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The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks.

Abstract：

:Mammalian cells possess multiple closely related SWI/SNF chromatin remodelling complexes. These complexes have been implicated in the cellular response to DNA double strand breaks (DSBs). Evidence suggests that SWI/SNF complexes contribute to successful repair via both the homologous recombination and non-homologous end joining pathways. In addition, repressing transcription near DSBs is dependent on SWI/SNF activity. Understanding these roles is important because SWI/SNF complexes are frequently dysregulated in cancer, and DNA DSB repair defects have the potential to be therapeutically exploited. In this graphical review, we summarise what is known about SWI/SNF contribution to DNA DSB responses in mammalian cells and provide an overview of the SWI/SNF-encoding gene alteration spectrum in human cancers.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Harrod A,Lane KA,Downs JA

doi

10.1016/j.dnarep.2020.102919

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

102919

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(20)30167-1

journal_volume

93

pub_type

杂志文章,评审

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