DNA repair, damage signaling and carcinogenesis.

Abstract:

:The First joint meeting of the German DGDR (German Society for Research on DNA Repair) and the French SFTG (French Society of Genotoxicology) on DNA Repair was held in Toulouse, France, from September 15 to 19, 2007. It was organized by Lisa Wiesmüller and Bernard Salles together with the scientific committee consisting of Gilbert de Murcia, Jean-Marc Egly, Frank Grosse, Karl-Peter Hopfner, Georges Iliakis, Bernd Kaina, Markus Löbrich, Bernard Lopez, Daniel Marzin and Alain Sarasin. This report summarizes information presented by the speakers (invited lectures and oral communications) during the seven plenary sessions, which include (1) excision repair, (2) DNA repair and carcinogenesis, (3) double-strand break repair, (4) replication in repair and lesion bypass, (5) cellular responses to genotoxic stress, (6) DNA repair machinery within the chromatin context and (7) genotoxicology and testing. A total of 23 plenary lectures, 32 oral communications and 66 posters were presented in this rather intense 4 days meeting, which stimulated extensive discussions and highly interdisciplinary scientific exchanges among the approximately 250 participants.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Lavelle C,Salles B,Wiesmüller L

doi

10.1016/j.dnarep.2007.12.007

subject

Has Abstract

pub_date

2008-04-02 00:00:00

pages

670-80

issue

4

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(07)00445-4

journal_volume

7

pub_type

  • Human OGG1 activity in nucleosomes is facilitated by transient unwrapping of DNA and is influenced by the local histone environment.

    abstract::If unrepaired, damage to genomic DNA can cause mutations and/or be cytotoxic. Single base lesions are repaired via the base excision repair (BER) pathway. The first step in BER is the recognition and removal of the nucleobase lesion by a glycosylase enzyme. For example, human oxoguanine glycosylase 1 (hOGG1) is respon...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2017.08.010

    authors: Bilotti K,Kennedy EE,Li C,Delaney S

    更新日期:2017-11-01 00:00:00

  • DNA polymerase I proofreading exonuclease activity is required for endonuclease V repair pathway both in vitro and in vivo.

    abstract::Deamination of adenine can occur spontaneously under physiological conditions to generate the highly mutagenic lesion, deoxyinosine (hypoxanthine deoxyribonucleotide, dI). In DNA, dI preferably pairs with cytosine rather than thymine and results in A:T to G:C transition mutations after DNA replication. The deamination...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2018.02.005

    authors: Su KY,Lin LI,Goodman SD,Yen RS,Wu CY,Chang WC,Yang YC,Cheng WC,Fang WH

    更新日期:2018-04-01 00:00:00

  • Multiple uracil-DNA glycosylase activities in Deinococcus radiodurans.

    abstract::The extremely radiation resistant bacterium, Deinococcus radiodurans, contains a spectrum of genes that encode for multiple activities that repair DNA damage. We have cloned and expressed the product of three predicted uracil-DNA glycosylases to determine their biochemical function. DR0689 is a homologue of the Escher...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2003.10.011

    authors: Sandigursky M,Sandigursky S,Sonati P,Daly MJ,Franklin WA

    更新日期:2004-02-03 00:00:00

  • Mechanism of cell killing after ionizing radiation by a dominant negative DNA polymerase beta.

    abstract::Several types of DNA lesion are induced after ionizing irradiation (IR) of which double strand breaks (DSBs) are expected to be the most lethal, although single strand breaks (SSBs) and DNA base damages are quantitatively in the majority. Proteins of the base excision repair (BER) pathway repair these numerous lesions...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2008.11.008

    authors: Neijenhuis S,Verwijs-Janssen M,Kasten-Pisula U,Rumping G,Borgmann K,Dikomey E,Begg AC,Vens C

    更新日期:2009-03-01 00:00:00

  • Determinants of sequence-specificity within human AID and APOBEC3G.

    abstract::Human APOBEC3G (A3G) and activation-induced deaminase (AID) belong to a family of DNA-cytosine deaminases. While A3G targets the last C in a run of C's, AID targets C in the consensus sequence WRC (W is A or T and R is a purine). Guided by the structures of the A3G carboxyl-terminal catalytic domain (A3G-CTD), we iden...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2010.02.010

    authors: Carpenter MA,Rajagurubandara E,Wijesinghe P,Bhagwat AS

    更新日期:2010-05-04 00:00:00

  • A shared DNA-damage-response pathway for induction of stem-cell death by UVB and by gamma irradiation.

    abstract::Both UVB radiation and DNA-breaking agents were previously reported to kill Arabidopsis stem cells. We demonstrate that death induced by UVB or by ionizing radiation (IR) requires Suppressor of Gamma Response 1 (SOG1), a transcription factor already found to govern many responses to these agents in Arabidopsis. DNA-da...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2010.06.006

    authors: Furukawa T,Curtis MJ,Tominey CM,Duong YH,Wilcox BW,Aggoune D,Hays JB,Britt AB

    更新日期:2010-09-04 00:00:00

  • The role of the DNA damage response in neuronal development, organization and maintenance.

    abstract::The DNA damage response is a key factor in the maintenance of genome stability. As such, it is a central axis in sustaining cellular homeostasis in a variety of contexts: development, growth, differentiation, and maintenance of the normal life cycle of the cell. It is now clear that diverse mechanisms encompassing cel...

    journal_title:DNA repair

    pub_type: 杂志文章,评审

    doi:10.1016/j.dnarep.2008.03.005

    authors: Barzilai A,Biton S,Shiloh Y

    更新日期:2008-07-01 00:00:00

  • Novel role of tyrosine in catalysis by human AP endonuclease 1.

    abstract::Apurinic/apyrimidinic endonuclease (AP endo, HAP1) recognizes abasic sites in ds DNA and makes a single nick in the backbone 5' to the abasic site. In this report we examine the roles of three conserved tyrosine residues in close proximity to the active site. We show that Tyr(128) and Tyr(269), which interact upstream...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2004.06.009

    authors: Mundle ST,Fattal MH,Melo LF,Coriolan JD,O'Regan NE,Strauss PR

    更新日期:2004-11-02 00:00:00

  • Current role of mammalian sirtuins in DNA repair.

    abstract::Cellular DNA is constantly challenged by damage-inducing factors derived from exogenous or endogenous sources. Thus, to protect against DNA damage, cells have evolved complex and finely regulated mechanisms collectively known as DNA-damage response (DDR). However, DNA repair in eukaryotes does not occur merely in nake...

    journal_title:DNA repair

    pub_type: 杂志文章,评审

    doi:10.1016/j.dnarep.2019.06.009

    authors: Lagunas-Rangel FA

    更新日期:2019-08-01 00:00:00

  • The hidden side of unstable DNA repeats: Mutagenesis at a distance.

    abstract::Structure-prone DNA repeats are common components of genomic DNA in all kingdoms of life. In humans, these repeats are linked to genomic instabilities that result in various hereditary disorders, including many cancers. It has long been known that DNA repeats are not only highly polymorphic in length but can also caus...

    journal_title:DNA repair

    pub_type: 杂志文章,评审

    doi:10.1016/j.dnarep.2015.04.020

    authors: Shah KA,Mirkin SM

    更新日期:2015-08-01 00:00:00

  • XPA protein as a limiting factor for nucleotide excision repair and UV sensitivity in human cells.

    abstract::Nucleotide excision repair (NER) acts on a variety of DNA lesions, including damage induced by many chemotherapeutic drugs. Cancer therapy with such drugs might be improved by reducing the NER capacity of tumors. It is not known, however to what extent any individual NER protein is rate-limiting for any step of the re...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2005.12.001

    authors: Köberle B,Roginskaya V,Wood RD

    更新日期:2006-05-10 00:00:00

  • Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease.

    abstract::Mammalian cells have evolved sophisticated DNA repair systems to correct mispaired or damaged bases and extrahelical loops. Emerging evidence suggests that, in some cases, the normal DNA repair machinery is "hijacked" to become a causative factor in mutation and disease, rather than act as a safeguard of genomic integ...

    journal_title:DNA repair

    pub_type: 杂志文章,评审

    doi:10.1016/j.dnarep.2008.03.013

    authors: McMurray CT

    更新日期:2008-07-01 00:00:00

  • Mutational studies of Pa-AGOG DNA glycosylase from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum.

    abstract::In all organisms studied to date, 8-oxoguanine (GO), an important oxidation product of guanine, is removed by highly conserved GO DNA glycosylases. The hyperthermophilic crenarchaeon Pyrobaculum aerophilum encodes a GO DNA glycosylase, Pa-AGOG (Archaeal GO DNA glycosylase) which has become the founding member of a new...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2009.03.009

    authors: Lingaraju GM,Prota AE,Winkler FK

    更新日期:2009-07-04 00:00:00

  • MutSα deficiency increases tolerance to DNA damage in yeast lacking postreplication repair.

    abstract::By combining mutations in DNA repair genes, important and unexpected interactions between different repair pathways can be discovered. In this study, we identified a novel link between mismatch repair (MMR) genes and postreplication repair (PRR) in Saccharomyces cerevisiae. Strains lacking Rad5 (HLTF in mammals), a pr...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2020.102870

    authors: Berg IL,Persson JO,Åström SU

    更新日期:2020-01-01 00:00:00

  • Reversibility of replicative senescence in Saccharomyces cerevisiae: effect of homologous recombination and cell cycle checkpoints.

    abstract::Primary human somatic cells grown in culture divide a finite number of times, exhibiting progressive changes in metabolism and morphology before cessation of cycling. This telomere-initiated cellular senescence occurs because cells have halted production of telomerase, a DNA polymerase required for stabilization of ch...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2011.10.003

    authors: Becerra SC,Thambugala HT,Erickson AR,Lee CK,Lewis LK

    更新日期:2012-01-02 00:00:00

  • Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae.

    abstract::In eukaryotes, mutations in a number of genes that affect DNA damage checkpoints or DNA replication also affect telomere length [Curr. Opin. Cell Biol. 13 (2001) 281]. Saccharomyces cerevisae strains with mutations in the TEL1 gene (encoding an ATM-like protein kinase) have very short telomeres, as do strains with mut...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/s1568-7864(03)00115-0

    authors: Mallory JC,Bashkirov VI,Trujillo KM,Solinger JA,Dominska M,Sung P,Heyer WD,Petes TD

    更新日期:2003-09-18 00:00:00

  • RecBC enzyme overproduction affects UV and gamma radiation survival of Deinococcus radiodurans.

    abstract::Deinococcus radiodurans recovering from the effect of acute dose of gamma (gamma) radiation shows a biphasic mechanism of DNA double strands breaks repair that involves an efficient homologous recombination. However, it shows higher sensitivity to near-UV (NUV) than Escherichia coli and lacks RecBC, a DNA strand break...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2007.07.007

    authors: Khairnar NP,Kamble VA,Misra HS

    更新日期:2008-01-01 00:00:00

  • Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability.

    abstract::MutT enzymes prevent DNA damage by hydrolysis of 8-oxodGTP, an oxidized substrate for DNA synthesis and antimutagenic, anticarcinogenic, and antineurodegenerative functions of MutT enzymes are well established. MutT has been found in almost all kingdoms of life, including many bacterial species, yeasts, plants and mam...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2010.10.009

    authors: Arczewska KD,Baumeier C,Kassahun H,Sengupta T,Bjørås M,Kuśmierek JT,Nilsen H

    更新日期:2011-02-07 00:00:00

  • Ischemic preconditioning induces XRCC1, DNA polymerase-beta, and DNA ligase III and correlates with enhanced base excision repair.

    abstract::Neuronal protection induced by ischemic preconditioning has an important role in the reduction of stroke volume and attenuation of neuronal cell death. Ischemic injury is associated with increased oxidative DNA damage, and failure to efficiently repair these oxidatively damaged lesions results in the accumulation of m...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2007.02.027

    authors: Li N,Wu H,Yang S,Chen D

    更新日期:2007-09-01 00:00:00

  • A C. elegans homolog of the Cockayne syndrome complementation group A gene.

    abstract::Cockayne syndrome (CS) is a debilitating and complex disorder that results from inherited mutations in the CS complementation genes A and B, CSA and CSB. The links between the molecular functions of the CS genes and the complex pathophysiology of CS are as of yet poorly understood and are the subject of intense debate...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2014.09.011

    authors: Babu V,Hofmann K,Schumacher B

    更新日期:2014-12-01 00:00:00

  • SSB recruitment of Exonuclease I aborts template-switching in Escherichia coli.

    abstract::Misalignment of a nascent strand and the use of an alternative template during DNA replication, a process termed "template-switching", can give rise to frequent mutations and genetic rearrangements. Mutational hotspots are frequently found associated with imperfect inverted repeats ("quasipalindromes" or "QPs") in man...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2017.05.007

    authors: Laranjo LT,Gross SJ,Zeiger DM,Lovett ST

    更新日期:2017-09-01 00:00:00

  • Human MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway.

    abstract::The Fanconi Anemia (FA) pathway encodes a DNA damage response activated by DNA damage-stalled replication forks. Current evidence suggests that the FA pathway initiates with DNA damage recognition by the FANCM complex (FANCM/FAAP24/MHF). However, genetic inactivation of FANCM in mouse and DT40 cells causes only a part...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2011.09.006

    authors: Huang M,Kennedy R,Ali AM,Moreau LA,Meetei AR,D'Andrea AD,Chen CC

    更新日期:2011-12-10 00:00:00

  • A second life in science--working after the age of 65.

    abstract::I was born in January, 1921 and was fortunate in working for a research organization that had no fixed retirement age. I was permitted to continue Science as long as there were some resources to support research that had some relevance to the organization's goals. A number of projects on which I worked were continuati...

    journal_title:DNA repair

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.dnarep.2003.04.002

    authors: Setlow RB

    更新日期:2004-04-01 00:00:00

  • The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression.

    abstract::The DNA damage response (DDR) pathway's primary purpose is to maintain the genome structure's integrity and stability. A great deal of effort has done to understand the exact molecular mechanisms of non-coding RNAs, such as lncRNA, miRNAs, and circRNAs, in distinct cellular and genomic processes and cancer progression...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2020.103036

    authors: Malakoti F,Alemi F,Younesi S,Majidinia M,Yousefi B,Morovat P,Khelghati N,Maleki M,Karimian A,Asemi Z

    更新日期:2021-01-07 00:00:00

  • Kinetic analysis of DNA double-strand break repair pathways in Arabidopsis.

    abstract::Double-strand breaks in genomic DNA (DSB) are potentially lethal lesions which separate parts of chromosome arms from their centromeres. Repair of DSB by recombination can generate mutations and further chromosomal rearrangements, making the regulation of recombination and the choice of recombination pathways of the h...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2011.04.002

    authors: Charbonnel C,Allain E,Gallego ME,White CI

    更新日期:2011-06-10 00:00:00

  • Poetry in motion: Increased chromosomal mobility after DNA damage.

    abstract::Double-strand breaks (DSBs) are among the most lethal DNA lesions, and a variety of pathways have evolved to manage their repair in a timely fashion. One such pathway is homologous recombination (HR), in which information from an undamaged donor site is used as a template for repair. Although many of the biochemical s...

    journal_title:DNA repair

    pub_type: 杂志文章,评审

    doi:10.1016/j.dnarep.2017.06.012

    authors: Smith MJ,Rothstein R

    更新日期:2017-08-01 00:00:00

  • Slow accumulation of mutations in Xpc-/- mice upon induction of oxidative stress.

    abstract::XPC is one of the key DNA damage recognition proteins in the global genome repair route of the nucleotide excision repair (NER) pathway. Previously, we demonstrated that NER-deficient mouse models Xpa(-/-) and Xpc(-/-) exhibit a divergent spontaneous tumor spectrum and proposed that XPC might be functionally involved ...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2013.08.019

    authors: Melis JP,Kuiper RV,Zwart E,Robinson J,Pennings JL,van Oostrom CT,Luijten M,van Steeg H

    更新日期:2013-12-01 00:00:00

  • Ultra-violet light induced changes in DNA dynamics may enhance TT-dimer recognition.

    abstract::Short-wave ultra-violet light promotes the formation of DNA dimers between adjacent thymine bases, and if unrepaired these dimers may induce skin cancer. Living cells have a very robust repair system capable of repairing hundreds of lesions every day. Although many of the details of the dimer repair mechanism are know...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2006.04.007

    authors: Blagoev KB,Alexandrov BS,Goodwin EH,Bishop AR

    更新日期:2006-07-13 00:00:00

  • Molecular basis for the functions of a bacterial MutS2 in DNA repair and recombination.

    abstract::Bacterial MutS2 proteins, consisting of functional domains for ATPase, DNA-binding, and nuclease activities, play roles in DNA recombination and repair. Here we observe a mechanism for generating MutS2 expression diversity in the human pathogen Helicobacter pylori, and identify a unique MutS2 domain responsible for sp...

    journal_title:DNA repair

    pub_type: 杂志文章

    doi:10.1016/j.dnarep.2017.07.004

    authors: Wang G,Maier RJ

    更新日期:2017-09-01 00:00:00

  • DNA mismatch repair preferentially safeguards actively transcribed genes.

    abstract::DNA mismatch repair (MMR) is an evolutionally conserved genome maintenance pathway and is well known for its role in maintaining replication fidelity by correcting biosynthetic errors generated during DNA replication. However, recent studies have shown that MMR preferentially protects actively transcribed genes from m...

    journal_title:DNA repair

    pub_type: 杂志文章,评审

    doi:10.1016/j.dnarep.2018.08.010

    authors: Huang Y,Li GM

    更新日期:2018-11-01 00:00:00