Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2.

abstract：:Oxidative stress via redox reactions can regulate DNA repair pathways. The base excision repair (BER) enzyme apurinic/apyrimidinic endonuclease 1 (APE1) is a key player in the redox regulation of DNA repair. Environmental factors can alter the methylation of DNA repair genes, change their expression and thus modulate ...

journal_title：DNA repair

authors： Langie SA,Kowalczyk P,Tomaszewski B,Vasilaki A,Maas LM,Moonen EJ,Palagani A,Godschalk RW,Tudek B,van Schooten FJ,Berghe WV,Zabielski R,Mathers JC

更新日期：2014-06-01 00:00:00

abstract：:The Karpas-620 human myeloma cell line (HMCL) expresses high levels of Cyclin D1 (CCND1), but has a der(8)t(8;11) and a der(14)t(8;14), and not a conventional t(11;14). Fluorescent in situ hybridization (FISH) and array comparative genomic hybridization (aCGH) studies suggest that der(14)t(11;14) from a primary transl...

journal_title：DNA repair

authors： Dib A,Glebov OK,Shou Y,Singer RH,Kuehl WM

更新日期：2009-03-01 00:00:00

abstract：:RecQ5 belongs to the RecQ DNA helicase family that includes genes causative of Bloom, Werner, and Rothmund-Thomson syndromes. Although no human disease has been genetically linked to a mutation in RecQ5, Drosophila melanogaster RecQ5 is highly expressed in early embryos, suggesting an important role for it in the DNA ...

journal_title：DNA repair

authors： Nakayama M,Yamaguchi S,Sagisu Y,Sakurai H,Ito F,Kawasaki K

更新日期：2009-02-01 00:00:00

abstract：:Mammalian cells have evolved sophisticated DNA repair systems to correct mispaired or damaged bases and extrahelical loops. Emerging evidence suggests that, in some cases, the normal DNA repair machinery is "hijacked" to become a causative factor in mutation and disease, rather than act as a safeguard of genomic integ...

journal_title：DNA repair

authors： McMurray CT

更新日期：2008-07-01 00:00:00

abstract：:OGG1 (8-oxoguanine-DNA glycosylase) is the major DNA repair glycosylase removing the premutagenic DNA base modification 8-oxo-7,8-dihydroguanine (8-oxoG) from the genome of mammalian cells. In addition, there is accumulating evidence that OGG1 and its substrate 8-oxoG might function in the regulation of certain genes,...

journal_title：DNA repair

authors： Seifermann M,Ulges A,Bopp T,Melcea S,Schäfer A,Oka S,Nakabeppu Y,Klungland A,Niehrs C,Epe B

更新日期：2017-10-01 00:00:00

abstract：:To investigate involvement of DNA mismatch repair in the response to short-wave ultraviolet (UVC) light, we compared UVC-induced mutant frequencies and mutational spectra at the Hprt gene between wild type and mismatch-repair-deficient mouse embryonic stem (ES) cells. Whereas mismatch repair gene status did not signif...

journal_title：DNA repair

authors： Borgdorff V,Pauw B,van Hees-Stuivenberg S,de Wind N

更新日期：2006-11-08 00:00:00

abstract：:The oxidation of the thymine methyl group can generate 5-formyluracil (FoU). Template FoU residues are known to miscode, generating base substitution mutations. The repair of the FoU lesion is therefore important in minimizing mutations induced by DNA oxidation. We have studied the repair of FoU in synthetic oligonucl...

journal_title：DNA repair

authors： Liu P,Burdzy A,Sowers LC

更新日期：2003-02-03 00:00:00

abstract：:The RecG protein of Escherichia coli is a double-stranded DNA translocase that unwinds a variety of branched DNAs in vitro, including Holliday junctions, replication forks, D-loops and R-loops. Coupled with the reported pleiotropy of recG mutations, this broad range of potential targets has made it hard to pin down wh...

journal_title：DNA repair

authors： Rudolph CJ,Upton AL,Briggs GS,Lloyd RG

更新日期：2010-03-02 00:00:00

abstract：:The Saccharomyces cerevisiae heterotrimeric checkpoint clamp consisting of the Rad17, Mec3, and Ddc1 subunits (Rad17/3/1, the 9-1-1 complex in humans) is an early response factor to DNA damage in a signal transduction pathway leading to the activation of the checkpoint system and eventually to cell cycle arrest. These...

journal_title：DNA repair

authors： Majka J,Burgers PM

更新日期：2005-09-28 00:00:00

abstract：:Nucleotide excision repair (NER), cell cycle regulation and apoptosis are major defence mechanisms against the carcinogenic effects of UVB radiation. NER eliminates UVB-induced DNA photolesions via two subpathways: global genome repair (GGR) and transcription-coupled repair (TCR). In a previous study, we found UVB-ind...

journal_title：DNA repair

authors： van Oosten M,Stout GJ,Backendorf C,Rebel H,de Wind N,Darroudi F,van Kranen HJ,de Gruijl FR,Mullenders LH

更新日期：2005-01-02 00:00:00

abstract：:Interaction between MutS and the replication factor β clamp has been extensively studied in a Mismatch Repair context; however, its functional consequences are not well understood. We have analyzed the role of the MutS-β clamp interaction in Pseudomonas aeruginosa by characterizing a β clamp binding motif mutant, deno...

journal_title：DNA repair

authors： Monti MR,Miguel V,Borgogno MV,Argaraña CE

更新日期：2012-05-01 00:00:00

abstract：:The XPB DNA helicase, a subunit of the basal transcription factor TFIIH, is also involved in nucleotide excision repair (NER). We examined recruitment of NER proteins in XP-B cells from patients with mild or severe xeroderma pigmentosum (XP) having different XPB mutations using local UV-irradiation through filters wit...

journal_title：DNA repair

authors： Oh KS,Imoto K,Boyle J,Khan SG,Kraemer KH

更新日期：2007-09-01 00:00:00

abstract：:RAre DAmage and Repair sequencing (RADAR-seq) is a highly adaptable sequencing method that enables the identification and detection of rare DNA damage events for a wide variety of DNA lesions at single-molecule resolution on a genome-wide scale. In RADAR-seq, DNA lesions are replaced with a patch of modified bases tha...

journal_title：DNA repair

authors： Zatopek KM,Potapov V,Maduzia LL,Alpaslan E,Chen L,Evans TC Jr,Ong JL,Ettwiller LM,Gardner AF

更新日期：2019-08-01 00:00:00

abstract：:Short-wave ultra-violet light promotes the formation of DNA dimers between adjacent thymine bases, and if unrepaired these dimers may induce skin cancer. Living cells have a very robust repair system capable of repairing hundreds of lesions every day. Although many of the details of the dimer repair mechanism are know...

journal_title：DNA repair

authors： Blagoev KB,Alexandrov BS,Goodwin EH,Bishop AR

更新日期：2006-07-13 00:00:00

abstract：:RECQL5 is one of the five human RecQ helicases, involved in the maintenance of genomic integrity. While much insight has been gained into the function of the Werner (WRN) and Bloom syndrome proteins (BLM), little is known about RECQL5. We have analyzed the recruitment and retention dynamics of RECQL5 at laser-induced ...

journal_title：DNA repair

authors： Popuri V,Ramamoorthy M,Tadokoro T,Singh DK,Karmakar P,Croteau DL,Bohr VA

更新日期：2012-07-01 00:00:00

abstract：:Deoxyinosine (dI) is produced in DNA by the hydrolytic or nitrosative deamination of deoxyadenosine. It is excised in a repair pathway that is initiated by endonuclease V, the product of the nfi gene. The repair was studied in vivo using high-efficiency oligonucleotide transformation mediated by the Beta protein of ba...

journal_title：DNA repair

authors： Weiss B

更新日期：2008-02-01 00:00:00

abstract：:Regulation of the vertebrate checkpoint kinase Chk1 involves several protein complexes including the recently identified protein Claspin. Claspin associates with Chk1 upon replication stress and DNA damage and is required for Chk1 activation in both Xenopus and human systems. More importantly, Claspin is involved in r...

journal_title：DNA repair

authors： Chini CC,Chen J

更新日期：2004-08-01 00:00:00

abstract：:Deinococcus radiodurans survives extremely high doses of ionizing and ultraviolet radiation and treatment with various DNA-damaging chemicals. As an effort to identify and characterize proteins that function in DNA repair in this organism, we have studied the protein encoded by locus DR1572. This gene is predicted to ...

journal_title：DNA repair

authors： Cao Z,Julin DA

更新日期：2009-05-01 00:00:00

abstract：:In eukaryotic cells, DNA associates with histones and exists in the form of a chromatin hierarchy. Thus, it is generally believed that many eukaryotic cellular DNA processing events such as replication, transcription, recombination and DNA repair are influenced by the packaging of DNA into chromatin. This mini-review ...

journal_title：DNA repair

authors： Liu X

更新日期：2015-12-01 00:00:00

abstract：:Accumulation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) in DNA is associated with mutagenesis and cell death. Little attention has been given to the biological significance of 8-oxo-dG accumulation in cardiovascular tissues during the different stage of hypertension and its prevention. We thus investigated the ...

journal_title：DNA repair

authors： Ohtsubo T,Ohya Y,Nakamura Y,Kansui Y,Furuichi M,Matsumura K,Fujii K,Iida M,Nakabeppu Y

更新日期：2007-06-01 00:00:00

abstract：:Brh2, the BRCA2 ortholog in the fungus Ustilago maydis, harbors two different DNA-binding domains, one located in the N-terminal region and the other located in the C-terminal region. Here we were interested in comparing the biochemical properties of Brh2 fragments, Brh2(NT) and Brh2(CT), respectively, harboring the t...

journal_title：DNA repair

authors： Zhou Q,Holloman WK

更新日期：2014-10-01 00:00:00

abstract：:Methylation of the O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter is associated with G:C to A:T transitions in the p53 gene in various human cancers, including lung cancer. In tumors with p53 mutation, MGMT promoter methylation is more common in advanced tumors than in early tumors. However, in tumors with w...

journal_title：DNA repair

authors： Lai JC,Cheng YW,Goan YG,Chang JT,Wu TC,Chen CY,Lee H

更新日期：2008-08-02 00:00:00

abstract：:The efficiency and fidelity of nucleotide incorporation and next-base extension by DNA polymerase (pol) κ past N(2)-ethyl-Gua were measured using steady-state and rapid kinetic analyses. DNA pol κ incorporated nucleotides and extended 3' termini opposite N(2)-ethyl-Gua with measured efficiencies and fidelities similar...

journal_title：DNA repair

authors： Pence MG,Blans P,Zink CN,Fishbein JC,Perrino FW

更新日期：2011-01-02 00:00:00

abstract：:Bacterial MutS2 proteins, consisting of functional domains for ATPase, DNA-binding, and nuclease activities, play roles in DNA recombination and repair. Here we observe a mechanism for generating MutS2 expression diversity in the human pathogen Helicobacter pylori, and identify a unique MutS2 domain responsible for sp...

journal_title：DNA repair

authors： Wang G,Maier RJ

更新日期：2017-09-01 00:00:00

abstract：:DNA polymerases play a crucial role in the cell cycle due to their involvement in genome replication and repair. Understanding the reaction mechanism by which these polymerases carry out their function can provide insights into these processes. Recently, the crystal structures of human DNA polymerase lambda (Pollambda...

journal_title：DNA repair

authors： Cisneros GA,Perera L,García-Díaz M,Bebenek K,Kunkel TA,Pedersen LG

更新日期：2008-11-01 00:00:00

abstract：:Mononucleotide microsatellites are tandem repeats of a single base pair, abundant within coding exons and frequent sites of mutation in the human genome. Because the repeated unit is one base pair, multiple mechanisms of insertion/deletion (indel) mutagenesis are possible, including strand-slippage, dNTP-stabilized, a...

journal_title：DNA repair

authors： Baptiste BA,Jacob KD,Eckert KA

更新日期：2015-05-01 00:00:00

abstract：:The First joint meeting of the German DGDR (German Society for Research on DNA Repair) and the French SFTG (French Society of Genotoxicology) on DNA Repair was held in Toulouse, France, from September 15 to 19, 2007. It was organized by Lisa Wiesmüller and Bernard Salles together with the scientific committee consisti...

journal_title：DNA repair

authors： Lavelle C,Salles B,Wiesmüller L

更新日期：2008-04-02 00:00:00

abstract：:DNA replication is a prerequisite for cell proliferation, yet it can be increasingly challenging for a eukaryotic cell to faithfully duplicate its genome as its size and complexity expands. Dormant origins now emerge as a key component for cells to successfully accomplish such a demanding but essential task. In this p...

journal_title：DNA repair

authors： Shima N,Pederson KD

更新日期：2017-08-01 00:00:00

abstract：:In all organisms studied to date, 8-oxoguanine (GO), an important oxidation product of guanine, is removed by highly conserved GO DNA glycosylases. The hyperthermophilic crenarchaeon Pyrobaculum aerophilum encodes a GO DNA glycosylase, Pa-AGOG (Archaeal GO DNA glycosylase) which has become the founding member of a new...

journal_title：DNA repair

authors： Lingaraju GM,Prota AE,Winkler FK

更新日期：2009-07-04 00:00:00

abstract：:Neuronal protection induced by ischemic preconditioning has an important role in the reduction of stroke volume and attenuation of neuronal cell death. Ischemic injury is associated with increased oxidative DNA damage, and failure to efficiently repair these oxidatively damaged lesions results in the accumulation of m...

journal_title：DNA repair

authors： Li N,Wu H,Yang S,Chen D

更新日期：2007-09-01 00:00:00