Abstract：
:Flaws in the DNA replication process have emerged as a leading driver of genome instability in human diseases. Alteration to replication fork progression is a defining feature of replication stress and the consequent failure to maintain fork integrity and complete genome duplication within a single round of S-phase compromises genetic integrity. This includes increased mutation rates, small and large scale genomic rearrangement and deleterious consequences for the subsequent mitosis that result in the transmission of additional DNA damage to the daughter cells. Therefore, preserving fork integrity and replication competence is an important aspect of how cells respond to replication stress and avoid genetic change. Homologous recombination is a pivotal pathway in the maintenance of genome integrity in the face of replication stress. Here we review our recent understanding of the mechanisms by which homologous recombination acts to protect, restart and repair replication forks. We discuss the dynamics of these genetically distinct functions and their contribution to faithful mitoticsegregation.
journal_name
DNA Repair (Amst)journal_title
DNA repairauthors
Ait Saada A,Lambert SAE,Carr AMdoi
10.1016/j.dnarep.2018.08.017subject
Has Abstractpub_date
2018-11-01 00:00:00pages
135-147eissn
1568-7864issn
1568-7856pii
S1568-7864(18)30182-4journal_volume
71pub_type
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