004.09.008keywords:
subject
Has Abstractpub_date
2005-02-03 00:00:00pages
221-9issue
2eissn
1568-7864issn
1568-7856pii
S1568-7864(04)00287-3journal_volume
4pub_type
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